Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.058 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.058 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Brugia malayi | Cathepsin L-like precursor | 0.0215 | 0.2094 | 0.2094 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Echinococcus granulosus | cathepsin l1 | 0.015 | 0.0666 | 0.0666 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0215 | 0.2094 | 0.2094 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Brugia malayi | Cathepsin L-like precursor | 0.0215 | 0.2094 | 0.2094 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0215 | 0.2094 | 0.2094 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Brugia malayi | Cathepsin L-like precursor | 0.015 | 0.0666 | 0.0666 |
Giardia lamblia | Cathepsin B precursor | 0.0216 | 0.2107 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.015 | 0.0666 | 0.3162 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0216 | 0.2107 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0216 | 0.2107 | 0.2033 |
Brugia malayi | Cathepsin L-like precursor | 0.0215 | 0.2094 | 0.2094 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0215 | 0.2094 | 0.2094 |
Onchocerca volvulus | 0.0215 | 0.2094 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.015 | 0.0666 | 0.3162 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.058 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Onchocerca volvulus | Cathepsin L homolog | 0.0215 | 0.2094 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0216 | 0.2107 | 0.2107 |
Onchocerca volvulus | 0.0215 | 0.2094 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.015 | 0.0666 | 0.0666 |
Entamoeba histolytica | cysteine proteinase, putative | 0.015 | 0.0666 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0216 | 0.2107 | 1 |
Plasmodium vivax | vivapain-2 | 0.0215 | 0.2094 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0215 | 0.2094 | 0.2094 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0666 | 0.058 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Giardia lamblia | Cathepsin B precursor | 0.0216 | 0.2107 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0666 | 0.058 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0215 | 0.2094 | 1 |
Onchocerca volvulus | 0.0215 | 0.2094 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0215 | 0.2094 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0215 | 0.2094 | 0.2094 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.015 | 0.0666 | 0.0666 |
Brugia malayi | Trypsin family protein | 0.0123 | 0.0092 | 0.0092 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0215 | 0.2094 | 0.2094 |
Onchocerca volvulus | 0.0215 | 0.2094 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0216 | 0.2107 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.058 | 1 | 1 |
Toxoplasma gondii | cathepsin B | 0.0216 | 0.2107 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.015 | 0.0666 | 0.0666 |
Onchocerca volvulus | Cathepsin F homolog | 0.0215 | 0.2094 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0215 | 0.2094 | 0.2094 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0215 | 0.2094 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0092 | 0.0092 |
Echinococcus multilocularis | cathepsin b | 0.058 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Echinococcus granulosus | cathepsin b | 0.058 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0215 | 0.2094 | 0.2094 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.2094 | 0.2021 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0216 | 0.2107 | 1 |
Echinococcus multilocularis | cathepsin b | 0.058 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0215 | 0.2094 | 0.2021 |
Entamoeba histolytica | cysteine protease, putative | 0.0215 | 0.2094 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Brugia malayi | Cathepsin L-like precursor | 0.0215 | 0.2094 | 0.2094 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0215 | 0.2094 | 0.2094 |
Brugia malayi | Cathepsin L-like precursor | 0.0215 | 0.2094 | 0.2094 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0215 | 0.2094 | 0.2094 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0092 | 0.0092 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Onchocerca volvulus | Cathepsin L homolog | 0.0215 | 0.2094 | 1 |
Onchocerca volvulus | 0.015 | 0.0666 | 0.2869 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Brugia malayi | cathepsin L-like precursor | 0.015 | 0.0666 | 0.0666 |
Loa Loa (eye worm) | fibroinase | 0.0215 | 0.2094 | 0.2021 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0215 | 0.2094 | 0.2094 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Plasmodium vivax | vivapain-2 | 0.0215 | 0.2094 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.058 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0215 | 0.2094 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.058 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.015 | 0.0666 | 0.0666 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0215 | 0.2094 | 0.2094 |
Echinococcus granulosus | cathepsin l1 | 0.0215 | 0.2094 | 0.2094 |
Loa Loa (eye worm) | ctsf protein | 0.0215 | 0.2094 | 0.2021 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0215 | 0.2094 | 0.2021 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0215 | 0.2094 | 0.2094 |
Loa Loa (eye worm) | cysteine protease | 0.0215 | 0.2094 | 0.2021 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0215 | 0.2094 | 0.2094 |
Brugia malayi | Cathepsin L-like precursor | 0.0215 | 0.2094 | 0.2094 |
Onchocerca volvulus | 0.0215 | 0.2094 | 1 | |
Onchocerca volvulus | 0.0215 | 0.2094 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0215 | 0.2094 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0215 | 0.2094 | 0.9939 |
Onchocerca volvulus | 0.0215 | 0.2094 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0666 | 0.058 |
Echinococcus granulosus | cathepsin b | 0.058 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0216 | 0.2107 | 0.2107 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0215 | 0.2094 | 0.2094 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0215 | 0.2094 | 0.2094 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0215 | 0.2094 | 0.9939 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 nM | Inhibition of protein kinase C (Inactive) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.