TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 632.48 | Formula: C28H24O17
H donors: 11 H acceptors: 13 LogP: -0.22 Rotable bonds: 6
Rule of 5 violations (Lipinski): 4
SMILES: OC[C@@H]([C@H]1OC(=O)C2(C1(O)Oc1c2c2O[C@@H]([C@@H](Cc2c(c1)O)OC(=O)c1cc(O)c(c(c1)O)O)c1cc(O)c(c(c1)O)O)O)O
InChi: 1S/C28H24O17/c29-7-16(35)24-28(41)27(40,26(39)44-24)19-17(45-28)6-11(30)10-5-18(42-25(38)9-3-14(33)21(37)15(34)4-9)22(43-23(10)19)8-1-12(31)20(36)13(32)2-8/h1-4,6,16,18,22,24,29-37,40-41H,5,7H2/t16-,18+,22+,24+,27?,28?/m0/s1
InChiKey: DKFWYWRZDCPNOB-CXBNSELASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	unconventional myosin IB	0.0095	0.0809	0.6944
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0124	0.1165	0.1165
Leishmania major	hypothetical protein, conserved	0.0095	0.0809	0.2233
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0095	0.0809	0.0809
Echinococcus granulosus	tyrosine kinase	0.0124	0.1165	0.1165
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.1165	0.1165
Loa Loa (eye worm)	glutathione reductase	0.0054	0.032	0.032
Toxoplasma gondii	thioredoxin reductase	0.0054	0.032	0.0884
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0165	0.0165
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0095	0.0809	0.6944
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0123	0.115	0.0857
Loa Loa (eye worm)	SH2 domain-containing protein	0.0097	0.0838	0.0838
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0097	0.0838	0.0838
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.003	0.0031	0.0031
Trypanosoma brucei	conserved protein	0.0095	0.0809	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0809	0.0809
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0137	0.1314	0.1027
Brugia malayi	SH2 domain containing protein	0.0097	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Onchocerca volvulus		0.0095	0.0809	0.6944
Onchocerca volvulus		0.0097	0.0838	0.7192
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0097	0.0838	0.0838
Echinococcus granulosus	N chimaerin	0.0097	0.0838	0.0838
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0219	0.2301	0.2301
Schistosoma mansoni	apoptosis stimulating of P53	0.0095	0.0809	0.0809
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0809	0.0809
Echinococcus granulosus	intersectin 2	0.0095	0.0809	0.0809
Onchocerca volvulus		0.0095	0.0809	0.6944
Mycobacterium tuberculosis	Probable reductase	0.0123	0.115	0.0857
Plasmodium falciparum	thioredoxin reductase	0.0054	0.032	0.0884
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0097	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0192	0.1974	0.1974
Schistosoma mansoni	hypothetical protein	0.0095	0.0809	0.0809
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0219	0.2301	0.2301
Schistosoma mansoni	sorbin	0.0095	0.0809	0.0809
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0165	0.0165
Giardia lamblia	Kinase, NEK	0.0027	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0809	0.0809
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Entamoeba histolytica	hypothetical protein	0.0041	0.0165	0.1421
Schistosoma mansoni	tyrosine kinase	0.0124	0.1165	0.1165
Onchocerca volvulus		0.0095	0.0809	0.6944
Loa Loa (eye worm)	protein-tyrosine kinase	0.0095	0.0809	0.0809
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0219	0.2301	0.2301
Schistosoma mansoni	hypothetical protein	0.0097	0.0838	0.0838
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0097	0.0838	0.0838
Brugia malayi	Variant SH3 domain containing protein	0.0192	0.1974	0.1974
Brugia malayi	Myosin tail family protein	0.0095	0.0809	0.0809
Brugia malayi	SH2 domain containing protein	0.0124	0.1165	0.1165
Entamoeba histolytica	hypothetical protein	0.0041	0.0165	0.1421
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0095	0.0809	0.6944
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0165	0.0165
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0097	0.0838	0.0838
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0095	0.0809	0.0809
Onchocerca volvulus		0.0095	0.0809	0.6944
Echinococcus multilocularis	SH2 domain containing protein 7	0.0097	0.0838	0.0838
Brugia malayi	Variant SH3 domain containing protein	0.0095	0.0809	0.0809
Brugia malayi	Thioredoxin reductase	0.0054	0.032	0.032
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0219	0.2301	0.2301
Schistosoma mansoni	shc transforming protein	0.0097	0.0838	0.0838
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.003	0.0031	0.0031
Schistosoma mansoni	GTPase activating protein	0.0097	0.0838	0.0838
Echinococcus granulosus	tensin	0.0097	0.0838	0.0838
Entamoeba histolytica	hypothetical protein	0.0095	0.0809	0.6944
Entamoeba histolytica	hypothetical protein	0.0041	0.0165	0.1421
Schistosoma mansoni	SH2A	0.0097	0.0838	0.0838
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0219	0.2301	0.2301
Schistosoma mansoni	dihydrofolate reductase	0.0861	1	1
Schistosoma mansoni	hypothetical protein	0.0097	0.0838	0.0838
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0329	0.3622	1
Onchocerca volvulus		0.0097	0.0838	0.7192
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0219	0.2301	0.2301
Echinococcus multilocularis	SH2 motif	0.0097	0.0838	0.0838
Onchocerca volvulus		0.0097	0.0838	0.7192
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0192	0.1974	0.1974
Echinococcus multilocularis	endophilin A3	0.0095	0.0809	0.0809
Loa Loa (eye worm)	SRC-1	0.0219	0.2301	0.2301
Entamoeba histolytica	hypothetical protein	0.0095	0.0809	0.6944
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0097	0.0838	0.0838
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0809	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0219	0.2301	0.2301
Echinococcus granulosus	tyrosine protein kinase shark	0.0124	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Trypanosoma cruzi	hypothetical protein, conserved	0.0095	0.0809	0.2233
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0095	0.0809	0.0809
Brugia malayi	Protein kinase domain containing protein	0.0124	0.1165	0.1165
Giardia lamblia	Kinase, NEK	0.0027	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0192	0.1974	0.1974
Echinococcus multilocularis	Spectrin alpha actinin	0.0095	0.0809	0.0809
Onchocerca volvulus	Putative cortactin	0.0095	0.0809	0.6944
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0095	0.0809	0.0809
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.1165	0.1165
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0219	0.2301	0.2301
Giardia lamblia	Kinase	0.0027	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0124	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0124	0.1165	0.1165
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0329	0.3622	1
Schistosoma mansoni	tyrosine kinase	0.0219	0.2301	0.2301
Echinococcus granulosus	src region	0.0095	0.0809	0.0809
Brugia malayi	Guanylate kinase family protein	0.0095	0.0809	0.0809
Schistosoma mansoni	C-fyn	0.0095	0.0809	0.0809
Schistosoma mansoni	signal transduction protein lnk-related	0.0097	0.0838	0.0838
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0097	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0809	0.0809
Brugia malayi	Protein kinase domain containing protein	0.0124	0.1165	0.1165
Plasmodium vivax	thioredoxin reductase, putative	0.0054	0.032	0.0884
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0861	1	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Echinococcus granulosus	SHC transforming protein 3	0.0097	0.0838	0.0838
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0095	0.0809	1
Entamoeba histolytica	hypothetical protein	0.0095	0.0809	0.6944
Schistosoma mansoni	formin binding protein and related proteins	0.0095	0.0809	0.0809
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0097	0.0838	0.0838
Schistosoma mansoni	hypothetical protein	0.0095	0.0809	0.0809
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0097	0.0838	0.0838
Brugia malayi	protein-tyrosine kinase	0.0124	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Brugia malayi	SH2 domain containing protein	0.0097	0.0838	0.0838
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0124	0.1165	0.1165
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0097	0.0838	0.0838
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0124	0.1165	0.1165
Brugia malayi	Calcitonin receptor-like protein seb-1	0.003	0.0031	0.0031
Entamoeba histolytica	hypothetical protein	0.0095	0.0809	0.6944
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0095	0.0809	0.0809
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0123	0.115	0.0857
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.1165	0.1165
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0809	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0097	0.0838	0.0838
Echinococcus granulosus	NCK adaptor protein	0.0192	0.1974	0.1974
Echinococcus granulosus	SH2 motif	0.0097	0.0838	0.0838
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0192	0.1974	0.1974
Onchocerca volvulus		0.0124	0.1165	1
Schistosoma mansoni	tensin-related	0.0097	0.0838	0.0838
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0192	0.1974	0.1974
Brugia malayi	RhoGAP domain containing protein	0.0097	0.0838	0.0838
Brugia malayi	Dihydrofolate reductase	0.0861	1	1
Brugia malayi	SH2 domain containing protein	0.0097	0.0838	0.0838
Schistosoma mansoni	suppressor of cytokine signaling	0.0097	0.0838	0.0838
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0097	0.0838	0.0838
Schistosoma mansoni	growth factor receptor-bound protein	0.0192	0.1974	0.1974
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.1165	0.1165
Brugia malayi	hypothetical protein	0.0041	0.0165	0.0165
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.1165	0.1165
Entamoeba histolytica	hypothetical protein	0.0095	0.0809	0.6944
Schistosoma mansoni	tyrosine kinase	0.0219	0.2301	0.2301
Loa Loa (eye worm)	guanylate kinase	0.0095	0.0809	0.0809
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0219	0.2301	0.2301
Entamoeba histolytica	hypothetical protein	0.0041	0.0165	0.1421
Loa Loa (eye worm)	thyroid receptor interactor	0.0095	0.0809	0.0809
Loa Loa (eye worm)	thioredoxin reductase	0.0054	0.032	0.032
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0095	0.0809	0.0809
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0097	0.0838	0.0838
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0095	0.0809	0.0809
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0095	0.0809	0.0809
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Schistosoma mansoni	Dab2-interacting protein-like	0.0095	0.0809	0.0809
Brugia malayi	Src substrate cortactin	0.0095	0.0809	0.0809
Schistosoma mansoni	vav2	0.0097	0.0838	0.0838
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0329	0.3622	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0097	0.0838	0.7192
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0124	0.1165	0.1165
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0219	0.2301	0.2301
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0095	0.0809	0.0809
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0097	0.0838	0.7192
Entamoeba histolytica	hypothetical protein	0.0095	0.0809	0.6944
Echinococcus granulosus	nostrin	0.0095	0.0809	0.0809
Loa Loa (eye worm)	TK/ABL protein kinase	0.0124	0.1165	0.1165
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0095	0.0809	0.0809
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0219	0.2301	0.2301
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0095	0.0809	0.0809
Brugia malayi	SH2 domain containing protein	0.0097	0.0838	0.0838
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0219	0.2301	0.2301
Echinococcus granulosus	SH2 motif	0.0097	0.0838	0.0838
Trypanosoma cruzi	hypothetical protein, conserved	0.0095	0.0809	0.2233
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0095	0.0809	0.0809
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0095	0.0809	0.0809
Schistosoma mansoni	tyrosine kinase	0.0219	0.2301	0.2301
Echinococcus granulosus	expressed conserved protein	0.0097	0.0838	0.0838
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0123	0.115	0.0857
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0097	0.0838	0.0838
Echinococcus granulosus	Spectrin alpha actinin	0.0095	0.0809	0.0809
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0095	0.0809	0.0809
Onchocerca volvulus		0.0124	0.1165	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0124	0.1165	0.1165
Echinococcus granulosus	endophilin A3	0.0095	0.0809	0.0809
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0137	0.1314	0.1027
Entamoeba histolytica	protein kinase, putative	0.0097	0.0838	0.7192
Schistosoma mansoni	tensin	0.0097	0.0838	0.0838
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0219	0.2301	0.2301
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0095	0.0809	0.0809
Echinococcus multilocularis	SH2 motif	0.0097	0.0838	0.0838
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0219	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Brugia malayi	hypothetical protein	0.0124	0.1165	0.1165
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0809	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0054	0.032	0.0884
Trypanosoma cruzi	hypothetical protein, conserved	0.0095	0.0809	0.2233
Loa Loa (eye worm)	SH2 domain-containing protein	0.0097	0.0838	0.0838
Echinococcus granulosus	expressed protein	0.0095	0.0809	0.0809
Brugia malayi	Peripheral plasma membrane protein CASK	0.0095	0.0809	0.0809
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0097	0.0838	0.0838
Entamoeba histolytica	hypothetical protein	0.0095	0.0809	0.6944
Onchocerca volvulus		0.0097	0.0838	0.7192
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0095	0.0809	0.0809
Echinococcus multilocularis	tyrosine protein kinase shark	0.0124	0.1165	0.1165
Brugia malayi	hypothetical protein	0.0097	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0809	0.0809
Brugia malayi	Variant SH3 domain containing protein	0.0095	0.0809	0.0809
Schistosoma mansoni	tyrosine kinase	0.0219	0.2301	0.2301
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0095	0.0809	0.2233
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0095	0.0809	0.0809
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0123	0.115	0.0857
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0097	0.0838	0.0838
Echinococcus multilocularis	dihydrofolate reductase	0.0861	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0095	0.0809	0.0809
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0219	0.2301	0.2301
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0329	0.3622	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0097	0.0838	0.0838
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0097	0.0838	0.0838
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.1165	0.1165
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0219	0.2301	0.2301
Echinococcus multilocularis	N chimaerin	0.0097	0.0838	0.0838
Schistosoma mansoni	dynamin-associated protein	0.0095	0.0809	0.0809
Schistosoma mansoni	nck2/grb4	0.0192	0.1974	0.1974
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0097	0.0838	0.0838
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0861	1	0.5
Brugia malayi	protein-tyrosine kinase	0.0095	0.0809	0.0809
Echinococcus granulosus	tyrosine kinase	0.0124	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Schistosoma mansoni	tensin	0.0097	0.0838	0.0838
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0097	0.0838	0.0838
Schistosoma mansoni	cell polarity protein	0.0095	0.0809	0.0809
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0095	0.0809	0.0809
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0329	0.3622	1
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0809	1
Schistosoma mansoni	sorting nexin	0.0095	0.0809	0.0809
Onchocerca volvulus		0.0124	0.1165	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0123	0.115	0.0857
Onchocerca volvulus		0.0124	0.1165	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0097	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0095	0.0809	0.6944
Entamoeba histolytica	hypothetical protein, conserved	0.0095	0.0809	0.6944
Plasmodium vivax	glutathione reductase, putative	0.0054	0.032	0.0884
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.1165	0.1165
Trypanosoma brucei	trypanothione reductase	0.0054	0.032	0.0884
Brugia malayi	Protein kinase domain containing protein	0.0124	0.1165	0.1165
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0097	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0809	0.0809
Brugia malayi	Tyrosine-protein kinase abl-1	0.0219	0.2301	0.2301
Onchocerca volvulus		0.0097	0.0838	0.7192
Echinococcus granulosus	c src tyrosine kinase	0.0219	0.2301	0.2301
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0097	0.0838	0.0838
Onchocerca volvulus		0.0097	0.0838	0.7192
Brugia malayi	glutathione reductase	0.0054	0.032	0.032
Entamoeba histolytica	hypothetical protein	0.0095	0.0809	0.6944
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0219	0.2301	0.2301
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0137	0.1314	0.0186
Loa Loa (eye worm)	TK protein kinase	0.0124	0.1165	0.1165
Brugia malayi	SH3 domain containing protein	0.0095	0.0809	0.0809
Echinococcus granulosus	tyrosine protein kinase Srms	0.0124	0.1165	0.1165
Entamoeba histolytica	protein kinase, putative	0.0095	0.0809	0.6944
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0097	0.0838	0.7192
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0097	0.0838	0.0838
Echinococcus granulosus	SH2 domain containing protein 7	0.0097	0.0838	0.0838
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0809	1
Echinococcus multilocularis	tensin	0.0097	0.0838	0.0838
Brugia malayi	SH2 domain containing protein	0.0097	0.0838	0.0838
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0095	0.0809	0.0809
Schistosoma mansoni	suppressor of cytokine signaling	0.0097	0.0838	0.0838
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0097	0.0838	0.0838
Loa Loa (eye worm)	dihydrofolate reductase	0.0861	1	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0097	0.0838	0.0838
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0124	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Onchocerca volvulus		0.0124	0.1165	1
Echinococcus multilocularis	c src tyrosine kinase	0.0219	0.2301	0.2301
Schistosoma mansoni	tyrosine kinase	0.0124	0.1165	0.1165
Brugia malayi	SH2 domain containing protein	0.0124	0.1165	0.1165
Echinococcus multilocularis	expressed protein	0.0095	0.0809	0.0809
Echinococcus multilocularis	nostrin	0.0095	0.0809	0.0809
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0124	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0809	0.0809
Brugia malayi	Protein kinase domain containing protein	0.0124	0.1165	0.1165
Schistosoma mansoni	dreadlocks/dock	0.0095	0.0809	0.0809
Brugia malayi	SH2 domain containing protein	0.0097	0.0838	0.0838
Chlamydia trachomatis	dihydrofolate reductase	0.0861	1	0.5
Schistosoma mansoni	adapter molecule crk	0.0192	0.1974	0.1974
Loa Loa (eye worm)	p53BP2	0.0095	0.0809	0.0809
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0809	1
Entamoeba histolytica	SH2 domain containing protein	0.0097	0.0838	0.7192
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0219	0.2301	0.2301
Giardia lamblia	Protein 21.1	0.0027	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0809	0.0809
Echinococcus multilocularis	intersectin 2	0.0095	0.0809	0.0809
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.1165	0.1165
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0097	0.0838	0.0838
Brugia malayi	Variant SH3 domain containing protein	0.0097	0.0838	0.0838
Echinococcus multilocularis	SH2 motif	0.0097	0.0838	0.0838
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0095	0.0809	0.0809
Mycobacterium tuberculosis	Probable oxidoreductase	0.0137	0.1314	0.1027
Brugia malayi	Variant SH3 domain containing protein	0.0095	0.0809	0.0809
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0809	1
Echinococcus multilocularis		0.0097	0.0838	0.0838
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0219	0.2301	0.2301
Brugia malayi	Tensin	0.0097	0.0838	0.0838
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0095	0.0809	0.0809
Echinococcus multilocularis	tyrosine kinase	0.0124	0.1165	0.1165
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0219	0.2301	0.2301
Brugia malayi	Variant SH3 domain containing protein	0.0095	0.0809	0.0809
Echinococcus multilocularis	signal transduction protein lnk realted	0.0097	0.0838	0.0838
Schistosoma mansoni	tensin	0.0097	0.0838	0.0838
Brugia malayi	Variant SH3 domain containing protein	0.0095	0.0809	0.0809
Schistosoma mansoni	eps8-related protein	0.0095	0.0809	0.0809
Brugia malayi	Protein kinase domain containing protein	0.0124	0.1165	0.1165
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0219	0.2301	0.2301
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0861	1	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0192	0.1974	0.1974
Onchocerca volvulus		0.0095	0.0809	0.6944
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Trichomonas vaginalis	p67phox protein, putative	0.0095	0.0809	1
Echinococcus multilocularis	NCK adaptor protein	0.0192	0.1974	0.1974
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0838	0.0838
Schistosoma mansoni	tensin-related	0.0097	0.0838	0.0838
Echinococcus granulosus	thioredoxin glutathione reductase	0.0054	0.032	0.032
Loa Loa (eye worm)	STAT protein	0.0097	0.0838	0.0838
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0097	0.0838	0.0838
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0124	0.1165	0.1165
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0329	0.3622	1
Schistosoma mansoni	run and tbc1 domain containing	0.0095	0.0809	0.0809
Echinococcus multilocularis	SHC transforming protein 3	0.0097	0.0838	0.0838
Onchocerca volvulus		0.0124	0.1165	1
Entamoeba histolytica	hypothetical protein, conserved	0.0095	0.0809	0.6944
Loa Loa (eye worm)	SH2 domain-containing protein	0.0097	0.0838	0.0838
Echinococcus granulosus	signal transduction protein lnk realted	0.0097	0.0838	0.0838
Brugia malayi	SRC-1	0.0219	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0809	0.0809
Schistosoma mansoni	hypothetical protein	0.0041	0.0165	0.0165
Echinococcus multilocularis	tensin	0.0097	0.0838	0.0838
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0054	0.032	0.032
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0097	0.0838	0.0838
Echinococcus multilocularis	transfer RNA-Ala	0.0095	0.0809	0.0809
Leishmania major	trypanothione reductase	0.0054	0.032	0.0884
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0192	0.1974	0.1974
Schistosoma mansoni	serine/threonine protein kinase	0.0122	0.1136	0.1136
Loa Loa (eye worm)	hypothetical protein	0.003	0.0031	0.0031
Echinococcus granulosus	hypothetical protein	0.0097	0.0838	0.0838
Schistosoma mansoni	growth factor receptor-bound protein	0.0192	0.1974	0.1974
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0097	0.0838	0.0838
Plasmodium falciparum	glutathione reductase	0.0054	0.032	0.0884
Brugia malayi	Spectrin alpha chain	0.0095	0.0809	0.0809
Loa Loa (eye worm)	TK/FER protein kinase	0.0124	0.1165	0.1165
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0124	0.1165	1
Echinococcus granulosus	dihydrofolate reductase	0.0861	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0097	0.0838	0.0838
Brugia malayi	SH2 domain containing protein	0.0097	0.0838	0.0838
Brugia malayi	Variant SH3 domain containing protein	0.0192	0.1974	0.1974

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 10 ug ml-1	Inhibition of HIV-1 replication in H9 (human lymphoma) cells.	ChEMBL.	No reference
IC50 (functional)	= 40 ug ml-1	Inhibition of uninfected H9 lymphocytic cell growth	ChEMBL.	No reference
IC50 (functional)	= 40 ug ml-1	Inhibition of uninfected H9 lymphocytic cell growth	ChEMBL.	No reference
Therapeutic index (functional)	= 4	Therapeutic index - IC50/EC50.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL352204

Bibliographic References

No literature references available for this target.

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Detailed information for compound 276511