Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Entamoeba histolytica | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 0.3644 |
Plasmodium vivax | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 0.3644 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.5169 | 0.5169 |
Wolbachia endosymbiont of Brugia malayi | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0274 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0274 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0274 | 1 | 1 |
Toxoplasma gondii | S-adenosyl methionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Leishmania major | adenine aminohydrolase | 0.0274 | 1 | 1 |
Leishmania major | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Loa Loa (eye worm) | methionine adenosyltransferase | 0.0157 | 0.3644 | 0.3644 |
Schistosoma mansoni | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0274 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0274 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0274 | 1 | 1 |
Trypanosoma cruzi | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.5169 | 0.5169 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Giardia lamblia | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.5 |
Echinococcus multilocularis | S adenosylmethionine synthase type 1 | 0.0157 | 0.3644 | 0.3644 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Treponema pallidum | adenosine deaminase | 0.0274 | 1 | 1 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0274 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0274 | 1 | 0.5 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Echinococcus granulosus | S adenosylmethionine synthase type 1 | 0.0157 | 0.3644 | 0.3644 |
Entamoeba histolytica | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 0.3644 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.5169 | 0.5169 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0274 | 1 | 1 |
Plasmodium falciparum | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Leishmania major | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Echinococcus granulosus | adenosine deaminase | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.5169 | 0.5169 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0274 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0274 | 1 | 1 |
Entamoeba histolytica | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 0.3644 |
Plasmodium vivax | adenosine deaminase, putative | 0.0274 | 1 | 1 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0274 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0274 | 1 | 1 |
Brugia malayi | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction of live worms (functional) | = 16 % | Antifilarial activity against L. carinii infections in the Jird at dose 100 mg/kg administered orally | ChEMBL. | 6887202 |
Reduction of live worms (functional) | = 19 % | Antifilarial activity against L. carinii infections in the Jird at dose 100 mg/kg administered subcutaneously | ChEMBL. | 6887202 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.