Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0039 | 0.0662 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.0566 | 0.1592 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0314 | 0.0883 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0009 | 0.0025 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0039 | 0.0662 |
Onchocerca volvulus | 0.0055 | 0.0608 | 0.3649 | |
Echinococcus multilocularis | lamin dm0 | 0.0055 | 0.0608 | 0.0564 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0039 | 0.0662 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.0566 | 0.0892 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0039 | 0.0662 |
Onchocerca volvulus | 0.0098 | 0.1121 | 1 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0478 | 0.5659 | 0.5639 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0039 | 0.0662 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0334 | 0.094 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0039 | 0.0662 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.024 | 0.2826 | 0.4933 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0051 | 0.0566 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0566 | 0.089 |
Schistosoma mansoni | lamin | 0.0055 | 0.0608 | 0.1712 |
Loa Loa (eye worm) | carboxylesterase | 0.0051 | 0.0566 | 0.089 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0039 | 0.0662 |
Schistosoma mansoni | intermediate filament proteins | 0.0055 | 0.0608 | 0.1712 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.0566 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.026 | 0.0343 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0039 | 0.0662 |
Loa Loa (eye worm) | intermediate filament protein | 0.0055 | 0.0608 | 0.0966 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0039 | 0.0662 |
Echinococcus granulosus | acetylcholinesterase | 0.0301 | 0.3553 | 0.6248 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0478 | 0.5659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0566 | 0.089 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0055 | 0.0608 | 0.0966 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0314 | 0.0439 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0068 | 0.0039 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.0566 | 0.0892 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0334 | 0.094 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0566 | 0.089 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0566 | 0.089 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.0566 | 0.1592 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0314 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.026 | 0.0343 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0039 | 0.0662 |
Onchocerca volvulus | 0.0051 | 0.0566 | 0.312 | |
Schistosoma mansoni | lamin | 0.0055 | 0.0608 | 0.1712 |
Schistosoma mansoni | gliotactin | 0.0051 | 0.0566 | 0.1592 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0051 | 0.0566 | 0.1592 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0051 | 0.0566 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.0566 | 0.1592 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0272 | 0.0364 |
Echinococcus multilocularis | acetylcholinesterase | 0.0301 | 0.3553 | 0.3523 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0039 | 0.0662 |
Echinococcus granulosus | lamin | 0.0055 | 0.0608 | 0.1001 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0039 | 0.0662 |
Onchocerca volvulus | 0.0051 | 0.0566 | 0.312 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0051 | 0.0566 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0051 | 0.0566 | 0.0522 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0051 | 0.0566 | 0.0522 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0051 | 0.0566 | 0.1592 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.0566 | 0.0892 |
Onchocerca volvulus | 0.0055 | 0.0608 | 0.3649 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0039 | 0.0662 |
Onchocerca volvulus | 0.0051 | 0.0566 | 0.312 | |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.3553 | 0.6234 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0608 | 0.0966 |
Brugia malayi | follicle stimulating hormone receptor | 0.024 | 0.2826 | 0.4934 |
Echinococcus granulosus | intermediate filament protein | 0.0055 | 0.0608 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0596 | 0.0945 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0301 | 0.3553 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0039 | 0.0662 |
Echinococcus multilocularis | musashi | 0.0055 | 0.0608 | 0.0564 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0566 | 0.0892 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.0712 | 0.2005 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0055 | 0.0608 | 0.0968 |
Loa Loa (eye worm) | carboxylesterase | 0.0051 | 0.0566 | 0.089 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0026 | 0.0272 | 0.0226 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0051 | 0.0566 | 0.0925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0039 | 0.0662 |
Onchocerca volvulus | 0.0051 | 0.0566 | 0.312 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0051 | 0.0566 | 0.0925 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0051 | 0.0566 | 0.0925 |
Echinococcus granulosus | neuroligin | 0.0051 | 0.0566 | 0.0925 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.3553 | 0.6234 |
Loa Loa (eye worm) | hypothetical protein | 0.0478 | 0.5659 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.1121 | 0.3154 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0334 | 0.0512 |
Echinococcus multilocularis | lamin | 0.0055 | 0.0608 | 0.0564 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0039 | 0.0662 |
Loa Loa (eye worm) | carboxylesterase | 0.0301 | 0.3553 | 0.6234 |
Echinococcus multilocularis | acetylcholinesterase | 0.0301 | 0.3553 | 0.3523 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0301 | 0.3553 | 0.6234 |
Brugia malayi | hypothetical protein | 0.0478 | 0.5659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0566 | 0.089 |
Schistosoma mansoni | acetylcholinesterase | 0.0051 | 0.0566 | 0.1592 |
Echinococcus multilocularis | neuroligin | 0.0051 | 0.0566 | 0.0522 |
Brugia malayi | Carboxylesterase family protein | 0.0301 | 0.3553 | 0.6235 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.0306 | 0.0426 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0334 | 0.0289 |
Onchocerca volvulus | 0.0051 | 0.0566 | 0.312 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0566 | 0.089 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0098 | 0.1121 | 0.1885 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.0632 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0051 | 0.0566 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0098 | 0.1121 | 0.3154 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0039 | 0.0662 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0.0566 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0301 | 0.3553 | 0.3523 |
Brugia malayi | intermediate filament protein | 0.0055 | 0.0608 | 0.0968 |
Brugia malayi | Carboxylesterase family protein | 0.0301 | 0.3553 | 0.6235 |
Echinococcus granulosus | carboxylesterase 5A | 0.0301 | 0.3553 | 0.6248 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0029 | 0.0306 | 0.0429 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0.0566 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0055 | 0.0608 | 0.1001 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0068 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0566 | 0.089 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0026 | 0.0272 | 0.0402 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0051 | 0.0566 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0039 | 0.0662 |
Echinococcus granulosus | acetylcholinesterase | 0.0301 | 0.3553 | 0.6248 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0046 | 0.0131 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 19 uM | Compound was tested for antiviral activity against HIV-1 resistant to TIBO A-17 | ChEMBL. | 9548815 |
IC50 (functional) | > 30 uM | Compound was tested for antiviral activity against HIV-2 | ChEMBL. | 9548815 |
IC50 (functional) | = 37 uM | Activity against HIV-1 by syncytial plaque assay performed in duplicate using CEM-SS cells | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Antiviral activity against human cytomegalovirus(HCMV) by plaque reduction assay | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Antiviral activity against herpes simplex virus type-1 (HSV-1) | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Visual cytotoxicity scored on HFF cells at a time of HCMV plaque enumeration | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Inhibition of KB cell growth determined by quadruplicate assays | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Cytotoxicity against CEM-SS cells in terms of incorporation of [3H]-dThd | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Visual cytotoxicity scored on HFF cells at a time of HCMV plaque enumeration | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Inhibition of KB cell growth determined by quadruplicate assays | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Cytotoxicity against CEM-SS cells in terms of incorporation of [3H]-dThd | ChEMBL. | 9548815 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.