Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 3-hydroxy-3-methylglutaryl-CoA reductase | Starlite/ChEMBL | References |
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.0168 | 0 | 0.5 | |
Onchocerca volvulus | 0.0168 | 0 | 0.5 | |
Onchocerca volvulus | 0.0168 | 0 | 0.5 | |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.033 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.033 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.0168 | 0 | 0.5 | |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.033 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.033 | 1 | 0.5 |
Onchocerca volvulus | 0.0168 | 0 | 0.5 | |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.0168 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.05 nM | Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line) | ChEMBL. | 2153213 |
IC50 (binding) | = 0.05 nM | Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line) | ChEMBL. | 2153213 |
IC50 (binding) | = 117 nM | In vitro inhibition of HMG-CoA reductase of rat liver | ChEMBL. | 2153213 |
IC50 (binding) | = 117 nM | In vitro inhibition of HMG-CoA reductase of rat liver | ChEMBL. | 2153213 |
Relative potency (binding) | = 6 | In vitro inhibition of solubilized, partially purified rat liver HMG-CoA reductase relative to mevinolin | ChEMBL. | 2153213 |
Relative potency (binding) | = 100 | Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line) relative to mevinolin | ChEMBL. | 2153213 |
Relative potency (binding) | = 6 | In vitro inhibition of solubilized, partially purified rat liver HMG-CoA reductase relative to mevinolin | ChEMBL. | 2153213 |
Relative potency (binding) | = 100 | Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line) relative to mevinolin | ChEMBL. | 2153213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.