Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.015 | 0.1217 | 0.3937 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0271 | 0.3003 | 0.3003 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0156 | 0.1303 | 0.4338 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0156 | 0.1303 | 0.4212 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0972 | 0.0972 |
Echinococcus granulosus | cathepsin l1 | 0.0271 | 0.3003 | 0.3003 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1786 | 0.1786 |
Plasmodium vivax | vivapain-1 | 0.015 | 0.1217 | 0.4054 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0156 | 0.1303 | 0.1303 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Loa Loa (eye worm) | ctsf protein | 0.0271 | 0.3003 | 0.3003 |
Onchocerca volvulus | 0.0271 | 0.3003 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0271 | 0.3003 | 0.3003 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1786 | 0.1786 |
Brugia malayi | Cathepsin L-like precursor | 0.0271 | 0.3003 | 0.3003 |
Brugia malayi | Cathepsin L-like precursor | 0.0083 | 0.0229 | 0.0229 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0277 | 0.3093 | 0.3093 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0133 | 0.0972 | 0.0972 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0229 | 0.0229 |
Leishmania major | cathepsin L-like protease | 0.0271 | 0.3003 | 0.9499 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0156 | 0.1303 | 0.4338 |
Brugia malayi | Trypsin family protein | 0.0133 | 0.0972 | 0.0972 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0156 | 0.1303 | 0.1303 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1786 | 0.1786 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0156 | 0.1303 | 0.4212 |
Loa Loa (eye worm) | fibroinase | 0.0271 | 0.3003 | 0.3003 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.015 | 0.1217 | 0.1217 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0156 | 0.1303 | 0.1303 |
Leishmania major | cathepsin L-like protease | 0.0271 | 0.3003 | 0.9499 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0271 | 0.3003 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Onchocerca volvulus | 0.0271 | 0.3003 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0271 | 0.3003 | 0.3003 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.015 | 0.1217 | 0.3937 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0271 | 0.3003 | 0.3003 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0229 | 0.0229 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.015 | 0.1217 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.015 | 0.1217 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.015 | 0.1217 | 0.1217 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0746 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.015 | 0.1217 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0271 | 0.3003 | 0.3003 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0188 | 0.1786 | 0.1786 |
Toxoplasma gondii | cathepsin CPL | 0.0271 | 0.3003 | 0.971 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0271 | 0.3003 | 0.3003 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0156 | 0.1303 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0271 | 0.3003 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.0271 | 0.3003 | 1 |
Leishmania major | cathepsin L-like protease | 0.0271 | 0.3003 | 0.9499 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0188 | 0.1786 | 0.1786 |
Leishmania major | cathepsin L-like protease | 0.0271 | 0.3003 | 0.9499 |
Brugia malayi | Cathepsin L-like precursor | 0.0271 | 0.3003 | 0.3003 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0271 | 0.3003 | 0.3003 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Toxoplasma gondii | cathepsin B | 0.0277 | 0.3093 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.015 | 0.1217 | 0.1217 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0277 | 0.3093 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0271 | 0.3003 | 0.3003 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0156 | 0.1303 | 0.1303 |
Onchocerca volvulus | 0.0133 | 0.0972 | 0.3236 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Echinococcus multilocularis | cathepsin b | 0.0746 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0271 | 0.3003 | 0.3003 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0156 | 0.1303 | 0.0455 |
Plasmodium vivax | RNA helicase-1, putative | 0.0156 | 0.1303 | 0.4338 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0271 | 0.3003 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0156 | 0.1303 | 0.1303 |
Leishmania major | cathepsin L-like protease | 0.0271 | 0.3003 | 0.9499 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0156 | 0.1303 | 0.4212 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0271 | 0.3003 | 0.3003 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0083 | 0.0229 | 0.0229 |
Leishmania major | cathepsin L-like protease | 0.0271 | 0.3003 | 0.9499 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0271 | 0.3003 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0271 | 0.3003 | 0.3003 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0156 | 0.1303 | 0.1303 |
Onchocerca volvulus | Cathepsin L homolog | 0.0271 | 0.3003 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0083 | 0.0229 | 0.0229 |
Entamoeba histolytica | cysteine protease, putative | 0.0271 | 0.3003 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.015 | 0.1217 | 0.1217 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0133 | 0.0965 | 0.0965 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0188 | 0.1786 | 0.1786 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.015 | 0.1217 | 0.1217 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0746 | 1 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0156 | 0.1303 | 0.4338 |
Echinococcus granulosus | cathepsin L | 0.015 | 0.1217 | 0.1217 |
Onchocerca volvulus | Cathepsin L homolog | 0.0271 | 0.3003 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0156 | 0.1303 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.0271 | 0.3003 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0271 | 0.3003 | 0.9499 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.015 | 0.1217 | 0.1217 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0156 | 0.1303 | 0.4212 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Entamoeba histolytica | cysteine proteinase, putative | 0.015 | 0.1217 | 0.4054 |
Schistosoma mansoni | cathepsin s | 0.0083 | 0.0229 | 0.0229 |
Giardia lamblia | Cathepsin B precursor | 0.0277 | 0.3093 | 1 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0133 | 0.0965 | 0.0965 |
Echinococcus granulosus | cysteine protease | 0.015 | 0.1217 | 0.1217 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0271 | 0.3003 | 0.3003 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0277 | 0.3093 | 0.3093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.1786 | 0.5774 |
Trypanosoma cruzi | cysteine protease, putative | 0.015 | 0.1217 | 0.1217 |
Onchocerca volvulus | 0.0271 | 0.3003 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0271 | 0.3003 | 0.3003 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0271 | 0.3003 | 0.3003 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.015 | 0.1217 | 0.1217 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0965 | 0.0965 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0271 | 0.3003 | 0.3003 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0188 | 0.1786 | 0.5946 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0156 | 0.1303 | 0.1303 |
Loa Loa (eye worm) | cathepsin B | 0.0277 | 0.3093 | 0.3093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0277 | 0.3093 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0188 | 0.1786 | 0.1786 |
Brugia malayi | cathepsin L-like precursor | 0.0188 | 0.1786 | 0.1786 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0277 | 0.3093 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0746 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0271 | 0.3003 | 0.3003 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Echinococcus multilocularis | cathepsin b | 0.0746 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0271 | 0.3003 | 0.9499 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.3003 | 0.3003 |
Onchocerca volvulus | 0.0271 | 0.3003 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0746 | 1 | 1 |
Onchocerca volvulus | 0.0271 | 0.3003 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0188 | 0.1786 | 0.1786 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0271 | 0.3003 | 0.3003 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0271 | 0.3003 | 1 |
Onchocerca volvulus | 0.0271 | 0.3003 | 1 | |
Onchocerca volvulus | 0.0271 | 0.3003 | 1 | |
Plasmodium vivax | vivapain-3 | 0.015 | 0.1217 | 0.4054 |
Plasmodium vivax | unspecified product | 0.015 | 0.1217 | 0.4054 |
Plasmodium vivax | unspecified product | 0.0083 | 0.0229 | 0.0761 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0083 | 0.0229 | 0.0229 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.015 | 0.1217 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0156 | 0.1303 | 0.1303 |
Entamoeba histolytica | cysteine proteinase, putative | 0.015 | 0.1217 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0083 | 0.0229 | 0.0229 |
Brugia malayi | Cathepsin L-like precursor | 0.0271 | 0.3003 | 0.3003 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0229 | 0.0229 |
Entamoeba histolytica | cysteine proteinase, putative | 0.015 | 0.1217 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.015 | 0.1217 | 0.1217 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0156 | 0.1303 | 0.1303 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Brugia malayi | Cathepsin L-like precursor | 0.0188 | 0.1786 | 0.1786 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0188 | 0.1786 | 0.5774 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0083 | 0.0229 | 0.0229 |
Brugia malayi | Cathepsin L-like precursor | 0.0271 | 0.3003 | 0.3003 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0271 | 0.3003 | 0.3003 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.015 | 0.1217 | 0.1217 |
Echinococcus multilocularis | cathepsin L | 0.015 | 0.1217 | 0.1217 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0271 | 0.3003 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0271 | 0.3003 | 0.3003 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0271 | 0.3003 | 0.3003 |
Giardia lamblia | Cathepsin B precursor | 0.0277 | 0.3093 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0156 | 0.1303 | 0.4212 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.015 | 0.1217 | 0.1217 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0271 | 0.3003 | 0.971 |
Leishmania major | cathepsin L-like protease | 0.0271 | 0.3003 | 0.9499 |
Loa Loa (eye worm) | cysteine protease | 0.0271 | 0.3003 | 0.3003 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Giardia lamblia | Cathepsin B precursor | 0.0277 | 0.3093 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0271 | 0.3003 | 0.9522 |
Entamoeba histolytica | cysteine protease, putative | 0.015 | 0.1217 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1303 | 0.1303 |
Onchocerca volvulus | 0.0188 | 0.1786 | 0.5946 | |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0972 | 0.0972 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0746 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0746 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0746 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0133 | 0.0972 | 0.0972 |
Onchocerca volvulus | 0.009 | 0.0337 | 0.1123 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 9.94 mg kg-1 | Anticonvulsant activity against tonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg | ChEMBL. | 9111300 |
ED50 (functional) | = 9.94 mg kg-1 | Anticonvulsant activity against tonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg | ChEMBL. | 9111300 |
ED50 (functional) | = 11.9 mg kg-1 | Anticonvulsant activity against clonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg | ChEMBL. | 9111300 |
ED50 (functional) | = 11.9 mg kg-1 | Anticonvulsant activity against clonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg | ChEMBL. | 9111300 |
ED50 (functional) | = 30.6 uM | In vivo anticonvulsant activity was measured as median effective dose required to prevent tonic phase of seizure in DBA/2 mice | ChEMBL. | 15027880 |
ED50 (functional) | = 30.6 uM | In vivo anticonvulsant activity was measured as median effective dose required to prevent tonic phase of seizure in DBA/2 mice | ChEMBL. | 15027880 |
ED50 (functional) | = 36.8 uM | In vivo anticonvulsant activity was measured as median effective dose required to prevent clonic phase of seizure in DBA/2 mice | ChEMBL. | 15027880 |
ED50 (functional) | = 36.8 uM | In vivo anticonvulsant activity was measured as median effective dose required to prevent clonic phase of seizure in DBA/2 mice | ChEMBL. | 15027880 |
ED50 (functional) | = 30.6 uM kg-1 | Anticonvulsant activity against tonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg | ChEMBL. | 9111300 |
ED50 (functional) | = 30.6 uM kg-1 | Anticonvulsant activity against tonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg | ChEMBL. | 9111300 |
ED50 (functional) | = 36.8 uM kg-1 | Anticonvulsant activity against clonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg | ChEMBL. | 9111300 |
ED50 (functional) | = 36.8 uM kg-1 | Anticonvulsant activity against clonic phase of the audiogenic seizures in DBA / 2 mice 30 min after ip administration at a dose range 10-66 microM/kg | ChEMBL. | 9111300 |
Rm | = -0.327 | Relative lipophilicity of compound | ChEMBL. | 9111300 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.