Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0174 | 0.6062 | 1 |
Onchocerca volvulus | 0.0174 | 0.6062 | 1 | |
Echinococcus multilocularis | peroxidasin | 0.0174 | 0.6062 | 0.6062 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0174 | 0.6062 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0188 | 0.6646 | 0.6646 |
Schistosoma mansoni | rab6-interacting | 0.0045 | 0.0717 | 0.0717 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0045 | 0.0717 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0174 | 0.6062 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0174 | 0.6062 | 1 |
Onchocerca volvulus | 0.0045 | 0.0717 | 0.1182 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0174 | 0.6062 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0045 | 0.0717 | 0.0717 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0717 | 0.1182 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.0238 | 0.5 |
Onchocerca volvulus | 0.0174 | 0.6062 | 1 | |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0045 | 0.0717 | 0.0717 |
Onchocerca volvulus | Dual oxidase homolog | 0.0174 | 0.6062 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0174 | 0.6062 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.0238 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0174 | 0.6062 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0472 | 0.0472 |
Brugia malayi | Animal haem peroxidase family protein | 0.0174 | 0.6062 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0336 | 0.0554 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0174 | 0.6062 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0045 | 0.0717 | 0.1182 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0045 | 0.0717 | 0.5 |
Schistosoma mansoni | polycystin 1-related | 0.0045 | 0.0717 | 0.0717 |
Schistosoma mansoni | lipoxygenase | 0.0269 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0174 | 0.6062 | 1 |
Onchocerca volvulus | 0.0174 | 0.6062 | 1 | |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0045 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0336 | 0.0336 |
Onchocerca volvulus | 0.0045 | 0.0717 | 0.1182 | |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0717 | 0.1182 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Brugia malayi | hypothetical protein | 0.0174 | 0.6062 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0336 | 0.0336 |
Brugia malayi | Doublecortin family protein | 0.0045 | 0.0717 | 0.1182 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0045 | 0.0717 | 0.0717 |
Brugia malayi | Animal haem peroxidase family protein | 0.0174 | 0.6062 | 1 |
Schistosoma mansoni | peroxidasin | 0.0174 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0269 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.014 | 0.0231 |
Brugia malayi | Peroxidasin | 0.0174 | 0.6062 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0174 | 0.6062 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0045 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0174 | 0.6062 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0174 | 0.6062 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0045 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0045 | 0.0717 | 0.0717 |
Echinococcus multilocularis | RUN | 0.0045 | 0.0717 | 0.0717 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0717 | 0.1182 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0336 | 0.0554 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Schistosoma mansoni | peroxidasin | 0.0174 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0174 | 0.6062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Schistosoma mansoni | loxhd1 | 0.0045 | 0.0717 | 0.0717 |
Echinococcus granulosus | peroxidasin | 0.0174 | 0.6062 | 0.6062 |
Echinococcus granulosus | RUN | 0.0045 | 0.0717 | 0.0717 |
Brugia malayi | Animal haem peroxidase family protein | 0.0174 | 0.6062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0717 | 0.1182 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0472 | 0.0472 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = 50 % | Percentage change in blood glucose concentration in male Wistar rats after 2 hr post treatment at a dose of 100 mg/Kg po. | ChEMBL. | 7097725 |
Change (functional) | = 59 % | Percentage change in blood glucose concentration in male Wistar rats after 4 hr post treatment at a dose of 100 mg/Kg po. | ChEMBL. | 7097725 |
Inhibition (functional) | = 48.8 % | Analgesic activity was measured by phenylquinone writhing test in male Swiss albino mice at a dose of 0.004 mg/Kg, sc | ChEMBL. | 7097725 |
Inhibition (functional) | = 48.8 % | Analgesic activity was measured by phenylquinone writhing test in male Swiss albino mice at a dose of 0.004 mg/Kg, sc | ChEMBL. | 7097725 |
P | = 26.4 | Partition coefficient was evaluated for the compound in octanol/water system | ChEMBL. | 7097725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.