Detailed information for compound 27779

Basic information

Technical information
  • TDR Targets ID: 27779
  • Name: [5-(methylcarbamoyloxymethyl)-2-methylsulfany l-3-phenylimidazol-4-yl]methyl N-methylcarbam ate
  • MW: 364.419 | Formula: C16H20N4O4S
  • H donors: 2 H acceptors: 3 LogP: 1.62 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)OCc1c(COC(=O)NC)nc(n1c1ccccc1)SC
  • InChi: 1S/C16H20N4O4S/c1-17-15(21)23-9-12-13(10-24-16(22)18-2)20(14(19-12)25-3)11-7-5-4-6-8-11/h4-8H,9-10H2,1-3H3,(H,17,21)(H,18,22)
  • InChiKey: SELPTWOWMVWBDF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-(methylcarbamoyloxymethyl)-2-methylsulfanyl-3-phenyl-imidazol-4-yl]methyl N-methylcarbamate
  • N-methylcarbamic acid [5-(methylcarbamoyloxymethyl)-2-(methylthio)-3-phenyl-4-imidazolyl]methyl ester
  • N-methylcarbamic acid [5-(methylcarbamoyloxymethyl)-2-(methylthio)-3-phenyl-imidazol-4-yl]methyl ester
  • 1H-Imidazole-4,5-dimethanol, 2-(methylthio)-1-phenyl-, bis(methylcarbamate) (ester)
  • NSC345643

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia 20S proteasome alpha subunit 1 0.001 0.0224 0.0224
Giardia lamblia Proteasome subunit beta type 9 precursor 0.001 0.0224 0.0224
Entamoeba histolytica P-glycoprotein-2, putative 0.0024 0.1258 0.1258
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.001 0.0224 0.0224
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.001 0.0224 0.0224
Brugia malayi Proteasome A-type and B-type family protein 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.001 0.0224 0.0224
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.1258 0.1258
Echinococcus multilocularis proteasome subunit beta type 7 0.001 0.0224 0.0224
Entamoeba histolytica P-glyco protein 6, putative 0.0024 0.1258 0.1258
Plasmodium falciparum proteasome subunit beta type-1, putative 0.001 0.0224 0.0224
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.001 0.0224 0.0224
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.1258 0.1258
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.001 0.0224 0.0224
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.1258 0.1258
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.001 0.0224 0.0224
Echinococcus multilocularis proteasome subunit alpha type 6 0.001 0.0224 0.0224
Entamoeba histolytica P-glycoprotein-2 0.0024 0.1258 0.1258
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.001 0.0224 0.0224
Brugia malayi Proteasome subunit alpha type 7-1 0.001 0.0224 0.0224
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.001 0.0224 0.0224
Echinococcus granulosus proteasome subunit beta type 7 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.001 0.0224 0.0224
Leishmania major proteasome alpha 7 subunit, putative 0.001 0.0224 0.0224
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.001 0.0224 0.0224
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.001 0.0224 0.0224
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.001 0.0224 0.0224
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.001 0.0224 0.0224
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.001 0.0224 0.0224
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.1258 0.1258
Loa Loa (eye worm) hypothetical protein 0.0024 0.1258 0.1258
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.001 0.0224 0.0224
Giardia lamblia 20S proteasome alpha subunit 4 0.001 0.0224 0.0224
Echinococcus granulosus proteasome subunit beta t family 0.001 0.0224 0.0224
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.1258 0.1258
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.001 0.0224 0.0224
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.001 0.0224 0.0224
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.001 0.0224 0.0224
Giardia lamblia 20S proteasome alpha subunit 5 0.001 0.0224 0.0224
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.1258 0.1258
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.1258 0.1258
Brugia malayi proteasome subunit alpha type 3 0.001 0.0224 0.0224
Trichomonas vaginalis abcb9, putative 0.0024 0.1258 0.1258
Leishmania major proteasome beta-1 subunit, putative 0.001 0.0224 0.0224
Giardia lamblia 20S proteasome alpha subunit 6 0.001 0.0224 0.0224
Trypanosoma brucei ATP-dependent protease subunit HslV 0.001 0.0224 0.0224
Toxoplasma gondii proteasome beta subunit 0.001 0.0224 0.0224
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome subunit beta type 3 0.001 0.0224 0.0224
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.001 0.0224 0.0224
Brugia malayi Proteasome A-type and B-type family protein 0.001 0.0224 0.0224
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.001 0.0224 0.0224
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.1258 0.1258
Brugia malayi Proteasome A-type and B-type family protein 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit beta type-3, putative 0.001 0.0224 0.0224
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.001 0.0224 0.0224
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0024 0.1258 0.5
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.001 0.0224 0.0224
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0705 0.0705
Echinococcus granulosus proteasome prosome macropain subunit beta 0.001 0.0224 0.0224
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.001 0.0224 0.0224
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.1258 0.1258
Schistosoma mansoni multidrug resistance protein 0.0024 0.1258 0.1258
Brugia malayi proteasome subunit alpha type 2 0.001 0.0224 0.0224
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0024 0.1238 0.1238
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.1258 0.1258
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.001 0.0224 0.0224
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.001 0.0224 0.0224
Plasmodium vivax proteasome subunit alpha type-2, putative 0.001 0.0224 0.0224
Trichomonas vaginalis ABC transporter, putative 0.0024 0.1258 0.1258
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0139 1 1
Toxoplasma gondii peptidase, T1 family protein 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome subunit beta type 2 0.001 0.0224 0.0224
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.1258 0.1258
Plasmodium falciparum proteasome subunit beta type-7, putative 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0139 1 1
Plasmodium vivax proteasome subunit beta type-1, putative 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.001 0.0224 0.0224
Trypanosoma brucei proteasome alpha 7 subunit 0.001 0.0224 0.0224
Entamoeba histolytica P-glycoprotein-2 0.0024 0.1258 0.1258
Giardia lamblia 20S proteasome alpha subunit 7 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0139 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.1258 0.1258
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.001 0.0224 0.0224
Entamoeba histolytica P-glycoprotein-5 0.0024 0.1258 0.1258
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.1258 0.1258
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.001 0.0224 0.0224
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.001 0.0224 0.0224
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.001 0.0224 0.0224
Plasmodium vivax proteasome subunit alpha type-1, putative 0.001 0.0224 0.0224
Brugia malayi proteasome subunit alpha type 4 0.001 0.0224 0.0224
Echinococcus multilocularis subfamily T1A non peptidase ue 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.001 0.0224 0.0224
Trypanosoma brucei proteasome beta 7 subunit 0.001 0.0224 0.0224
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.001 0.0224 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.001 0.0224 0.0224
Mycobacterium ulcerans proteasome PrcA 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.001 0.0224 0.0224
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.001 0.0224 0.0224
Entamoeba histolytica P-glycoprotein 5, putative 0.0024 0.1258 0.1258
Plasmodium vivax proteasome subunit alpha type-6, putative 0.001 0.0224 0.0224
Trichomonas vaginalis ABC transporter, putative 0.0024 0.1258 0.1258
Plasmodium vivax proteasome subunit alpha type-3, putative 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.001 0.0224 0.0224
Giardia lamblia Proteasome subunit beta type 2 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.001 0.0224 0.0224
Brugia malayi proteasome subunit beta type 1 0.001 0.0224 0.0224
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.001 0.0224 0.0224
Plasmodium vivax proteasome subunit beta type-4, putative 0.001 0.0224 0.0224
Leishmania major proteasome alpha 7 subunit, putative 0.001 0.0224 0.0224
Echinococcus multilocularis Proteasome subunit alpha type 7 0.001 0.0224 0.0224
Echinococcus granulosus proteasome subunit alpha type 6 0.001 0.0224 0.0224
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.001 0.0224 0.0224
Toxoplasma gondii proteasome subunit beta type, putative 0.0139 1 1
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.001 0.0224 0.0224
Giardia lamblia Proteasome subunit beta type 1 0.001 0.0224 0.0224
Plasmodium vivax proteasome subunit alpha type-5, putative 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.001 0.0224 0.0224
Loa Loa (eye worm) PAS-3 protein 0.001 0.0224 0.0224
Onchocerca volvulus 0.0024 0.1258 1
Plasmodium vivax proteasome subunit beta type-2, putative 0.001 0.0224 0.0224
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.001 0.0224 0.0224
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.1238 0.1238
Toxoplasma gondii proteasome subunit beta type 2, putative 0.001 0.0224 0.0224
Echinococcus multilocularis proteasome (prosome, macropain) 0.0139 1 1
Plasmodium falciparum multidrug resistance protein 1 0.0024 0.1258 0.1258
Echinococcus granulosus subfamily T1A non peptidase ue 0.001 0.0224 0.0224
Brugia malayi proteasome subunit beta type 3 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.001 0.0224 0.0224
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.1258 0.1258
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.001 0.0224 0.0224
Trypanosoma brucei proteasome beta 2 subunit, putative 0.001 0.0224 0.0224
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.1258 0.1258
Plasmodium vivax proteasome subunit beta type-3, putative 0.001 0.0224 0.0224
Echinococcus multilocularis Proteasome, subunit alpha beta 0.001 0.0224 0.0224
Giardia lamblia Proteasome subunit beta type 7 precursor 0.001 0.0224 0.0224
Trypanosoma brucei proteasome beta 6 subunit 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.001 0.0224 0.0224
Leishmania major proteasome alpha 1 subunit, putative 0.001 0.0224 0.0224
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.001 0.0224 0.0224
Plasmodium vivax proteasome subunit alpha type-7, putative 0.001 0.0224 0.0224
Loa Loa (eye worm) multidrug resistance protein 3 0.0024 0.1258 0.1258
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.1258 0.1258
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit beta type-4 0.001 0.0224 0.0224
Toxoplasma gondii proteasome subunit alpha1, putative 0.001 0.0224 0.0224
Trypanosoma brucei proteasome beta 3 subunit, putative 0.001 0.0224 0.0224
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.1258 0.1258
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.001 0.0224 0.0224
Trichomonas vaginalis taga, putative 0.0024 0.1258 0.1258
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.001 0.0224 0.0224
Giardia lamblia Proteasome subunit beta type 4 precursor 0.001 0.0224 0.0224
Leishmania major proteasome beta 2 subunit, putative 0.001 0.0224 0.0224
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.1258 0.1258
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.001 0.0224 0.0224
Plasmodium vivax proteasome subunit beta type-5, putative 0.0139 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.1258 0.1258
Echinococcus granulosus proteasome prosome macropain 0.0139 1 1
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.001 0.0224 0.0224
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.1258 0.1258
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0024 0.1258 0.1258
Leishmania major proteasome beta 5 subunit, putative 0.0139 1 1
Trypanosoma brucei proteasome beta-1 subunit, putative 0.001 0.0224 0.0224
Trichomonas vaginalis ABC transporter, putative 0.0024 0.1258 0.1258
Echinococcus granulosus proteasome prosome macropain subunit beta 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.001 0.0224 0.0224
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.1258 0.1258
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.1258 0.1258
Echinococcus multilocularis Proteasome subunit alpha type 7 0.001 0.0224 0.0224
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit beta type 1, putative 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit beta type-2, putative 0.001 0.0224 0.0224
Toxoplasma gondii proteasome subunit alpha type, putative 0.001 0.0224 0.0224
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0705 0.0705
Brugia malayi proteasome subunit alpha type 6 0.001 0.0224 0.0224
Leishmania major proteasome alpha 3 subunit, putative 0.001 0.0224 0.0224
Leishmania major proteasome beta 3 subunit, putative 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0139 1 1
Echinococcus granulosus Proteasome subunit alpha beta 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.001 0.0224 0.0224
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.001 0.0224 0.0224
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.001 0.0224 0.0224
Leishmania major proteasome alpha 1 subunit, putative 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.001 0.0224 0.0224
Brugia malayi Proteasome subunit alpha type 1 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.001 0.0224 0.0224
Echinococcus multilocularis proteasome subunit alpha type 2 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.001 0.0224 0.0224
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0705 0.0705
Entamoeba histolytica proteasome subunit beta type 3, putative 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit beta type-5 0.0139 1 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.001 0.0224 0.0224
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.001 0.0224 0.0224
Echinococcus granulosus 20S proteasome subunit alpha 6 0.001 0.0224 0.0224
Brugia malayi proteasome subunit beta type 2 0.001 0.0224 0.0224
Trichomonas vaginalis ABC transporter, putative 0.0024 0.1258 0.1258
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0024 0.1258 0.1258
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.001 0.0224 0.0224
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.1258 0.1258
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome subunit alpha type 3 0.001 0.0224 0.0224
Trypanosoma brucei proteasome subunit beta type-2, putative 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.001 0.0224 0.0224
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.001 0.0224 0.0224
Toxoplasma gondii heat shock protein hslv, putative 0.001 0.0224 0.0224
Brugia malayi multidrug resistance protein 3 0.0024 0.1258 0.1258
Leishmania major proteasome alpha 2 subunit, putative 0.001 0.0224 0.0224
Entamoeba histolytica P-glycoprotein-1 0.0024 0.1258 0.1258
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0139 1 1
Echinococcus multilocularis Proteasome subunit alpha type 7 0.001 0.0224 0.0224
Leishmania major proteasome beta 7 subunit, putative 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.001 0.0224 0.0224
Trichomonas vaginalis abcb9, putative 0.0024 0.1258 0.1258
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome subunit alpha type 2 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.001 0.0224 0.0224
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.1258 0.1258
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.001 0.0224 0.0224
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0139 1 1
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.001 0.0224 0.0224
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.0705 0.0705
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.1258 0.1258
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0139 1 1
Schistosoma mansoni multidrug resistance protein 0.0024 0.1258 0.1258
Loa Loa (eye worm) hypothetical protein 0.0024 0.1238 0.1238
Echinococcus granulosus proteasome subunit alpha type 2 0.001 0.0224 0.0224
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.001 0.0224 0.0224
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome subunit beta type 1 0.001 0.0224 0.0224
Toxoplasma gondii proteasome subunit 0.001 0.0224 0.0224
Echinococcus multilocularis proteasome subunit beta type 6 0.001 0.0224 0.0224
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit beta type-6, putative 0.001 0.0224 0.0224
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome subunit alpha type 6 0.001 0.0224 0.0224
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.1258 0.1258
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0139 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.1258 0.1258
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.001 0.0224 0.0224
Brugia malayi ABC transporter family protein 0.0024 0.1258 0.1258
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.001 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0024 0.1258 0.1258
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0139 1 1
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.001 0.0224 0.0224
Trichomonas vaginalis abcb9, putative 0.0024 0.1258 0.1258
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0024 0.1258 0.1258
Plasmodium vivax proteasome subunit beta type-6, putative 0.001 0.0224 0.0224
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.001 0.0224 0.0224
Brugia malayi proteasome subunit alpha type 1 0.001 0.0224 0.0224
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.1258 0.1258
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.1258 0.1258
Mycobacterium ulcerans proteasome PrcB 0.0139 1 1
Leishmania major proteasome beta 2 subunit, putative 0.001 0.0224 0.0224
Plasmodium vivax proteasome subunit alpha type-4, putative 0.001 0.0224 0.0224
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.1258 0.1258
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.001 0.0224 0.0224
Giardia lamblia Proteasome subunit beta type 3 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.001 0.0224 0.0224
Schistosoma mansoni multidrug resistance protein 0.0024 0.1258 0.1258
Plasmodium vivax multidrug resistance protein 1, putative 0.0024 0.1258 0.1258
Toxoplasma gondii proteasome subunit beta type 1, putative 0.001 0.0224 0.0224
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.001 0.0224 0.0224
Leishmania major p-glycoprotein 0.0024 0.1258 0.1258
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.001 0.0224 0.0224
Giardia lamblia 20S proteasome alpha subunit 2 0.001 0.0224 0.0224
Echinococcus granulosus proteasome subunit beta type 6 0.001 0.0224 0.0224
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.1258 0.1258
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.001 0.0224 0.0224
Brugia malayi 20S proteasome alpha5 subunit 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.001 0.0224 0.0224
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.1258 0.1258
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.1258 0.1258
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.001 0.0224 0.0224
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.1258 0.1258
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.1258 0.1258
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.001 0.0224 0.0224
Echinococcus granulosus Proteasome subunit alpha type 7 0.001 0.0224 0.0224
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.001 0.0224 0.0224
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0024 0.1258 0.1258
Trypanosoma cruzi 20S proteasome subunit 0.001 0.0224 0.0224
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.001 0.0224 0.0224
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.1258 0.1258
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.1258 0.1258
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.001 0.0224 0.0224
Giardia lamblia 20S proteasome alpha subunit 3 0.001 0.0224 0.0224
Schistosoma mansoni smdr2 0.0024 0.1258 0.1258
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0139 1 1
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.001 0.0224 0.0224
Loa Loa (eye worm) proteasome subunit alpha type 1 0.001 0.0224 0.0224
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.001 0.0224 0.0224
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.001 0.0224 0.0224
Plasmodium vivax proteasome subunit beta type-7, putative 0.001 0.0224 0.0224

Activities

Activity type Activity value Assay description Source Reference
BWD (functional) = -5.2 g Body Weight Difference (BWD) of test animals administered with 400 mg/kg compound is determined on day 5 for P388 tumor cells ChEMBL. 2909723
BWD (functional) = -5.2 g Body Weight Difference (BWD) of test animals administered with 400 mg/kg compound is determined on day 5 for P388 tumor cells ChEMBL. 2909723
BWD (functional) = -3 g Body Weight Difference (BWD) of test animals administered with 200 mg/kg compound is determined on day 5 for P388 tumor cells ChEMBL. 2909723
BWD (functional) = -3 g Body Weight Difference (BWD) of test animals administered with 200 mg/kg compound is determined on day 5 for P388 tumor cells ChEMBL. 2909723
BWD (functional) = -1.6 g Body Weight Difference (BWD) of test animals administered with 100 mg/kg compound is determined on day 5 for P388 tumor cells ChEMBL. 2909723
BWD (functional) = -1.6 g Body Weight Difference (BWD) of test animals administered with 100 mg/kg compound is determined on day 5 for P388 tumor cells ChEMBL. 2909723
BWD (functional) = -1.4 g Body Weight Difference (BWD) of test animals administered with 50 mg/kg compound is determined on day 5 for P388 tumor cells ChEMBL. 2909723
BWD (functional) = -1.4 g Body Weight Difference (BWD) of test animals administered with 50 mg/kg compound is determined on day 5 for P388 tumor cells ChEMBL. 2909723
KE (functional) = 0.17 Ability of 100 mg/kg of compound to kill tumor cells in mice is expressed as the log of the tumor cell population at the onset of treatment minus the log of the tumor cell population at the end of treatment ChEMBL. 2909723
KE (functional) = 0.6 Ability of 50 mg/kg of compound to kill tumor cells in mice is expressed as the log of the tumor cell population at the onset of treatment minus the log of the tumor cell population at the end of treatment ChEMBL. 2909723
KE (functional) = 1.46 Ability of 200 mg/kg of compound to kill tumor cells in mice is expressed as the log of the tumor cell population at the onset of treatment minus the log of the tumor cell population at the end of treatment ChEMBL. 2909723
Survivors / animals tested (ADMET) = 4 Toxicity day evaluation was carried out on day 5 for animal dosed with 400 mg/kg compound; 4/5 ChEMBL. 2909723
Survivors / animals tested (ADMET) = 5 Toxicity day evaluation was carried out on day 5 for animal dosed with 200 mg/kg compound; 5/5 ChEMBL. 2909723
Survivors / animals tested (ADMET) = 5 Toxicity day evaluation was carried out on day 5 for animal dosed with 100 mg/kg compound; 5/5 ChEMBL. 2909723
Survivors / animals tested (ADMET) = 5 Toxicity day evaluation was carried out on day 5 for animal dosed with 50 mg/kg compound; 5/5 ChEMBL. 2909723
T/C (functional) = 133 % The percent of the median survival time of test mice compared to control mice is determined for mice administered with 100 mg/kg compound ChEMBL. 2909723
T/C (functional) = 133 % The percent of the median survival time of test mice compared to control mice is determined for mice administered with 100 mg/kg compound ChEMBL. 2909723
T/C (functional) = 141 % The percent of the median survival time of test mice compared to control mice is determined for mice administered with 50 mg/kg compound ChEMBL. 2909723
T/C (functional) = 141 % The percent of the median survival time of test mice compared to control mice is determined for mice administered with 50 mg/kg compound ChEMBL. 2909723
T/C (functional) = 156 % The percent of the median survival time of test mice compared to control mice is determined for mice administered with 200 mg/kg compound ChEMBL. 2909723
T/C (functional) = 156 % The percent of the median survival time of test mice compared to control mice is determined for mice administered with 200 mg/kg compound ChEMBL. 2909723

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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