Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | purine nucleoside phosphorylase | 289 aa | 255 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0154 | 1 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0032 | 0 | 0.5 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0032 | 0 | 0.5 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0154 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0154 | 1 | 1 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0032 | 0 | 0.5 |
Treponema pallidum | pfs protein (pfs) | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Trypanosoma brucei | uridine phosphorylase | 0.0032 | 0 | 0.5 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0122 | 0.7389 | 0.7389 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.7389 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0032 | 0 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Chlamydia trachomatis | AMP nucleosidase | 0.0032 | 0 | 0.5 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0122 | 0.7389 | 0.7389 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0122 | 0.7389 | 0.7389 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21.9 nM | Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate | ChEMBL. | 8421291 |
IC50 (binding) | = 21.9 nM | Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate | ChEMBL. | 8421291 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.