Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative GMP reductase | 0.0079 | 0.1263 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.8852 | 1 |
Trypanosoma cruzi | GMP reductase | 0.019 | 0.5745 | 0.5693 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.8852 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.019 | 0.5745 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.019 | 0.5745 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.019 | 0.5745 | 0.6471 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0079 | 0.1263 | 0.1383 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 0.5745 | 0.5693 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.019 | 0.5745 | 0.2394 |
Echinococcus granulosus | acetylcholinesterase | 0.0266 | 0.8852 | 1 |
Loa Loa (eye worm) | GMP reductase | 0.0079 | 0.1263 | 0.1383 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 0.5745 | 0.5693 |
Brugia malayi | Carboxylesterase family protein | 0.0266 | 0.8852 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.019 | 0.5745 | 0.3224 |
Echinococcus granulosus | acetylcholinesterase | 0.0266 | 0.8852 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0266 | 0.8852 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0266 | 0.8852 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0266 | 0.8852 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0079 | 0.1263 | 0.1383 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.019 | 0.5745 | 0.3224 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.4357 | 0.6554 |
Toxoplasma gondii | IMP dehydrogenas | 0.019 | 0.5745 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.372 | 0.3643 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0266 | 0.8852 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0266 | 0.8852 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.019 | 0.5745 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0178 | 0.5289 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.019 | 0.5745 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0178 | 0.5289 | 0.8869 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0266 | 0.8852 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0266 | 0.8852 | 1 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.019 | 0.5745 | 0.2394 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0178 | 0.5289 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.01 | 0.2103 | 0.0954 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.019 | 0.5745 | 0.6471 |
Echinococcus multilocularis | acetylcholinesterase | 0.0266 | 0.8852 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 0.5745 | 0.5693 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.4357 | 0.619 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.019 | 0.5745 | 0.3224 |
Trypanosoma brucei | GMP reductase | 0.019 | 0.5745 | 0.3224 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.019 | 0.5745 | 0.2394 |
Trypanosoma cruzi | GMP reductase | 0.019 | 0.5745 | 0.5693 |
Brugia malayi | GMP reductase | 0.0079 | 0.1263 | 0.1383 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Effect (functional) | = 3.3 % | Compound effect on differentiation of K562 cells, % of benzidine positive cells at 1.0 microM | ChEMBL. | 11806722 |
Effect (functional) | = 3.3 % | Compound effect on differentiation of K562 cells, % of benzidine positive cells at 1.0 microM | ChEMBL. | 11806722 |
Effect (functional) | = 67 % | Compound effect on differentiation of K562 cells, % of benzidine positive cells at 20 microM | ChEMBL. | 11806722 |
Effect (functional) | = 67 % | Compound effect on differentiation of K562 cells, % of benzidine positive cells at 20 microM | ChEMBL. | 11806722 |
IC50 (functional) | = 43.2 uM | Concentration of the Antiproliferative compound required for the 50% inhibition of Growth against K562 cells | ChEMBL. | 11806722 |
IC50 (functional) | = 43.2 uM | Concentration of the Antiproliferative compound required for the 50% inhibition of Growth against K562 cells | ChEMBL. | 11806722 |
Ki (binding) | = 0.4 uM | Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) | ChEMBL. | 11806722 |
Ki (binding) | = 0.4 uM | Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) | ChEMBL. | 11806722 |
Ki (binding) | = 0.89 uM | Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I) | ChEMBL. | 11806722 |
Ki (binding) | = 0.89 uM | Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I) | ChEMBL. | 11806722 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.