Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.9396 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.9396 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.9396 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.7096 | 0.716 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1297 | 0 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.9396 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.9396 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7096 | 0.716 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7096 | 0.716 | 0.5 |
Brugia malayi | thymidylate synthase | 0.2727 | 0.1766 | 0.1766 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.9396 | 1 | 1 |
Onchocerca volvulus | 0.2727 | 0.1766 | 0.5 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.7096 | 0.716 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.9396 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2727 | 0.1766 | 0.1766 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.7096 | 0.716 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.9396 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.7096 | 0.716 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.9396 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 62 nM | Binding affinity at the dopamine transporter using [125I]-RTI-55 in rat caudate membranes. | ChEMBL. | 9057857 |
IC50 (binding) | = 62 nM | Binding affinity at the dopamine transporter using [125I]-RTI-55 in rat caudate membranes. | ChEMBL. | 9057857 |
IC50 (functional) | = 73 nM | Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-dopamine on synaptosomes obtained from rat caudate. | ChEMBL. | 9057857 |
IC50 (functional) | = 73 nM | Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-dopamine on synaptosomes obtained from rat caudate. | ChEMBL. | 9057857 |
IC50 (binding) | = 551 nM | Binding affinity at the serotonin transporter using [125I]-RTI-55 in rat caudate membranes. | ChEMBL. | 9057857 |
IC50 (binding) | = 551 nM | Binding affinity at the serotonin transporter using [125I]-RTI-55 in rat caudate membranes. | ChEMBL. | 9057857 |
IC50 (functional) | = 10470 nM | Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum. | ChEMBL. | 9057857 |
IC50 (functional) | = 10470 nM | Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum. | ChEMBL. | 9057857 |
Ki (binding) | = 61.8 nM | Displacement of [125I]RTI55 from DAT in rat brain synaptosomes | ChEMBL. | 17127069 |
Ki (binding) | = 61.8 nM | Displacement of [125I]RTI55 from DAT in rat brain synaptosomes | ChEMBL. | 17127069 |
Ki (binding) | = 550.5 nM | Displacement of [125I]RTI55 from SERT in rat brain synaptosomes | ChEMBL. | 17127069 |
Ki (binding) | = 550.5 nM | Displacement of [125I]RTI55 from SERT in rat brain synaptosomes | ChEMBL. | 17127069 |
Ratio (functional) | = 1.2 | Ratio of reuptake inhibition on DA with respect to binding affinity of DA | ChEMBL. | 9057857 |
Ratio (functional) | = 1.2 | Ratio of reuptake inhibition on DA with respect to binding affinity of DA | ChEMBL. | 9057857 |
Ratio (binding) | = 9 | Ratio of binding affinity on SERT with respect to DA | ChEMBL. | 9057857 |
Ratio (functional) | = 14 | Ratio of reuptake inhibition of 5-HT with respect to DA | ChEMBL. | 9057857 |
Ratio pKi (binding) | = 0.95 | Selectivity for rat DAT over rat SERT | ChEMBL. | 17127069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.