Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.0203 | 0.2617 | 0.0616 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0396 | 1 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0396 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.4566 | 0.3716 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0396 | 1 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0396 | 1 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0396 | 1 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0396 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0246 | 0.4264 | 0.3632 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.4566 | 0.3716 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0352 | 0.8338 | 0.8187 |
Loa Loa (eye worm) | thymidylate synthase | 0.019 | 0.2132 | 0.0903 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0396 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0271 | 0.5211 | 0.4817 |
Brugia malayi | Dihydrofolate reductase | 0.0203 | 0.2617 | 0.0616 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0396 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0203 | 0.2617 | 0.0616 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0203 | 0.2617 | 0.0826 |
Schistosoma mansoni | DNA topoisomerase II | 0.0396 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0344 | 0.8002 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0396 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0344 | 0.8002 | 0.6517 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0371 | 0.9053 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0377 | 0.927 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0371 | 0.9053 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0304 | 0.6476 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0268 | 0.5106 | 0.1467 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0344 | 0.8002 | 0.7481 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0246 | 0.4264 | 0.3059 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0246 | 0.4264 | 0.3632 |
Leishmania major | DNA topoisomerase ii | 0.0352 | 0.8338 | 0.8187 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0203 | 0.2617 | 0.0826 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0396 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0371 | 0.9053 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0352 | 0.8338 | 0.8187 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0344 | 0.8002 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0203 | 0.2617 | 0.0616 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.019 | 0.2132 | 0.8148 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0268 | 0.5106 | 0.383 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0352 | 0.8338 | 0.8187 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0352 | 0.8338 | 0.8187 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0344 | 0.8002 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0344 | 0.8002 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0344 | 0.8002 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0203 | 0.2617 | 0.1463 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0344 | 0.8002 | 0.6517 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0268 | 0.5106 | 0.1467 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0371 | 0.9053 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0304 | 0.6476 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0304 | 0.6476 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0203 | 0.2617 | 0.0616 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0203 | 0.2617 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.79 mg kg-1 | Effective dose against pentylenetetrazol intoxicity in mice administered through subcutaneous route | ChEMBL. | 2861285 |
ED50 (functional) | = 0.79 mg kg-1 | Effective dose against pentylenetetrazol intoxicity in mice administered through subcutaneous route | ChEMBL. | 2861285 |
ED50 (functional) | = 1.23 mg kg-1 | Effective dose was evaluated by their anticonflict effect in rats when administered through oral route | ChEMBL. | 2861285 |
ED50 (functional) | = 1.61 mg kg-1 | Effective dose against pentylenetetrazol intoxicity in mice administered orally | ChEMBL. | 2861285 |
ED50 (functional) | = 1.61 mg kg-1 | Effective dose against pentylenetetrazol intoxicity in mice administered orally | ChEMBL. | 2861285 |
ED50 (functional) | = 2.45 mg kg-1 | Effective dose against tetrabenazine induced ptosis in mice administered subcutaneously | ChEMBL. | 2861285 |
ED50 (functional) | = 2.45 mg kg-1 | Effective dose against tetrabenazine induced ptosis in mice administered subcutaneously | ChEMBL. | 2861285 |
ED50 (functional) | = 3.85 mg kg-1 | Effective dose against tetrabenazine induced ptosis in mice administered orally | ChEMBL. | 2861285 |
ED50 (functional) | = 3.85 mg kg-1 | Effective dose against tetrabenazine induced ptosis in mice administered orally | ChEMBL. | 2861285 |
K2 (binding) | = 0.049 uM | Binding constant was determined by displacing potential to [3H]-diazepam binding in cerebral cortex homogenates of rat | ChEMBL. | 2861285 |
K2 (binding) | = 0.049 uM | Binding constant was determined by displacing potential to [3H]-diazepam binding in cerebral cortex homogenates of rat | ChEMBL. | 2861285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.