Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | immunophilin | 0.0107 | 0.6719 | 0.6596 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0126 | 0.9983 | 0.9982 |
Echinococcus multilocularis | aminopeptidase N | 0.0126 | 1 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0107 | 0.6719 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0107 | 0.6719 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0126 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0092 | 0.424 | 0.4004 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0126 | 0.9983 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0126 | 0.9983 | 1 |
Brugia malayi | hypothetical protein | 0.0103 | 0.5989 | 0.5824 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0107 | 0.6719 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0107 | 0.6719 | 0.6596 |
Leishmania major | fk506-binding protein 1-like protein | 0.0107 | 0.6719 | 1 |
Onchocerca volvulus | 0.0126 | 1 | 0.5 | |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0107 | 0.6719 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0092 | 0.424 | 0.4004 |
Schistosoma mansoni | immunophilin | 0.0107 | 0.6719 | 0.6596 |
Mycobacterium leprae | PROBABLE AMINOPEPTIDASE PEPC | 0.0069 | 0.0395 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.424 | 0.4011 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0107 | 0.6719 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0107 | 0.6719 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0107 | 0.6719 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0107 | 0.6719 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0107 | 0.6719 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0107 | 0.6719 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0126 | 0.9983 | 0.9982 |
Trichomonas vaginalis | immunophilin, putative | 0.0107 | 0.6719 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.6006 | 0.5852 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0107 | 0.6719 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0107 | 0.6719 | 0.6584 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0105 | 0.6317 | 0.6177 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2323 | 0.2011 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0107 | 0.6719 | 0.6584 |
Echinococcus multilocularis | fk506 binding protein | 0.0107 | 0.6719 | 0.6584 |
Loa Loa (eye worm) | FKBP5 protein | 0.0107 | 0.6719 | 0.6596 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0107 | 0.6719 | 0.6584 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0107 | 0.6719 | 0.6596 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0107 | 0.6719 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0107 | 0.6719 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0107 | 0.6719 | 1 |
Mycobacterium tuberculosis | Probable aminopeptidase PepC | 0.0069 | 0.0395 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0107 | 0.6719 | 0.6584 |
Schistosoma mansoni | immunophilin | 0.0092 | 0.424 | 0.4011 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0107 | 0.6719 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0107 | 0.6719 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0107 | 0.6719 | 0.6584 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0107 | 0.6719 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0107 | 0.6719 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = 44 % | Percent change in triglycerides in hypercholesterolemic rats at a dose of 100 mg/kg/day for 8 days | ChEMBL. | 14736248 |
Change (functional) | = 53 % | Percent change in total plasma cholesterol in hypercholesterolemic rats dosed at 100 mg/kg/day for 8 days | ChEMBL. | 14736248 |
Change (functional) | = 76 % | Percent change in high-density lipoprotein cholesterol in hypercholesterolemic rats dosed at 100 mg/kg/day for 8 days | ChEMBL. | 14736248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.