Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.5169 | 0.5169 |
Loa Loa (eye worm) | methionine adenosyltransferase | 0.0157 | 0.3644 | 0.3644 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 1 | 1 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Entamoeba histolytica | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 0.3644 |
Schistosoma mansoni | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Leishmania major | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.5169 | 0.5169 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Plasmodium falciparum | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Plasmodium vivax | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 0.3644 |
Trypanosoma cruzi | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0274 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0274 | 1 | 0.5 |
Entamoeba histolytica | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 0.3644 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0274 | 1 | 0.5 |
Entamoeba histolytica | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 0.3644 |
Echinococcus multilocularis | S adenosylmethionine synthase type 1 | 0.0157 | 0.3644 | 0.3644 |
Leishmania major | adenine aminohydrolase | 0.0274 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.5169 | 0.5169 |
Wolbachia endosymbiont of Brugia malayi | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.5 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Leishmania major | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0274 | 1 | 1 |
Echinococcus granulosus | S adenosylmethionine synthase type 1 | 0.0157 | 0.3644 | 0.3644 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0274 | 1 | 1 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0274 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0274 | 1 | 1 |
Giardia lamblia | S-adenosylmethionine synthetase | 0.0157 | 0.3644 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0274 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0274 | 1 | 1 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0274 | 1 | 1 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0274 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0274 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0274 | 1 | 1 |
Trypanosoma cruzi | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0274 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.5169 | 0.5169 |
Toxoplasma gondii | S-adenosyl methionine synthetase | 0.0157 | 0.3644 | 0.3644 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0157 | 0.3644 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0274 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction of live worms (functional) | = 0 % | Antifilarial activity against L. carinii infections in the Jird at dose 100 mg/kg administered subcutaneously | ChEMBL. | 6887202 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.