Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 8.7 uM kg-1 | Compound was tested for narcotic antagonist activity determined using an intraperitoneal ED80 of morphine in rat tail-flick assay | ChEMBL. | 6114178 |
ED50 (functional) | = 9 uM kg-1 | Compound was tested for analgesic activity by writhing assay in mouse after subcutaneous administration | ChEMBL. | 6114178 |
ED50 (functional) | = 9 uM kg-1 | Compound was tested for analgesic activity by writhing assay in mouse after subcutaneous administration | ChEMBL. | 6114178 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.