Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.0031 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5841 | 0.6463 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0133 | 0.9021 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.8538 | 0.9462 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0133 | 0.9021 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0133 | 0.9021 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.7304 | 0.8089 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0082 | 0.4009 | 0.4425 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0082 | 0.4009 | 0.4425 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0133 | 0.9021 | 0.9018 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0133 | 0.9021 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0133 | 0.9021 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0082 | 0.4009 | 0.4425 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0133 | 0.9021 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0133 | 0.9021 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 1 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0133 | 0.9021 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0133 | 0.9021 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0133 | 0.9021 | 0.9018 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0082 | 0.4009 | 0.4425 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.0031 | 0.0035 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0133 | 0.9021 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0133 | 0.9021 | 1 |
Brugia malayi | Adenosylhomocysteinase | 0.0133 | 0.9021 | 0.9018 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0133 | 0.9021 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0133 | 0.9021 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0133 | 0.9021 | 0.5 |
Onchocerca volvulus | 0.0143 | 1 | 1 | |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0133 | 0.9021 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0133 | 0.9021 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 40 nM | Inhibition of [3H]-Leu-enkephalin binding to Aminopeptidase N from hog kidney | ChEMBL. | 1348542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.