TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 270.25 | Formula: C13H13F3N2O
H donors: 1 H acceptors: 1 LogP: 3.01 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)C(F)(F)F)NN1CCC=CC1
InChi: 1S/C13H13F3N2O/c14-13(15,16)11-6-4-10(5-7-11)12(19)17-18-8-2-1-3-9-18/h1-2,4-7H,3,8-9H2,(H,17,19)
InChiKey: AJDDHBCMYRDFMW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0191	0.4035	0.4043
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0079	0.0984	0.0986
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.0984	0.1065
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0144	0.275	0.9095
Echinococcus multilocularis	calpain	0.0144	0.275	0.272
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0208	0.0225
Entamoeba histolytica	cysteine proteinase 2	0.0079	0.0984	0.3256
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0062	0.0501	0.1656
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Mycobacterium tuberculosis	Probable reductase	0.0106	0.1703	0.8342
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3024	0.3272
Onchocerca volvulus		0.0154	0.3024	0.5408
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0062	0.0501	0.1656
Schistosoma mansoni	calpain-7 (C02 family)	0.0144	0.275	0.2755
Echinococcus multilocularis	calpain A	0.041	1	1
Trypanosoma brucei	trypanothione reductase	0.0046	0.0083	0.0273
Brugia malayi	Fibulin-1 precursor	0.0062	0.0501	0.0542
Echinococcus multilocularis	calpain 7 (C02 family)	0.0144	0.275	0.272
Trypanosoma cruzi	kinesin, putative	0.0101	0.1568	0.5186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.1633	0.5402
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0056	0.0331	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0184	0.3823	0.4137
Leishmania major	cathepsin L-like protease	0.0154	0.3024	1
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3024	0.3272
Echinococcus granulosus	calpain 7 C02 family	0.0144	0.275	0.272
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.0984	0.3256
Echinococcus multilocularis	cysteine protease	0.0154	0.3024	0.2995
Trypanosoma cruzi	cysteine peptidase, putative	0.0051	0.0208	0.0689
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0984	0.3256
Onchocerca volvulus		0.0154	0.3024	0.5408
Echinococcus multilocularis	hypothetical protein	0.0144	0.275	0.272
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0154	0.3024	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0079	0.0984	0.0986
Brugia malayi	Calcium binding EGF domain containing protein	0.0062	0.0501	0.0542
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0154	0.3024	0.3272
Onchocerca volvulus		0.0103	0.1633	0.2616
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0079	0.0984	0.3256
Brugia malayi	cathepsin F-like cysteine proteinase	0.0051	0.0208	0.0225
Onchocerca volvulus	Cathepsin F homolog	0.0154	0.3024	0.5408
Onchocerca volvulus		0.0154	0.3024	0.5408
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0154	0.3024	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3024	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3024	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0041	0.0041
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0144	0.275	0.9095
Echinococcus granulosus	Tolloid protein 1	0.0191	0.4035	0.4011
Loa Loa (eye worm)	calpain 5	0.0101	0.1568	0.1697
Onchocerca volvulus		0.0154	0.3024	0.5408
Echinococcus multilocularis	fibrillin 1	0.0062	0.0501	0.0461
Entamoeba histolytica	protein kinase, putative	0.0101	0.1568	0.5186
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3024	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0103	0.1633	0.1767
Trypanosoma brucei	calpain-like protein, putative	0.0144	0.275	0.9095
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0154	0.3024	0.2995
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0154	0.3024	0.2995
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0144	0.275	0.9095
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.0984	0.3256
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0144	0.275	0.9095
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3024	1
Loa Loa (eye worm)	calpain family protein 1	0.0282	0.6492	0.7024
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0083	0.0273
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0062	0.0501	0.0542
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0056	0.0331	0.0358
Plasmodium vivax	unspecified product	0.0079	0.0984	0.3066
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0144	0.275	0.9095
Toxoplasma gondii	cathepsin CPL	0.0154	0.3024	1
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3024	0.3272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0144	0.275	0.2755
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.1703	0.8342
Brugia malayi	Cathepsin L-like precursor	0.0051	0.0208	0.0225
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0041	0.0045
Schistosoma mansoni	cathepsin s	0.0051	0.0208	0.0209
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0083	0.0089
Brugia malayi	calpain 7	0.0144	0.275	0.2976
Brugia malayi	Thioredoxin reductase	0.0046	0.0083	0.0089
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0382	0.9242	0.9259
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0154	0.3024	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0154	0.3024	0.2995
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0331	0.0358
Brugia malayi	calpain family protein 1	0.0382	0.9242	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.3024	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.0984	0.3256
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3024	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Onchocerca volvulus		0.0238	0.531	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0208	0.0225
Onchocerca volvulus		0.0154	0.3024	0.5408
Trypanosoma cruzi	kinesin, putative	0.0101	0.1568	0.5186
Echinococcus multilocularis	cysteine protease	0.0154	0.3024	0.2995
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1633	0.1767
Schistosoma mansoni	egf-like domain protein	0.0056	0.0331	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0208	0.0225
Schistosoma mansoni	cathepsin F (C01 family)	0.0154	0.3024	0.3029
Loa Loa (eye worm)	cysteine protease	0.0154	0.3024	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0943	0.102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.1633	0.5402
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0154	0.3024	0.2995
Echinococcus granulosus	cathepsin l1	0.0103	0.1633	0.1599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0984	0.3256
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3024	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.2025	1
Loa Loa (eye worm)	calpain family protein 1	0.0382	0.9242	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0984	0.3256
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0154	0.3024	1
Echinococcus multilocularis	calpain family protein 1, d	0.0282	0.6492	0.6477
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.0984	0.3256
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0041	0.0041
Trypanosoma brucei	calpain-like protein, putative	0.0144	0.275	0.9095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Leishmania major	trypanothione reductase	0.0046	0.0083	0.0273
Leishmania major	cathepsin L-like protease	0.0154	0.3024	1
Loa Loa (eye worm)	ctsf protein	0.0154	0.3024	0.3272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Leishmania major	kinesin, putative	0.0101	0.1568	0.5186
Echinococcus multilocularis	cathepsin L	0.0079	0.0984	0.0947
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0083	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Onchocerca volvulus		0.0154	0.3024	0.5408
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0041	0.0045
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.2025	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3024	0.3272
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0144	0.275	0.9095
Trypanosoma cruzi	cysteine proteinase, putative	0.0079	0.0984	0.3256
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0154	0.3024	0.3272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0144	0.275	0.9095
Loa Loa (eye worm)	fibroinase	0.0154	0.3024	0.3272
Leishmania major	cathepsin L-like protease	0.0154	0.3024	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0083	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0238	0.531	0.5745
Brugia malayi	calpain family protein 1	0.0382	0.9242	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.041	0.9981	1
Loa Loa (eye worm)	calpain	0.0144	0.275	0.2976
Trypanosoma cruzi	cruzipain precursor, putative	0.0154	0.3024	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0144	0.275	0.9095
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1633	0.1767
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.3024	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Plasmodium vivax	calpain, putative	0.0144	0.275	0.907
Entamoeba histolytica	cysteine proteinase 1, putative	0.0079	0.0984	0.3256
Schistosoma mansoni	calpain C (C02 family)	0.0144	0.275	0.2755
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Schistosoma mansoni	cathepsin F (C01 family)	0.0103	0.1633	0.1636
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.3024	0.3272
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.3024	1
Leishmania major	cathepsin L-like protease	0.0154	0.3024	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.041	0.9981	0.9981
Onchocerca volvulus	Cathepsin L homolog	0.0154	0.3024	0.5408
Loa Loa (eye worm)	hypothetical protein	0.0282	0.6492	0.7024
Plasmodium vivax	vivapain-3	0.0079	0.0984	0.3066
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.0984	0.1065
Trypanosoma cruzi	cysteine protease, putative	0.0079	0.0984	0.3256
Echinococcus granulosus	cysteine protease	0.0079	0.0984	0.0947
Echinococcus granulosus	calpain A	0.0144	0.275	0.272
Echinococcus multilocularis	Tolloid protein 1	0.0191	0.4035	0.4011
Echinococcus granulosus	cathepsin L	0.0079	0.0984	0.0947
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.0984	0.3256
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0083	0.0273
Trypanosoma cruzi	cysteine proteinase, putative	0.0079	0.0984	0.3256
Loa Loa (eye worm)	hypothetical protein	0.0382	0.9242	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.1703	0.8342
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0144	0.275	0.9095
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0079	0.0984	0.3256
Leishmania major	cathepsin L-like protease	0.0154	0.3024	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0144	0.275	0.9095
Leishmania major	cathepsin L-like protease	0.0154	0.3024	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0331	0.0358
Loa Loa (eye worm)	AStacin protease	0.012	0.208	0.225
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.1703	0.8342
Echinococcus multilocularis	cathepsin L cysteine protease	0.0154	0.3024	0.2995
Plasmodium vivax	unspecified product	0.0051	0.0208	0.0428
Echinococcus granulosus	cathepsin L cysteine protease	0.0079	0.0984	0.0947
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3024	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.1703	0.8342
Trypanosoma cruzi	cruzipain precursor, putative	0.0051	0.0208	0.0689
Trypanosoma brucei	kinesin, putative	0.0101	0.1568	0.5186
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0041	0.0041
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.2025	1
Onchocerca volvulus	Cathepsin L homolog	0.0154	0.3024	0.5408
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3024	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0501	0.0542
Echinococcus granulosus	laminin	0.0062	0.0501	0.0461
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0079	0.0984	0.0986
Brugia malayi	cathepsin L-like precursor	0.0103	0.1633	0.1767
Leishmania major	cathepsin L-like protease	0.0154	0.3024	1
Brugia malayi	Cathepsin L-like precursor	0.0103	0.1633	0.1767
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.041	0.9981	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.0984	0.3256
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3024	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0051	0.0208	0.0225
Entamoeba histolytica	cysteine proteinase, putative	0.0103	0.1633	0.5402
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0101	0.1568	0.5186
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3024	0.3272
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0144	0.275	0.9095
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0154	0.3024	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.3024	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Plasmodium falciparum	glutathione reductase	0.0046	0.0083	0.0273
Entamoeba histolytica	cysteine protease, putative	0.0154	0.3024	1
Brugia malayi	glutathione reductase	0.0046	0.0083	0.0089
Plasmodium vivax	vivapain-2	0.0154	0.3024	1
Trypanosoma brucei	calpain-like protein, putative	0.0144	0.275	0.9095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Entamoeba histolytica	cysteine proteinase, putative	0.0154	0.3024	1
Echinococcus granulosus	calpain 5	0.0144	0.275	0.272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0103	0.1633	0.5402
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0083	0.0273
Echinococcus multilocularis	calpain 5	0.0144	0.275	0.272
Brugia malayi	Cathepsin L-like precursor	0.0103	0.1633	0.1767
Trypanosoma brucei	antigen, putative	0.0144	0.275	0.9095
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Schistosoma mansoni	calpain (C02 family)	0.0144	0.275	0.2755
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0191	0.4035	0.4366
Leishmania major	cathepsin L-like protease	0.0154	0.3024	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1633	0.1767
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Entamoeba histolytica	cysteine proteinase, putative	0.0154	0.3024	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0154	0.3024	0.2995
Echinococcus granulosus	calpain	0.0144	0.275	0.272
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0144	0.275	0.9095
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Loa Loa (eye worm)	hypothetical protein	0.0339	0.806	0.8721
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3024	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0144	0.275	0.9095
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0144	0.275	0.9095
Echinococcus granulosus	cathepsin l1	0.0154	0.3024	0.2995
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.2025	1
Echinococcus multilocularis	laminin	0.0062	0.0501	0.0461
Plasmodium vivax	vivapain-1	0.0079	0.0984	0.3066
Brugia malayi	calpain 5	0.0101	0.1568	0.1697
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.1703	0.8342
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3024	1
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.041	0.9981	0.9981
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0051	0.0208	0.0225
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0083	0.0041
Schistosoma mansoni	calpain-7 (C02 family)	0.0144	0.275	0.2755
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0984	0.3256
Loa Loa (eye worm)	hypothetical protein	0.0154	0.3024	0.3272
Onchocerca volvulus		0.0154	0.3024	0.5408
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0144	0.275	0.9095
Leishmania major	cysteine peptidase A (CPA)	0.0154	0.3024	1
Plasmodium vivax	vivapain-2	0.0154	0.3024	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0154	0.3024	0.3029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3024	1
Trypanosoma brucei	calpain-like protein, putative	0.0144	0.275	0.9095

Activities

Activity type	Activity value	Assay description	Source	Reference
Change (functional)	= 37.3 %	Percentage change in blood glucose concentration in male Wistar rats after 4 hr post treatment at a dose of 100 mg/Kg po.	ChEMBL.	7097725
Change (functional)	= 43.3 %	Percentage change in blood glucose concentration in male Wistar rats after 2 hr post treatment at a dose of 100 mg/Kg po.	ChEMBL.	7097725
Inhibition (functional)	= 46.4 %	Analgesic activity was measured by phenylquinone writhing test in male Swiss albino mice at a dose of 0.004 mg/Kg, sc	ChEMBL.	7097725
Inhibition (functional)	= 46.4 %	Analgesic activity was measured by phenylquinone writhing test in male Swiss albino mice at a dose of 0.004 mg/Kg, sc	ChEMBL.	7097725
P	= 138	Partition coefficient was evaluated for the compound in octanol/water system	ChEMBL.	7097725

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL161058

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 276216