Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.2657 | 0.3189 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1201 | 0.1279 | 0.1188 |
Echinococcus granulosus | integrin alpha 3 | 0.1217 | 0.1301 | 0.1301 |
Echinococcus multilocularis | dihydrofolate reductase | 0.7853 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.6416 | 0.8116 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.6416 | 0.8116 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.7853 | 1 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0712 | 0.0638 | 0.0493 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6416 | 0.8116 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.7853 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.7853 | 1 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.1588 | 0.1786 | 0.1701 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.2448 | 0.2914 | 0.284 |
Loa Loa (eye worm) | hypothetical protein | 0.1247 | 0.1339 | 0.1249 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.6416 | 0.8116 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1264 | 0.1362 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2657 | 0.3189 | 0.2115 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.7853 | 1 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0371 | 0.0191 | 0.0039 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.7853 | 1 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0712 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.7853 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.7853 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.2657 | 0.3189 | 0.3189 |
Echinococcus granulosus | integrin alpha ps | 0.0341 | 0.0152 | 0.0152 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2657 | 0.3189 | 0.3084 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.0152 | 0.0049 |
Echinococcus multilocularis | integrin alpha ps | 0.0712 | 0.0638 | 0.0638 |
Echinococcus multilocularis | thymidylate synthase | 0.2657 | 0.3189 | 0.3189 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.6416 | 0.8116 | 0.5 |
Echinococcus multilocularis | integrin alpha 3 | 0.1217 | 0.1301 | 0.1301 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.1201 | 0.1279 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.0191 | 0.0088 |
Loa Loa (eye worm) | thymidylate synthase | 0.2657 | 0.3189 | 0.3118 |
Echinococcus granulosus | dihydrofolate reductase | 0.7853 | 1 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0712 | 0.0638 | 0.0638 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6416 | 0.8116 | 0.5 |
Echinococcus multilocularis | integrin alpha ps | 0.0341 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0876 | 0.0853 | 0.0758 |
Schistosoma mansoni | integrin alpha | 0.1588 | 0.1786 | 0.166 |
Brugia malayi | thymidylate synthase | 0.2657 | 0.3189 | 0.3118 |
Brugia malayi | hypothetical protein | 0.1264 | 0.1362 | 0.1272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.