Detailed information for compound 277368

Basic information

Technical information
  • TDR Targets ID: 277368
  • Name: 1-[2-(4-benzyl-3-methylphenoxy)ethyl]pyrrolid ine
  • MW: 295.419 | Formula: C20H25NO
  • H donors: 0 H acceptors: 0 LogP: 4.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(OCCN2CCCC2)ccc1Cc1ccccc1
  • InChi: 1S/C20H25NO/c1-17-15-20(22-14-13-21-11-5-6-12-21)10-9-19(17)16-18-7-3-2-4-8-18/h2-4,7-10,15H,5-6,11-14,16H2,1H3
  • InChiKey: LLNFFVBRLDSEGK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(4-benzyl-3-methyl-phenoxy)ethyl]pyrrolidine
  • 1-[2-[3-methyl-4-(phenylmethyl)phenoxy]ethyl]pyrrolidine
  • 1-[2-[4-(benzyl)-3-methyl-phenoxy]ethyl]pyrrolidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens leukotriene A4 hydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) Get druggable targets OG5_129538 All targets in OG5_129538
Echinococcus multilocularis leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Schistosoma japonicum ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative Get druggable targets OG5_129538 All targets in OG5_129538
Echinococcus granulosus leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
Loa Loa (eye worm) leukotriene A4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 leukotriene A4 hydrolase 611 aa 508 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Brugia malayi hypothetical protein 0.0025 0.0214 0.0678
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0015 0.0084 0.5689
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0214 0.0613
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Brugia malayi putative neuropeptide receptor 0.0025 0.0214 0.0678
Loa Loa (eye worm) hypothetical protein 0.0049 0.0512 0.1491
Brugia malayi RE15519p 0.0025 0.0214 0.0678
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0074 0.0074
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0143 0.0136
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0118 0.0641
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0214 0.0613
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.5868 0.5866
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0352 0.1018
Leishmania major DNA polymerase eta, putative 0.0019 0.0135 0.1698
Schistosoma mansoni hypothetical protein 0.0166 0.1981 0.1981
Brugia malayi cytochrome P450 0.0018 0.0118 0.0363
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Echinococcus multilocularis RUN 0.002 0.0143 0.0136
Loa Loa (eye worm) hypothetical protein 0.0049 0.0511 0.1488
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0118 0.0641
Toxoplasma gondii aminopeptidase N protein 0.0015 0.0084 0.0628
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.321
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0129 0.8957
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0214 0.0208
Trypanosoma brucei unspecified product 0.0013 0.0062 0.0776
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0059 0.0681
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.0214 0.0678
Trypanosoma cruzi aminopeptidase, putative 0.0015 0.0084 0.1512
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0118 0.0328
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0084 0.1512
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0143 0.0136
Echinococcus granulosus orexin receptor type 2 0.0025 0.0214 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0118 0.0901
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0214 0.0208
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0132 0.0053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0135 0.0129
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0214 0.0613
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0161 0.0154
Echinococcus granulosus somatostatin receptor 0.0025 0.0214 0.0208
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0118 0.0641
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0214 0.0208
Schistosoma mansoni cpg binding protein 0.006 0.0648 0.0648
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.061 0.1888
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0214 0.0214
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.321
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0214 0.0208
Echinococcus multilocularis 0.0018 0.0118 0.0111
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0132 0.2112
Schistosoma mansoni neuropeptide receptor 0.0025 0.0214 0.0214
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0341 1
Leishmania major cytochrome p450-like protein 0.0018 0.0118 0.139
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0118 0.0641
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0074 0.0068
Schistosoma mansoni microtubule-associated protein tau 0.0683 0.846 0.846
Brugia malayi TATA binding protein associated factor 0.0015 0.0084 0.0253
Brugia malayi sulfakinin receptor protein 0.0025 0.0214 0.0678
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0059 0.0681
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0214 0.0214
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0135 0.0129
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0562 0.1639
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0143 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.1242 1
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0084 0.0253
Echinococcus granulosus voltage gated potassium channel 0.001 0.003 0.0023
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0341 1
Brugia malayi G-protein coupled receptor 0.0025 0.0214 0.0678
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0214 0.0208
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0214 0.0208
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.061 0.0604
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0227 0.6222
Echinococcus multilocularis cpg binding protein 0.006 0.0648 0.0642
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0341 0.0855
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0214 0.0613
Schistosoma mansoni histamine h1 receptor 0.0025 0.0214 0.0214
Brugia malayi hypothetical protein 0.0025 0.0214 0.0678
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.1362 0.1356
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0229
Leishmania major cytochrome p450-like protein 0.0026 0.0227 0.3291
Schistosoma mansoni amine GPCR 0.0025 0.0214 0.0214
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0214 0.0208
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0214 0.0208
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0214 0.0208
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0341 1
Schistosoma mansoni adenoreceptor 0.0025 0.0214 0.0214
Echinococcus granulosus serotonin receptor 0.0025 0.0214 0.0208
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0132 0.9172
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.321
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0214 0.0208
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.1362 0.1356
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0059 0.0681
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0073 0.0542
Onchocerca volvulus 0.0025 0.0214 0.2486
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0132 0.3083
Brugia malayi Doublecortin family protein 0.002 0.0143 0.0445
Onchocerca volvulus 0.0025 0.0214 0.2486
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0214 0.0208
Brugia malayi hypothetical protein 0.0015 0.0084 0.0253
Schistosoma mansoni neuropeptide receptor 0.0025 0.0214 0.0214
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0214 0.0214
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0143 0.2538
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0135 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0059 0.0681
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.321
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0214 0.0214
Brugia malayi beta-lactamase 0.0035 0.0341 0.1092
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0341 0.0855
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0214 0.0214
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0214 0.0613
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0214 0.0208
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.321
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0074 0.0068
Loa Loa (eye worm) hypothetical protein 0.002 0.0143 0.0402
Leishmania major DNA polymerase kappa, putative 0.0019 0.0135 0.1698
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.321
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.003 0.0023
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0214 0.0208
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2725 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0118 0.0641
Schistosoma mansoni aminopeptidase A (M01 family) 0.0015 0.0084 0.0084
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0214 0.0208
Schistosoma mansoni neuropeptide receptor 0.0025 0.0214 0.0214
Onchocerca volvulus 0.0025 0.0214 0.2486
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0118 0.2627
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.321
Brugia malayi beta-lactamase family protein 0.0035 0.0341 0.1092
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0132 0.0125
Echinococcus granulosus g protein coupled receptor 0.0025 0.0214 0.0208
Brugia malayi follicle stimulating hormone receptor 0.0253 0.3068 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0084 0.0253
Brugia malayi neuropeptide F receptor 0.0025 0.0214 0.0678
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.321
Echinococcus multilocularis serotonin receptor 0.0025 0.0214 0.0208
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0118 0.0641
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0214 0.0214
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0132 0.3083
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0214 0.0208
Echinococcus multilocularis aminopeptidase N 0.0015 0.0084 0.0078
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0214 0.0678
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.321
Brugia malayi Dopamine receptor 0.0025 0.0214 0.0678
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0341 0.0341
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0118 0.0641
Trypanosoma cruzi Aminopeptidase M1, putative 0.0015 0.0084 0.1512
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus multilocularis geminin 0.0166 0.1981 0.1976
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0118 0.139
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0214 0.0678
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0161 0.4039
Onchocerca volvulus 0.0025 0.0214 0.2486
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus multilocularis serotonin receptor 0.0025 0.0214 0.0208
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0214 0.0208
Brugia malayi Dopamine receptor protein 2 0.0025 0.0214 0.0678
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0318 0.3884 0.388
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus granulosus dna polymerase kappa 0.0019 0.0135 0.0129
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0118 0.0641
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.321
Brugia malayi hypothetical protein 0.0025 0.0214 0.0678
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0062 0.0776
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0341 0.0855
Echinococcus granulosus aminopeptidase N 0.0015 0.0084 0.0078
Brugia malayi Melatonin receptor type 1A 0.0025 0.0214 0.0678
Brugia malayi CXXC zinc finger family protein 0.0057 0.0608 0.1963
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0135 0.321
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0214 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.321
Brugia malayi larval opioid receptor 0.0025 0.0214 0.0678
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0214 0.0208
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0393 0.0393
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0135 0.0976
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0214 0.0208
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0015 0.0084 0.0321
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0214 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0118 0.0641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Schistosoma mansoni amine GPCR 0.0025 0.0214 0.0214
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0341 1
Loa Loa (eye worm) aminopeptidase N 0.0015 0.0084 0.0229
Loa Loa (eye worm) RecQ helicase 0.0021 0.0161 0.0454
Brugia malayi hypothetical protein 0.0025 0.0214 0.0678
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0059 0.0681
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0135 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0132 0.0903
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0511 0.1648
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0132 0.5
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0015 0.0084 0.1512
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0105 0.0105
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0118 0.0641
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0214 0.0208
Mycobacterium tuberculosis Conserved protein 0.0035 0.0341 0.0855
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0341 0.1092
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.061 1
Onchocerca volvulus 0.0025 0.0214 0.2486
Schistosoma mansoni opsin-like receptor 0.0025 0.0214 0.0214
Schistosoma mansoni cpg binding protein 0.0057 0.0608 0.0608
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0214 0.0613
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0118 0.0111
Schistosoma mansoni biogenic amine receptor 0.0025 0.0214 0.0214
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0132 0.3083
Onchocerca volvulus 0.0035 0.0341 0.4903
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.5868 0.5866
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0214 0.0208
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0214 0.0208
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.0214 0.2486
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0214 0.0208
Schistosoma mansoni amine GPCR 0.0025 0.0214 0.0214
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0135 0.0421
Schistosoma mansoni neuropeptide receptor 0.0025 0.0214 0.0214
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0015 0.0084 0.0321
Brugia malayi hypothetical protein 0.002 0.0143 0.0445
Onchocerca volvulus 0.0025 0.0214 0.2486
Echinococcus granulosus microtubule associated protein 2 0.0683 0.846 0.8459
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.061 0.061
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0214 0.0208
Echinococcus multilocularis voltage gated potassium channel 0.001 0.003 0.0023
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0214 0.0208
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0118 0.0641
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0118 0.0641
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0092 0.028
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0214 0.0208
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0393 0.0393
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0214 0.0208
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0084 0.0253
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0015 0.0084 0.1512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0092
Schistosoma mansoni amine GPCR 0.0025 0.0214 0.0214
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0059 0.0681
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0092
Brugia malayi G protein-coupled receptor 0.0025 0.0214 0.0678
Schistosoma mansoni amine GPCR 0.0025 0.0214 0.0214
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0511 0.1488
Mycobacterium tuberculosis Conserved protein 0.0035 0.0341 0.0855
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0015 0.0084 0.1512
Brugia malayi hypothetical protein 0.0128 0.1506 0.4899
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0214 0.0208
Giardia lamblia DINP protein human, muc B family 0.0019 0.0135 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0214 0.0208
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0084 0.08
Onchocerca volvulus 0.0025 0.0214 0.2486
Toxoplasma gondii aminopeptidase N, putative 0.0015 0.0084 0.0628
Onchocerca volvulus 0.0049 0.0512 0.8173
Echinococcus granulosus neuropeptide receptor 0.0025 0.0214 0.0208
Echinococcus multilocularis dna polymerase eta 0.0019 0.0135 0.0129
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Brugia malayi neuropeptide F receptor 0.0025 0.0214 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0059 0.0681
Echinococcus granulosus cpg binding protein 0.006 0.0648 0.0642
Echinococcus multilocularis sex peptide receptor 0.0025 0.0214 0.0208
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Brugia malayi hypothetical protein 0.0015 0.0084 0.0253
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0092 0.0086
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0214 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0062 0.0776
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0214 0.0613
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0135 0.0129
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0322 0.9372
Brugia malayi Cytochrome P450 family protein 0.0055 0.0591 0.191
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0059 0.0681
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0227 0.6222
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0341 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Brugia malayi Serotonin receptor 0.0025 0.0214 0.0678
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0214 0.0214
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0214 0.0214
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0084 0.0084
Schistosoma mansoni biogenic amine receptor 0.0025 0.0214 0.0214
Echinococcus granulosus sex peptide receptor 0.0025 0.0214 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus granulosus bloom syndrome protein 0.0021 0.0161 0.0154
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0135 0.0976
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0059 0.0681
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.1403 0.1403
Brugia malayi hypothetical protein 0.0025 0.0214 0.0678
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0214 0.0208
Loa Loa (eye worm) hypothetical protein 0.0031 0.0292 0.0841
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.061 1
Onchocerca volvulus 0.0025 0.0214 0.2486
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.321
Onchocerca volvulus 0.0025 0.0214 0.2486
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0253
Entamoeba histolytica aminopeptidase, putative 0.0015 0.0084 0.4711
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.003 0.0023
Mycobacterium ulcerans beta-lactamase 0.0035 0.0341 0.488
Brugia malayi hypothetical protein 0.0025 0.0214 0.0678
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0084 0.08
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0214 0.0208
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0015 0.0084 0.5689
Loa Loa (eye worm) hypothetical protein 0.0035 0.0341 0.0986
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0074 0.0068
Schistosoma mansoni rab6-interacting 0.002 0.0143 0.0143
Onchocerca volvulus 0.0025 0.0214 0.2486
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0132 0.0125
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.5868 0.5866
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Schistosoma mansoni voltage-gated potassium channel 0.001 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0068
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0591 0.1725
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0214 0.0208
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0214 0.0208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0214 0.0214
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.0214 0.2486
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0341 0.0855
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0135 0.0135
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0279 0.3396 0.3392
Schistosoma mansoni voltage-gated potassium channel 0.001 0.003 0.003
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0214 0.0208
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0118 0.0641
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0214 0.0678
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0132 0.3083
Leishmania major hypothetical protein, conserved 0.0035 0.0341 0.529
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus granulosus dna polymerase eta 0.0019 0.0135 0.0129
Onchocerca volvulus 0.0025 0.0214 0.2486
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0161 0.0503
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0084 0.08
Brugia malayi beta-lactamase family protein 0.0035 0.0341 0.1092
Schistosoma mansoni hypothetical protein 0.0025 0.0214 0.0214
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0352 0.1127
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0118 0.2627
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0214 0.0214
Brugia malayi Dopamine receptor protein 1 0.0025 0.0214 0.0678
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0341 0.0334
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0118 0.0111
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0118 0.0641
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0135 0.1698
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0214 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0059 0.0681
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0214 0.0208
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0214 0.0208
Loa Loa (eye worm) hypothetical protein 0.0035 0.0341 0.0986
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0341 0.0334
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0214 0.0678
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.061 0.0604
Loa Loa (eye worm) hypothetical protein 0.0035 0.0341 0.0986
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0214 0.0208
Mycobacterium ulcerans hypothetical protein 0.0035 0.0341 0.488
Onchocerca volvulus 0.0025 0.0214 0.2486
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0059 0.0681
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Loa Loa (eye worm) beta-lactamase 0.0035 0.0341 0.0986
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0214 0.0214
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0135 0.321
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0132 0.1631
Schistosoma mansoni rab6-interacting 0.002 0.0143 0.0143
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0214 0.0214
Brugia malayi hypothetical protein 0.0025 0.0214 0.0678
Schistosoma mansoni myosin xvIII 0.0025 0.0214 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0059 0.0681
Trypanosoma brucei unspecified product 0.0013 0.0062 0.0776
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0227 0.0649
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0118 0.0111
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0132 0.0409
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0214 0.0208
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0092 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0059 0.0681
Trypanosoma cruzi aminopeptidase, putative 0.0015 0.0084 0.1512
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Schistosoma mansoni ap endonuclease 0.0019 0.0132 0.0132
Brugia malayi Cytochrome P450 family protein 0.0026 0.0227 0.0719
Mycobacterium ulcerans lipase LipD 0.0035 0.0341 0.488
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0352 0.0345
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0341 0.488
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0214 0.0214
Trypanosoma brucei Aminopeptidase M1, putative 0.0015 0.0084 0.1512
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0143 0.0136
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0118 0.0641
Schistosoma mansoni cytochrome P450 0.0018 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Schistosoma mansoni biogenic amine receptor 0.0025 0.0214 0.0214
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0118 0.0641
Echinococcus multilocularis microtubule associated protein 2 0.0683 0.846 0.8459
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0059 0.0681
Schistosoma mansoni hypothetical protein 0.002 0.0143 0.0143
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0341 0.0855
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0214 0.0208
Loa Loa (eye worm) hypothetical protein 0.0035 0.0341 0.0986
Echinococcus multilocularis tumor protein p63 0.0334 0.4091 0.4087
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0135 0.038
Echinococcus granulosus hypothetical protein 0.0025 0.0214 0.0208
Schistosoma mansoni hypothetical protein 0.0166 0.1981 0.1981
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0118 0.2627
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0118 0.0641
Echinococcus granulosus neuropeptide s receptor 0.0476 0.5868 0.5866
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0341 1
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0214 0.0208
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0512 0.0512
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0279 0.3396 1
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0214 0.0208
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0132 0.9702
Onchocerca volvulus 0.0035 0.0341 0.4903
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Schistosoma mansoni DNA polymerase eta 0.0019 0.0135 0.0135
Brugia malayi GnHR receptor homolog 0.0025 0.0214 0.0678
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0227 0.6222
Onchocerca volvulus 0.0035 0.0341 0.4903
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.00000000039905
Schistosoma mansoni lipoxygenase 0.0082 0.0921 0.0921
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0135 0.321
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0132 0.3083
Echinococcus granulosus neuropeptide receptor 0.0025 0.0214 0.0208
Schistosoma mansoni DNA helicase recq5 0.0009 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.0214 0.0678
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0214 0.0613
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0214 0.0214
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Brugia malayi Serotonin receptor 0.0025 0.0214 0.0678
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0092 0.028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0214 0.0214
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0214 0.0613
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0214 0.0214
Loa Loa (eye worm) TATA binding protein associated factor 0.0015 0.0084 0.0229
Loa Loa (eye worm) hypothetical protein 0.0033 0.0317 0.0916
Schistosoma mansoni hypothetical protein 0.0805 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.0214 0.0208
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0143 0.0136
Echinococcus granulosus allatostatin A receptor 0.0025 0.0214 0.0208
Brugia malayi Cytochrome P450 family protein 0.0018 0.0118 0.0363
Schistosoma mansoni hypothetical protein 0.0018 0.0118 0.0118
Schistosoma mansoni lipoxygenase 0.0117 0.1362 0.1362
Onchocerca volvulus 0.002 0.0143 0.1123
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0214 0.0208
Onchocerca volvulus 0.0025 0.0214 0.2486
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0214 0.0613
Schistosoma mansoni cpg binding protein 0.006 0.0648 0.0648
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0135 0.0068
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0317 0.1014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.321
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0341 0.0855
Echinococcus granulosus GPCR family 2 0.0015 0.0092 0.0086
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0214 0.0214
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0143 0.0136
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0341 1
Echinococcus granulosus fmrfamide receptor 0.0025 0.0214 0.0208
Echinococcus granulosus g protein coupled receptor 0.0025 0.0214 0.0208
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0084 0.1512
Loa Loa (eye worm) doublecortin family protein 0.002 0.0143 0.0402
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0074 0.0068
Schistosoma mansoni hypothetical protein 0.0025 0.0214 0.0214
Schistosoma mansoni polycystin 1-related 0.002 0.0143 0.0143
Onchocerca volvulus 0.0025 0.0214 0.2486
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0084 0.0078
Echinococcus granulosus RUN 0.002 0.0143 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Echinococcus granulosus geminin 0.0166 0.1981 0.1976
Brugia malayi Cytochrome P450 family protein 0.0026 0.0227 0.0719
Trypanosoma brucei Aminopeptidase M1, putative 0.0015 0.0084 0.1512
Brugia malayi hypothetical protein 0.0025 0.0214 0.0678
Toxoplasma gondii exonuclease III APE 0.0019 0.0132 0.1012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0341 0.0986
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0135 0.0421
Loa Loa (eye worm) hypothetical protein 0.0019 0.0135 0.038
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0214 0.0214
Trypanosoma brucei unspecified product 0.0019 0.0135 0.321
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0015 0.0084 0.0078
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0015 0.0084 0.1512
Loa Loa (eye worm) hypothetical protein 0.002 0.0143 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0059 0.0681
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0214 0.0208
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0341 0.0341
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0118 0.2627
Echinococcus multilocularis dnaJ subfamily B 0.0805 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0092 0.0253
Onchocerca volvulus 0.0057 0.0608 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0214 0.0678
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0341 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0214 0.0208
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0341 0.0986
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0279 0.3396 0.3396
Brugia malayi hypothetical protein 0.0025 0.0214 0.0678
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0092 0.0086
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0214 0.0208
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0227 0.2708
Trichomonas vaginalis helicase, putative 0.0013 0.0059 0.0681
Onchocerca volvulus 0.0025 0.0214 0.2486
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0229
Mycobacterium tuberculosis Conserved protein 0.0035 0.0341 0.0855
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0132 0.9604
Schistosoma mansoni opsin-like receptor 0.0025 0.0214 0.0214
Mycobacterium leprae Probable lipase LipE 0.0035 0.0341 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0322 0.9372
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0015 0.0084 0.1512
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0227 0.0649
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0341 0.488
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0298
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.321
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0511 0.1648
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0214 0.0208
Brugia malayi hypothetical protein 0.002 0.0143 0.0445
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0015 0.0084 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0341 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0214 0.0214
Echinococcus granulosus tumor protein p63 0.0334 0.4091 0.4087
Echinococcus multilocularis GPCR, family 2 0.0015 0.0092 0.0086
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0132 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Schistosoma mansoni ap endonuclease 0.0019 0.0132 0.0132
Schistosoma mansoni opsin-like receptor 0.0025 0.0214 0.0214
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0135 0.321
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0214 0.0214
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.321
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.3068 0.9032
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0015 0.0084 0.1512
Echinococcus granulosus tachykinin peptides receptor 99D 0.0318 0.3884 0.388
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0214 0.0208
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.321
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Echinococcus granulosus leukotriene A 4 hydrolase 0.0279 0.3396 0.3392
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0015 0.0084 0.0084
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0143 0.0136
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0608 0.1773
Echinococcus granulosus g protein coupled receptor 0.0025 0.0214 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0059 0.0681
Loa Loa (eye worm) hypothetical protein 0.0035 0.0341 0.0986
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0118 0.0641
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0341 0.0855
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0062 0.0776
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0214 0.0214
Trichomonas vaginalis esterase, putative 0.0035 0.0341 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Schistosoma mansoni loxhd1 0.002 0.0143 0.0143
Schistosoma mansoni DNA helicase recq1 0.0009 0.0007 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0214 0.0208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0214 0.0214
Echinococcus multilocularis somatostatin receptor 0.0025 0.0214 0.0208
Toxoplasma gondii aminopeptidase n, putative 0.0015 0.0084 0.0628
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0214 0.0208
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0229
Brugia malayi ORL1-like opioid receptor 0.0025 0.0214 0.0678
Trypanosoma brucei aminopeptidase, putative 0.0015 0.0084 0.1512
Onchocerca volvulus 0.0025 0.0214 0.2486
Loa Loa (eye worm) peptidase family M1 containing protein 0.0015 0.0084 0.0229
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0214 0.0208
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.061 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0059 0.0681
Leishmania major cytochrome p450-like protein 0.0018 0.0118 0.139
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0118 0.0641
Schistosoma mansoni hypothetical protein 0.0025 0.0214 0.0214
Brugia malayi hypothetical protein 0.0025 0.0214 0.0678
Onchocerca volvulus 0.002 0.0143 0.1123
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0092
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0227 0.0649
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0214 0.0208
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0214 0.0678
Loa Loa (eye worm) cytochrome P450 0.0018 0.0118 0.0328
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.061 0.1971
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0214 0.0214
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0118 0.0641
Schistosoma mansoni hypothetical protein 0.0025 0.0214 0.0214
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0341 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0092 0.0086
Toxoplasma gondii ABC1 family protein 0.0035 0.0341 0.2705
Brugia malayi AKH receptor 0.0025 0.0214 0.0678
Brugia malayi G-protein coupled receptor 0.0025 0.0214 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.321
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0214 0.0208
Schistosoma mansoni hypothetical protein 0.0033 0.0317 0.0317
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0214 0.0208
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0115 0.0354
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0084 0.1512
Onchocerca volvulus 0.0025 0.0214 0.2486
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0084 0.08
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0352 0.0345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.0613
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0161 0.4039
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0132 0.0369

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 3 uM Inhibitory activity was determined against Leukotriene A4 hydrolase ChEMBL. 10691697
IC50 (binding) > 3 uM Inhibitory activity was determined against Leukotriene A4 hydrolase ChEMBL. 10691697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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