Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | amine GPCR | Adrenergic receptor alpha-2 | 450 aa | 439 aa | 29.2 % |
Echinococcus multilocularis | fmrfamide receptor | Adrenergic receptor alpha-2 | 450 aa | 366 aa | 19.9 % |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 478 aa | 20.7 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 476 aa | 21.0 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Adrenergic receptor alpha-2 | 450 aa | 423 aa | 31.7 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 420 aa | 19.8 % | |
Loa Loa (eye worm) | TYRA-2 protein | Adrenergic receptor alpha-2 | 450 aa | 488 aa | 23.8 % |
Echinococcus multilocularis | neuropeptides capa receptor | Adrenergic receptor alpha-2 | 450 aa | 486 aa | 20.6 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Adrenergic receptor alpha-2 | 450 aa | 473 aa | 24.1 % |
Echinococcus multilocularis | serotonin receptor | Adrenergic receptor alpha-2 | 450 aa | 426 aa | 31.9 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 467 aa | 25.1 % | |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adrenergic receptor alpha-2 | 450 aa | 433 aa | 27.9 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Adrenergic receptor alpha-2 | 450 aa | 378 aa | 20.9 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 380 ug kg-1 | In vivo inhibition of clonidine induced mydriasis in the rat following i.v. administration. | ChEMBL. | 1671705 |
ID50 (functional) | = 380 ug kg-1 | In vivo inhibition of clonidine induced mydriasis in the rat following i.v. administration. | ChEMBL. | 1671705 |
ID50 (functional) | = 1600 ug kg-1 | In vivo inhibition of clonidine induced mydriasis in the rat following p.o. administration. | ChEMBL. | 1671705 |
ID50 (functional) | = 1600 ug kg-1 | In vivo inhibition of clonidine induced mydriasis in the rat following p.o. administration. | ChEMBL. | 1671705 |
Ki (binding) | = -8.01 | Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]-yohimbine displacement from rat cortical membrane | ChEMBL. | 1671705 |
Ki (binding) | = -4.46 | Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]-Prazosin displacement from rat cortical membrane | ChEMBL. | 1671705 |
Log Ki (binding) | = 4.46 | Binding affinity to alpha-1 adrenergic receptor determined by measurement of [3H]-Prazosin displacement from rat cortical membrane | ChEMBL. | 1671705 |
Log Ki (binding) | = 8.01 | Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]-yohimbine displacement from rat cortical membrane | ChEMBL. | 1671705 |
Selectivity ratio (binding) | = 3500 | Selectivity ratio measured as the pKi (alpha-2) /pKi(alpha-1) receptor values. | ChEMBL. | 1671705 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.