Detailed information for compound 277564

Basic information

Technical information
  • TDR Targets ID: 277564
  • Name: (2S)-2-[[4-[(E)-2-[4-[hydroxy(phenyl)methyl]p yridin-3-yl]ethenyl]-2-(2-methylphenyl)benzoy l]amino]-4-methylsulfanylbutanoic acid
  • MW: 552.683 | Formula: C33H32N2O4S
  • H donors: 3 H acceptors: 5 LogP: 5.84 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CSCC[C@@H](C(=O)O)NC(=O)c1ccc(cc1c1ccccc1C)/C=C/c1cnccc1C(c1ccccc1)O
  • InChi: 1S/C33H32N2O4S/c1-22-8-6-7-11-26(22)29-20-23(13-15-28(29)32(37)35-30(33(38)39)17-19-40-2)12-14-25-21-34-18-16-27(25)31(36)24-9-4-3-5-10-24/h3-16,18,20-21,30-31,36H,17,19H2,1-2H3,(H,35,37)(H,38,39)/b14-12+/t30-,31?/m0/s1
  • InChiKey: PJUKABGUVXKGFB-KZGYZUDHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-[[4-[(E)-2-[4-[hydroxy(phenyl)methyl]-3-pyridyl]vinyl]-2-(o-tolyl)benzoyl]amino]-4-methylsulfanyl-butanoic acid
  • (2S)-2-[[[4-[(E)-2-[4-[hydroxy(phenyl)methyl]-3-pyridyl]vinyl]-2-(o-tolyl)phenyl]-oxomethyl]amino]-4-(methylthio)butanoic acid
  • (2S)-2-[[4-[(E)-2-[4-[hydroxy(phenyl)methyl]pyridin-3-yl]ethenyl]-2-(2-methylphenyl)phenyl]carbonylamino]-4-methylsulfanyl-butanoic acid
  • (2S)-2-[[4-[(E)-2-[4-[hydroxy(phenyl)methyl]-3-pyridyl]vinyl]-2-(o-tolyl)benzoyl]amino]-4-(methylthio)butyric acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens farnesyltransferase, CAAX box, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium falciparum protein farnesyltransferase subunit alpha Get druggable targets OG5_128459 All targets in OG5_128459
Neospora caninum hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus multilocularis protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma mansoni protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium vivax prenyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Babesia bovis protein prenyltransferase alpha subunit repeat domain containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Theileria parva hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus granulosus protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium hominis farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Giardia lamblia Rab geranylgeranyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium parvum farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium berghei protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0038 0.0129 0.0153
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0376 0.255 0.2548
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0408 0.2778 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.0576 0.3355
Loa Loa (eye worm) nuclear hormone receptor 0.0054 0.0247 0.0293
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0179 0.0177
Leishmania major trypanothione reductase 0.004 0.0142 0.0194
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0028
Onchocerca volvulus 0.0115 0.0682 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0114 0.0032
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.0217 0.0638
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.027 0.1793 0.3973
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0023 0.0021
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2685 0.2684
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0115 0.0682 0.0804
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.0129 0.0126
Loa Loa (eye worm) GABA receptor subunit 0.002 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0115 0.0682 0.0804
Onchocerca volvulus 0.0029 0.0064 0.0881
Schistosoma mansoni hypothetical protein 0.0049 0.0207 0.0205
Brugia malayi nuclear receptor NHR-88 0.0115 0.0682 0.0804
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0058 0.0069
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.0412 0.0489
Entamoeba histolytica hypothetical protein 0.0161 0.101 0.815
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0412 0.1793
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0059 0.0282 0.028
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0059 0.0282 0.063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.079 0.4913
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.005 0.0217 0.1593
Schistosoma mansoni hypothetical protein 0.0023 0.0023 0.0021
Schistosoma mansoni polycystin 1-related 0.0023 0.0023 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Mycobacterium ulcerans lipase LipD 0.0036 0.0114 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0247 0.0245
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0129 0.0126
Echinococcus multilocularis jun protein 0.0084 0.046 0.0458
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0109 0.0129
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0271 0.18 1
Echinococcus granulosus sterol regulatory element binding protein 0.0112 0.0658 0.0656
Trichomonas vaginalis cdc25b, putative 0.0059 0.0282 0.063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0129 0.0147
Schistosoma mansoni cpg binding protein 0.0028 0.0058 0.0056
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0038 0.0129 0.0147
Brugia malayi beta-lactamase family protein 0.0036 0.0114 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0115 0.0682 0.0804
Loa Loa (eye worm) hypothetical protein 0.0055 0.0249 0.0296
Brugia malayi nuclear receptor NHR-88 0.0054 0.0247 0.0288
Trichomonas vaginalis cdc25c, putative 0.0059 0.0282 0.063
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Echinococcus granulosus nuclear receptor nhr 48 0.0054 0.0247 0.0245
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0129 0.0147
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0271 0.18 0.1798
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Entamoeba histolytica hypothetical protein 0.0161 0.101 0.815
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.079 0.1607
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0038 0.0129 0.0126
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0294 0.0292
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0054 0.0247 0.3586
Onchocerca volvulus 0.0038 0.0129 0.1833
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Loa Loa (eye worm) transcriptional regulator 0.0108 0.0629 0.0746
Brugia malayi Nuclear hormone receptor-like 1 0.0115 0.0682 0.0804
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0115 0.0682 0.068
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.0412 0.0484
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0054 0.0247 0.0245
Onchocerca volvulus 0.0038 0.0129 0.1833
Mycobacterium ulcerans hypothetical protein 0.0036 0.0114 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0513 0.0511
Echinococcus multilocularis nAChR subunit 0.002 0.0004 0.0002
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.1239 0.422
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.0129 0.0153
Schistosoma mansoni nAChR subunit 0.0038 0.0129 0.0126
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.005 0.0217 0.0215
Onchocerca volvulus 0.0036 0.0114 0.1626
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Toxoplasma gondii hypothetical protein 0.005 0.0217 0.1337
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.046 0.0458
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0129 0.0126
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0217 0.0638
Echinococcus granulosus cpg binding protein 0.0032 0.0085 0.0083
Onchocerca volvulus 0.0059 0.0282 0.4102
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0376 0.255 0.2548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0115 0.0682 0.0809
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0129 0.0126
Echinococcus multilocularis chromatin regulatory protein sir2 0.0108 0.0629 0.0627
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0161 0.101 0.1008
Brugia malayi hypothetical protein 0.0061 0.0294 0.0344
Leishmania major protein farnesyltransferase alpha subunit, putative 0.005 0.0217 0.0638
Brugia malayi hypothetical protein 0.0054 0.0247 0.0288
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0129 0.0126
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0129 0.0126
Schistosoma mansoni lamin 0.0029 0.0064 0.0062
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0217 0.0638
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0129 0.0126
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0207 0.0205
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0207 0.024
Schistosoma mansoni microtubule-associated protein tau 0.1418 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.079 0.0788
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.0576 0.3355
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0129 0.0147
Trichomonas vaginalis glutaminase, putative 0.0269 0.1785 0.6272
Schistosoma mansoni nuclear receptor 0.0054 0.0247 0.0245
Brugia malayi hypothetical protein 0.0161 0.101 0.1194
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0114 0.075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0007 0.0004
Schistosoma mansoni zinc finger protein 0.0054 0.0247 0.0245
Schistosoma mansoni hypothetical protein 0.0395 0.2685 0.2684
Onchocerca volvulus 0.0054 0.0247 0.3586
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0007 0.0004
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0143 0.0881 0.2878
Schistosoma mansoni RAR-like nuclear receptor 0.0115 0.0682 0.068
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0059 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0513 0.0511
Onchocerca volvulus 0.0036 0.0114 0.1626
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0115 0.0682 0.068
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0109 0.0129
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0504 0.2832
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0115 0.0682 0.068
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0333 0.039
Loa Loa (eye worm) hypothetical protein 0.0049 0.0207 0.0245
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.079 0.0788
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0115 0.0682 0.068
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0038 0.0129 0.0153
Toxoplasma gondii hypothetical protein 0.0143 0.0881 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0333 0.0395
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0146 0.0144
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0007 0.0009
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0193 0.1239 0.147
Echinococcus multilocularis protein dispatched 1 0.0112 0.0658 0.0656
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0114 0.0112
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0161 0.101 0.1008
Brugia malayi ecdysone receptor 0.0054 0.0247 0.0288
Echinococcus granulosus thyroid hormone receptor alpha 0.0054 0.0247 0.0245
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.005 0.0217 0.0638
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Schistosoma mansoni hypothetical protein 0.0544 0.3753 0.3751
Schistosoma mansoni rab6-interacting 0.0023 0.0023 0.0021
Schistosoma mansoni hypothetical protein 0.0105 0.061 0.0608
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0146 0.0144
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0004 0.0002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.016 0.0158
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0061 0.0294 0.0292
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0333 0.033
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0108 0.0629 0.0627
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0504 0.2832
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.005 0.0217 0.0215
Brugia malayi intermediate filament protein 0.0029 0.0064 0.0071
Loa Loa (eye worm) hypothetical protein 0.0115 0.0682 0.0809
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0138 0.0845 0.1736
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0333 0.033
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0192 0.1236 0.2658
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0138 0.0845 0.1736
Echinococcus multilocularis sterol regulatory element binding protein 0.0112 0.0658 0.0656
Treponema pallidum quinoline 2-oxidoreductase 0.0065 0.0323 0.8682
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0129 0.0126
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.005 0.0217 0.0215
Echinococcus multilocularis lamin dm0 0.0029 0.0064 0.0062
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.0217 0.0638
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.079 0.8812
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0038 0.0129 0.0126
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0112 0.0658 0.0781
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0129 0.0126
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.025 0.0297
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0129 0.0147
Echinococcus granulosus Protein patched homolog 1 0.0112 0.0658 0.0656
Loa Loa (eye worm) hypothetical protein 0.1198 0.8426 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0115 0.0682 0.0804
Echinococcus granulosus geminin 0.0375 0.2539 0.2537
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0129 0.0147
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0038 0.0129 0.0126
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0115 0.0682 0.0804
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0957 0.1131
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0544 0.3753 0.3751
Loa Loa (eye worm) glutathione reductase 0.004 0.0142 0.0168
Trichomonas vaginalis aldehyde oxidase, putative 0.0408 0.2778 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0108 0.0629 0.0627
Schistosoma mansoni thyroid hormone receptor 0.0659 0.4575 0.4574
Entamoeba histolytica hypothetical protein 0.0161 0.101 0.815
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0629 0.0627
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0193 0.1239 0.1237
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0127 0.077 0.246
Brugia malayi hypothetical protein 0.0023 0.0023 0.0023
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0207 0.0245
Toxoplasma gondii thioredoxin reductase 0.004 0.0142 0.0358
Brugia malayi photoreceptor-specific nuclear receptor 0.0115 0.0682 0.0804
Echinococcus granulosus RUN 0.0023 0.0023 0.0021
Loa Loa (eye worm) steroid hormone receptor 0.0115 0.0682 0.0809
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0023 0.0021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0115 0.0682 0.068
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0271 0.18 1
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0179 0.0177
Onchocerca volvulus 0.0038 0.0129 0.1833
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0294 0.0344
Onchocerca volvulus 0.0023 0.0023 0.028
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0023 0.0021
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.0412 0.3304
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0054 0.0247 0.0245
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0059 0.0282 0.063
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0629 0.506
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0061 0.0294 0.0292
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0115 0.0682 0.068
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0294 0.0344
Schistosoma mansoni bromodomain containing protein 0.0076 0.0401 0.0399
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0276 0.099
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.0412 0.041
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Echinococcus multilocularis microtubule associated protein 2 0.1418 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0115 0.0682 0.0804
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.061 0.0719
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.005 0.0217 0.1593
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0136
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0059 0.0282 0.028
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.0412 0.041
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0504 0.2832
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0371 0.0369
Brugia malayi CHE-14 protein 0.0112 0.0658 0.0776
Brugia malayi Cation transporter family protein 0.0038 0.0129 0.0147
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0038 0.0129 0.0147
Brugia malayi orphan nuclear receptor NR2E1 0.0054 0.0247 0.0288
Echinococcus granulosus tumor protein p63 0.0361 0.2444 0.2442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Echinococcus granulosus FTZ F1 alpha 0.0115 0.0682 0.068
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0271 0.18 1
Onchocerca volvulus 0.0038 0.0129 0.1833
Loa Loa (eye worm) hypothetical protein 0.0112 0.0658 0.0781
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0115 0.0682 0.068
Brugia malayi Cytochrome P450 family protein 0.0035 0.0109 0.0124
Plasmodium falciparum glutathione reductase 0.004 0.0142 0.0976
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.002 0.0004 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0115 0.0682 0.068
Echinococcus granulosus Nuclear hormone receptor HR96 0.0054 0.0247 0.0245
Brugia malayi nuclear hormone receptor family member odr-7 0.0054 0.0247 0.0288
Entamoeba histolytica hypothetical protein 0.0161 0.101 0.815
Loa Loa (eye worm) nuclear receptor NHR-67 0.0054 0.0247 0.0293
Echinococcus multilocularis geminin 0.0375 0.2539 0.2537
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0504 0.2832
Loa Loa (eye worm) beta-lactamase 0.0036 0.0114 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0115 0.0682 0.0809
Loa Loa (eye worm) glutaminase 2 0.0269 0.1785 0.2119
Schistosoma mansoni lipoxygenase 0.0096 0.0545 0.0543
Onchocerca volvulus Putative nachr subunit 0.0038 0.0129 0.1833
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0023 0.0021
Schistosoma mansoni lipoxygenase 0.0137 0.084 0.0838
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0114 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0115 0.0682 0.0804
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0054 0.0247 0.0245
Echinococcus granulosus intermediate filament protein 0.0029 0.0064 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0513 0.0511
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0038 0.0129 0.0153
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0629 0.506
Loa Loa (eye worm) hypothetical protein 0.0154 0.0957 0.1136
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0038 0.0129 0.0126
Schistosoma mansoni jun-related protein 0.0068 0.0348 0.0346
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0028
Schistosoma mansoni loxhd1 0.0023 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0045 0.0181 0.0214
Schistosoma mansoni thyroid hormone receptor 0.0659 0.4575 0.4574
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.0576 0.3355
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0023 0.0021
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.1239 0.422
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0115 0.0682 0.0804
Brugia malayi ecdysteroid receptor 0.0115 0.0682 0.0804
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0333 0.033
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0038 0.0129 0.0147
Schistosoma mansoni nuclear receptor 0.0054 0.0247 0.0245
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2685 0.2684
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0127 0.077 0.246
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Brugia malayi hypothetical protein 0.0023 0.0023 0.0023
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0023 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0115 0.0682 0.0809
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0513 0.0511
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0217 0.0638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.079 0.0788
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0142 0.0194
Echinococcus granulosus tar DNA binding protein 0.0066 0.0333 0.033
Echinococcus granulosus Nuclear hormone receptor HR96 0.0054 0.0247 0.0245
Schistosoma mansoni nAChR subunit 0.0038 0.0129 0.0126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0957 0.1136
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0333 0.033
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0059 0.0282 0.063
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0192 0.1236 0.2658
Echinococcus multilocularis nAChR subunit 0.0038 0.0129 0.0126
Schistosoma mansoni zinc finger protein 0.0025 0.0035 0.0032
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0129 0.0126
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0061 0.0294 0.0292
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.079 0.4027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.005 0.0217 0.0252
Mycobacterium tuberculosis Probable reductase 0.009 0.0504 0.2832
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0115 0.0682 0.068
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0137 0.084 0.0838
Echinococcus granulosus chromatin regulatory protein sir2 0.0108 0.0629 0.0627
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.039 0.1661
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0137 0.084 0.0838
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0127 0.077 0.246
Leishmania major cathepsin L-like protease 0.0074 0.039 0.1661
Brugia malayi hypothetical protein 0.0054 0.0247 0.0288
Loa Loa (eye worm) glutaminase 0.0269 0.1785 0.2119
Schistosoma mansoni transcription factor LCR-F1 0.0161 0.101 0.1008
Echinococcus granulosus GPCR family 2 0.0049 0.0207 0.0205
Onchocerca volvulus 0.005 0.0217 0.3139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0513 0.0511
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0072
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0078 0.0417 0.2198
Onchocerca volvulus 0.0059 0.0282 0.4102
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.079 0.1607
Loa Loa (eye worm) hypothetical protein 0.0059 0.0282 0.0335
Brugia malayi Nuclear hormone receptor E75 0.0054 0.0247 0.0288
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0115 0.0682 0.068
Echinococcus granulosus lamin dm0 0.0029 0.0064 0.0062
Echinococcus multilocularis zinc finger protein 0.0025 0.0035 0.0032
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.005 0.0217 0.1722
Loa Loa (eye worm) hypothetical protein 0.0059 0.0282 0.0335
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.016 0.0158
Leishmania major cathepsin L-like protease 0.0074 0.039 0.1661
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0114 0.0032
Echinococcus multilocularis thyroid hormone receptor alpha 0.0659 0.4575 0.4574
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0629 0.1931
Echinococcus granulosus zinc finger protein 0.0025 0.0035 0.0032
Mycobacterium ulcerans glutaminase 0.0269 0.1785 0.3956
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0115 0.0682 0.068
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0129 0.0126
Brugia malayi hypothetical protein 0.0061 0.0294 0.0344
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0114 0.0131
Schistosoma mansoni nuclear receptor nhr-48 0.0054 0.0247 0.0245
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0513 0.0608
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0193 0.1239 0.1237
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.039 0.1661
Brugia malayi Cation transporter family protein 0.0038 0.0129 0.0147
Schistosoma mansoni cpg binding protein 0.0032 0.0085 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0115 0.0682 0.0809
Mycobacterium ulcerans beta-lactamase 0.0036 0.0114 0.0013
Onchocerca volvulus 0.0036 0.0114 0.1626
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0038 0.0129 0.0126
Loa Loa (eye worm) RNA binding protein 0.0066 0.0333 0.0395
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0038 0.0129 0.0126
Onchocerca volvulus 0.0066 0.0331 0.4826
Onchocerca volvulus 0.0029 0.0064 0.0881
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0193 0.1239 0.422
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0247 0.0245
Loa Loa (eye worm) hypothetical protein 0.0061 0.0294 0.0349
Schistosoma mansoni rab6-interacting 0.0023 0.0023 0.0021
Schistosoma mansoni hypothetical protein 0.0375 0.2539 0.2537
Giardia lamblia Hypothetical protein 0.0108 0.0629 0.4032
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0207 0.0205
Loa Loa (eye worm) hypothetical protein 0.0115 0.0682 0.0809
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Echinococcus multilocularis FTZ F1 alpha 0.0115 0.0682 0.068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0007 0.0004
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0054 0.0247 0.3586
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0513 0.0511
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0129 0.0126
Brugia malayi beta-lactamase family protein 0.0036 0.0114 0.0131
Loa Loa (eye worm) hypothetical protein 0.0193 0.1239 0.147
Echinococcus multilocularis nuclear receptor nhr 48 0.0054 0.0247 0.0245
Brugia malayi steroid hormone receptor 0.0115 0.0682 0.0804
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0129 0.0147
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0371 0.0369
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0629 0.1931
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0023 0.0028
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0629 0.0627
Echinococcus granulosus lamin 0.0029 0.0064 0.0062
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0271 0.18 0.2132
Brugia malayi Rhodanese-like domain containing protein 0.0059 0.0282 0.033
Onchocerca volvulus Bile acid receptor homolog 0.0115 0.0682 1
Echinococcus multilocularis musashi 0.0029 0.0064 0.0062
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0136
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0109 0.0129
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0129 0.0153
Schistosoma mansoni hypothetical protein 0.0068 0.0348 0.0346
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1489 1
Echinococcus granulosus jun protein 0.0084 0.046 0.0458
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0064 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0217 0.0638
Schistosoma mansoni coup transcription factor 0.0115 0.0682 0.068
Loa Loa (eye worm) hypothetical protein 0.0115 0.0682 0.0809
Loa Loa (eye worm) hypothetical protein 0.0083 0.0452 0.0536
Onchocerca volvulus 0.0059 0.0282 0.4102
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0121 0.0725 0.1453
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0078 0.0417 0.0726
Loa Loa (eye worm) hypothetical protein 0.0061 0.0294 0.0349
Echinococcus multilocularis RUN 0.0023 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Onchocerca volvulus 0.0059 0.0282 0.4102
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0114 0.0013
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0054 0.0247 0.0293
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0078 0.0417 0.0726
Brugia malayi nuclear receptor NHR-67 0.0054 0.0247 0.0288
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0115 0.0682 0.0809
Loa Loa (eye worm) hypothetical protein 0.0115 0.0682 0.0809
Brugia malayi Bromodomain containing protein 0.0045 0.018 0.0209
Brugia malayi CXXC zinc finger family protein 0.0028 0.0058 0.0063
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Brugia malayi conserved hypotetical protein 0.0054 0.0247 0.0288
Loa Loa (eye worm) hypothetical protein 0.0082 0.0444 0.0527
Schistosoma mansoni hypothetical protein 0.0375 0.2539 0.2537
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0129 0.0147
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0333 0.033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0115 0.0682 0.068
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.039 0.1661
Loa Loa (eye worm) hypothetical protein 0.0055 0.0249 0.0296
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0513 0.0603
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0038 0.0129 0.0147
Plasmodium vivax glutathione reductase, putative 0.004 0.0142 0.0976
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0136
Loa Loa (eye worm) hypothetical protein 0.0061 0.0294 0.0349
Schistosoma mansoni intermediate filament proteins 0.0029 0.0064 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0115 0.0682 0.068
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0408 0.2778 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0115 0.0682 0.0809
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0207 0.0205
Echinococcus granulosus nAChR subunit 0.002 0.0004 0.0002
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0271 0.18 0.399
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.028 0.0278
Brugia malayi Cytochrome P450 family protein 0.0035 0.0109 0.0124
Loa Loa (eye worm) hypothetical protein 0.0061 0.0294 0.0349
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0129 0.0147
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0247 0.0245
Giardia lamblia Rab geranylgeranyltransferase 0.0193 0.1239 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0504 0.8441
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0114 0.0112
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.005 0.0217 0.0385
Brugia malayi beta-lactamase 0.0036 0.0114 0.0131
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0108 0.0629 0.3075
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.0576 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0038 0.0129 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0115 0.0682 0.0804
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0412 0.1793
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0059 0.0282 0.063
Leishmania major hypothetical protein, conserved 0.0036 0.0114 0.0032
Onchocerca volvulus 0.0054 0.0247 0.3586
Onchocerca volvulus 0.0023 0.0023 0.028
Echinococcus granulosus ecdysone induced protein 78C 0.0115 0.0682 0.068
Trichomonas vaginalis cdc25b, putative 0.0059 0.0282 0.063
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0115 0.0682 0.068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0207 0.0205
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Schistosoma mansoni lamin 0.0029 0.0064 0.0062
Echinococcus multilocularis GPCR, family 2 0.0049 0.0207 0.0205
Loa Loa (eye worm) LGC-31 protein 0.0038 0.0129 0.0153
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0129 0.0147
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0193 0.1239 1
Schistosoma mansoni hypothetical protein 0.0049 0.0207 0.0205
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0127 0.077 0.5411
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0957 0.1131
Schistosoma mansoni glutaminase 0.0269 0.1785 0.1784
Brugia malayi Bromodomain containing protein 0.0089 0.0499 0.0587
Brugia malayi nuclear hormone receptor 0.0054 0.0247 0.0288
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.0412 0.1793
Brugia malayi bZIP transcription factor family protein 0.0084 0.046 0.0541
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0344 0.1389
Brugia malayi RNA binding protein 0.0066 0.0333 0.039
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0005
Brugia malayi glutaminase DH11.1 0.0269 0.1785 0.2115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.079 0.0788
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0054 0.0247 0.0245
Mycobacterium ulcerans hydrolase/amidase 0.0627 0.4347 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0038 0.0129 0.0126
Onchocerca volvulus Protein ultraspiracle homolog 0.0115 0.0682 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0115 0.0682 0.0804
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0255 0.1834
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0038 0.0129 0.0153
Entamoeba histolytica rodhanase-like domain containing protein 0.0059 0.0282 0.2251
Onchocerca volvulus 0.0038 0.0129 0.1833
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.0629 0.3075
Entamoeba histolytica rodhanase-like domain containing protein 0.0059 0.0282 0.2251
Schistosoma mansoni hypothetical protein 0.0049 0.0207 0.0205
Echinococcus multilocularis ecdysone induced protein 78C 0.0115 0.0682 0.068
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0271 0.18 1
Schistosoma mansoni nuclear hormone receptor 0.0115 0.0682 0.068
Loa Loa (eye worm) hypothetical protein 0.0271 0.18 0.2136
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0115 0.0682 0.068
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0412 0.1793
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0138 0.0845 0.5312
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0333 0.0395
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0054 0.0247 0.0245
Brugia malayi hypothetical protein 0.0066 0.0331 0.0388
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0061 0.0294 0.0349
Brugia malayi follicle stimulating hormone receptor 0.0274 0.1817 0.2152
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0115 0.0682 0.068
Schistosoma mansoni steroid hormone receptor ad4bp 0.0115 0.0682 0.068
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0114 0.0112
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.0629 0.0742
Brugia malayi Steroid receptor seven-up type 2 0.0115 0.0682 0.0804
Echinococcus multilocularis protein patched 0.0112 0.0658 0.0656
Schistosoma mansoni nAChR subunit 0.0038 0.0129 0.0126
Brugia malayi glutathione reductase 0.004 0.0142 0.0163
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.0658 0.0656
Schistosoma mansoni hypothetical protein 0.0161 0.101 0.1008
Brugia malayi Nuclear hormone receptor E75 0.0054 0.0247 0.0288
Loa Loa (eye worm) hypothetical protein 0.0115 0.0682 0.0809
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.046 0.0458
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0207 0.024
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.005 0.0217 0.0215
Leishmania major silent information regulator 2, putative 0.0108 0.0629 0.3075
Echinococcus multilocularis tumor protein p63 0.0361 0.2444 0.2442
Brugia malayi PHD-finger family protein 0.0031 0.0079 0.0089
Onchocerca volvulus 0.0028 0.0058 0.0789
Entamoeba histolytica rodhanase-like domain containing protein 0.0059 0.0282 0.2251
Echinococcus multilocularis cpg binding protein 0.0032 0.0085 0.0083
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0059 0.0282 0.063
Loa Loa (eye worm) hypothetical protein 0.0052 0.0228 0.027
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0504 0.2832
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0115 0.0682 0.068
Loa Loa (eye worm) hypothetical protein 0.0105 0.061 0.0724
Loa Loa (eye worm) hypothetical protein 0.0115 0.0682 0.0809
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.079 0.1607
Brugia malayi Rhodanese-like domain containing protein 0.0059 0.0282 0.033
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0064 0.0076
Loa Loa (eye worm) hypothetical protein 0.0048 0.0201 0.0238
Treponema pallidum hypothetical protein 0.0066 0.0334 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0115 0.0682 0.0804
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.039 0.1661
Schistosoma mansoni nAChR subunit 0.0038 0.0129 0.0126
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0129 0.0147
Loa Loa (eye worm) hypothetical protein 0.0115 0.0682 0.0809
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0114 0.0013
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0038 0.0129 0.0147
Brugia malayi Thioredoxin reductase 0.004 0.0142 0.0163
Echinococcus granulosus protein prenyltransferase alpha subunit 0.005 0.0217 0.0215
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0064 0.0071
Onchocerca volvulus 0.0053 0.0238 0.3445
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0032 0.0038
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0376 0.255 0.3026
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0629 0.0627
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0513 0.0511
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0333 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0115 0.0682 0.0809
Onchocerca volvulus 0.0038 0.0129 0.1833
Schistosoma mansoni retinoic acid receptor RXR 0.0115 0.0682 0.068
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0129 0.0126
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0142 0.0976
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0114 0.0032
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0054 0.0247 0.0245
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0376 0.255 0.2548
Schistosoma mansoni hypothetical protein 0.0024 0.0032 0.003
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0059 0.0282 0.028
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0038 0.0129 0.0147
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0142 0.0199
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.0629 0.3075
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0142 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Trypanosoma brucei trypanothione reductase 0.004 0.0142 0.0194
Schistosoma mansoni patched 1 0.0112 0.0658 0.0656
Schistosoma mansoni nAChR subunit 0.0038 0.0129 0.0126
Brugia malayi nuclear receptor RXR 0.0061 0.0294 0.0344
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0129 0.0126
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0129 0.0126
Loa Loa (eye worm) hypothetical protein 0.0061 0.0294 0.0349
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0192 0.1236 0.8154
Schistosoma mansoni nAChR subunit 0.0038 0.0129 0.0126
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Brugia malayi nuclear hormone receptor 0.0115 0.0682 0.0804
Mycobacterium ulcerans hypothetical protein 0.0066 0.0334 0.053
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0054 0.0247 0.0245
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0193 0.1239 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Schistosoma mansoni cpg binding protein 0.0032 0.0085 0.0083
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0136
Loa Loa (eye worm) hypothetical protein 0.0054 0.0247 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.005 0.0217 0.0257
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0129 0.0126
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0193 0.1239 0.1466
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0217 0.0638
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0544 0.3753 0.3751
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0193 0.1239 0.1237
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0136
Brugia malayi Cation transporter family protein 0.0038 0.0129 0.0147
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0129 0.0126
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0376 0.255 0.3022
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0038 0.0129 0.0126
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0247 0.0245
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0038 0.0129 0.0126
Loa Loa (eye worm) DR-78 0.0054 0.0247 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0115 0.0682 0.0804
Brugia malayi tailless protein 0.0054 0.0247 0.0288
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.0412 0.041
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0076
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.0658 0.0656
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0005
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0059 0.0057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0114 0.0136
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0238 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0115 0.0682 0.0804
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0129 0.0153
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.0658 0.0656
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0115 0.0682 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0007 0.0004
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0038 0.0129 0.0126
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0129 0.0126
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0004 0.0002
Brugia malayi nuclear receptor RXR 0.0054 0.0247 0.0288
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0115 0.0682 0.068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Plasmodium falciparum thioredoxin reductase 0.004 0.0142 0.0976
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0658 0.2041
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0271 0.18 0.1798
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0115 0.0682 0.068
Leishmania major cathepsin L-like protease 0.0074 0.039 0.1661
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0054 0.0247 0.0288
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0271 0.18 0.1798
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0217 0.0638
Brugia malayi Cytochrome P450 family protein 0.0055 0.025 0.0292
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.0129 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0115 0.0682 0.0809
Schistosoma mansoni hypothetical protein 0.0049 0.0207 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.039 0.1661
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0129 0.0126
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0038 0.0129 0.0153
Echinococcus multilocularis lamin 0.0029 0.0064 0.0062
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0059 0.0057
Brugia malayi hypothetical protein 0.1198 0.8426 1
Echinococcus granulosus nAChR subunit 0.0038 0.0129 0.0126
Brugia malayi nuclear hormone receptor family member nhr-6 0.0054 0.0247 0.0288
Loa Loa (eye worm) hypothetical protein 0.0053 0.0238 0.0282
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.1817 0.2156
Brugia malayi TAR-binding protein 0.0066 0.0333 0.039
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0129 0.0126
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0193 0.1239 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0005
Brugia malayi Doublecortin family protein 0.0023 0.0023 0.0023
Schistosoma mansoni nAChR subunit 0.0038 0.0129 0.0126

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.58 nM Inhibitory activity against farnesyltransferase (FT) using SPA assay ChEMBL. 10201832
IC50 (binding) = 0.58 nM Inhibitory activity against farnesyltransferase (FT) using SPA assay ChEMBL. 10201832
Inhibition (functional) = 67 % Inhibition of H-ras processing in subconfluent H-Ras-transformed NIH3T3 cells ChEMBL. 10201832
Inhibition (functional) = 67 % Inhibition of H-ras processing in subconfluent H-Ras-transformed NIH3T3 cells ChEMBL. 10201832

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.