Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0174 | 0.3469 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.3548 | 0.32 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0327 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.4347 | 0.4042 |
Schistosoma mansoni | tyrosine kinase | 0.0327 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0327 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.4347 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.4347 | 0.4042 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 0.4347 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4347 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0174 | 0.3469 | 0.3117 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.4347 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0176 | 0.3548 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0176 | 0.3548 | 0.3299 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 0.4347 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4347 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0105 | 0.0512 | 0.0145 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.4347 | 0.4129 |
Schistosoma mansoni | tyrosine kinase | 0.0176 | 0.3548 | 0.32 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4347 | 0.4042 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0327 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0105 | 0.0512 | 0.0512 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4347 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4347 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0174 | 0.3469 | 0.3117 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0176 | 0.3548 | 0.32 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4347 | 0.5 |
Onchocerca volvulus | 0.0195 | 0.4347 | 0.5 | |
Echinococcus multilocularis | insulin receptor | 0.0105 | 0.0512 | 0.0145 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0195 | 0.4347 | 0.4347 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control growth (functional) | 0 % | In vitro inhibitory activity against L1210 cells when co-incubated with compound at concentrations of 2 and 10 times IC50 values and 10 uM Thymidine; 68/6 | ChEMBL. | 8576912 |
IC50 (binding) | = 1.21 uM | In vitro inhibitory activity against thymidylate synthase partially purified from L1210 mouse leukemia cells | ChEMBL. | 8576912 |
IC50 (binding) | = 1.21 uM | In vitro inhibitory activity against thymidylate synthase partially purified from L1210 mouse leukemia cells | ChEMBL. | 8576912 |
IC50 (functional) | = 2.4 uM | In vitro inhibitory activity against L1210 cell growth | ChEMBL. | 8576912 |
IC50 (functional) | = 2.4 uM | In vitro inhibitory activity against L1210 cell growth | ChEMBL. | 8576912 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 8576912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.