TDR Targets

Basic information

Technical information

TDR Targets ID: 276478
Name: 2-(4-methylsulfonylphenyl)-1H-imidazo[4,5-b]p yridine
MW: 273.31 | Formula: C13H11N3O2S
H donors: 1 H acceptors: 4 LogP: 1.37 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CS(=O)(=O)c1ccc(cc1)c1nc2c(n1)ccc[nH]2
InChi: 1S/C13H11N3O2S/c1-19(17,18)10-6-4-9(5-7-10)12-15-11-3-2-8-14-13(11)16-12/h2-8H,1H3,(H,14,15,16)
InChiKey: AYKPAHFUKLPNKV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-mesylphenyl)-1H-imidazo[4,5-b]pyridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Entamoeba histolytica	hypothetical protein	0.0029	0.1555	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0016	0.05	0.3213
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0009	0.00000000025853	0.00000000025853
Loa Loa (eye worm)	transcription factor SMAD2	0.0097	0.6832	0.9867
Brugia malayi	Associated with TFs and helicases family protein	0.0009	0.00000000025853	0.0000000003784
Echinococcus multilocularis	lysine specific demethylase 5A	0.0029	0.1511	0.1511
Loa Loa (eye worm)	CHromoDomain protein family member	0.0009	0.00000000025853	0.00000000037338
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0009	0.00000000025853	0.00000000025853
Trichomonas vaginalis	DNA helicase recq, putative	0.001	0.009	0.0158
Echinococcus granulosus	chromobox protein 1	0.0057	0.3687	0.3687
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1028	0.1802
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0013	0.0277	0.0399
Schistosoma mansoni	tar DNA-binding protein	0.0051	0.3287	0.3287
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0016	0.05	0.05
Plasmodium vivax	hypothetical protein, conserved	0.0024	0.1123	0.1969
Schistosoma mansoni	transcription factor LCR-F1	0.0029	0.1555	0.1555
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0024	0.1123	0.1123
Schistosoma mansoni	tar DNA-binding protein	0.0051	0.3287	0.3287
Giardia lamblia	PHD finger protein 15	0.0024	0.1123	0.1198
Brugia malayi	jmjC domain containing protein	0.0078	0.532	0.7787
Brugia malayi	Latrophilin receptor protein 2	0.0013	0.0277	0.0405
Echinococcus multilocularis	chromobox protein 1	0.0057	0.3687	0.3687
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0016	0.05	0.05
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Entamoeba histolytica	hypothetical protein	0.0029	0.1555	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0013	0.0306	0.0536
Echinococcus multilocularis	GPCR, family 2	0.0013	0.0277	0.0277
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.0049	0.3132	0.5491
Schistosoma mansoni	hypothetical protein	0.0029	0.1555	0.1555
Loa Loa (eye worm)	glucose-6-phosphate dehydrogenase	0.0076	0.5179	0.7479
Onchocerca volvulus		0.0025	0.1216	0.6276
Trypanosoma cruzi	DNA polymerase eta, putative	0.0036	0.2111	0.3972
Schistosoma mansoni	hypothetical protein	0.0024	0.1123	0.1123
Schistosoma mansoni	glucose-6-phosphate 1-dehydrogenase	0.0076	0.5179	0.5179
Brugia malayi	RNA recognition motif domain containing protein	0.0051	0.3287	0.481
Brugia malayi	RNA binding protein	0.0051	0.3287	0.481
Brugia malayi	MH2 domain containing protein	0.0097	0.6832	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0016	0.05	0.0876
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0029	0.1511	0.1511
Trichomonas vaginalis	chromobox protein, putative	0.0057	0.3687	0.6464
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1028	0.1802
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0013	0.0277	0.0277
Trichomonas vaginalis	chromobox protein, putative	0.0034	0.1937	0.3396
Schistosoma mansoni	hypothetical protein	0.0009	0.00000000025853	0.00000000025853
Treponema pallidum	glucose-6-phosphate 1-dehydrogenase	0.0076	0.5179	0.5
Echinococcus multilocularis	jumonji domain containing protein	0.0033	0.1846	0.1846
Brugia malayi	Heterochromatin protein 1	0.0057	0.3687	0.5396
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0013	0.0277	0.0405
Echinococcus granulosus	glucose 6 phosphate 1 dehydrogenase	0.0076	0.5179	0.5179
Loa Loa (eye worm)	RecQ helicase	0.002	0.0797	0.1152
Echinococcus granulosus	chromobox protein 1	0.0057	0.3687	0.3687
Echinococcus granulosus	jumonji domain containing protein	0.0033	0.1846	0.1846
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0009	0.00000000025853	0.0000000003784
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Trypanosoma brucei	DNA polymerase kappa, putative	0.0011	0.0121	0.006
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0083	0.5704	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Brugia malayi	CHD4 protein	0.0009	0.00000000025853	0.0000000003784
Trypanosoma brucei	DNA polymerase IV, putative	0.0016	0.05	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0098	0.6924	1
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.175	0.3067
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.175	0.3067
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Schistosoma mansoni	hypothetical protein	0.0013	0.0277	0.0277
Schistosoma mansoni	DNA polymerase eta	0.0036	0.2111	0.2111
Schistosoma mansoni	tar DNA-binding protein	0.0051	0.3287	0.3287
Echinococcus granulosus	tar DNA binding protein	0.0051	0.3287	0.3287
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Echinococcus multilocularis	dna polymerase eta	0.0036	0.2111	0.2111
Loa Loa (eye worm)	hypothetical protein	0.0041	0.2441	0.3525
Leishmania major	DNA polymerase eta, putative	0.0026	0.1269	0.2317
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0016	0.05	0.0721
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0013	0.0277	0.0277
Loa Loa (eye worm)	heterochromatin protein 1	0.0057	0.3687	0.5325
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.0083	0.5704	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Loa Loa (eye worm)	jmjC domain-containing protein	0.0049	0.3087	0.4459
Schistosoma mansoni	hypothetical protein	0.0013	0.0277	0.0277
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0026	0.1269	0.2225
Leishmania major	DNA polymerase eta, putative	0.0036	0.2111	0.3972
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1216	0.1756
Entamoeba histolytica	recQ family helicase, putative	0.001	0.009	0.0579
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0076	0.5179	1
Entamoeba histolytica	hypothetical protein	0.0029	0.1555	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.002	0.0797	0.1398
Leishmania major	glucose-6-phosphate 1-dehydrogenase, putative	0.0076	0.5179	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0024	0.1123	0.1969
Echinococcus granulosus	dna polymerase eta	0.0036	0.2111	0.2111
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0029	0.1555	0.1555
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0029	0.1555	0.1555
Echinococcus granulosus	bloom syndrome protein	0.002	0.0797	0.0797
Echinococcus multilocularis	tar DNA binding protein	0.0051	0.3287	0.3287
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0051	0.3287	0.4747
Trypanosoma brucei	unspecified product	0.0016	0.05	0.0805
Plasmodium falciparum	glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0.0083	0.5704	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Echinococcus multilocularis	peregrin	0.0024	0.1123	0.1123
Loa Loa (eye worm)	TAR-binding protein	0.0051	0.3287	0.4747
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Loa Loa (eye worm)	hypothetical protein	0.0028	0.1435	0.2072
Schistosoma mansoni	hypothetical protein	0.0138	1	1
Trypanosoma cruzi	Glucose-6-phosphate dehydrogenase, putative	0.0024	0.1177	0.2136
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0049	0.3132	0.5626
Trichomonas vaginalis	DNA polymerase eta, putative	0.0016	0.05	0.0876
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0797	0.1398
Echinococcus granulosus	GPCR family 2	0.0013	0.0277	0.0277
Schistosoma mansoni	hypothetical protein	0.0138	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1123	0.1622
Mycobacterium tuberculosis	Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)	0.0026	0.1325	1
Chlamydia trachomatis	glucose-6-phosphate 1-dehydrogenase	0.0076	0.5179	0.5
Echinococcus granulosus	PHD finger protein rhinoceros	0.0024	0.1123	0.1123
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0041	0.2433	0.3561
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0016	0.05	0.0805
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0009	0.00000000025853	0.0000000016628
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.0797	0.1167
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Schistosoma mansoni	blooms syndrome DNA helicase	0.0015	0.0478	0.0478
Trypanosoma brucei	DNA polymerase eta, putative	0.0036	0.2111	0.3972
Echinococcus granulosus	lysine specific demethylase 5A	0.0029	0.1511	0.1511
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0017	0.0613	0.1075
Giardia lamblia	Glucose-6-phosphate 1-dehydrogenase	0.0083	0.5704	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0078	0.532	0.532
Echinococcus multilocularis	chromobox protein 1	0.0057	0.3687	0.3687
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0029	0.1511	0.1511
Schistosoma mansoni	jumonji domain containing protein	0.0062	0.4078	0.4078
Trypanosoma brucei	glucose-6-phosphate 1-dehydrogenase	0.0076	0.5179	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0083	0.5704	1
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.1123	0.1622
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Schistosoma mansoni	tar DNA-binding protein	0.0051	0.3287	0.3287
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Echinococcus multilocularis	Chromo domain	0.0009	0.00000000025853	0.00000000025853
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0009	0.00000000025853	0.00000000045326
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0009	0.00000000025853	0.00000000025853
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0277	0.0399
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0041	0.2433	0.3513
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0009	0.00000000025853	0.00000000025853
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0016	0.05	0.05
Schistosoma mansoni	hypothetical protein	0.0013	0.0277	0.0277
Trypanosoma cruzi	DNA polymerase eta, putative	0.0026	0.1269	0.2317
Trypanosoma brucei	DNA polymerase kappa, putative	0.0011	0.0121	0.006
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0016	0.05	0.05
Loa Loa (eye worm)	hypothetical protein	0.0009	0.00000000025853	0.00000000037338
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0025	0.1234	0.2247
Trypanosoma brucei	DNA polymerase IV, putative	0.0016	0.05	0.0805
Plasmodium vivax	hypothetical protein, conserved	0.0009	0.00000000025853	0.00000000045326
Brugia malayi	glucose-6-phosphate dehydrogenase	0.0076	0.5179	0.758
Echinococcus multilocularis	glucose 6 phosphate 1 dehydrogenase	0.0076	0.5179	0.5179
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0013	0.0277	0.0277
Leishmania major	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Brugia malayi	hypothetical protein	0.0029	0.1555	0.2276
Echinococcus multilocularis	geminin	0.0138	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.2111	0.3049
Plasmodium falciparum	phd finger protein, putative	0.0024	0.1123	0.1969
Entamoeba histolytica	hypothetical protein	0.0029	0.1555	1
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0009	0.00000000025853	0.0000000016628
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.1511	0.2183
Brugia malayi	PHD-finger family protein	0.0024	0.1123	0.1644
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0032	0.175	0.9031
Toxoplasma gondii	PHD-finger domain-containing protein	0.0024	0.1123	0.1969
Entamoeba histolytica	hypothetical protein	0.0009	0.00000000025853	0.0000000016628
Loa Loa (eye worm)	hypothetical protein	0.0041	0.2433	0.3513
Loa Loa (eye worm)	hypothetical protein	0.0032	0.175	0.2527
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0076	0.5179	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0016	0.05	0.0731
Trypanosoma brucei	DNA polymerase kappa, putative	0.0011	0.0121	0.006
Echinococcus granulosus	dna polymerase kappa	0.0016	0.05	0.05
Echinococcus multilocularis	dna polymerase kappa	0.0016	0.05	0.05
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0034	0.1937	1
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0009	0.00000000025853	0.00000000025853
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0009	0.00000000025853	0.00000000045326
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0078	0.532	0.532
Plasmodium vivax	glucose-6-phosphate 1-dehydrogenase, putative	0.0083	0.5704	1
Echinococcus granulosus	Chromo domain	0.0009	0.00000000025853	0.00000000025853
Brugia malayi	ImpB/MucB/SamB family protein	0.0036	0.2111	0.309
Schistosoma mansoni	tar DNA-binding protein	0.0051	0.3287	0.3287
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0009	0.00000000025853	0.00000000025853
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0797	0.0797
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Schistosoma mansoni	chromobox protein	0.0057	0.3687	0.3687
Brugia malayi	latrophilin 2 splice variant baaae	0.0028	0.1435	0.21
Brugia malayi	Bromodomain containing protein	0.0024	0.1123	0.1644
Trichomonas vaginalis	chromobox protein, putative	0.0034	0.1937	0.3396
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0024	0.1123	0.1123
Brugia malayi	TAR-binding protein	0.0051	0.3287	0.481
Onchocerca volvulus	Alhambra homolog	0.0024	0.1123	0.5798
Trichomonas vaginalis	6-phosphogluconolactonase, putative	0.0083	0.5704	1
Loa Loa (eye worm)	RNA binding protein	0.0051	0.3287	0.4747
Brugia malayi	jmjC domain containing protein	0.0029	0.1511	0.2212
Echinococcus granulosus	peregrin	0.0024	0.1123	0.1123
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0013	0.0293	0.0514
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0009	0.00000000025853	0.0000000016628
Loa Loa (eye worm)	MH2 domain-containing protein	0.0097	0.6832	0.9867
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0013	0.0277	0.0277
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0009	0.00000000025853	0.00000000045326
Schistosoma mansoni	chromobox protein	0.0057	0.3687	0.3687
Schistosoma mansoni	hypothetical protein	0.0028	0.1435	0.1435
Trypanosoma brucei	DNA polymerase IV, putative	0.0016	0.05	0.0805
Trypanosoma brucei	unspecified product	0.0011	0.0121	0.006
Trichomonas vaginalis	chromobox protein, putative	0.0057	0.3687	0.6464
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0041	0.2433	0.3561
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Brugia malayi	chromobox protein homolog 3	0.0032	0.175	0.2561
Schistosoma mansoni	hypothetical protein	0.0013	0.0277	0.0277
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.05	0.0805
Trypanosoma brucei	unspecified product	0.0011	0.0121	0.006

Activities

Activity type	Activity value	Assay description	Source	Reference
Change (functional)	= -2 %	Percent change in mean arterial blood pressure in anesthetized dog	ChEMBL.	4009593
Change (functional)	= 8 %	Percent change in heart rate in anesthetized dog	ChEMBL.	4009593
Control (functional)	0 %	Compound tested for contractility in isolated cat papillary muscle at 10 e-5 M; NT = not tested	ChEMBL.	4009593
Control (functional)	0 %	Compound tested for contractility in isolated cat papillary muscle at 10 e-4 M; NT = not tested	ChEMBL.	4009593
ED50 (functional)	= 18 mg kg-1	Compound tested for contractility in anesthetized dog when administered intravenously.	ChEMBL.	4009593

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL160041
PubChem: 13450858

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 276478