TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 521.688 | Formula: C32H43NO5
H donors: 2 H acceptors: 3 LogP: 2.54 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: OCCc1ccccc1c1ccc(cc1)COC1CC[C@@H]([C@H]1OC/C=C\CCC(=O)O)N1CCCCCC1
InChi: 1S/C32H43NO5/c34-22-19-26-10-5-6-11-28(26)27-15-13-25(14-16-27)24-38-30-18-17-29(33-20-7-1-2-8-21-33)32(30)37-23-9-3-4-12-31(35)36/h3,5-6,9-11,13-16,29-30,32,34H,1-2,4,7-8,12,17-24H2,(H,35,36)/b9-3-/t29-,30?,32+/m0/s1
InChiKey: CCRMJQHMJZIQLV-NFWRABKRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thromboxane A2 receptor	Starlite/ChEMBL	No references
Rattus norvegicus	Thromboxane A2 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	opsin-like receptor	Thromboxane A2 receptor	341 aa	313 aa	22.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.013	0.1297	0.1297
Onchocerca volvulus		0.017	0.1867	0.6046
Entamoeba histolytica	BAR/SH3 domain containing protein	0.013	0.1297	0.6944
Onchocerca volvulus		0.017	0.1867	0.6046
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.013	0.1297	0.3516
Schistosoma mansoni	eps8-related protein	0.013	0.1297	0.1297
Echinococcus multilocularis	signal transduction protein lnk realted	0.0133	0.1343	0.1343
Echinococcus granulosus	Spectrin alpha actinin	0.013	0.1297	0.1297
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0133	0.1343	0.3641
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0133	0.1343	0.1343
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.017	0.1867	0.1867
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.013	0.1297	0.1297
Schistosoma mansoni	dreadlocks/dock	0.013	0.1297	0.1297
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0133	0.1343	0.1343
Loa Loa (eye worm)	STAT protein	0.0133	0.1343	0.3641
Echinococcus granulosus	SHC transforming protein 3	0.0133	0.1343	0.1343
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1297	0.3516
Brugia malayi	Sex muscle abnormal protein 5	0.0262	0.3164	0.8579
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0133	0.1343	0.1343
Entamoeba histolytica	protein kinase, putative	0.0133	0.1343	0.7192
Onchocerca volvulus		0.013	0.1297	0.4198
Entamoeba histolytica	hypothetical protein, conserved	0.013	0.1297	0.6944
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Schistosoma mansoni	nck2/grb4	0.0262	0.3164	0.3164
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.013	0.1297	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.013	0.1297	0.1297
Trichomonas vaginalis	set domain proteins, putative	0.0257	0.3088	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0133	0.1343	0.1343
Entamoeba histolytica	protein kinase, putative	0.013	0.1297	0.6944
Schistosoma mansoni	tensin	0.0133	0.1343	0.1343
Brugia malayi	hypothetical protein	0.017	0.1867	0.5063
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.013	0.1297	0.4198
Brugia malayi	Protein kinase domain containing protein	0.017	0.1867	0.5063
Schistosoma mansoni	hypothetical protein	0.013	0.1297	0.1297
Schistosoma mansoni	shc transforming protein	0.0133	0.1343	0.1343
Brugia malayi	SRC-1	0.03	0.3688	1
Schistosoma mansoni	run and tbc1 domain containing	0.013	0.1297	0.1297
Loa Loa (eye worm)	SH2 domain-containing protein	0.0133	0.1343	0.3641
Echinococcus granulosus	signal transduction protein lnk realted	0.0133	0.1343	0.1343
Echinococcus granulosus	hypothetical protein	0.0133	0.1343	0.1343
Loa Loa (eye worm)	SRC-1	0.03	0.3688	1
Trypanosoma cruzi	hypothetical protein, conserved	0.013	0.1297	0.5
Schistosoma mansoni	apoptosis stimulating of P53	0.013	0.1297	0.1297
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1297	0.3516
Onchocerca volvulus		0.0133	0.1343	0.4348
Loa Loa (eye worm)	TK protein kinase	0.017	0.1867	0.5063
Brugia malayi	Peripheral plasma membrane protein CASK	0.013	0.1297	0.3516
Echinococcus multilocularis	SH2 motif	0.0133	0.1343	0.1343
Schistosoma mansoni	SH2A	0.0133	0.1343	0.1343
Loa Loa (eye worm)	hypothetical protein	0.013	0.1297	0.3516
Onchocerca volvulus		0.0133	0.1343	0.4348
Brugia malayi	Variant SH3 domain containing protein	0.0262	0.3164	0.8579
Echinococcus multilocularis		0.0133	0.1343	0.1343
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.03	0.3688	0.3688
Brugia malayi	Tyrosine-protein kinase abl-1	0.03	0.3688	1
Schistosoma mansoni	tyrosine kinase	0.03	0.3688	0.3688
Echinococcus multilocularis	expressed protein	0.013	0.1297	0.1297
Entamoeba histolytica	hypothetical protein	0.013	0.1297	0.6944
Echinococcus granulosus	tyrosine protein kinase Srms	0.017	0.1867	0.1867
Echinococcus multilocularis	N chimaerin	0.0133	0.1343	0.1343
Echinococcus granulosus	tyrosine protein kinase Blk	0.017	0.1867	0.1867
Entamoeba histolytica	BAR/SH3 domain containing protein	0.013	0.1297	0.6944
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.013	0.1297	0.1297
Brugia malayi	Variant SH3 domain containing protein	0.0133	0.1343	0.3641
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0262	0.3164	0.3164
Brugia malayi	SH2 domain containing protein	0.0133	0.1343	0.3641
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.013	0.1297	0.4198
Schistosoma mansoni	tyrosine kinase	0.03	0.3688	0.3688
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1297	0.4198
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1297	0.4198
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1297	0.3516
Schistosoma mansoni	adapter molecule crk	0.0262	0.3164	0.3164
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.03	0.3688	0.3688
Echinococcus multilocularis	nostrin	0.013	0.1297	0.1297
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.017	0.1867	0.1867
Brugia malayi	Variant SH3 domain containing protein	0.0262	0.3164	0.8579
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.017	0.1867	0.1867
Schistosoma mansoni	serine/threonine protein kinase	0.0167	0.1821	0.1821
Echinococcus granulosus	fch and double sh3 domains protein 2	0.013	0.1297	0.1297
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.013	0.1297	0.1297
Loa Loa (eye worm)	hypothetical protein	0.013	0.1297	0.3516
Echinococcus granulosus	SH2 domain containing protein 7	0.0133	0.1343	0.1343
Entamoeba histolytica	hypothetical protein	0.013	0.1297	0.6944
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0133	0.1343	0.1343
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1297	0.4198
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0133	0.1343	0.3641
Schistosoma mansoni	hypothetical protein	0.0133	0.1343	0.1343
Schistosoma mansoni	suppressor of cytokine signaling	0.0133	0.1343	0.1343
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.03	0.3688	0.3688
Brugia malayi	Protein kinase domain containing protein	0.017	0.1867	0.5063
Giardia lamblia	Protein 21.1	0.0037	0	0.5
Schistosoma mansoni	tensin-related	0.0133	0.1343	0.1343
Schistosoma mansoni	dynamin-associated protein	0.013	0.1297	0.1297
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0133	0.1343	0.1343
Loa Loa (eye worm)	TK/FER protein kinase	0.017	0.1867	0.5063
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1297	0.4198
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Loa Loa (eye worm)	guanylate kinase	0.013	0.1297	0.3516
Loa Loa (eye worm)	SH2 domain-containing protein	0.0133	0.1343	0.3641
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0133	0.1343	0.1343
Onchocerca volvulus	Putative cortactin	0.013	0.1297	0.4198
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0133	0.1343	0.3641
Onchocerca volvulus		0.0133	0.1343	0.4348
Echinococcus multilocularis	tyrosine protein kinase Srms	0.017	0.1867	0.1867
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.017	0.1867	0.1867
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.013	0.1297	0.3516
Echinococcus granulosus	tyrosine protein kinase shark	0.017	0.1867	0.1867
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0133	0.1343	0.1343
Schistosoma mansoni	microtubule-associated protein tau	0.0749	1	1
Brugia malayi	SH2 domain containing protein	0.017	0.1867	0.5063
Loa Loa (eye worm)	hypothetical protein	0.013	0.1297	0.3516
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.013	0.1297	0.1297
Brugia malayi	SH2 domain containing protein	0.017	0.1867	0.5063
Echinococcus multilocularis	tyrosine protein kinase Abl	0.03	0.3688	0.3688
Schistosoma mansoni	hypothetical protein	0.013	0.1297	0.1297
Onchocerca volvulus		0.017	0.1867	0.6046
Entamoeba histolytica	hypothetical protein	0.013	0.1297	0.6944
Loa Loa (eye worm)	hypothetical protein	0.013	0.1297	0.3516
Brugia malayi	Variant SH3 domain containing protein	0.0133	0.1343	0.3641
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0133	0.1343	0.1343
Onchocerca volvulus		0.017	0.1867	0.6046
Echinococcus granulosus	NCK adaptor protein	0.0262	0.3164	0.3164
Onchocerca volvulus		0.013	0.1297	0.4198
Echinococcus granulosus	intersectin 2	0.013	0.1297	0.1297
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.013	0.1297	0.5
Schistosoma mansoni	tensin-related	0.0133	0.1343	0.1343
Entamoeba histolytica	hypothetical protein, conserved	0.013	0.1297	0.6944
Loa Loa (eye worm)	thyroid receptor interactor	0.013	0.1297	0.3516
Echinococcus granulosus	tyrosine protein kinase Fyn	0.03	0.3688	0.3688
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.013	0.1297	0.1297
Loa Loa (eye worm)	TK/ABL protein kinase	0.017	0.1867	0.5063
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0262	0.3164	0.8579
Echinococcus granulosus	src region	0.013	0.1297	0.1297
Echinococcus granulosus	nostrin	0.013	0.1297	0.1297
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0133	0.1343	0.1343
Entamoeba histolytica	hypothetical protein	0.013	0.1297	0.6944
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0133	0.1343	0.1343
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.03	0.3688	0.3688
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0133	0.1343	0.7192
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.03	0.3688	0.3688
Schistosoma mansoni	GTPase activating protein	0.0133	0.1343	0.1343
Echinococcus multilocularis	SHC transforming protein 3	0.0133	0.1343	0.1343
Brugia malayi	hypothetical protein	0.0133	0.1343	0.3641
Schistosoma mansoni	growth factor receptor-bound protein	0.0262	0.3164	0.3164
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1297	0.3516
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.013	0.1297	0.1297
Entamoeba histolytica	hypothetical protein	0.013	0.1297	0.6944
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0133	0.1343	0.3641
Echinococcus granulosus	tyrosine protein kinase Lyn	0.03	0.3688	0.3688
Trypanosoma cruzi	hypothetical protein, conserved	0.013	0.1297	0.5
Echinococcus granulosus	expressed conserved protein	0.0133	0.1343	0.1343
Loa Loa (eye worm)	SH2 domain-containing protein	0.0133	0.1343	0.3641
Onchocerca volvulus		0.017	0.1867	0.6046
Loa Loa (eye worm)	TK/FER protein kinase	0.017	0.1867	0.5063
Brugia malayi	Myosin tail family protein	0.013	0.1297	0.3516
Brugia malayi	protein-tyrosine kinase	0.013	0.1297	0.3516
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0133	0.1343	0.3641
Echinococcus granulosus	expressed protein	0.013	0.1297	0.1297
Onchocerca volvulus		0.0133	0.1343	0.4348
Echinococcus multilocularis	Spectrin alpha actinin	0.013	0.1297	0.1297
Schistosoma mansoni	C-fyn	0.013	0.1297	0.1297
Loa Loa (eye worm)	hypothetical protein	0.013	0.1297	0.3516
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.03	0.3688	0.3688
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.03	0.3688	0.3688
Echinococcus granulosus	tensin	0.0133	0.1343	0.1343
Entamoeba histolytica	hypothetical protein	0.013	0.1297	0.6944
Echinococcus multilocularis	microtubule associated protein 2	0.0749	1	1
Brugia malayi	Fes/CIP4 homology domain containing protein	0.013	0.1297	0.3516
Schistosoma mansoni	signal transduction protein lnk-related	0.0133	0.1343	0.1343
Echinococcus multilocularis	SH2 motif	0.0133	0.1343	0.1343
Echinococcus granulosus	epidermal growth factor receptor kinase	0.013	0.1297	0.1297
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.013	0.1297	0.1297
Schistosoma mansoni	tyrosine kinase	0.03	0.3688	0.3688
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Loa Loa (eye worm)	hypothetical protein	0.013	0.1297	0.3516
Echinococcus multilocularis	tensin	0.0133	0.1343	0.1343
Echinococcus granulosus	endophilin A3	0.013	0.1297	0.1297
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0133	0.1343	0.1343
Schistosoma mansoni	Dab2-interacting protein-like	0.013	0.1297	0.1297
Entamoeba histolytica	hypothetical protein	0.013	0.1297	0.6944
Schistosoma mansoni	suppressor of cytokine signaling	0.0133	0.1343	0.1343
Giardia lamblia	Kinase, NEK	0.0037	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0133	0.1343	0.1343
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.03	0.3688	0.3688
Echinococcus multilocularis	tensin	0.0133	0.1343	0.1343
Brugia malayi	Pre-SET motif family protein	0.0226	0.265	0.7185
Onchocerca volvulus		0.0133	0.1343	0.4348
Echinococcus multilocularis	SH2 domain containing protein 7	0.0133	0.1343	0.1343
Brugia malayi	Protein kinase domain containing protein	0.017	0.1867	0.5063
Echinococcus multilocularis	transfer RNA-Ala	0.013	0.1297	0.1297
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.03	0.3688	0.3688
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.013	0.1297	0.1297
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.03	0.3688	0.3688
Brugia malayi	SH2 domain containing protein	0.0133	0.1343	0.3641
Echinococcus multilocularis	c src tyrosine kinase	0.03	0.3688	0.3688
Echinococcus granulosus	tyrosine protein kinase Src42A	0.03	0.3688	0.3688
Brugia malayi	Protein kinase domain containing protein	0.017	0.1867	0.5063
Echinococcus granulosus	SH2 motif	0.0133	0.1343	0.1343
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0133	0.1343	0.4348
Brugia malayi	Spectrin alpha chain	0.013	0.1297	0.3516
Onchocerca volvulus		0.0133	0.1343	0.4348
Schistosoma mansoni	tensin	0.0133	0.1343	0.1343
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Echinococcus granulosus	tyrosine kinase	0.017	0.1867	0.1867
Echinococcus multilocularis	tyrosine protein kinase shark	0.017	0.1867	0.1867
Loa Loa (eye worm)	hypothetical protein	0.013	0.1297	0.3516
Loa Loa (eye worm)	TK/FER protein kinase	0.017	0.1867	0.5063
Trypanosoma brucei	conserved protein	0.013	0.1297	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.017	0.1867	1
Schistosoma mansoni	tyrosine kinase	0.017	0.1867	0.1867
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1297	0.4198
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0133	0.1343	0.1343
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Echinococcus granulosus	tyrosine protein kinase Fyn	0.03	0.3688	0.3688
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.013	0.1297	0.1297
Schistosoma mansoni	sorbin	0.013	0.1297	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.013	0.1297	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0262	0.3164	0.8579
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Echinococcus multilocularis	NCK adaptor protein	0.0262	0.3164	0.3164
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1297	0.4198
Echinococcus multilocularis	tyrosine kinase	0.017	0.1867	0.1867
Loa Loa (eye worm)	TK/FER protein kinase	0.017	0.1867	0.5063
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.03	0.3688	0.3688
Brugia malayi	SH2 domain containing protein	0.0133	0.1343	0.3641
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0133	0.1343	0.1343
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.1343	0.3641
Echinococcus granulosus	tyrosine protein kinase ABL1	0.017	0.1867	0.1867
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0133	0.1343	0.1343
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0133	0.1343	0.1343
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0133	0.1343	0.1343
Loa Loa (eye worm)	p53BP2	0.013	0.1297	0.3516
Echinococcus granulosus	SH2 motif	0.0133	0.1343	0.1343
Brugia malayi	RhoGAP domain containing protein	0.0133	0.1343	0.3641
Entamoeba histolytica	unconventional myosin IB	0.013	0.1297	0.6944
Loa Loa (eye worm)	TK/FER protein kinase	0.017	0.1867	0.5063
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.013	0.1297	0.1297
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.03	0.3688	0.3688
Onchocerca volvulus		0.013	0.1297	0.4198
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.017	0.1867	0.1867
Brugia malayi	Guanylate kinase family protein	0.013	0.1297	0.3516
Onchocerca volvulus		0.017	0.1867	0.6046
Schistosoma mansoni	growth factor receptor-bound protein	0.0262	0.3164	0.3164
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1297	0.3516
Loa Loa (eye worm)	TK/FER protein kinase	0.017	0.1867	0.5063
Leishmania major	hypothetical protein, conserved	0.013	0.1297	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.03	0.3688	0.3688
Echinococcus multilocularis	SH2 motif	0.0133	0.1343	0.1343
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0226	0.265	0.7185
Loa Loa (eye worm)	hypothetical protein	0.013	0.1297	0.3516
Trypanosoma cruzi	hypothetical protein, conserved	0.013	0.1297	0.5
Brugia malayi	Tensin	0.0133	0.1343	0.3641
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1297	0.4198
Brugia malayi	SH2 domain containing protein	0.0133	0.1343	0.3641
Loa Loa (eye worm)	TK/FER protein kinase	0.017	0.1867	0.5063
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0133	0.1343	0.1343
Brugia malayi	protein-tyrosine kinase	0.017	0.1867	0.5063
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0133	0.1343	0.4348
Loa Loa (eye worm)	TK/FER protein kinase	0.017	0.1867	0.5063
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Schistosoma mansoni	hypothetical protein	0.0133	0.1343	0.1343
Brugia malayi	Src substrate cortactin	0.013	0.1297	0.3516
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0133	0.1343	0.1343
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0133	0.1343	0.3641
Schistosoma mansoni	sorting nexin	0.013	0.1297	0.1297
Echinococcus granulosus	growth factor receptor bound protein 2	0.0262	0.3164	0.3164
Echinococcus multilocularis	intersectin 2	0.013	0.1297	0.1297
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0262	0.3164	0.3164
Echinococcus multilocularis	tyrosine protein kinase Blk	0.017	0.1867	0.1867
Entamoeba histolytica	hypothetical protein	0.013	0.1297	0.6944
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.013	0.1297	0.1297
Loa Loa (eye worm)	hypothetical protein	0.013	0.1297	0.3516
Brugia malayi	SH2 domain containing protein	0.0133	0.1343	0.3641
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0133	0.1343	0.1343
Onchocerca volvulus		0.0257	0.3088	1
Brugia malayi	Protein kinase domain containing protein	0.017	0.1867	0.5063
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1297	0.3516
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.03	0.3688	0.3688
Echinococcus granulosus	c src tyrosine kinase	0.03	0.3688	0.3688
Brugia malayi	SH2 domain containing protein	0.0133	0.1343	0.3641
Onchocerca volvulus		0.013	0.1297	0.4198
Trichomonas vaginalis	p67phox protein, putative	0.013	0.1297	0.4198
Schistosoma mansoni	tyrosine kinase	0.017	0.1867	0.1867
Schistosoma mansoni	cell polarity protein	0.013	0.1297	0.1297
Schistosoma mansoni	tensin	0.0133	0.1343	0.1343
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.1343	0.3641
Schistosoma mansoni	tyrosine kinase	0.03	0.3688	0.3688
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0133	0.1343	0.1343
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1343	0.3641
Loa Loa (eye worm)	TK/FER protein kinase	0.017	0.1867	0.5063
Echinococcus multilocularis	endophilin A3	0.013	0.1297	0.1297
Onchocerca volvulus		0.013	0.1297	0.4198
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0262	0.3164	0.8579
Entamoeba histolytica	SH2 domain containing protein	0.0133	0.1343	0.7192
Brugia malayi	SH3 domain containing protein	0.013	0.1297	0.3516
Brugia malayi	SH2 domain containing protein	0.0133	0.1343	0.3641
Echinococcus granulosus	tyrosine protein kinase Src64B	0.03	0.3688	0.3688
Loa Loa (eye worm)	protein-tyrosine kinase	0.013	0.1297	0.3516
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.013	0.1297	0.1297
Echinococcus granulosus	tyrosine kinase	0.017	0.1867	0.1867
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.03	0.3688	0.3688
Loa Loa (eye worm)	TK/FER protein kinase	0.017	0.1867	0.5063
Echinococcus granulosus	N chimaerin	0.0133	0.1343	0.1343
Schistosoma mansoni	formin binding protein and related proteins	0.013	0.1297	0.1297
Loa Loa (eye worm)	hypothetical protein	0.017	0.1867	0.5063
Schistosoma mansoni	vav2	0.0133	0.1343	0.1343

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (functional)	= 7.5	In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced contraction of rat isolated thoracic aortic strip	ChEMBL.	No reference
Kd (functional)	= 8.7	In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood	ChEMBL.	No reference
pA2 (functional)	= 7.5	In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced contraction of rat isolated thoracic aortic strip	ChEMBL.	No reference
pA2 (functional)	= 8.7	In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL161252

Bibliographic References

No literature references available for this target.

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Detailed information for compound 276837