Detailed information for compound 277189

Basic information

Technical information
  • TDR Targets ID: 277189
  • Name: 1-(2-chloroethyl)-3-(2,4,6-trimethylphenyl)ur ea
  • MW: 240.729 | Formula: C12H17ClN2O
  • H donors: 2 H acceptors: 1 LogP: 2.61 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCNC(=O)Nc1c(C)cc(cc1C)C
  • InChi: 1S/C12H17ClN2O/c1-8-6-9(2)11(10(3)7-8)15-12(16)14-5-4-13/h6-7H,4-5H2,1-3H3,(H2,14,15,16)
  • InChiKey: HEVQKTSFRAXZIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-chloroethyl)-3-mesityl-urea
  • 3-(2-chloroethyl)-1-(2,4,6-trimethylphenyl)urea
  • 33021-67-9
  • 1-(2-Chloroethyl)-3-mesitylurea
  • BRN 2119908
  • NSC 102251
  • Urea, 1-(2-chloroethyl)-3-mesityl-
  • NCIOpen2_006754
  • NSC102251

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serotonin receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0161 0.0068 0.0981
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Echinococcus granulosus somatostatin receptor 0.041 0.0217 0.3127
Echinococcus granulosus glycine receptor subunit alpha 1 0.0332 0.0171 0.2457
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0128 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.041 0.0217 0.1764
Echinococcus multilocularis neuropeptides capa receptor 0.041 0.0217 0.3127
Brugia malayi G-protein coupled receptor 0.041 0.0217 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.041 0.0217 0.3127
Schistosoma mansoni alpha-1 adrenergic receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Echinococcus granulosus neuropeptide receptor 0.041 0.0217 0.3127
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0332 0.0171 0.2457
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0789 0.0443 0.1301
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0332 0.0171 0.2457
Echinococcus granulosus fmrfamide receptor 0.041 0.0217 0.3127
Echinococcus multilocularis rhodopsin orphan GPCR 0.041 0.0217 0.3127
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0332 0.0171 0.2457
Onchocerca volvulus Putative nachr subunit 0.0332 0.0171 0.761
Echinococcus granulosus rhodopsin orphan GPCR 0.041 0.0217 0.3127
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0011 0.1292
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0011 0.0155
Loa Loa (eye worm) hypothetical protein 0.0084 0.0022 0.0181
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0332 0.0171 0.1386
Echinococcus granulosus glycine receptor subunit beta 0.0332 0.0171 0.2457
Schistosoma mansoni biogenic amine receptor 0.041 0.0217 0.3127
Echinococcus multilocularis glycine receptor subunit beta 0.0332 0.0171 0.2457
Loa Loa (eye worm) serotonin transporter b 0.0161 0.0068 0.0553
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.041 0.0217 0.3127
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.041 0.0217 0.3127
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0332 0.0171 0.2457
Brugia malayi hypothetical protein 0.0054 0.0005 0.0005
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Schistosoma mansoni neuropeptide f receptor 76f 0.041 0.0217 0.3127
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Echinococcus multilocularis neuropeptide FF receptor 2 0.041 0.0217 0.3127
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0128 0.0048 0.0393
Onchocerca volvulus 0.041 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.041 0.0217 0.3127
Schistosoma mansoni amine GPCR 0.041 0.0217 0.3127
Echinococcus granulosus tm gpcr rhodopsin 0.041 0.0217 0.3127
Mycobacterium leprae ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0133 0.0052 0.0152
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Brugia malayi G protein-coupled receptor 0.041 0.0217 0.0217
Loa Loa (eye worm) acetylcholine receptor protein 0.0128 0.0048 0.0393
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0332 0.0171 0.2457
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0332 0.0171 0.2457
Onchocerca volvulus 0.0332 0.0171 0.761
Brugia malayi GnHR receptor homolog 0.041 0.0217 0.0217
Brugia malayi putative neuropeptide receptor NPR1 0.041 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Treponema pallidum sodium- and chloride- dependent transporter 0.0161 0.0068 0.3553
Echinococcus granulosus rhodopsin orphan GPCR 0.041 0.0217 0.3127
Schistosoma mansoni biogenic amine receptor 0.041 0.0217 0.3127
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0041 0.0119
Onchocerca volvulus 0.0128 0.0048 0.1336
Loa Loa (eye worm) hypothetical protein 0.0205 0.0094 0.0767
Onchocerca volvulus 0.041 0.0217 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0002 0.0032
Onchocerca volvulus 0.041 0.0217 1
Onchocerca volvulus 0.0332 0.0171 0.761
Echinococcus multilocularis g protein coupled receptor 0.041 0.0217 0.3127
Echinococcus granulosus nAChR subunit 0.0205 0.0094 0.136
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0332 0.0171 0.2457
Echinococcus granulosus neuropeptide receptor A26 0.041 0.0217 0.3127
Brugia malayi Serotonin/octopamine receptor family protein 7 0.041 0.0217 0.0217
Onchocerca volvulus 0.0161 0.0068 0.2351
Brugia malayi RE15519p 0.041 0.0217 0.0217
Echinococcus multilocularis orexin receptor type 2 0.041 0.0217 0.3127
Plasmodium falciparum cysteine--tRNA ligase 0.0084 0.0022 0.3045
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Echinococcus granulosus g protein coupled receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0332 0.0171 0.1386
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.041 0.0217 0.3127
Onchocerca volvulus 0.041 0.0217 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.0128 0.0048 0.0696
Echinococcus multilocularis allatostatin A receptor 0.041 0.0217 0.3127
Brugia malayi hypothetical protein 0.0128 0.0048 0.0048
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0205 0.0094 0.0094
Brugia malayi gonadotropin-releasing hormone receptor 2 0.041 0.0217 0.0217
Loa Loa (eye worm) glutathione reductase 0.005 0.0002 0.0018
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0002 0.0006
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0205 0.0094 0.0094
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0332 0.0171 0.2457
Echinococcus granulosus neuropeptide FF receptor 2 0.041 0.0217 0.3127
Brugia malayi hypothetical protein 0.041 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Mycobacterium tuberculosis Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0133 0.0052 0.0152
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0011 0.0031
Chlamydia trachomatis UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 0.0182 0.0081 0.535
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0332 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0332 0.0171 0.1386
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0332 0.0171 0.0171
Onchocerca volvulus 0.041 0.0217 1
Onchocerca volvulus 0.0128 0.0048 0.1336
Onchocerca volvulus 0.0252 0.0123 0.5144
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.041 0.0217 0.3127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.041 0.0217 0.3127
Echinococcus granulosus alpha 1A adrenergic receptor 0.041 0.0217 0.3127
Echinococcus granulosus orexin receptor type 2 0.041 0.0217 0.3127
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0011 0.0031
Echinococcus granulosus neuropeptide Y receptor 0.041 0.0217 0.3127
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.041 0.0217 0.3127
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0205 0.0094 0.136
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0128 0.0048 0.0696
Loa Loa (eye worm) hypothetical protein 0.0205 0.0094 0.0767
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0161 0.0068 1
Brugia malayi AKH receptor 0.041 0.0217 0.0217
Echinococcus multilocularis sex peptide receptor 0.041 0.0217 0.3127
Schistosoma mansoni opsin-like receptor 0.041 0.0217 0.3127
Schistosoma mansoni neuropeptide receptor 0.041 0.0217 0.3127
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0128 0.0048 0.0696
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0332 0.0171 0.1386
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Loa Loa (eye worm) hypothetical protein 0.0205 0.0094 0.0767
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.041 0.0217 0.1764
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0161 0.0068 1
Entamoeba histolytica hypothetical protein 0.0205 0.0094 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0128 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Echinococcus granulosus serotonin transporter 0.0161 0.0068 0.0981
Schistosoma mansoni rhodopsin-like orphan GPCR 0.041 0.0217 0.3127
Schistosoma mansoni myosin xvIII 0.041 0.0217 0.3127
Brugia malayi Dopamine receptor 0.041 0.0217 0.0217
Echinococcus multilocularis tachykinin peptides receptor 99D 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Echinococcus granulosus glycine receptor subunit alpha 1 0.0332 0.0171 0.2457
Onchocerca volvulus 0.0332 0.0171 0.761
Brugia malayi hypothetical protein 0.0128 0.0048 0.0048
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0041 0.0119
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.5754 0.3408 1
Schistosoma mansoni nAChR subunit 0.0332 0.0171 0.2457
Schistosoma mansoni biogenic amine (dopamine) receptor 0.041 0.0217 0.3127
Echinococcus multilocularis G protein coupled receptor 139 0.041 0.0217 0.3127
Echinococcus granulosus g protein coupled receptor 0.041 0.0217 0.3127
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0128 0.0048 0.0696
Echinococcus multilocularis nAChR subunit 0.0332 0.0171 0.2457
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.041 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Schistosoma mansoni neurotransmitter gated ion channel 0.0128 0.0048 0.0696
Echinococcus granulosus glycine receptor subunit beta 0.0332 0.0171 0.2457
Echinococcus multilocularis neuropeptide receptor 0.041 0.0217 0.3127
Brugia malayi hypothetical protein 0.0128 0.0048 0.0048
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0161 0.0068 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.041 0.0217 0.3127
Echinococcus granulosus rhodopsin orphan GPCR 0.041 0.0217 0.3127
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0332 0.0171 0.2457
Brugia malayi Melatonin receptor type 1A 0.041 0.0217 0.0217
Leishmania major cysteinyl-tRNA synthetase, putative 0.0084 0.0022 0.3045
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0011 0.1292
Schistosoma mansoni nAChR subunit 0.0332 0.0171 0.2457
Brugia malayi Cation transporter family protein 0.0332 0.0171 0.0171
Brugia malayi hypothetical protein 0.041 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0054 0.0005 0.0369
Echinococcus granulosus neuropeptide Y receptor 0.041 0.0217 0.3127
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.041 0.0217 0.3127
Brugia malayi hypothetical protein 0.041 0.0217 0.0217
Onchocerca volvulus 0.041 0.0217 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0852 0.0481 0.6929
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0332 0.0171 0.1386
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Echinococcus granulosus allatostatin A receptor 0.041 0.0217 0.3127
Echinococcus multilocularis g-protein coupled receptor 0.041 0.0217 0.3127
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0114 0.004 0.0119
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Echinococcus multilocularis neuropeptide Y receptor 0.041 0.0217 0.3127
Echinococcus multilocularis neuropeptide receptor A26 0.041 0.0217 0.3127
Brugia malayi Cation transporter family protein 0.0332 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0332 0.0171 0.2457
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0128 0.0048 0.0393
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Brugia malayi larval opioid receptor 0.041 0.0217 0.0217
Echinococcus granulosus tachykinin peptides receptor 99D 0.041 0.0217 0.3127
Chlamydia trachomatis cysteine--tRNA ligase 0.0084 0.0022 0.1474
Echinococcus multilocularis rhodopsin orphan GPCR 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Brugia malayi Tachykinin-like peptides receptor 99D 0.041 0.0217 0.0217
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0011 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.041 0.0217 0.3127
Echinococcus granulosus thymidylate synthase 0.0114 0.004 0.0582
Echinococcus multilocularis rhodopsin orphan GPCR 0.041 0.0217 0.3127
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0084 0.0022 0.0022
Brugia malayi Dopamine receptor protein 2 0.041 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Echinococcus granulosus nAChR subunit 0.0332 0.0171 0.2457
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0048 0.0142
Schistosoma mansoni neurotransmitter gated ion channel 0.0205 0.0094 0.136
Echinococcus multilocularis neuropeptide s receptor 0.041 0.0217 0.3127
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.03 0.0151 1
Loa Loa (eye worm) hypothetical protein 0.2108 0.1231 1
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.5754 0.3408 1
Echinococcus multilocularis nAChR subunit 0.0205 0.0094 0.136
Brugia malayi hypothetical protein 0.041 0.0217 0.0217
Schistosoma mansoni peptide (allatostatin)-like receptor 0.041 0.0217 0.3127
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) melatonin receptor type 1A 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Echinococcus multilocularis rhodopsin orphan GPCR 0.041 0.0217 0.3127
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0128 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Echinococcus multilocularis dro:myosuppressin receptor 0.041 0.0217 0.3127
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0128 0.0048 0.0696
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.041 0.0217 0.3127
Brugia malayi follicle stimulating hormone receptor 0.041 0.0217 0.0217
Loa Loa (eye worm) solute carrier family 6 member 4 0.0161 0.0068 0.0553
Brugia malayi hypothetical protein 0.041 0.0217 0.0217
Giardia lamblia Cysteinyl-tRNA synthetase 0.0084 0.0022 0.5
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.03 0.0151 1
Onchocerca volvulus 0.041 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.0094 0.0767
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Treponema pallidum undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.0182 0.0081 0.4546
Schistosoma mansoni adenoreceptor 0.041 0.0217 0.3127
Echinococcus multilocularis alpha 1A adrenergic receptor 0.041 0.0217 0.3127
Echinococcus granulosus hypothetical protein 0.041 0.0217 0.3127
Onchocerca volvulus 0.041 0.0217 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0011 0.0155
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0128 0.0048 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.041 0.0217 0.3127
Loa Loa (eye worm) G-protein coupled receptor 0.041 0.0217 0.1764
Schistosoma mansoni nAChR subunit 0.0332 0.0171 0.2457
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Echinococcus granulosus 7tm_1 domain containing protein 0.041 0.0217 0.3127
Onchocerca volvulus 0.0332 0.0171 0.761
Schistosoma mansoni histamine h1 receptor 0.041 0.0217 0.3127
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0161 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Schistosoma mansoni amine GPCR 0.041 0.0217 0.3127
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0161 0.0068 1
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0084 0.0022 0.1498
Loa Loa (eye worm) thymidylate synthase 0.0114 0.004 0.0328
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0048 0.0142
Onchocerca volvulus 0.041 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Brugia malayi hypothetical protein 0.0128 0.0048 0.0048
Mycobacterium leprae Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0789 0.0443 0.1301
Onchocerca volvulus 0.041 0.0217 1
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase 0.0182 0.0081 0.1393
Onchocerca volvulus 0.0114 0.004 0.0928
Schistosoma mansoni neuropeptide F-like receptor 0.041 0.0217 0.3127
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0332 0.0171 0.0171
Onchocerca volvulus 0.0205 0.0094 0.3703
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0128 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Schistosoma mansoni opsin-like receptor 0.041 0.0217 0.3127
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.041 0.0217 0.3127
Echinococcus granulosus tm gpcr rhodopsin 0.041 0.0217 0.3127
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0332 0.0171 0.2457
Schistosoma mansoni biogenic amine (dopamine) receptor 0.041 0.0217 0.3127
Schistosoma mansoni nAChR subunit 0.0332 0.0171 0.2457
Echinococcus granulosus g-protein coupled receptor 0.041 0.0217 0.3127
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.041 0.0217 0.3127
Echinococcus granulosus thyrotropin releasing hormone receptor 0.041 0.0217 0.3127
Onchocerca volvulus 0.0128 0.0048 0.1336
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0332 0.0171 0.0171
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0332 0.0171 0.2457
Mycobacterium ulcerans undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.0182 0.0081 0.0237
Schistosoma mansoni neuropeptide receptor 0.041 0.0217 0.3127
Onchocerca volvulus 0.041 0.0217 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0332 0.0171 0.2457
Plasmodium falciparum cysteine--tRNA ligase 0.0084 0.0022 0.3045
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Schistosoma mansoni nAChR subunit 0.0332 0.0171 0.2457
Schistosoma mansoni amine GPCR 0.041 0.0217 0.3127
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0041 0.0119
Echinococcus granulosus G protein coupled receptor 139 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.0161 0.0068 0.0553
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.041 0.0217 0.3127
Echinococcus multilocularis glycine receptor subunit beta 0.0332 0.0171 0.2457
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Schistosoma mansoni nAChR subunit 0.0128 0.0048 0.0696
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Echinococcus multilocularis neuropeptide receptor 0.041 0.0217 0.3127
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0011 0.0155
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Loa Loa (eye worm) norepinephrine transporter 0.0161 0.0068 0.0553
Echinococcus granulosus biogenic amine 5HT receptor 0.0852 0.0481 0.6929
Onchocerca volvulus 0.041 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.0094 0.0767
Brugia malayi hypothetical protein 0.041 0.0217 0.0217
Trichomonas vaginalis set domain proteins, putative 0.0252 0.0123 1
Echinococcus multilocularis somatostatin receptor 0.041 0.0217 0.3127
Echinococcus multilocularis serotonin receptor 0.1209 0.0694 1
Echinococcus multilocularis fmrfamide receptor 0.041 0.0217 0.3127
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0332 0.0171 0.2457
Echinococcus granulosus g protein coupled receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Schistosoma mansoni amine GPCR 0.041 0.0217 0.3127
Schistosoma mansoni neuropeptide F-like receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.1209 0.0694 0.564
Loa Loa (eye worm) hypothetical protein 0.0205 0.0094 0.0767
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0332 0.0171 0.2457
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0789 0.0443 0.1301
Plasmodium vivax cysteine--tRNA ligase, putative 0.0084 0.0022 0.3045
Schistosoma mansoni neuropeptide receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0084 0.0022 0.0181
Echinococcus granulosus peptide allatostatin:somatostatin 0.041 0.0217 0.3127
Loa Loa (eye worm) TYRA-2 protein 0.041 0.0217 0.1764
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0332 0.0171 0.0171
Brugia malayi hypothetical protein 0.041 0.0217 0.0217
Echinococcus granulosus rhodopsin orphan GPCR 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Onchocerca volvulus 0.0332 0.0171 0.761
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.041 0.0217 0.1764
Echinococcus granulosus neuropeptide s receptor 0.041 0.0217 0.3127
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0161 0.0068 1
Loa Loa (eye worm) GABA receptor subunit 0.0205 0.0094 0.0767
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0084 0.0022 0.0321
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.041 0.0217 0.0217
Brugia malayi excitatory GABA receptor EXP-1A 0.0332 0.0171 0.0171
Loa Loa (eye worm) follicle stimulating hormone receptor 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Brugia malayi Cation transporter family protein 0.0332 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.041 0.0217 0.3127
Echinococcus multilocularis fmrfamide receptor 0.041 0.0217 0.3127
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0084 0.0022 0.0321
Echinococcus multilocularis serotonin transporter 0.0161 0.0068 0.0981
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0332 0.0171 0.2457
Loa Loa (eye worm) hypothetical protein 0.0205 0.0094 0.0767
Schistosoma mansoni hypothetical protein 0.041 0.0217 0.3127
Brugia malayi sulfakinin receptor protein 0.041 0.0217 0.0217
Schistosoma mansoni hypothetical protein 0.041 0.0217 0.3127
Onchocerca volvulus Neuropeptide F receptor homolog 0.041 0.0217 1
Onchocerca volvulus 0.041 0.0217 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.041 0.0217 0.3127
Schistosoma mansoni nAChR subunit 0.0332 0.0171 0.2457
Schistosoma mansoni biogenic amine receptor 0.041 0.0217 0.3127
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0041 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.041 0.0217 0.3127
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0332 0.0171 0.0171
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.041 0.0217 0.3127
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0332 0.0171 0.0171
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.041 0.0217 0.3127
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0332 0.0171 0.0171
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.041 0.0217 0.0217
Echinococcus granulosus leucyl tRNA synthetase 0.0084 0.0022 0.0321
Echinococcus multilocularis g protein coupled receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) ACC-1 protein 0.0332 0.0171 0.1386
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0332 0.0171 0.2457
Echinococcus multilocularis neuropeptides capa receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Brugia malayi thymidylate synthase 0.0114 0.004 0.004
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0002 0.0032
Echinococcus granulosus neuropeptides capa receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0041 0.0119
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0332 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Schistosoma mansoni hypothetical protein 0.041 0.0217 0.3127
Echinococcus multilocularis neuropeptide Y receptor 0.041 0.0217 0.3127
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0332 0.0171 0.2457
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0084 0.0022 0.3045
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0205 0.0094 0.136
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.0205 0.0094 0.0767
Echinococcus granulosus cysteinyl tRNA synthetase 0.0084 0.0022 0.0321
Brugia malayi Dopamine receptor protein 1 0.041 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.1209 0.0694 0.564
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Schistosoma mansoni rhodopsin-like orphan GPCR 0.041 0.0217 0.3127
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0084 0.0022 0.0065
Brugia malayi ORL1-like opioid receptor 0.041 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Echinococcus multilocularis rhodopsin orphan GPCR 0.041 0.0217 0.3127
Echinococcus granulosus dro:myosuppressin receptor 0.041 0.0217 0.3127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.041 0.0217 0.3127
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.041 0.0217 0.0217
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.0104 0.0847
Loa Loa (eye worm) neuropeptide F receptor 0.041 0.0217 0.1764
Schistosoma mansoni amine GPCR 0.041 0.0217 0.3127
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0332 0.0171 0.2457
Schistosoma mansoni rhodopsin-like orphan GPCR 0.041 0.0217 0.3127
Brugia malayi putative neuropeptide receptor 0.041 0.0217 0.0217
Onchocerca volvulus 0.041 0.0217 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.0205 0.0094 0.0767
Brugia malayi G-protein coupled receptor 0.041 0.0217 0.0217
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0084 0.0022 0.3045
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Schistosoma mansoni nAChR subunit 0.0128 0.0048 0.0696
Brugia malayi hypothetical protein 0.041 0.0217 0.0217
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.041 0.0217 0.3127
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0332 0.0171 0.2457
Echinococcus multilocularis serotonin receptor 0.1209 0.0694 1
Echinococcus granulosus sex peptide receptor 0.041 0.0217 0.3127
Schistosoma mansoni acetylcholine receptor-related 0.0128 0.0048 0.0696
Echinococcus multilocularis thymidylate synthase 0.0114 0.004 0.0582
Brugia malayi neuropeptide F receptor 0.041 0.0217 0.0217
Onchocerca volvulus 0.041 0.0217 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0011 0.0031
Onchocerca volvulus 0.0332 0.0171 0.761
Loa Loa (eye worm) LGC-31 protein 0.0332 0.0171 0.1386
Echinococcus multilocularis rhodopsin orphan GPCR 0.041 0.0217 0.3127
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0084 0.0022 0.3045
Brugia malayi glutathione reductase 0.005 0.0002 0.0002
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.041 0.0217 0.3127
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0332 0.0171 0.0171
Schistosoma mansoni sodium/chloride dependent transporter 0.0161 0.0068 0.0981
Brugia malayi Pre-SET motif family protein 0.0221 0.0104 0.0104
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0128 0.0048 0.0048
Echinococcus multilocularis G-protein coupled receptor, putative 0.041 0.0217 0.3127
Loa Loa (eye worm) G-protein coupled receptor 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Schistosoma mansoni neuropeptide receptor 0.041 0.0217 0.3127
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0332 0.0171 0.2457
Echinococcus granulosus tm gpcr rhodopsin 0.041 0.0217 0.3127
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0852 0.0481 0.6929
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.041 0.0217 0.3127
Schistosoma mansoni hypothetical protein 0.041 0.0217 0.3127
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0114 0.004 0.0119
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0332 0.0171 0.1386
Schistosoma mansoni growth hormone secretagogue receptor 0.041 0.0217 0.3127
Brugia malayi hypothetical protein 0.041 0.0217 0.0217
Onchocerca volvulus 0.0205 0.0094 0.3703
Echinococcus granulosus biogenic amine 5HT receptor 0.1209 0.0694 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0041 0.0119
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0332 0.0171 0.0171
Brugia malayi G protein-coupled receptor F59B2.13 0.041 0.0217 0.0217
Onchocerca volvulus 0.041 0.0217 1
Mycobacterium tuberculosis Hypothetical protein 0.0054 0.0005 0.0014
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0332 0.0171 0.2457
Echinococcus granulosus 7TM GPCR rhodopsin 0.041 0.0217 0.3127
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0048 0.0142
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0332 0.0171 0.0171
Mycobacterium tuberculosis Probable reductase 0.0115 0.0041 0.0119
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Loa Loa (eye worm) ACC-1 protein 0.0332 0.0171 0.1386
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0048 0.0142
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0161 0.0068 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0332 0.0171 0.0171
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0084 0.0022 0.0321
Echinococcus granulosus glycine receptor subunit alpha 1 0.0332 0.0171 0.2457
Brugia malayi hypothetical protein 0.041 0.0217 0.0217
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0084 0.0022 0.3045
Schistosoma mansoni biogenic amine (5HT) receptor 0.1209 0.0694 1
Brugia malayi Serotonin receptor 0.041 0.0217 0.0217
Mycobacterium ulcerans thymidylate synthase 0.0114 0.004 0.0119
Schistosoma mansoni neurotransmitter gated ion channel 0.0128 0.0048 0.0696
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.041 0.0217 0.3127
Brugia malayi hypothetical protein 0.0128 0.0048 0.0048
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0205 0.0094 0.0094
Echinococcus granulosus neuropeptides capa receptor 0.041 0.0217 0.3127
Loa Loa (eye worm) hypothetical protein 0.0128 0.0048 0.0393
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0332 0.0171 0.0171
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0114 0.004 0.0582
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Echinococcus granulosus rhodopsin orphan GPCR 0.041 0.0217 0.3127
Onchocerca volvulus 0.041 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.0068 0.0553
Echinococcus granulosus neuropeptide receptor 0.041 0.0217 0.3127
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0789 0.0443 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0332 0.0171 0.2457
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.041 0.0217 0.3127
Echinococcus multilocularis g protein coupled receptor 0.041 0.0217 0.3127
Schistosoma mansoni nAChR subunit 0.0332 0.0171 0.2457
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0011 0.0155
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0205 0.0094 0.0094
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0332 0.0171 0.2457
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Loa Loa (eye worm) hypothetical protein 0.0332 0.0171 0.1386
Echinococcus multilocularis rhodopsin orphan GPCR 0.041 0.0217 0.3127
Brugia malayi neuropeptide F receptor 0.041 0.0217 0.0217
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0128 0.0048 0.0696
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.5754 0.3408 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0332 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.041 0.0217 0.1764
Loa Loa (eye worm) neuropeptide F receptor 0.041 0.0217 0.1764
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0332 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0161 0.0068 0.0553
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.041 0.0217 0.3127
Brugia malayi Thioredoxin reductase 0.005 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.041 0.0217 0.3127

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 587 uM Antiproliferative activity against human MDA-MB-231 cells ChEMBL. 18023585
GI50 (functional) = 587 uM Antiproliferative activity against human MDA-MB-231 cells ChEMBL. 18023585
NA (functional) 0 Dose required to inhibit cell growth was determined against LoVo cell line of human adenocarcinoma; NA= Not active represents IC50 >400 uM ChEMBL. 11262080
NA (functional) 0 Dose required to inhibit cell growth was determined against MDA-MB231 cell line of human non-hormone dependent breast carcinoma; NA= Not active represents IC50 >400 uM ChEMBL. 11262080
NA (functional) 0 Dose required to inhibit cell growth was determined against P388D1 cell line of murine lymphocytotic leukemia; NA= Not active represents IC50 >400 uM ChEMBL. 11262080
ND (functional) 0 Dose required to inhibit cell growth was determined against CHO cell line; ND= not determined ChEMBL. 11262080
ND (functional) 0 Dose required to inhibit cell growth was determined against K562 cell line of chronic myelogenous leukemia; ND= not determined ChEMBL. 11262080
ND (functional) 0 Dose required to inhibit cell growth was determined against L1210 cell line of murine lymphocytotic leukemia; ND= not determined ChEMBL. 11262080
ND (functional) 0 Dose required to inhibit cell growth was determined against HT-29 cell line of human adenocarcinoma; ND= not determined ChEMBL. 11262080

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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