Detailed information for compound 276602

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 526.517 | Formula: C25H27FN6O6
  • H donors: 3 H acceptors: 6 LogP: 0.61 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CNc1nccc(n1)c1[nH]c(nc1c1ccc(cc1)F)[C@@H]1OC[C@@](CO1)(C)C(=O)N1CCOCC1
  • InChi: 1S/C25H27FN6O6/c1-25(23(35)32-8-10-36-11-9-32)13-37-22(38-14-25)21-30-19(15-2-4-16(26)5-3-15)20(31-21)17-6-7-27-24(29-17)28-12-18(33)34/h2-7,22H,8-14H2,1H3,(H,30,31)(H,33,34)(H,27,28,29)/t22-,25-
  • InChiKey: SJQWBEVDMPJRGT-RZFKFIIISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0188 0.403 0.7287
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0013 0.015 0.0337
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0013 0.015 0.015
Echinococcus granulosus dual specificity protein kinase clk2 0.0069 0.1387 0.1387
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3575 0.6375
Brugia malayi MH2 domain containing protein 0.0009 0.0052 0.0057
Brugia malayi Cytochrome P450 family protein 0.0048 0.0929 0.1649
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0007 0.0021 0.0021
Schistosoma mansoni smad1 5 8 and 0.0009 0.0052 0.013
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0108 0.2254 0.2254
Echinococcus granulosus roundabout 2 0.0007 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.016 0.3412 0.6164
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.3575 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0092 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0007 0.0021 0.0021
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0092 0.5
Mycobacterium leprae putative cytochrome p450 0.0011 0.0092 0.5
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0013 0.015 0.015
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0052 0.013
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0092 0.5
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0013 0.015 0.0235
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0013 0.015 0.0337
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0013 0.015 0.0373
Schistosoma mansoni tar DNA-binding protein 0.013 0.2741 0.6802
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0108 0.2254 0.2254
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.1831 0.4544
Echinococcus multilocularis roundabout 2 0.0007 0.0021 0.0021
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0177 0.378 0.378
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0092 0.5
Leishmania major hypothetical protein, conserved 0.0013 0.015 0.0337
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0089 0.1831 0.329
Giardia lamblia Kinase, NEK 0.0117 0.2441 1
Echinococcus multilocularis neuropeptide receptor A26 0.0458 1 1
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0092 0.0128
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0095 0.1962 0.3529
Brugia malayi protein unc-22 0.0009 0.0065 0.008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0547 0.0547
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0117 0.2441 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0013 0.015 0.0235
Brugia malayi MH2 domain containing protein 0.0128 0.2698 0.4867
Echinococcus granulosus nephrin 0.0007 0.0021 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0092 0.5
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0069 0.1387 0.2483
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0013 0.015 0.015
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0092 0.5
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0069 0.1387 0.7447
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0547 0.0956
Echinococcus granulosus dual specificity 0.0089 0.1831 0.1831
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0052 0.0052
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.1346 0.2409
Echinococcus granulosus roundabout 2 0.0007 0.0021 0.0021
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0013 0.015 0.0373
Loa Loa (eye worm) PDE1B protein 0.0013 0.015 0.0235
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0013 0.015 0.0337
Loa Loa (eye worm) hypothetical protein 0.0087 0.1787 0.321
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.5522 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0013 0.015 0.015
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0013 0.015 0.0337
Echinococcus multilocularis Smad4 0.0009 0.0052 0.0052
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0052 0.0057
Schistosoma mansoni neuroglian 0.0007 0.0021 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.015 0.0337
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0092 0.5
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0092 0.5
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0092 0.5
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0108 0.2254 0.2254
Brugia malayi RNA recognition motif domain containing protein 0.013 0.2741 0.4944
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.1387 0.3442
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0095 0.1962 0.1962
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.5522 1
Brugia malayi TAR-binding protein 0.013 0.2741 0.4944
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0065 0.0162
Echinococcus multilocularis titin 0.0009 0.0065 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.3775 0.6747
Echinococcus granulosus titin 0.0009 0.0065 0.0065
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Echinococcus granulosus Smad4 0.0009 0.0052 0.0052
Schistosoma mansoni tar DNA-binding protein 0.013 0.2741 0.6802
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0108 0.2254 0.9183
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0092 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0052 0.0057
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0069 0.1387 0.7447
Trichomonas vaginalis STE family protein kinase 0.0117 0.2441 0.4264
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0092 0.5
Schistosoma mansoni myosin-binding protein-related 0.0007 0.0021 0.0053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Schistosoma mansoni protein kinase 0.0177 0.378 0.9378
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.5522 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0013 0.015 0.0337
Brugia malayi Protein kinase domain containing protein 0.0188 0.403 0.7287
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Echinococcus multilocularis tar DNA binding protein 0.013 0.2741 0.2741
Schistosoma mansoni hypothetical protein 0.0031 0.0547 0.1358
Loa Loa (eye worm) hypothetical protein 0.0013 0.015 0.0235
Brugia malayi Cytochrome P450 family protein 0.0011 0.0092 0.0128
Giardia lamblia Kinase, NEK 0.0117 0.2441 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0092 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0052 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Brugia malayi Cytochrome P450 family protein 0.0011 0.0092 0.0128
Schistosoma mansoni hypothetical protein 0.0168 0.3575 0.887
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0013 0.015 0.0337
Leishmania major cAMP-specific phosphodiesterase, putative 0.0013 0.015 0.0337
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0092 0.5
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0069 0.1387 0.7447
Schistosoma mansoni cell adhesion molecule 0.0007 0.0021 0.0053
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0013 0.015 0.0337
Schistosoma mansoni hypothetical protein 0.0168 0.3575 0.887
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0092 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.2698 0.4867
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0092 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.1831 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0007 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.015 0.0235
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0069 0.1387 0.7447
Echinococcus multilocularis 0.0067 0.1343 0.1343
Schistosoma mansoni tar DNA-binding protein 0.013 0.2741 0.6802
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0092 0.5
Echinococcus multilocularis muscleblind protein 0.016 0.3412 0.3412
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0092 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0007 0.0021 0.0021
Echinococcus multilocularis GPCR, family 2 0.0031 0.0547 0.0547
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0013 0.015 0.0235
Brugia malayi RNA binding protein 0.013 0.2741 0.4944
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0092 0.5
Schistosoma mansoni titin 0.0007 0.0021 0.0053
Schistosoma mansoni smad1 5 8 and 0.0009 0.0052 0.013
Schistosoma mansoni cell adhesion molecule 0.0007 0.0021 0.0053
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1346 0.2409
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0013 0.015 0.015
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0013 0.015 0.0337
Echinococcus multilocularis 0.0011 0.0092 0.0092
Schistosoma mansoni nephrin 0.0007 0.0021 0.0053
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0117 0.2441 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0013 0.015 0.0373
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0013 0.015 0.015
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0092 0.5
Schistosoma mansoni hypothetical protein 0.0031 0.0547 0.1358
Brugia malayi MH1 domain containing protein 0.0009 0.0052 0.0057
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0069 0.1387 0.7447
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0092 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.2035 0.366
Schistosoma mansoni hypothetical protein 0.0007 0.0021 0.0053
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.1831 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0065 0.008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0092 0.5
Entamoeba histolytica hypothetical protein 0.0089 0.1831 0.5
Loa Loa (eye worm) hypothetical protein 0.0098 0.2035 0.366
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.5522 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0013 0.015 0.0337
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0092 0.5
Giardia lamblia Kinase, NEK 0.0117 0.2441 1
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3575 0.6375
Schistosoma mansoni titin 0.0009 0.0065 0.0162
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0013 0.015 0.0373
Schistosoma mansoni cytochrome P450 0.0011 0.0092 0.0227
Schistosoma mansoni hypothetical protein 0.0067 0.1346 0.334
Schistosoma mansoni tar DNA-binding protein 0.013 0.2741 0.6802
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0092 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.2698 0.4867
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0013 0.015 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.015 0.0337
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.3775 0.6747
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0069 0.1387 0.7447
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0.0092 0.5
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0013 0.015 0.0235
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.1831 1
Brugia malayi Smad1 0.0009 0.0052 0.0057
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0013 0.015 0.0373
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3575 0.6375
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.5522 1
Trichomonas vaginalis AGC family protein kinase 0.0117 0.2441 0.4264
Echinococcus multilocularis smad 0.0009 0.0052 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Brugia malayi MH1 domain containing protein 0.0009 0.0052 0.0057
Echinococcus granulosus tar DNA binding protein 0.013 0.2741 0.2741
Loa Loa (eye worm) hypothetical protein 0.0013 0.015 0.0235
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0013 0.015 0.0373
Echinococcus granulosus muscleblind protein 0.016 0.3412 0.3412
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0092 0.5
Loa Loa (eye worm) Smad1 0.0009 0.0052 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.1387 0.3442
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0092 0.5
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0013 0.015 0.015
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.2741 0.4944
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0013 0.015 0.0337
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0092 0.0128
Echinococcus multilocularis dual specificity 0.0089 0.1831 0.1831
Leishmania major protein kinase, putative 0.0069 0.1387 0.7447
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0013 0.015 0.015
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0095 0.1962 0.1962
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0013 0.015 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.015 0.0337
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0013 0.015 0.0373
Echinococcus multilocularis transfer RNA-Phe 0.0007 0.0021 0.0021
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0108 0.2254 0.5592
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0092 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Onchocerca volvulus 0.0009 0.0065 0.0124
Echinococcus multilocularis roundabout 2 0.0007 0.0021 0.0021
Loa Loa (eye worm) RNA binding protein 0.013 0.2741 0.4944
Echinococcus granulosus smad 0.0009 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0031 0.0547 0.1358
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3575 0.6375
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0007 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0011 0.0092 0.0227
Loa Loa (eye worm) TAR-binding protein 0.013 0.2741 0.4944
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0108 0.2254 0.2254
Giardia lamblia Kinase, CMGC CLK 0.0069 0.1387 0.54
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0092 0.0128
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0092 0.0092
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0089 0.1831 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0092 0.5
Schistosoma mansoni nephrin 0.0007 0.0021 0.0053
Entamoeba histolytica protein kinase, putative 0.0089 0.1831 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0092 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.5522 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0013 0.015 0.0337
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0009 0.0065 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.015 0.0337
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0013 0.015 0.0235
Echinococcus granulosus neuroglian 0.0007 0.0021 0.0021
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0013 0.015 0.0235
Loa Loa (eye worm) hypothetical protein 0.0031 0.0547 0.0956
Echinococcus granulosus neuropeptide receptor A26 0.0458 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0013 0.015 0.0337
Loa Loa (eye worm) hypothetical protein 0.0108 0.2254 0.4058
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Plasmodium vivax serine/threonine kinase-1, putative 0.0069 0.1387 0.54
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0052 0.0052
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0089 0.1831 1
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0069 0.1387 0.5514
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0092 0.5
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0092 0.5
Echinococcus multilocularis muscleblind protein 1 0.016 0.3412 0.3412
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.016 0.3412 0.6164
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0547 0.0956
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0547 0.0547
Echinococcus multilocularis roundabout 2 0.0007 0.0021 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3575 0.6375
Schistosoma mansoni smad 0.0009 0.0052 0.013
Plasmodium falciparum NIMA related kinase 1 0.0117 0.2441 1
Entamoeba histolytica protein kinase, putative 0.0089 0.1831 0.5
Brugia malayi Protein kinase domain containing protein 0.0089 0.1831 0.329
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0547 0.0547
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0052 0.0052
Schistosoma mansoni Smad4 0.0009 0.0052 0.013
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0007 0.0021 0.0053
Plasmodium falciparum protein serine/threonine kinase-1 0.0069 0.1387 0.54
Trichomonas vaginalis CMGC family protein kinase 0.0069 0.1387 0.2302
Loa Loa (eye worm) hypothetical protein 0.0087 0.1787 0.321
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0013 0.015 0.015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Brugia malayi cytochrome P450 0.0011 0.0092 0.0128
Echinococcus multilocularis geminin 0.0168 0.3575 0.3575
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.5522 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0095 0.1962 0.3529
Leishmania major hypothetical protein, conserved 0.0013 0.015 0.0337
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0092 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3575 0.6375
Schistosoma mansoni tar DNA-binding protein 0.013 0.2741 0.6802
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0013 0.015 0.0373
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.5522 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0092 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.2035 0.366
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0013 0.015 0.0373
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0013 0.015 0.0373
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.015 0.0337
Echinococcus granulosus roundabout 2 0.0007 0.0021 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.403 1
Schistosoma mansoni hemicentin 0.0007 0.0021 0.0053
Schistosoma mansoni smad1 5 8 and 0.0009 0.0052 0.013
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0092 0.5
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0013 0.015 0.015
Brugia malayi MH2 domain containing protein 0.0009 0.0052 0.0057
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0547 0.0956
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0007 0.0021 0.0021
Leishmania major protein kinase, putative 0.0069 0.1387 0.7447
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0013 0.015 0.0235
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0092 0.5
Echinococcus granulosus contactin 0.0007 0.0021 0.0021
Schistosoma mansoni protein kinase 0.0177 0.378 0.9378
Echinococcus multilocularis neuroglian 0.0007 0.0021 0.0021
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0092 0.5
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0013 0.015 0.0337
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0092 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0458 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1343 0.2403
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0177 0.378 0.378
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.015 0.0337
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0009 0.0065 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3575 0.6375
Echinococcus granulosus GPCR family 2 0.0031 0.0547 0.0547
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0929 0.1649
Echinococcus multilocularis dual specificity protein kinase clk2 0.0069 0.1387 0.1387
Echinococcus granulosus titin 0.0009 0.0065 0.0065
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0092 0.5
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0092 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.015 0.025
Schistosoma mansoni cell adhesion molecule 0.0007 0.0021 0.0053
Brugia malayi Cytochrome P450 family protein 0.0011 0.0092 0.0128
Brugia malayi Protein kinase domain containing protein 0.0069 0.1387 0.2483
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.2035 0.366
Loa Loa (eye worm) CAMK protein kinase 0.0009 0.0065 0.008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0108 0.2254 0.9204
Schistosoma mansoni hypothetical protein 0.0031 0.0547 0.1358
Echinococcus granulosus geminin 0.0168 0.3575 0.3575
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0092 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0013 0.015 0.0337
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0013 0.015 0.0337
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0092 0.5
Loa Loa (eye worm) cytochrome P450 0.0011 0.0092 0.0128
Schistosoma mansoni cell adhesion molecule 0.0007 0.0021 0.0053
Brugia malayi Muscleblind-like protein 0.016 0.3412 0.6164
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.015 0.0337
Echinococcus granulosus hypothetical protein 0.0067 0.1343 0.1343

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 10000 nM Inhibitory concentration against lipopolysaccharide induced TNF-alpha release on human monocytes ChEMBL. 11266171

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.