Detailed information for compound 276896

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 850.967 | Formula: C39H58N14O8
  • H donors: 13 H acceptors: 8 LogP: -3.21 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=NCCCC(C(=O)N[C@H](C(=O)N)CCCN=C(N)N)NC(=O)[C@@H]1CC(=O)NCCCC(C(=O)NC(C(=O)N1)Cc1ccccc1)NC(=O)C(Cc1ccc(cc1)O)N)N
  • InChi: 1S/C39H58N14O8/c40-25(19-23-12-14-24(54)15-13-23)33(57)50-27-10-5-16-46-31(55)21-30(53-36(60)29(52-35(27)59)20-22-7-2-1-3-8-22)37(61)51-28(11-6-18-48-39(44)45)34(58)49-26(32(41)56)9-4-17-47-38(42)43/h1-3,7-8,12-15,25-30,54H,4-6,9-11,16-21,40H2,(H2,41,56)(H,46,55)(H,49,58)(H,50,57)(H,51,61)(H,52,59)(H,53,60)(H4,42,43,47)(H4,44,45,48)/t25?,26-,27?,28?,29?,30+/m0/s1
  • InChiKey: UFLXRFZGSMQQIS-NMBXPOJZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.012 0.012
Echinococcus granulosus lamin dm0 0.0027 0.0045 0.0045
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni neuropeptide receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Trichomonas vaginalis STE family protein kinase 0.2501 1 1
Schistosoma mansoni amine GPCR 0.1097 0.4352 0.4352
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0035 0.008 0.0147
Brugia malayi Hemopexin family protein 0.0277 0.1052 0.1052
Onchocerca volvulus 0.1097 0.4352 0.8051
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus neuropeptides capa receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0015 0.0015
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0015 0.0015
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0309 0.1181 0.1181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Trypanosoma brucei carbonic anhydrase-like protein 0.1244 0.494 0.494
Loa Loa (eye worm) hypothetical protein 0.0238 0.0895 0.0895
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus g protein coupled receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Loa Loa (eye worm) matrix metalloproteinase 0.0195 0.0723 0.0723
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni transcription factor LCR-F1 0.0069 0.0215 0.0215
Schistosoma mansoni lamin 0.0027 0.0045 0.0045
Loa Loa (eye worm) excitatory amino acid transporter 0.1359 0.5406 0.5406
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0069 0.0215 1
Brugia malayi ecdysteroid receptor 0.0019 0.0015 0.0015
Toxoplasma gondii isocitrate dehydrogenase 0.003 0.0059 0.0503
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Echinococcus multilocularis lamin 0.0027 0.0045 0.0045
Echinococcus granulosus carbonic anhydrase II 0.1244 0.494 0.494
Echinococcus granulosus carbonic anhydrase 0.0309 0.1181 0.1181
Echinococcus granulosus Excitatory amino acid transporter 0.1359 0.5406 0.5406
Echinococcus multilocularis neutral amino acid transporter A 0.1359 0.5406 0.5406
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni biogenic amine receptor 0.1097 0.4352 0.4352
Brugia malayi Matrixin family protein 0.0195 0.0723 0.0723
Echinococcus multilocularis neuropeptide receptor 0.1097 0.4352 0.4352
Brugia malayi Esterase D 0.0035 0.008 0.008
Schistosoma mansoni lamin 0.0027 0.0045 0.0045
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0035 0.008 0.0242
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0038
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni carbonic anhydrase-related 0.0309 0.1181 0.1181
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Leishmania major hypothetical protein, conserved 0.0025 0.0038 0.0038
Trichomonas vaginalis TKL family protein kinase 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus G protein coupled receptor 139 0.1097 0.4352 0.4352
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.003 0.0059 0.0059
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.003 0.0059 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0336 0.0336
Giardia lamblia Kinase, NEK-like 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0057 0.0482
Onchocerca volvulus 0.1097 0.4352 0.8051
Onchocerca volvulus 0.1097 0.4352 0.8051
Leishmania major carbonic anhydrase-like protein 0.1244 0.494 0.494
Giardia lamblia Kinase, NEK-like 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Pre-SET motif family protein 0.003 0.0057 0.0057
Echinococcus multilocularis excitatory amino acid transporter 2 0.1359 0.5406 0.5406
Entamoeba histolytica hypothetical protein 0.0069 0.0215 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni protein kinase 0.2501 1 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.0427 0.0791
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus serotonin receptor 0.1097 0.4352 0.4352
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1097 0.4352 0.4352
Onchocerca volvulus 0.0195 0.0723 0.1338
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1097 0.4352 0.4352
Echinococcus granulosus neuropeptide Y receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0059 0.0059
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0064 0.0064
Toxoplasma gondii hypothetical protein 0.0309 0.1181 1
Loa Loa (eye worm) neuropeptide F receptor 0.1097 0.4352 0.4352
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0309 0.1181 0.1181
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis Excitatory amino acid transporter 0.1359 0.5406 0.5406
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis neutral amino acid transporter A 0.1359 0.5406 0.5406
Brugia malayi larval opioid receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus sodium:dicarboxylate symporter 0.1359 0.5406 0.5406
Schistosoma mansoni neuropeptide receptor 0.1097 0.4352 0.4352
Echinococcus granulosus carbonic anhydrase 0.0309 0.1181 0.1181
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1097 0.4352 0.4352
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus 0.003 0.0057 0.0105
Echinococcus granulosus GPCR family 2 0.0031 0.0064 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Onchocerca volvulus Matrix metalloproteinase homolog 0.0433 0.168 0.3109
Echinococcus multilocularis neuropeptide Y receptor 0.1097 0.4352 0.4352
Echinococcus granulosus neuropeptide FF receptor 2 0.1097 0.4352 0.4352
Onchocerca volvulus 0.1097 0.4352 0.8051
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis neutral amino acid transporter A 0.1359 0.5406 0.5406
Mycobacterium tuberculosis Conserved protein 0.0035 0.008 0.0147
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.0068 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0602 0.2361 0.2361
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Entamoeba histolytica hypothetical protein 0.0069 0.0215 1
Treponema pallidum glutamate/aspartate transporter 0.0602 0.2361 0.5
Echinococcus multilocularis musashi 0.0027 0.0045 0.0045
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.003 0.0059 0.0059
Schistosoma mansoni amine GPCR 0.1097 0.4352 0.4352
Loa Loa (eye worm) isocitrate dehydrogenase 0.003 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis Excitatory amino acid transporter 0.1359 0.5406 0.5406
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi hypothetical protein 0.0016 0.0003 0.0003
Echinococcus multilocularis dro:myosuppressin receptor 0.1097 0.4352 0.4352
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0195 0.0723 0.0723
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0035 0.008 0.0242
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0069 0.0215 0.0215
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0057 0.0057
Giardia lamblia Kinase, NEK-like 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0059 0.0059
Brugia malayi GnHR receptor homolog 0.1097 0.4352 0.4352
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1359 0.5406 0.5406
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0045 0.0045
Brugia malayi nuclear receptor NHR-88 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Echinococcus multilocularis G-protein coupled receptor, putative 0.1097 0.4352 0.4352
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.003 0.0059 0.0059
Onchocerca volvulus 0.1097 0.4352 0.8051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0064
Schistosoma mansoni neuropeptide f receptor 76f 0.1097 0.4352 0.4352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1097 0.4352 0.8051
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0015 0.0015
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0038 0.645
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0057 0.0057
Echinococcus granulosus tm gpcr rhodopsin 0.1097 0.4352 0.4352
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.071 0.2795 0.2795
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0038 0.0038
Loa Loa (eye worm) esterase D 0.0035 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus tm gpcr rhodopsin 0.1722 0.6866 0.6866
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Brugia malayi G-protein coupled receptor 0.1097 0.4352 0.4352
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0059 0.0059
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0053 0.0053
Schistosoma mansoni opsin-like receptor 0.1097 0.4352 0.4352
Onchocerca volvulus 0.1097 0.4352 0.8051
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Chlamydia trachomatis glutamate symporter 0.1359 0.5406 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0059 0.0059
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni carbonic anhydrase 0.0309 0.1181 0.1181
Giardia lamblia Kinase, NEK-like 0.0016 0.0000000050008 0.0000000050008
Brugia malayi neuropeptide F receptor 0.1097 0.4352 0.4352
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0038 0.0038
Echinococcus granulosus excitatory amino acid transporter 3 0.1359 0.5406 0.5406
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0309 0.1181 0.1181
Echinococcus multilocularis orexin receptor type 2 0.1097 0.4352 0.4352
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0309 0.1181 0.1181
Onchocerca volvulus 0.1097 0.4352 0.8051
Echinococcus granulosus biogenic amine 5HT receptor 0.1097 0.4352 0.4352
Schistosoma mansoni neuropeptide F-like receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.012 0.012
Brugia malayi G-protein coupled receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi intermediate filament protein 0.0027 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus 0.1097 0.4352 0.8051
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis g-protein coupled receptor 0.1097 0.4352 0.4352
Plasmodium vivax SET domain protein, putative 0.003 0.0057 0.9577
Brugia malayi Matrixin family protein 0.0195 0.0723 0.0723
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0015 0.0015
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1097 0.4352 0.4352
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0035 0.008 0.0147
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0035 0.008 0.0242
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0015 0.0015
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0057
Giardia lamblia Kinase, NEK-like 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) melatonin receptor type 1A 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) matrixin family protein 0.0433 0.168 0.168
Onchocerca volvulus Huntingtin homolog 0.0122 0.0427 0.0791
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0885 0.0885
Mycobacterium tuberculosis Possible conserved membrane protein 0.0035 0.008 0.0147
Schistosoma mansoni myosin xvIII 0.1097 0.4352 0.4352
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0015 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0057 0.0057
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0602 0.2361 0.2361
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0015 0.0015
Echinococcus granulosus dual specificity mitogen activated protein 0.2501 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0309 0.1181 0.1181
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0309 0.1181 0.1181
Echinococcus granulosus neuropeptide Y receptor 0.1097 0.4352 0.4352
Echinococcus granulosus allatostatin A receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0035 0.008 0.0147
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0831 0.3281 1
Echinococcus multilocularis neuropeptide receptor 0.1097 0.4352 0.4352
Brugia malayi follicle stimulating hormone receptor 0.1097 0.4352 0.4352
Echinococcus granulosus neuropeptide receptor 0.1097 0.4352 0.4352
Schistosoma mansoni neuropeptide receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.077 0.077
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1244 0.494 0.494
Brugia malayi sulfakinin receptor protein 0.1097 0.4352 0.4352
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1244 0.494 0.494
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1097 0.4352 0.4352
Onchocerca volvulus 0.0019 0.0015 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0015 0.0015
Echinococcus multilocularis g protein coupled receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0015 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus g protein coupled receptor 0.1097 0.4352 0.4352
Onchocerca volvulus 0.0236 0.0885 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0015 0.0015
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1097 0.4352 0.4352
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0099 0.0336 0.0336
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Echinococcus granulosus orexin receptor type 2 0.1097 0.4352 0.4352
Brugia malayi Excitatory amino acid transporter 0.1359 0.5406 0.5406
Echinococcus multilocularis dual specificity mitogen activated protein 0.2501 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0015 0.0015
Schistosoma mansoni intermediate filament proteins 0.0027 0.0045 0.0045
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1097 0.4352 0.4352
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0057 0.0057
Onchocerca volvulus 0.1097 0.4352 0.8051
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0309 0.1181 0.1181
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus neutral amino acid transporter A 0.1359 0.5406 0.5406
Brugia malayi Dopamine receptor protein 1 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis g protein coupled receptor 0.1097 0.4352 0.4352
Schistosoma mansoni opsin-like receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0238 0.0895 0.1655
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0064 0.0064
Echinococcus granulosus excitatory amino acid transporter 2 0.1359 0.5406 0.5406
Echinococcus multilocularis serotonin receptor 0.1097 0.4352 0.4352
Mycobacterium ulcerans hydrolase 0.0238 0.0895 0.2726
Loa Loa (eye worm) hypothetical protein 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1244 0.494 0.494
Schistosoma mansoni coup transcription factor 0.0019 0.0015 0.0015
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0015 0.0029
Echinococcus multilocularis neuropeptides capa receptor 0.1097 0.4352 0.4352
Echinococcus granulosus somatostatin receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Mycobacterium ulcerans hypothetical protein 0.0035 0.008 0.0242
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) carbonic anhydrase 3 0.1244 0.494 0.494
Entamoeba histolytica protein kinase, putative 0.0016 0.000000024579 0.0000011427
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Loa Loa (eye worm) neuropeptide F receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0602 0.2361 0.2361
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus biogenic amine 5HT receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni hypothetical protein 0.1097 0.4352 0.4352
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0015 0.0029
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0602 0.2361 0.2361
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0415 0.0415
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1097 0.4352 0.4352
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0238 0.0895 0.0895
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1097 0.4352 0.4352
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus 0.1097 0.4352 0.8051
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus 0.1097 0.4352 0.8051
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.071 0.2795 0.2795
Schistosoma mansoni carbonic anhydrase-related 0.0309 0.1181 0.1181
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0015 0.0015
Schistosoma mansoni opsin-like receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.0309 0.1181 0.1181
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1097 0.4352 0.4352
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0015 0.0015
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1097 0.4352 0.4352
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0069 0.0215 0.0215
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1097 0.4352 0.4352
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1359 0.5406 0.5406
Giardia lamblia Kinase, NEK-GL-like 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Plasmodium falciparum carbonic anhydrase 0.0309 0.1181 1
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1244 0.494 0.494
Loa Loa (eye worm) G-protein coupled receptor 0.1097 0.4352 0.4352
Schistosoma mansoni amine GPCR 0.1097 0.4352 0.4352
Brugia malayi Isocitrate dehydrogenase 0.003 0.0059 0.0059
Brugia malayi Serotonin receptor 0.1097 0.4352 0.4352
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0015 0.0015
Brugia malayi putative neuropeptide receptor 0.1097 0.4352 0.4352
Echinococcus granulosus sex peptide receptor 0.1097 0.4352 0.4352
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.003 0.0059 0.011
Echinococcus multilocularis neuropeptide s receptor 0.1522 0.6062 0.6062
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.0195 0.0723 0.0723
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0045
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.0031 0.0064 0.0064
Mycobacterium ulcerans hypothetical protein 0.0035 0.008 0.0242
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1097 0.4352 0.4352
Brugia malayi putative neuropeptide receptor NPR1 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.0031 0.0064 0.0064
Giardia lamblia Kinase, STE STE20 0.2501 1 1
Echinococcus multilocularis fmrfamide receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus neuropeptide receptor 0.1097 0.4352 0.4352
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1244 0.494 0.494
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1097 0.4352 0.4352
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1097 0.4352 0.4352
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0035 0.008 0.0242
Echinococcus multilocularis neuropeptide FF receptor 2 0.1097 0.4352 0.4352
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0038 0.0324
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0015 0.0015
Brugia malayi MH2 domain containing protein 0.0119 0.0415 0.0415
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Echinococcus granulosus 7TM GPCR rhodopsin 0.1097 0.4352 0.4352
Onchocerca volvulus Matrilysin homolog 0.0433 0.168 0.3109
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0038 0.0324
Schistosoma mansoni growth hormone secretagogue receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.012 0.012
Loa Loa (eye worm) matrixin family protein 0.0472 0.1838 0.1838
Onchocerca volvulus Matrilysin homolog 0.0195 0.0723 0.1338
Schistosoma mansoni carbonic anhydrase-related 0.0309 0.1181 0.1181
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni alpha-1 adrenergic receptor 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.0031 0.0064 0.0064
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1097 0.4352 0.4352
Echinococcus granulosus 7tm_1 domain containing protein 0.1097 0.4352 0.4352
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0122 0.0427 0.0427
Echinococcus multilocularis excitatory amino acid transporter 2 0.1359 0.5406 0.5406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Melatonin receptor type 1A 0.1097 0.4352 0.4352
Schistosoma mansoni biogenic amine (5HT) receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.3181 0.3181
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Dopamine receptor protein 2 0.1097 0.4352 0.4352
Mycobacterium tuberculosis Probable conserved exported protein 0.0035 0.008 0.0147
Mycobacterium ulcerans hypothetical protein 0.0035 0.008 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0015 0.0015
Echinococcus multilocularis g protein coupled receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.0069 0.0215 0.0215
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0045 0.0045
Echinococcus multilocularis lamin dm0 0.0027 0.0045 0.0045
Loa Loa (eye worm) TYRA-2 protein 0.1097 0.4352 0.4352
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.2501 1 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.1181 0.1181
Echinococcus granulosus lamin 0.0027 0.0045 0.0045
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.021 0.021
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase 0.0016 0.0000000050008 0.0000000050008
Brugia malayi steroid hormone receptor 0.0019 0.0015 0.0015
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0035 0.008 0.0242
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni amine GPCR 0.1097 0.4352 0.4352
Schistosoma mansoni histamine h1 receptor 0.1097 0.4352 0.4352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Schistosoma mansoni biogenic amine receptor 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.0031 0.0064 0.0064
Echinococcus multilocularis serotonin receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis isocitrate dehydrogenase 0.003 0.0059 0.0059
Echinococcus granulosus peptide allatostatin:somatostatin 0.1097 0.4352 0.4352
Trichomonas vaginalis TKL family protein kinase 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus fmrfamide receptor 0.1097 0.4352 0.4352
Echinococcus granulosus tm gpcr rhodopsin 0.1097 0.4352 0.4352
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0057 0.0057
Trichomonas vaginalis STE family protein kinase 0.2501 1 1
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus intermediate filament protein 0.0027 0.0045 0.0045
Loa Loa (eye worm) G-protein coupled receptor 0.1097 0.4352 0.4352
Echinococcus granulosus neutral amino acid transporter A 0.1359 0.5406 0.5406
Onchocerca volvulus 0.0027 0.0045 0.0084
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1097 0.4352 0.4352
Schistosoma mansoni biogenic amine receptor 0.1097 0.4352 0.4352
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.2501 1 1
Echinococcus multilocularis carbonic anhydrase II 0.1244 0.494 0.494
Echinococcus multilocularis neuropeptide receptor A26 0.1522 0.6062 0.6062
Onchocerca volvulus 0.1097 0.4352 0.8051
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi RE15519p 0.1097 0.4352 0.4352
Onchocerca volvulus 0.1097 0.4352 0.8051
Schistosoma mansoni neuropeptide receptor 0.1097 0.4352 0.4352
Treponema pallidum glutamate transporter 0.0602 0.2361 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi Matrixin family protein 0.0472 0.1838 0.1838
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1097 0.4352 0.4352
Brugia malayi AKH receptor 0.1097 0.4352 0.4352
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.2501 1 1
Echinococcus multilocularis carbonic anhydrase 0.0309 0.1181 0.1181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0015 0.0015
Brugia malayi neuropeptide F receptor 0.1097 0.4352 0.4352
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.012 0.012
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0064 0.0064
Toxoplasma gondii isocitrate dehydrogenase 0.003 0.0059 0.0503
Echinococcus granulosus Excitatory amino acid transporter 0.1359 0.5406 0.5406
Echinococcus multilocularis carbonic anhydrase 0.0309 0.1181 0.1181
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Matrixin family protein 0.0195 0.0723 0.0723
Echinococcus granulosus g-protein coupled receptor 0.1097 0.4352 0.4352
Brugia malayi hypothetical protein 0.0069 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus hypothetical protein 0.1097 0.4352 0.4352
Onchocerca volvulus 0.1097 0.4352 0.8051
Echinococcus multilocularis excitatory amino acid transporter 3 0.1359 0.5406 0.5406
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0086 0.0284 0.0284
Onchocerca volvulus 0.0027 0.0045 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0057 0.0057
Onchocerca volvulus Neuropeptide F receptor homolog 0.1097 0.4352 0.8051
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1097 0.4352 0.4352
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.003 0.0059 0.0059
Echinococcus granulosus neutral amino acid transporter 0.1359 0.5406 0.5406
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0015 0.0015
Brugia malayi Tachykinin-like peptides receptor 99D 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Protein kinase domain containing protein 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1359 0.5406 0.5406
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0015 0.0015
Onchocerca volvulus 0.1097 0.4352 0.8051
Mycobacterium ulcerans hypothetical protein 0.0035 0.008 0.0242
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.0277 0.1052 0.1052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0069 0.0215 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0831 0.3281 0.607
Brugia malayi G protein-coupled receptor F59B2.13 0.1097 0.4352 0.4352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.012 0.012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.012 0.012
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0015 0.0015
Trichomonas vaginalis harmonin-interacting ankyrin-repeat containing protein (harp), sans, putative 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0122 0.0427 0.0427
Echinococcus granulosus tachykinin peptides receptor 99D 0.1097 0.4352 0.4352
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1244 0.494 0.494
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis zinc finger transcription factor gli2 0.0286 0.1087 0.1087
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus neuropeptide s receptor 0.1522 0.6062 0.6062
Brugia malayi Matrixin family protein 0.0195 0.0723 0.0723
Echinococcus granulosus S formylglutathione hydrolase 0.0035 0.008 0.008
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0035 0.008 0.3699
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0015 0.0015
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0195 0.0723 0.0723
Loa Loa (eye worm) hypothetical protein 0.0068 0.021 0.021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0045 0.0045
Echinococcus multilocularis allatostatin A receptor 0.1097 0.4352 0.4352
Onchocerca volvulus 0.1097 0.4352 0.8051
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.2501 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis GPCR, family 2 0.0031 0.0064 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Schistosoma mansoni amine GPCR 0.1097 0.4352 0.4352
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1244 0.494 0.494
Trichomonas vaginalis TKL family protein kinase 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus alpha 1A adrenergic receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis sex peptide receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0015 0.0015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1097 0.4352 0.4352
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi Protein kinase domain containing protein 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis S formylglutathione hydrolase 0.0035 0.008 0.008
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1097 0.4352 0.4352
Schistosoma mansoni adenoreceptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi ORL1-like opioid receptor 0.1097 0.4352 0.4352
Brugia malayi isocitrate dehydrogenase 0.003 0.0059 0.0059
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni neuropeptide F-like receptor 0.1097 0.4352 0.4352
Brugia malayi G protein-coupled receptor 0.1097 0.4352 0.4352
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0064 0.0064
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0336 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0015 0.0015
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0195 0.0723 0.0723
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1097 0.4352 0.4352
Trichomonas vaginalis STE family protein kinase 0.2501 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0015 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.012 0.012
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus neuropeptide receptor A26 0.1522 0.6062 0.6062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.012 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1359 0.5406 1
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus dro:myosuppressin receptor 0.1097 0.4352 0.4352
Echinococcus granulosus g protein coupled receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0038 0.0324
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0035 0.008 0.0147
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus neuropeptides capa receptor 0.1097 0.4352 0.4352
Echinococcus granulosus zinc finger transcription factor gli2 0.0286 0.1087 0.1087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0064 0.0064
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1722 0.6866 0.6866
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0015 0.0029
Echinococcus granulosus excitatory amino acid transporter 2 0.1359 0.5406 0.5406
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.003 0.0059 0.0503
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Trichomonas vaginalis TKL family protein kinase 0.0016 0.0000000050008 0.0000000050008
Brugia malayi nuclear hormone receptor 0.0019 0.0015 0.0015
Echinococcus multilocularis somatostatin receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis neuropeptides capa receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, STE STE20 0.0016 0.0000000050008 0.0000000050008
Mycobacterium leprae PROBABLE HYDROLASE 0.0238 0.0895 0.2726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0015 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0015 0.0015
Echinococcus multilocularis carbonic anhydrase 0.0309 0.1181 0.1181
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.012 0.012
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) zinc finger protein 0.0286 0.1087 0.1087
Onchocerca volvulus 0.1097 0.4352 0.8051
Echinococcus granulosus carbonic anhydrase 0.0309 0.1181 0.1181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi Pre-SET motif family protein 0.0207 0.077 0.077
Brugia malayi hypothetical protein 0.0025 0.0038 0.0038
Brugia malayi Zinc finger, C2H2 type family protein 0.0286 0.1087 0.1087
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1359 0.5406 1
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0831 0.3281 1
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis neuropeptide Y receptor 0.1097 0.4352 0.4352
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1359 0.5406 0.5
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0057 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0038 0.0038
Chlamydia trachomatis neutral amino acid transporter 0.0602 0.2361 0.4368
Brugia malayi Dopamine receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis G protein coupled receptor 139 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0015 0.0015
Brugia malayi Serotonin receptor 0.1097 0.4352 0.4352
Schistosoma mansoni biogenic amine (5HT) receptor 0.1097 0.4352 0.4352
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0015 0.0015
Brugia malayi hypothetical protein 0.0122 0.0427 0.0427
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Trypanosoma brucei isocitrate dehydrogenase, putative 0.003 0.0059 0.0059
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0309 0.1181 0.1181
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0015 0.0015
Echinococcus multilocularis fmrfamide receptor 0.1097 0.4352 0.4352
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0059 0.0059
Onchocerca volvulus 0.0277 0.1052 0.1946

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 40.9 nM Concentration of compound to inhibit 50% (IC50) electrically evoked contractions was tested in Guinea pig ileum(GPI) assay. ChEMBL. 2537427
IC50 (functional) = 745 nM Concentration of compound to inhibit 50% (IC50) electrically evoked contractions was tested in Mouse vas deferens (MVD) assay. ChEMBL. 2537427
Ke (functional) = 2.02 nM Ke value for naloxone as antagonist(compound) was measured by using Mouse vas deferens (MVD) assay. ChEMBL. 2537427
Ke (functional) = 2.03 nM Ke value for naloxon as antagonist(compound) was measured by using Guinea pig ileum assay. ChEMBL. 2537427
Ki (binding) = 23.6 nM Binding affinity against mu opioid receptor by displacement of radioligand [3H]-DAGO in rat brain membrane ChEMBL. 2537427
Ki (binding) = 1880 nM Binding affinity against delta opioid receptor by displacement of radioligand [3H]-DSLET in rat brain membrane ChEMBL. 2537427
Ratio (functional) = 18.2 Ratio of IC50 in Mouse vas deferens and Guinea pig ileum assay ChEMBL. 2537427
Ratio (binding) = 79.7 Ratio of binding affinity of mu and delta opioid receptor ChEMBL. 2537427
Relative potency (binding) = 0.00135 The relative potency of compound was measured against delta opioid receptor to that of [Leu]enkephalin in [3H]-DSLET binding assay. ChEMBL. 2537427
Relative potency (functional) = 0.0153 The relative potency of compound was measured by comparing the potency of compound to the [Leu]enkephalin in Mouse vas deferens (MVD) assay. ChEMBL. 2537427
Relative potency (binding) = 0.399 The relative potency of compound was measured against mu opioid receptor to that of [Leu]enkephalin in [3H]-DAGO binding assay. ChEMBL. 2537427
Relative potency (functional) = 6.01 The relative potency of compound was measured by comparing the potency of compound to the [Leu]enkephalin in Guinea pig ileum(GPI) assay. ChEMBL. 2537427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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