Detailed information for compound 278490

Basic information

Technical information
  • TDR Targets ID: 278490
  • Name: 6-(4-ethylpiperazin-1-yl)-7,8,9,10-tetrahydro phenanthridine
  • MW: 295.422 | Formula: C19H25N3
  • H donors: 0 H acceptors: 1 LogP: 4.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)c1nc2ccccc2c2c1CCCC2
  • InChi: 1S/C19H25N3/c1-2-21-11-13-22(14-12-21)19-17-9-4-3-7-15(17)16-8-5-6-10-18(16)20-19/h5-6,8,10H,2-4,7,9,11-14H2,1H3
  • InChiKey: OCJHRAFKWMOMGL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-(4-ethyl-1-piperazinyl)-7,8,9,10-tetrahydrophenanthridine
  • 6-(4-ethylpiperazino)-7,8,9,10-tetrahydrophenanthridine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 3 (5-HT3) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Serotonin 3 (5-HT3) receptor   483 aa 541 aa 25.5 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.4 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein Serotonin 3 (5-HT3) receptor   483 aa 388 aa 21.9 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 463 aa 26.8 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 26.8 %
Onchocerca volvulus Putative zinc finger protein Serotonin 3 (5-HT3) receptor   483 aa 489 aa 25.8 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 489 aa 31.3 %
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.7 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Serotonin 3 (5-HT3) receptor   483 aa 464 aa 24.8 %
Brugia malayi Cation transporter family protein Serotonin 3 (5-HT3) receptor   483 aa 507 aa 28.2 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 473 aa 27.5 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 484 aa 26.0 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 461 aa 24.3 %
Echinococcus multilocularis nAChR subunit Serotonin 3 (5-HT3) receptor   483 aa 495 aa 24.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Serotonin 3 (5-HT3) receptor   483 aa 514 aa 23.2 %
Onchocerca volvulus Large subunit GTPase 1 homolog Serotonin 3 (5-HT3) receptor   483 aa 394 aa 19.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 477 aa 26.6 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 482 aa 23.9 %
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 Serotonin 3 (5-HT3) receptor   483 aa 387 aa 25.6 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Serotonin 3 (5-HT3) receptor   483 aa 503 aa 22.3 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.6 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.9 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Serotonin 3 (5-HT3) receptor   483 aa 478 aa 25.1 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 457 aa 24.7 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Serotonin 3 (5-HT3) receptor   483 aa 490 aa 31.0 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 27.7 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 505 aa 21.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 452 aa 29.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 482 aa 25.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0087 0.0645 0.1527
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0035 0.0068 0.0285
Brugia malayi Dopamine receptor protein 2 0.0053 0.0265 0.0413
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Onchocerca volvulus 0.0056 0.0296 0.0889
Echinococcus granulosus neuropeptide s receptor 0.0053 0.0265 0.0265
Brugia malayi conserved hypotetical protein 0.0137 0.1195 0.1862
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.018 0.1671 0.1671
Onchocerca volvulus 0.033 0.3327 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) hypothetical protein 0.0154 0.1378 0.3264
Onchocerca volvulus 0.0053 0.0265 0.0796
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0576 0.0897
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Echinococcus multilocularis orexin receptor type 2 0.0053 0.0265 0.0265
Brugia malayi Steroid receptor seven-up type 2 0.0291 0.2897 0.4513
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0255 0.2506 0.5937
Brugia malayi larval opioid receptor 0.0053 0.0265 0.0413
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0053 0.0265 0.0367
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0034 0.0054
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0137 0.1195 0.1195
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0056 0.0296 0.041
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0296 0.2202
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Schistosoma mansoni pyruvate kinase 0.0032 0.0034 0.0048
Onchocerca volvulus Protein ultraspiracle homolog 0.0291 0.2897 0.8707
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Schistosoma mansoni neuropeptide f receptor 76f 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.01
Brugia malayi dihydrofolate reductase family protein 0.0365 0.3717 0.5791
Schistosoma mansoni neuropeptide receptor 0.0053 0.0265 0.0367
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.0265 0.0367
Schistosoma mansoni neurotransmitter gated ion channel 0.0035 0.0061 0.0084
Brugia malayi hypothetical protein 0.0035 0.0061 0.0095
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Onchocerca volvulus 0.0137 0.1195 0.3593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus granulosus pyruvate kinase 0.0032 0.0034 0.0034
Loa Loa (eye worm) solute carrier family 6 member 4 0.033 0.3327 0.7882
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0291 0.2897 0.2897
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0087 0.0645 0.0894
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0051 0.0135
Onchocerca volvulus 0.0053 0.0265 0.0796
Brugia malayi orphan nuclear receptor NR2E1 0.0137 0.1195 0.1862
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0291 0.2897 0.2897
Brugia malayi Tachykinin-like peptides receptor 99D 0.0053 0.0265 0.0413
Giardia lamblia hypothetical protein 0.0035 0.0068 0.0057
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0034 0.0104
Loa Loa (eye worm) hypothetical protein 0.0154 0.1378 0.3264
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis somatostatin receptor 0.0053 0.0265 0.0265
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.039 0.1241
Brugia malayi hypothetical protein 0.0035 0.0061 0.0095
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0053 0.0265 0.0265
Brugia malayi hypothetical protein 0.0137 0.1195 0.1862
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0291 0.2897 0.2897
Brugia malayi hypothetical protein 0.0041 0.0133 0.0207
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0291 0.2897 0.4016
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0068 0.0057
Schistosoma mansoni hypothetical protein 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0087 0.0645 0.0894
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0035 0.0068 0.0106
Loa Loa (eye worm) hypothetical protein 0.033 0.3327 0.7882
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0576 0.0897
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0056 0.0296 0.0296
Echinococcus multilocularis sodium and chloride dependent glycine 0.0056 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0162
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Brugia malayi nuclear hormone receptor family member nhr-6 0.0137 0.1195 0.1862
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0645 0.1004
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0053 0.0265 0.0413
Onchocerca volvulus 0.0137 0.1195 0.3593
Brugia malayi Cation transporter family protein 0.0087 0.0645 0.1004
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0576 0.0897
Echinococcus granulosus neuropeptide receptor 0.0053 0.0265 0.0265
Echinococcus granulosus g-protein coupled receptor 0.0053 0.0265 0.0265
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0291 0.2897 0.4016
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0056 0.0296 0.0296
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0087 0.0645 0.1004
Brugia malayi Death domain containing protein 0.0029 0.000000018783 0.00000002926
Echinococcus multilocularis fmrfamide receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0087 0.0645 0.1527
Brugia malayi G protein-coupled receptor F59B2.13 0.0053 0.0265 0.0413
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0035 0.0068 0.0106
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0053 0.0265 0.0367
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0491 0.0681
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0265 0.0265
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi nuclear hormone receptor 0.0291 0.2897 0.4513
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0051 0.0135
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0087 0.0645 0.1527
Schistosoma mansoni steroid hormone receptor ad4bp 0.0291 0.2897 0.4016
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0034 0.0104
Brugia malayi neuropeptide F receptor 0.0053 0.0265 0.0413
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0291 0.2897 0.6863
Onchocerca volvulus 0.0053 0.026 0.0782
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Brugia malayi Nuclear hormone receptor E75 0.0137 0.1195 0.1862
Echinococcus granulosus sodium and chloride dependent glycine 0.0056 0.0296 0.0296
Onchocerca volvulus 0.0041 0.0133 0.0399
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Brugia malayi bZIP transcription factor family protein 0.0171 0.1568 0.2443
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0291 0.2899 0.4018
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0137 0.1195 0.1657
Brugia malayi Nuclear hormone receptor-like 1 0.0154 0.1378 0.2146
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.039 0.3993 0.3993
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0053 0.0265 0.0796
Brugia malayi nuclear receptor NHR-88 0.0291 0.2897 0.4513
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0212 0.0501
Loa Loa (eye worm) hypothetical protein 0.0154 0.1378 0.3264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0035 0.0068 0.0095
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0035 0.0061 0.0061
Onchocerca volvulus 0.0053 0.0265 0.0796
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0571 0.6007 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Loa Loa (eye worm) hypothetical protein 0.0048 0.0213 0.0505
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Schistosoma mansoni nuclear receptor 0.0137 0.1195 0.1657
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0068 0.0285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0291 0.2897 0.4513
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0035 0.0068 0.0106
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0291 0.2897 0.2897
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0291 0.2897 0.6863
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Schistosoma mansoni biogenic amine receptor 0.0053 0.0265 0.0367
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0701
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0154 0.1378 0.3264
Echinococcus granulosus neuropeptide receptor 0.0053 0.0265 0.0265
Schistosoma mansoni rab6-interacting 0.0041 0.0133 0.0184
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0056 0.0296 0.071
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0068 0.0057
Brugia malayi follicle stimulating hormone receptor 0.0053 0.0265 0.0413
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0279 0.2769 0.7424
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0291 0.2897 0.8707
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0162
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0291 0.2897 0.4513
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0035 0.0068 0.0068
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0051 0.0056
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Schistosoma mansoni jun-related protein 0.0139 0.1214 0.1683
Schistosoma mansoni hypothetical protein 0.006 0.0345 0.0478
Echinococcus multilocularis Ankyrin 0.0029 0.0003 0.0003
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0913
Brugia malayi neuropeptide F receptor 0.0053 0.0265 0.0413
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0291 0.2897 0.4016
Onchocerca volvulus 0.0053 0.0265 0.0796
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0051 0.0051
Brugia malayi hypothetical protein 0.0154 0.1378 0.2146
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Echinococcus multilocularis thyroid hormone receptor alpha 0.068 0.7214 0.7214
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0139 0.1221 0.4144
Onchocerca volvulus 0.0053 0.0265 0.0796
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Brugia malayi Cation transporter family protein 0.0087 0.0645 0.1004
Brugia malayi tailless protein 0.0137 0.1195 0.1862
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0035 0.0068 0.0162
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0139 0.1221 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.039 0.054
Echinococcus multilocularis dihydrofolate reductase 0.0365 0.3717 0.3717
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Onchocerca volvulus 0.0053 0.026 0.0782
Loa Loa (eye worm) melatonin receptor type 1A 0.0053 0.0265 0.0628
Brugia malayi putative neuropeptide receptor NPR1 0.0053 0.0265 0.0413
Schistosoma mansoni coup transcription factor 0.0291 0.2897 0.4016
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0053 0.0265 0.0265
Echinococcus multilocularis RUN 0.0041 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0139 0.1214 0.1683
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0365 0.3717 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0053 0.0265 0.0628
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0291 0.2897 0.2897
Echinococcus granulosus peptide allatostatin:somatostatin 0.0053 0.0265 0.0265
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0056 0.0296 0.041
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.000000018783 0.000000026037
Loa Loa (eye worm) glutaminase 0.0269 0.266 0.6302
Echinococcus granulosus 7tm_1 domain containing protein 0.0053 0.0265 0.0265
Onchocerca volvulus 0.0081 0.0576 0.1731
Echinococcus multilocularis FTZ F1 alpha 0.0291 0.2897 0.2897
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.039 0.039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0291 0.2897 0.4513
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0035 0.0068 0.0285
Schistosoma mansoni hypothetical protein 0.0053 0.0265 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0291 0.2897 0.6863
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0056 0.0296 0.041
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0035 0.0068 0.0068
Loa Loa (eye worm) dihydrofolate reductase 0.0365 0.3717 0.8806
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0087 0.0645 0.1004
Echinococcus granulosus sex peptide receptor 0.0053 0.0265 0.0265
Schistosoma mansoni histamine h1 receptor 0.0053 0.0265 0.0367
Brugia malayi hypothetical protein 0.0035 0.0061 0.0095
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Schistosoma mansoni lipoxygenase 0.0106 0.0849 0.1176
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0055 0.0131
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0576 0.1364
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0315
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0087 0.0645 0.0645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0087 0.0645 0.1527
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0255 0.2506 0.2506
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0053 0.0265 0.0413
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0087 0.0645 0.0645
Schistosoma mansoni nuclear hormone receptor 0.0137 0.1195 0.1657
Brugia malayi Nuclear hormone receptor-like 1 0.0291 0.2897 0.4513
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0932 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Echinococcus multilocularis g-protein coupled receptor 0.0053 0.0265 0.0265
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0056 0.0296 0.041
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.0265 0.0628
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0099 0.0099
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0055 0.0055
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0087 0.0645 0.0645
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Onchocerca volvulus Peroxidase homolog 0.0081 0.0576 0.1731
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0323 0.0765
Schistosoma mansoni sodium/chloride dependent transporter 0.0056 0.0296 0.041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0056 0.0296 0.041
Schistosoma mansoni thyroid hormone receptor 0.068 0.7214 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.0035 0.0061 0.0084
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0291 0.2899 0.2899
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0137 0.1195 0.1195
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0291 0.2897 0.2897
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0576 0.0897
Brugia malayi Sodium:neurotransmitter symporter family protein 0.033 0.3327 0.5183
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Onchocerca volvulus 0.0035 0.0061 0.0182
Brugia malayi Dopamine receptor protein 1 0.0053 0.0265 0.0413
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0265 0.0265
Leishmania major hypothetical protein, conserved 0.0034 0.0051 0.0135
Onchocerca volvulus 0.0035 0.0061 0.0182
Onchocerca volvulus 0.0081 0.0576 0.1731
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0291 0.2897 0.4513
Schistosoma mansoni neurotransmitter gated ion channel 0.0053 0.026 0.036
Schistosoma mansoni peroxidasin 0.0081 0.0576 0.0798
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0053 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0038 0.0099 0.0137
Schistosoma mansoni amine GPCR 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis nAChR subunit 0.0053 0.026 0.026
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0133 0.0133
Brugia malayi DnaJ domain containing protein 0.006 0.0345 0.0537
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.0265 0.0265
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0035 0.0068 0.0068
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0137 0.1195 0.1195
Toxoplasma gondii hypothetical protein 0.0056 0.0296 0.0913
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Plasmodium vivax amine transporter, putative 0.0056 0.0296 0.2202
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0053 0.026 0.036
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0035 0.0061 0.0095
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0087 0.0645 0.1527
Schistosoma mansoni alpha-1 adrenergic receptor 0.0053 0.0265 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0291 0.2897 0.4513
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.039 0.3993 0.3993
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0034 0.0082
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0035 0.0061 0.0095
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0137 0.1195 0.1195
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0034 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0291 0.2897 0.4513
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0913
Echinococcus multilocularis glycine receptor subunit beta 0.0087 0.0645 0.0645
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0034 0.0104
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0035 0.0068 0.0068
Echinococcus multilocularis dro:myosuppressin receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0291 0.2897 0.4513
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0035 0.0068 0.0285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.039 0.0965
Schistosoma mansoni nAChR subunit 0.0035 0.0061 0.0084
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0461
Leishmania major cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0571 0.6007 1
Brugia malayi Uncoordinated protein 44 0.0029 0.000000018783 0.00000002926
Echinococcus granulosus 7TM GPCR rhodopsin 0.0053 0.0265 0.0265
Schistosoma mansoni zinc finger protein 0.0137 0.1195 0.1657
Echinococcus multilocularis neuropeptide receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0053 0.0265 0.0367
Brugia malayi Melatonin receptor type 1A 0.0053 0.0265 0.0413
Schistosoma mansoni acetylcholine receptor-related 0.0035 0.0061 0.0084
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Giardia lamblia Hypothetical protein 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Brugia malayi excitatory GABA receptor EXP-1A 0.0087 0.0645 0.1004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0212 0.0501
Brugia malayi putative neuropeptide receptor 0.0053 0.0265 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0291 0.2897 0.4513
Echinococcus multilocularis ecdysone induced protein 78C 0.0291 0.2897 0.2897
Echinococcus multilocularis neuropeptide receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) nuclear receptor NHR-67 0.0137 0.1195 0.2832
Echinococcus granulosus biogenic amine 5HT receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0645 0.0894
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0133 0.0829
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0053 0.0265 0.0628
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0291 0.2897 0.2897
Plasmodium falciparum amino acid transporter, putative 0.0056 0.0296 0.2202
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0291 0.2897 0.2897
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.0265 0.0628
Echinococcus multilocularis pyruvate kinase 0.0032 0.0034 0.0034
Plasmodium falciparum phosphodiesterase delta, putative 0.0035 0.0068 0.0285
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.000000018783 0.000000018783
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0291 0.2897 0.2897
Echinococcus granulosus g protein coupled receptor 0.0053 0.0265 0.0265
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0139 0.1221 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Echinococcus multilocularis glycine receptor subunit beta 0.0087 0.0645 0.0645
Brugia malayi hypothetical protein 0.0137 0.1195 0.1862
Schistosoma mansoni myosin xvIII 0.0053 0.0265 0.0367
Brugia malayi hypothetical protein 0.0035 0.0061 0.0095
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0133 0.0133
Echinococcus granulosus G protein coupled receptor 139 0.0053 0.0265 0.0265
Loa Loa (eye worm) blistered cuticle protein 3 0.0081 0.0576 0.1364
Brugia malayi hypothetical protein 0.0041 0.0133 0.0207
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Schistosoma mansoni opsin-like receptor 0.0053 0.0265 0.0367
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0291 0.2899 0.2899
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0087 0.0645 0.1004
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Echinococcus granulosus sodium and chloride dependent glycine 0.0056 0.0296 0.0296
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0087 0.0645 0.0645
Echinococcus granulosus neuropeptide receptor A26 0.0053 0.0265 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Schistosoma mansoni nAChR subunit 0.0035 0.0061 0.0084
Onchocerca volvulus 0.0087 0.0645 0.1938
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0576 0.1364
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Loa Loa (eye worm) TYRA-2 protein 0.0053 0.0265 0.0628
Giardia lamblia Fructose-bisphosphate aldolase 0.0571 0.6007 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.041 0.4221 0.5852
Loa Loa (eye worm) GABA receptor subunit 0.0053 0.026 0.0616
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0137 0.1195 0.3593
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0056 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0162
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0212 0.033
Plasmodium vivax phosphodiesterase gamma, putative 0.0035 0.0068 0.0285
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0056 0.0296 0.041
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0034 0.0054
Loa Loa (eye worm) hypothetical protein 0.02 0.1894 0.4487
Schistosoma mansoni amine GPCR 0.0053 0.0265 0.0367
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0265 0.0265
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0461
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0035 0.0068 0.0095
Loa Loa (eye worm) serotonin transporter b 0.033 0.3327 0.7882
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.0265 0.0265
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0055 0.0077
Brugia malayi nuclear receptor RXR 0.0154 0.1378 0.2146
Schistosoma mansoni loxhd1 0.0041 0.0133 0.0184
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Echinococcus granulosus nAChR subunit 0.0053 0.026 0.026
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi ecdysteroid receptor 0.0291 0.2897 0.4513
Schistosoma mansoni neurotransmitter gated ion channel 0.0035 0.0061 0.0084
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Echinococcus granulosus g protein coupled receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) PDE1B protein 0.0035 0.0068 0.0162
Loa Loa (eye worm) hypothetical protein 0.0154 0.1378 0.3264
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Onchocerca volvulus 0.0291 0.2897 0.8707
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0291 0.2897 0.6863
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.000000018783 0.000000018783
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0645 0.1004
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0053 0.0265 0.0413
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0315
Echinococcus granulosus arachidonate 5 lipoxygenase 0.018 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Brugia malayi Blistered cuticle protein 3 0.0081 0.0576 0.0897
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0702 0.0702
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0035 0.0068 0.0285
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0035 0.0068 0.0106
Schistosoma mansoni amine GPCR 0.0053 0.0265 0.0367
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Brugia malayi nuclear hormone receptor family member odr-7 0.0137 0.1195 0.1862
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0051 0.0135
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0291 0.2897 0.4513
Echinococcus granulosus orexin receptor type 2 0.0053 0.0265 0.0265
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0137 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Echinococcus multilocularis serotonin transporter 0.033 0.3327 0.3327
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Plasmodium falciparum phosphodiesterase gamma, putative 0.0035 0.0068 0.0285
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Onchocerca volvulus 0.0053 0.0265 0.0796
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus granulosus somatostatin receptor 0.0053 0.0265 0.0265
Entamoeba histolytica hypothetical protein 0.0053 0.026 0.0273
Echinococcus multilocularis sex peptide receptor 0.0053 0.0265 0.0265
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0291 0.2897 0.2897
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Schistosoma mansoni pyruvate kinase 0.0032 0.0034 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.039 0.0965
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Onchocerca volvulus 0.0053 0.0265 0.0796
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Schistosoma mansoni hypothetical protein 0.0331 0.3346 0.4639
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0291 0.2897 0.4513
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0035 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.041 0.4221 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.039 0.039
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Schistosoma mansoni lipoxygenase 0.018 0.1671 0.2316
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Onchocerca volvulus Peroxidase homolog 0.0081 0.0576 0.1731
Brugia malayi jmjC domain containing protein 0.0093 0.0702 0.1094
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0053 0.026 0.036
Loa Loa (eye worm) nuclear hormone receptor 0.0137 0.1195 0.2832
Brugia malayi Doublecortin family protein 0.0041 0.0133 0.0207
Brugia malayi RE15519p 0.0053 0.0265 0.0413
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0053 0.0265 0.0265
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0035 0.0061 0.0095
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.0265 0.0367
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0035 0.0068 0.0068
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0053 0.0265 0.0265
Brugia malayi Nuclear hormone receptor-like 1 0.0154 0.1378 0.2146
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0345 0.0345
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0035 0.0061 0.0144
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0154 0.1378 0.1378
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0576 0.1364
Onchocerca volvulus 0.0087 0.0645 0.1938
Schistosoma mansoni growth hormone secretagogue receptor 0.0053 0.0265 0.0367
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0051 0.0135
Brugia malayi photoreceptor-specific nuclear receptor 0.0291 0.2897 0.4513
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0133 0.0829
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0576 0.1731
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0576 0.1364
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0053 0.0265 0.0265
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0087 0.0645 0.0645
Echinococcus granulosus RUN 0.0041 0.0133 0.0133
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0056 0.0296 0.0296
Onchocerca volvulus 0.0053 0.0265 0.0796
Schistosoma mansoni nuclear hormone receptor 0.0291 0.2897 0.4016
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0056 0.0296 0.0461
Brugia malayi G protein-coupled receptor 0.0053 0.0265 0.0413
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Echinococcus multilocularis fmrfamide receptor 0.0053 0.0265 0.0265
Echinococcus granulosus fmrfamide receptor 0.0053 0.0265 0.0265
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0029 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0053 0.0265 0.0367
Echinococcus granulosus allatostatin A receptor 0.0053 0.0265 0.0265
Schistosoma mansoni thyroid hormone receptor 0.068 0.7214 1
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0576 0.1731
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0365 0.3717 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.039 0.0965
Onchocerca volvulus 0.0041 0.0133 0.0399
Onchocerca volvulus 0.0087 0.0645 0.1938
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0053 0.0265 0.0367
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0035 0.0068 0.0285
Echinococcus granulosus serotonin transporter 0.033 0.3327 0.3327
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Brugia malayi Protein kinase domain containing protein 0.0029 0.000000018783 0.00000002926
Brugia malayi AKH receptor 0.0053 0.0265 0.0413
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0139 0.1221 1
Loa Loa (eye worm) hypothetical protein 0.02 0.1894 0.4487
Schistosoma mansoni biogenic amine (5HT) receptor 0.0053 0.0265 0.0367
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0212 0.033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.039 0.0965
Onchocerca volvulus 0.0053 0.0265 0.0796
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Schistosoma mansoni hypothetical protein 0.0053 0.0265 0.0367
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0154 0.1378 0.1378
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0087 0.0645 0.0645
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0035 0.0068 0.0285
Echinococcus granulosus nuclear factor of activated T cells 5 0.015 0.1335 0.1335
Onchocerca volvulus 0.0053 0.0265 0.0796
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Onchocerca volvulus 0.0053 0.0265 0.0796
Schistosoma mansoni biogenic amine (5HT) receptor 0.02 0.1894 0.2626
Loa Loa (eye worm) hypothetical protein 0.033 0.3327 0.7882
Onchocerca volvulus 0.0087 0.0645 0.1938
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Echinococcus granulosus geminin 0.0331 0.3346 0.3346
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0056 0.0296 0.0296
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Loa Loa (eye worm) hypothetical protein 0.0291 0.2899 0.6866
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0053 0.0265 0.0367
Echinococcus granulosus glycine receptor subunit beta 0.0087 0.0645 0.0645
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0099 0.0099
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0087 0.0645 0.1004
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0056 0.0296 0.041
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0461
Brugia malayi nuclear receptor NHR-67 0.0137 0.1195 0.1862
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0345 0.0817
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0053 0.0265 0.0413
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Echinococcus granulosus serotonin receptor 0.0053 0.0265 0.0265
Schistosoma mansoni dihydrofolate reductase 0.0365 0.3717 0.5153
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0087 0.0645 0.0645
Brugia malayi sulfakinin receptor protein 0.0053 0.0265 0.0413
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0345 0.0345
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0087 0.0645 0.0645
Echinococcus multilocularis serotonin receptor 0.02 0.1894 0.1894
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0035 0.0068 0.0068
Brugia malayi ecdysone receptor 0.0137 0.1195 0.1862
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.1195 0.1195
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0133 0.0133
Brugia malayi Augmenter of liver regeneration 0.0034 0.0051 0.0079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0291 0.2897 0.2897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0291 0.2897 0.6863
Echinococcus granulosus glycine receptor subunit beta 0.0087 0.0645 0.0645
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Echinococcus granulosus neuropeptide FF receptor 2 0.0053 0.0265 0.0265
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0056 0.0296 0.041
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0645 0.0894
Echinococcus multilocularis jun protein 0.0171 0.1568 0.1568
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0133 0.0315
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Echinococcus granulosus dihydrofolate reductase 0.0365 0.3717 0.3717
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0291 0.2897 0.4513
Echinococcus multilocularis geminin 0.0331 0.3346 0.3346
Brugia malayi hypothetical protein 0.0134 0.1162 0.181
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0291 0.2897 0.4016
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0087 0.0645 0.0645
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0291 0.2897 0.4016
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Onchocerca volvulus Putative nachr subunit 0.0087 0.0645 0.1938
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0645 0.1004
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0112 0.0112
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Brugia malayi Dihydrofolate reductase 0.0365 0.3717 0.5791
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0053 0.026 0.0405
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0291 0.2899 0.2899
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0279 0.2769 0.7424
Schistosoma mansoni nuclear receptor nhr-48 0.0137 0.1195 0.1657
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Brugia malayi hypothetical protein 0.0154 0.1378 0.2146
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0139 0.1221 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0042 0.0066
Echinococcus granulosus alpha 1A adrenergic receptor 0.0053 0.0265 0.0265
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Onchocerca volvulus 0.0056 0.0296 0.0889
Brugia malayi Peroxidasin 0.0081 0.0576 0.0897
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0291 0.2897 0.2897
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0139 0.1221 1
Loa Loa (eye worm) glutaminase 2 0.0269 0.266 0.6302
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0051 0.0056
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0087 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0137 0.1195 0.1657
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0035 0.0068 0.0285
Schistosoma mansoni rab6-interacting 0.0041 0.0133 0.0184
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0034 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Schistosoma mansoni sodium-dependent amino acid transporter 0.0056 0.0296 0.041
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0087 0.0645 0.0645
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0035 0.0068 0.0068
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0701
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Echinococcus multilocularis nuclear factor of activated T cells 5 0.015 0.1335 0.1335
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.0265 0.0628
Schistosoma mansoni neuropeptide receptor 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0035 0.0068 0.0068
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.0265 0.0628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0291 0.2897 0.6863
Loa Loa (eye worm) ACC-1 protein 0.0087 0.0645 0.1527
Schistosoma mansoni amine GPCR 0.0053 0.0265 0.0367
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0112 0.0112
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0053 0.0265 0.0628
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0133 0.0133
Echinococcus multilocularis G-protein coupled receptor, putative 0.0053 0.0265 0.0265
Trichomonas vaginalis glutaminase, putative 0.0269 0.266 0.4396
Echinococcus multilocularis neuropeptide s receptor 0.0053 0.0265 0.0265
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0345 0.052
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Echinococcus granulosus tachykinin peptides receptor 99D 0.0053 0.0265 0.0265
Onchocerca volvulus 0.0053 0.0265 0.0796
Toxoplasma gondii hypothetical protein 0.0056 0.0296 0.0913
Brugia malayi Serotonin/octopamine receptor family protein 7 0.041 0.4221 0.6576
Schistosoma mansoni nuclear receptor 0.0137 0.1195 0.1657
Schistosoma mansoni biogenic amine receptor 0.0053 0.0265 0.0367
Echinococcus multilocularis pyruvate kinase 0.0032 0.0034 0.0034
Brugia malayi GnHR receptor homolog 0.0053 0.0265 0.0413
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0133 0.0133
Brugia malayi nuclear receptor RXR 0.0137 0.1195 0.1862
Onchocerca volvulus 0.0035 0.0061 0.0182
Loa Loa (eye worm) ACC-1 protein 0.0087 0.0645 0.1527
Echinococcus granulosus ecdysone induced protein 78C 0.0291 0.2897 0.2897
Brugia malayi glutaminase DH11.1 0.0269 0.266 0.4144
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis neuropeptide receptor A26 0.0053 0.0265 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Onchocerca volvulus 0.0081 0.0576 0.1731
Schistosoma mansoni neuropeptide receptor 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.041 0.4221 1
Brugia malayi Dopamine receptor 0.0053 0.0265 0.0413
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni peroxidasin 0.0081 0.0576 0.0798
Brugia malayi jmjC domain containing protein 0.0034 0.0055 0.0086
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0137 0.1195 0.1862
Loa Loa (eye worm) steroid hormone receptor 0.0291 0.2897 0.6863
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi hypothetical protein 0.0035 0.0061 0.0095
Brugia malayi hypothetical protein 0.0056 0.0296 0.0461
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0051 0.0135
Echinococcus multilocularis serotonin receptor 0.02 0.1894 0.1894
Echinococcus granulosus thyroid hormone receptor alpha 0.0137 0.1195 0.1195
Onchocerca volvulus 0.0053 0.0265 0.0796
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0053 0.0265 0.0367
Loa Loa (eye worm) DR-78 0.0137 0.1195 0.2832
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0055 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Loa Loa (eye worm) acetylcholine receptor protein 0.0035 0.0061 0.0144
Onchocerca volvulus 0.0134 0.1162 0.3492
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0099 0.0137
Brugia malayi hypothetical protein 0.0038 0.0099 0.0154
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0035 0.0061 0.0061
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0087 0.0645 0.0645
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.039 0.054
Brugia malayi Cation transporter family protein 0.0087 0.0645 0.1004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni hypothetical protein 0.039 0.3993 0.5535
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0645 0.0894
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0087 0.0645 0.1004
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0087 0.0645 0.1527
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0171 0.1568 0.1568
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Brugia malayi nuclear hormone receptor 0.0137 0.1195 0.1862
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0068 0.0057
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0265 0.0265
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.0265 0.0265
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Echinococcus multilocularis neuropeptide FF receptor 2 0.0053 0.0265 0.0265
Onchocerca volvulus 0.0053 0.0265 0.0796
Schistosoma mansoni RAR-like nuclear receptor 0.0291 0.2897 0.4016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Mycobacterium ulcerans glutaminase 0.0269 0.266 0.7129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Schistosoma mansoni biogenic amine receptor 0.0053 0.0265 0.0367
Schistosoma mansoni hypothetical protein 0.0331 0.3346 0.4639
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.0265 0.0265
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0265 0.0367
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0087 0.0645 0.1004
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Echinococcus multilocularis nAChR subunit 0.0087 0.0645 0.0645
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0265 0.0265
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0133 0.0133
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0291 0.2897 0.2897
Schistosoma mansoni retinoic acid receptor RXR 0.0291 0.2897 0.4016
Onchocerca volvulus Dual oxidase homolog 0.0081 0.0576 0.1731
Echinococcus granulosus nuclear receptor nhr 48 0.0137 0.1195 0.1195
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Schistosoma mansoni sodium/chloride dependent transporter 0.033 0.3327 0.4612
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0087 0.0645 0.0894
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus granulosus Nuclear hormone receptor HR96 0.0137 0.1195 0.1195
Loa Loa (eye worm) LGC-31 protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0035 0.0061 0.0061
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.033 0.3327 0.4612
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0051 0.0135
Brugia malayi Serotonin receptor 0.0053 0.0265 0.0413
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Treponema pallidum fructose-bisphosphate aldolase 0.0571 0.6007 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Schistosoma mansoni adenoreceptor 0.0053 0.0265 0.0367
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0291 0.2899 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0087 0.0645 0.1004
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0171 0.1568 0.1568
Loa Loa (eye worm) hypothetical protein 0.0166 0.1516 0.3592
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0913
Schistosoma mansoni nuclear hormone receptor 0.0137 0.1195 0.1657
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0035 0.0068 0.0285
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0051 0.012
Echinococcus granulosus biogenic amine 5HT receptor 0.02 0.1894 0.1894
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Echinococcus multilocularis peroxidasin 0.0081 0.0576 0.0576
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0053 0.0265 0.0628
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0035 0.0061 0.0095
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0255 0.2506 0.2506
Brugia malayi ORL1-like opioid receptor 0.0053 0.0265 0.0413
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0291 0.2899 0.2899
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0051 0.0051
Onchocerca volvulus 0.0056 0.0296 0.0889
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.0265 0.0265
Onchocerca volvulus Chorion peroxidase homolog 0.0081 0.0576 0.1731
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0056 0.0296 0.0296
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0035 0.0068 0.0095
Schistosoma mansoni opsin-like receptor 0.0053 0.0265 0.0367
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0053 0.0265 0.0628
Echinococcus multilocularis allatostatin A receptor 0.0053 0.0265 0.0265
Onchocerca volvulus 0.0053 0.0265 0.0796
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0035 0.0061 0.0061
Echinococcus granulosus pyruvate kinase 0.0032 0.0034 0.0034
Echinococcus multilocularis sodium and chloride dependent glycine 0.0056 0.0296 0.0296
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0035 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0033 0.0042 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0291 0.2897 0.6863
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0035 0.0068 0.0068
Schistosoma mansoni sodium/chloride dependent transporter 0.0056 0.0296 0.041
Chlamydia trachomatis dihydrofolate reductase 0.0365 0.3717 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0291 0.2897 0.4016
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Echinococcus granulosus jun protein 0.0171 0.1568 0.1568
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Echinococcus granulosus FTZ F1 alpha 0.0291 0.2897 0.2897
Schistosoma mansoni neuropeptide receptor 0.0053 0.0265 0.0367
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0137 0.1195 0.3593
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0035 0.0061 0.0144
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0053 0.0265 0.0265
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0265 0.0265
Echinococcus granulosus peroxidasin 0.0081 0.0576 0.0576
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0154 0.1378 0.191
Onchocerca volvulus Neuropeptide F receptor homolog 0.0053 0.0265 0.0796
Onchocerca volvulus 0.0087 0.0645 0.1938
Echinococcus granulosus Nuclear hormone receptor HR96 0.0137 0.1195 0.1195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0137 0.1195 0.2832
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0035 0.0068 0.0285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0035 0.0068 0.0106
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0053 0.0265 0.0265
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0365 0.3717 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0035 0.0061 0.0095
Loa Loa (eye worm) norepinephrine transporter 0.033 0.3327 0.7882
Echinococcus multilocularis nuclear receptor nhr 48 0.0137 0.1195 0.1195
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.0265 0.0265
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0154 0.1378 0.191
Brugia malayi Serotonin receptor 0.0609 0.6419 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Onchocerca volvulus 0.0053 0.0265 0.0796
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0087 0.0645 0.0645
Brugia malayi Nuclear hormone receptor E75 0.0137 0.1195 0.1862
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.039 0.2995
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0291 0.2899 0.4796
Onchocerca volvulus 0.0087 0.0645 0.1938
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.0082
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0053 0.026 0.0405
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.0265 0.0367
Onchocerca volvulus 0.0053 0.0265 0.0796
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0035 0.0068 0.0106
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0279 0.2769 0.7424
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0053 0.0265 0.0265
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0053 0.0265 0.0367
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Echinococcus multilocularis G protein coupled receptor 139 0.0053 0.0265 0.0265
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi G-protein coupled receptor 0.0053 0.0265 0.0413
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.0265 0.0265
Brugia malayi hypothetical protein 0.0081 0.0576 0.0897
Brugia malayi steroid hormone receptor 0.0291 0.2897 0.4513
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0087 0.0645 0.0645
Schistosoma mansoni hypothetical protein 0.0041 0.0133 0.0184
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0265 0.0367
Echinococcus granulosus nAChR subunit 0.0087 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Onchocerca volvulus Bile acid receptor homolog 0.0291 0.2897 0.8707
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0087 0.0645 0.0645
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0053 0.026 0.0405
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Echinococcus granulosus g protein coupled receptor 0.0053 0.0265 0.0265
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0576 0.0897
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0053 0.026 0.0405
Echinococcus granulosus Ankyrin 0.0029 0.0003 0.0003
Plasmodium falciparum transporter, putative 0.0056 0.0296 0.2202
Schistosoma mansoni glutaminase 0.0269 0.266 0.3688
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0255 0.2506 0.3904
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Brugia malayi G-protein coupled receptor 0.0053 0.0265 0.0413
Echinococcus granulosus hypothetical protein 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0154 0.1378 0.3264
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Echinococcus granulosus dro:myosuppressin receptor 0.0053 0.0265 0.0265
Schistosoma mansoni amine GPCR 0.0053 0.0265 0.0367
Schistosoma mansoni polycystin 1-related 0.0041 0.0133 0.0184
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Loa Loa (eye worm) hypothetical protein 0.033 0.3327 0.7882
Schistosoma mansoni opsin-like receptor 0.0053 0.0265 0.0367
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0056 0.0296 0.0296
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0291 0.2897 0.4513
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0291 0.2897 0.4513
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0035 0.0061 0.0095
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0035 0.0068 0.0068
Brugia malayi nuclear receptor NHR-88 0.0137 0.1195 0.1862
Leishmania major hypothetical protein, conserved 0.0035 0.0068 0.0285
Leishmania major hypothetical protein, conserved 0.0035 0.0068 0.0285

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.9 nM Ability to displace [3H]-granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membrane ChEMBL. 9513601
Ki (binding) = 1.9 nM Ability to displace [3H]-granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membrane ChEMBL. 9513601

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.