Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0025 | 0.0184 | 0.03 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0025 | 0.0184 | 0.0374 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1076 | 0.2186 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0152 | 0.6134 | 1 |
Trypanosoma brucei | beta lactamase | 0.0063 | 0.1971 | 0.3213 |
Mycobacterium ulcerans | hypothetical protein | 0.0152 | 0.6134 | 1 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0152 | 0.6134 | 0.6134 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.6134 | 0.6134 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0152 | 0.6134 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0225 | 0.9576 | 0.9576 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0025 | 0.0184 | 0.03 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.4923 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1333 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0184 | 0.0184 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.4923 | 0.4923 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.4923 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0234 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1333 | 0.1333 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1076 | 0.2186 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1076 | 0.2186 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.4923 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.4923 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0132 | 0.5193 | 0.774 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0025 | 0.0184 | 0.0374 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0132 | 0.5193 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0025 | 0.0184 | 0.03 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0025 | 0.0184 | 0.0374 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.4923 | 0.4923 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0225 | 0.9576 | 0.9576 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0152 | 0.6134 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1076 | 0.2186 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0025 | 0.0184 | 0.0374 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0063 | 0.1971 | 0.3567 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1076 | 0.2186 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0152 | 0.6134 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0025 | 0.0184 | 0.0374 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.4923 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0152 | 0.6134 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0152 | 0.6134 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0025 | 0.0184 | 0.0374 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1333 | 0.1333 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0025 | 0.0184 | 0.0184 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1076 | 0.1076 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0025 | 0.0184 | 0.03 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0234 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0152 | 0.6134 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0025 | 0.0184 | 0.03 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1076 | 0.1076 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0025 | 0.0184 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0593 | 0.0593 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.4923 | 0.4923 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0593 | 0.0593 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1076 | 0.2186 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0152 | 0.6134 | 1 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0063 | 0.1971 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.4923 | 0.4923 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0152 | 0.6134 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0025 | 0.0184 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0025 | 0.0184 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1076 | 0.2186 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.4923 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0025 | 0.0184 | 0.03 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0025 | 0.0184 | 0.03 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.4923 | 0.4923 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1333 | 0.1333 |
Brugia malayi | RNA binding protein | 0.0126 | 0.4923 | 0.4923 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0025 | 0.0184 | 0.03 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0025 | 0.0184 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.4923 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0593 | 0.1205 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0025 | 0.0184 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 6.5 ug ml-1 | Inhibition of HIV-1 replication in H9 (human lymphoma) cells. | ChEMBL. | No reference |
IC50 (functional) | = 40 ug ml-1 | Inhibition of uninfected H9 lymphocytic cell growth | ChEMBL. | No reference |
IC50 (functional) | = 40 ug ml-1 | Inhibition of uninfected H9 lymphocytic cell growth | ChEMBL. | No reference |
Therapeutic index (functional) | = 6.2 | Therapeutic index - IC50/EC50. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.