TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 402.317 | Formula: C21H21Cl2N3O
H donors: 0 H acceptors: 1 LogP: 4.44 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCC(CC1)N1C(=O)CN=C(c2c1ccc(c2)Cl)c1cccc(c1)Cl
InChi: 1S/C21H21Cl2N3O/c1-25-9-7-17(8-10-25)26-19-6-5-16(23)12-18(19)21(24-13-20(26)27)14-3-2-4-15(22)11-14/h2-6,11-12,17H,7-10,13H2,1H3
InChiKey: MFDMFRRPWZMPKC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.013	0.1104	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0133	0.1276	0.1276
Echinococcus granulosus	tyrosine protein kinase Srms	0.0171	0.3226	0.3226
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0263	0.805	0.805
Schistosoma mansoni	tensin-related	0.0133	0.1276	0.0194
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3226	0.3226
Onchocerca volvulus		0.0133	0.1276	0.3956
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Echinococcus granulosus	epidermal growth factor receptor kinase	0.013	0.1104	0.1104
Echinococcus granulosus	tyrosine protein kinase Blk	0.0171	0.3226	0.3226
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0301	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.013	0.1104	0.5
Loa Loa (eye worm)	guanylate kinase	0.013	0.1104	0.1104
Brugia malayi	SH3 domain containing protein	0.013	0.1104	0.1104
Trichomonas vaginalis	p67phox protein, putative	0.013	0.1104	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.1104	0.1104
Onchocerca volvulus		0.0171	0.3226	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0171	0.3226	0.3226
Loa Loa (eye worm)	hypothetical protein	0.0263	0.805	0.805
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3226	0.3226
Echinococcus multilocularis	SHC transforming protein 3	0.0133	0.1276	0.1276
Brugia malayi	SH2 domain containing protein	0.0171	0.3226	0.3226
Brugia malayi	hypothetical protein	0.0171	0.3226	0.3226
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1104	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0133	0.1276	0.3956
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0133	0.1276	0.1276
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0301	1	1
Onchocerca volvulus		0.0171	0.3226	1
Entamoeba histolytica	protein kinase, putative	0.0133	0.1276	0.0812
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.1276	0.1276
Brugia malayi	Src substrate cortactin	0.013	0.1104	0.1104
Echinococcus granulosus	hypothetical protein	0.0133	0.1276	0.1276
Echinococcus multilocularis	tensin	0.0133	0.1276	0.1276
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0301	1	1
Schistosoma mansoni	tyrosine kinase	0.0171	0.3226	0.2386
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0133	0.1276	0.0194
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.013	0.1104	0.1104
Schistosoma mansoni	tensin-related	0.0133	0.1276	0.0194
Loa Loa (eye worm)	TK protein kinase	0.0171	0.3226	0.3226
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0301	1	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0133	0.1276	0.1276
Onchocerca volvulus		0.013	0.1104	0.3421
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0133	0.1276	0.0194
Brugia malayi	Variant SH3 domain containing protein	0.0263	0.805	0.805
Brugia malayi	Variant SH3 domain containing protein	0.0133	0.1276	0.1276
Brugia malayi	Peripheral plasma membrane protein CASK	0.013	0.1104	0.1104
Echinococcus multilocularis	SH2 motif	0.0133	0.1276	0.1276
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3226	0.3226
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1104	0.1104
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0301	1	1
Schistosoma mansoni	tensin	0.0133	0.1276	0.0194
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1104	0.1104
Onchocerca volvulus	Putative cortactin	0.013	0.1104	0.3421
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0133	0.1276	0.1276
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.013	0.1104	0.1104
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3226	0.3226
Brugia malayi	SH2 domain containing protein	0.0133	0.1276	0.1276
Echinococcus granulosus	expressed conserved protein	0.0133	0.1276	0.1276
Echinococcus granulosus	endophilin A3	0.013	0.1104	0.1104
Schistosoma mansoni	nck2/grb4	0.0263	0.805	0.7808
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0171	0.3226	0.3226
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0133	0.1276	0.1276
Echinococcus granulosus	expressed protein	0.013	0.1104	0.1104
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0301	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1104	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.013	0.1104	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0133	0.1276	0.1276
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.013	0.1104	0.1104
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0301	1	1
Trypanosoma brucei	conserved protein	0.013	0.1104	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1104	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3226	0.3226
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Echinococcus granulosus	nostrin	0.013	0.1104	0.1104
Schistosoma mansoni	tensin	0.0133	0.1276	0.0194
Echinococcus multilocularis	SH2 domain containing protein 7	0.0133	0.1276	0.1276
Echinococcus granulosus	signal transduction protein lnk realted	0.0133	0.1276	0.1276
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3226	0.3226
Echinococcus multilocularis		0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.013	0.1104	0.1104
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0133	0.1276	0.1276
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3226	0.3226
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3226	0.3226
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1104	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0133	0.1276	0.3956
Brugia malayi	protein-tyrosine kinase	0.0171	0.3226	0.3226
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0301	1	1
Echinococcus granulosus	Spectrin alpha actinin	0.013	0.1104	0.1104
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0133	0.1276	0.1276
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1104	0.1104
Echinococcus granulosus	tyrosine protein kinase shark	0.0171	0.3226	0.3226
Echinococcus granulosus	intersectin 2	0.013	0.1104	0.1104
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3226	0.3226
Brugia malayi	SH2 domain containing protein	0.0133	0.1276	0.1276
Entamoeba histolytica	SH2 domain containing protein	0.0133	0.1276	0.0812
Echinococcus multilocularis	NCK adaptor protein	0.0263	0.805	0.805
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0133	0.1276	0.1276
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0171	0.3226	0.3226
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0301	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0133	0.1276	0.0194
Onchocerca volvulus		0.0171	0.3226	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0301	1	1
Schistosoma mansoni	shc transforming protein	0.0133	0.1276	0.0194
Brugia malayi	SH2 domain containing protein	0.0133	0.1276	0.1276
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0171	0.3226	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0133	0.1276	0.1276
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3226	0.3226
Schistosoma mansoni	tyrosine kinase	0.0301	1	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0171	0.3226	0.3226
Brugia malayi	Guanylate kinase family protein	0.013	0.1104	0.1104
Schistosoma mansoni	growth factor receptor-bound protein	0.0263	0.805	0.7808
Echinococcus multilocularis	expressed protein	0.013	0.1104	0.1104
Brugia malayi	SRC-1	0.0301	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0263	0.805	0.7808
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3226	0.3226
Echinococcus granulosus	N chimaerin	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.013	0.1104	0.1104
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0133	0.1276	0.1276
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0171	0.3226	0.3226
Brugia malayi	protein-tyrosine kinase	0.013	0.1104	0.1104
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.013	0.1104	0.1104
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.1276	0.1276
Brugia malayi	Variant SH3 domain containing protein	0.0263	0.805	0.805
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0133	0.1276	0.1276
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0133	0.1276	0.1276
Echinococcus granulosus	NCK adaptor protein	0.0263	0.805	0.805
Brugia malayi	RhoGAP domain containing protein	0.0133	0.1276	0.1276
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1104	0.5
Loa Loa (eye worm)	protein-tyrosine kinase	0.013	0.1104	0.1104
Echinococcus granulosus	src region	0.013	0.1104	0.1104
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.013	0.1104	0.1104
Schistosoma mansoni	suppressor of cytokine signaling	0.0133	0.1276	0.0194
Echinococcus multilocularis	nostrin	0.013	0.1104	0.1104
Loa Loa (eye worm)	hypothetical protein	0.013	0.1104	0.1104
Schistosoma mansoni	tyrosine kinase	0.0301	1	1
Onchocerca volvulus		0.013	0.1104	0.3421
Loa Loa (eye worm)	hypothetical protein	0.013	0.1104	0.1104
Echinococcus multilocularis	tensin	0.0133	0.1276	0.1276
Brugia malayi	Tensin	0.0133	0.1276	0.1276
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0263	0.805	0.805
Brugia malayi	Spectrin alpha chain	0.013	0.1104	0.1104
Onchocerca volvulus		0.0133	0.1276	0.3956
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0133	0.1276	0.1276
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.013	0.1104	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0171	0.3226	0.3226
Loa Loa (eye worm)	hypothetical protein	0.013	0.1104	0.1104
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1104	0.1104
Trypanosoma cruzi	hypothetical protein, conserved	0.013	0.1104	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3226	0.3226
Echinococcus granulosus	SH2 motif	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.013	0.1104	0.3421
Echinococcus granulosus	tensin	0.0133	0.1276	0.1276
Echinococcus multilocularis	c src tyrosine kinase	0.0301	1	1
Echinococcus multilocularis	intersectin 2	0.013	0.1104	0.1104
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3226	0.3226
Schistosoma mansoni	GTPase activating protein	0.0133	0.1276	0.0194
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0301	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0301	1	1
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.013	0.1104	0.1104
Onchocerca volvulus		0.013	0.1104	0.3421
Loa Loa (eye worm)	hypothetical protein	0.013	0.1104	0.1104
Brugia malayi	SH2 domain containing protein	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Echinococcus granulosus	SHC transforming protein 3	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0133	0.1276	0.1276
Brugia malayi	Fes/CIP4 homology domain containing protein	0.013	0.1104	0.1104
Onchocerca volvulus		0.0133	0.1276	0.3956
Echinococcus multilocularis	tyrosine protein kinase shark	0.0171	0.3226	0.3226
Onchocerca volvulus		0.0133	0.1276	0.3956
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0133	0.1276	0.0812
Echinococcus granulosus	fch and double sh3 domains protein 2	0.013	0.1104	0.1104
Echinococcus multilocularis	endophilin A3	0.013	0.1104	0.1104
Schistosoma mansoni	hypothetical protein	0.0133	0.1276	0.0194
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.013	0.1104	0.1104
Onchocerca volvulus		0.0133	0.1276	0.3956
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0133	0.1276	0.1276
Echinococcus granulosus	c src tyrosine kinase	0.0301	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1104	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0167	0.3054	0.2192
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0133	0.1276	0.1276
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0301	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0301	1	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0301	1	1
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1104	0.1104
Onchocerca volvulus		0.013	0.1104	0.3421
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.013	0.1104	0.1104
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.013	0.1104	0.1104
Schistosoma mansoni	hypothetical protein	0.0133	0.1276	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0171	0.3226	0.3226
Echinococcus granulosus	tyrosine kinase	0.0171	0.3226	0.3226
Echinococcus multilocularis	signal transduction protein lnk realted	0.0133	0.1276	0.1276
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.1104	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0301	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0301	1	1
Schistosoma mansoni	tyrosine kinase	0.0171	0.3226	0.2386
Echinococcus multilocularis	SH2 motif	0.0133	0.1276	0.1276
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.013	0.1104	0.1104
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0133	0.1276	0.1276
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0301	1	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0133	0.1276	0.1276
Echinococcus multilocularis	N chimaerin	0.0133	0.1276	0.1276
Loa Loa (eye worm)	p53BP2	0.013	0.1104	0.1104
Echinococcus multilocularis	Spectrin alpha actinin	0.013	0.1104	0.1104
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.013	0.1104	0.1104
Schistosoma mansoni	SH2A	0.0133	0.1276	0.0194
Echinococcus multilocularis	transfer RNA-Ala	0.013	0.1104	0.1104
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0171	0.3226	0.3226
Schistosoma mansoni	tyrosine kinase	0.0301	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0133	0.1276	0.1276
Loa Loa (eye worm)	SH2 domain-containing protein	0.0133	0.1276	0.1276
Echinococcus granulosus	tyrosine kinase	0.0171	0.3226	0.3226
Echinococcus granulosus	growth factor receptor bound protein 2	0.0263	0.805	0.805
Echinococcus multilocularis	tyrosine kinase	0.0171	0.3226	0.3226
Echinococcus multilocularis	SH2 motif	0.0133	0.1276	0.1276
Onchocerca volvulus		0.0171	0.3226	1
Onchocerca volvulus		0.0133	0.1276	0.3956
Onchocerca volvulus		0.013	0.1104	0.3421
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3226	0.3226
Schistosoma mansoni	tensin	0.0133	0.1276	0.0194
Onchocerca volvulus		0.0171	0.3226	1
Loa Loa (eye worm)	STAT protein	0.0133	0.1276	0.1276
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0133	0.1276	0.1276
Loa Loa (eye worm)	SRC-1	0.0301	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0133	0.1276	0.0194
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0263	0.805	0.7808
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Schistosoma mansoni	adapter molecule crk	0.0263	0.805	0.7808
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0133	0.1276	0.1276
Echinococcus granulosus	SH2 motif	0.0133	0.1276	0.1276
Brugia malayi	Myosin tail family protein	0.013	0.1104	0.1104
Brugia malayi	SH2 domain containing protein	0.0133	0.1276	0.1276
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0301	1	1
Brugia malayi	SH2 domain containing protein	0.0133	0.1276	0.1276
Onchocerca volvulus		0.0171	0.3226	1
Loa Loa (eye worm)	thyroid receptor interactor	0.013	0.1104	0.1104
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0301	1	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.1104	0.1104
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Brugia malayi	Sex muscle abnormal protein 5	0.0263	0.805	0.805
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0171	0.3226	0.3226
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0301	1	1
Schistosoma mansoni	vav2	0.0133	0.1276	0.0194
Brugia malayi	SH2 domain containing protein	0.0171	0.3226	0.3226
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.013	0.1104	0.1104
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0133	0.1276	0.0194
Brugia malayi	SH2 domain containing protein	0.0133	0.1276	0.1276
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0133	0.1276	0.0194
Brugia malayi	Variant SH3 domain containing protein	0.0133	0.1276	0.1276
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3226	0.3226
Schistosoma mansoni	tyrosine kinase	0.0301	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Leishmania major	hypothetical protein, conserved	0.013	0.1104	0.5
Brugia malayi	Variant SH3 domain containing protein	0.013	0.1104	0.1104
Echinococcus granulosus	SH2 domain containing protein 7	0.0133	0.1276	0.1276
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0263	0.805	0.805
Brugia malayi	hypothetical protein	0.0133	0.1276	0.1276
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.013	0.1104	0.1104
Loa Loa (eye worm)	SH2 domain-containing protein	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1276	0.1276
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3226	0.3226
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.013	0.1104	0.1104
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.013	0.1104	0.1104

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	0 mg kg-1	Effective dose against pentylenetetrazol intoxicity in mice administered through subcutaneous route;NE = no effect at 10 mg/kg	ChEMBL.	2861285
ED50 (functional)	= 19.26 mg kg-1	Effective dose against tetrabenazine induced ptosis in mice administered subcutaneously	ChEMBL.	2861285
ED50 (functional)	= 19.26 mg kg-1	Effective dose against tetrabenazine induced ptosis in mice administered subcutaneously	ChEMBL.	2861285
K2 (binding)	= 23 uM	Binding constant was determined by displacing potential to [3H]-diazepam binding in cerebral cortex homogenates of rat	ChEMBL.	2861285
K2 (binding)	= 23 uM	Binding constant was determined by displacing potential to [3H]-diazepam binding in cerebral cortex homogenates of rat	ChEMBL.	2861285

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL159848

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 277559