Detailed information for compound 278989

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 265.762 | Formula: C13H18ClN4-
  • H donors: 2 H acceptors: 0 LogP: 2.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N/N=C(\N1CC2CCCc3c2c(C1)ccc3)/N.[Cl-]
  • InChi: 1S/C13H18N4.ClH/c14-13(16-15)17-7-10-5-1-3-9-4-2-6-11(8-17)12(9)10;/h1,3,5,11H,2,4,6-8,15H2,(H2,14,16);1H/p-1
  • InChiKey: IYAQLPDQJTYAIJ-UHFFFAOYSA-M  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) glutaminase 0.0844 1 1
Loa Loa (eye worm) trypsin family protein 0.0091 0.0813 0.074
Onchocerca volvulus 0.0092 0.0822 0.0942
Schistosoma mansoni hypothetical protein 0.0033 0.0104 0.0025
Loa Loa (eye worm) hypothetical protein 0.0046 0.0264 0.0186
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Echinococcus multilocularis slit 2 protein 0.0033 0.0104 0.0032
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.016 0.0104
Echinococcus granulosus neural cadherin 0.0033 0.0104 0.0032
Schistosoma mansoni hypothetical protein 0.0091 0.0813 0.074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.1024 0.1024
Echinococcus granulosus protein jagged 2 0.0033 0.0104 0.0032
Loa Loa (eye worm) PAN domain-containing protein 0.0092 0.0822 0.0748
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0121 0.0054
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.0813 0.074
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0538 0.0462
Brugia malayi RNA, U transporter 1 0.0088 0.0772 0.0772
Onchocerca volvulus 0.0092 0.0822 0.0942
Onchocerca volvulus 0.0092 0.0822 0.0942
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0066 0.0508 0.0501
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0272 0.3019 0.2963
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0264 0.0186
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0911 0.0838
Loa Loa (eye worm) hypothetical protein 0.0099 0.0914 0.0842
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1375 0.1677
Mycobacterium ulcerans lipase LipD 0.0074 0.0601 0.0449
Onchocerca volvulus 0.0092 0.0822 0.0942
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0601 0.0449
Brugia malayi hypothetical protein 0.0046 0.0264 0.0264
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0601 0.0526
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0099 0.0911 0.1076
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0264 0.0239
Schistosoma mansoni notch 0.0033 0.0104 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0601 0.1979
Toxoplasma gondii hypothetical protein 0.0092 0.0822 0.2778
Loa Loa (eye worm) hypothetical protein 0.0084 0.0723 0.0649
Loa Loa (eye worm) hypothetical protein 0.0272 0.3019 0.2963
Onchocerca volvulus 0.0092 0.0822 0.0942
Brugia malayi Carboxylesterase family protein 0.0272 0.3019 0.3019
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0601 0.0836
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.0813 0.074
Echinococcus multilocularis neurogenic locus notch protein 0.0033 0.0104 0.0032
Brugia malayi RNA binding protein 0.0068 0.0538 0.0538
Schistosoma mansoni notch 0.0033 0.0104 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Onchocerca volvulus 0.0046 0.0264 0.021
Loa Loa (eye worm) PAN domain-containing protein 0.0092 0.0822 0.0748
Toxoplasma gondii microneme protein MIC17C 0.0092 0.0822 0.2778
Toxoplasma gondii PAN domain-containing protein 0.0092 0.0822 0.2778
Echinococcus multilocularis Tolloid protein 1 0.0086 0.0752 0.0872
Mycobacterium ulcerans hypothetical protein 0.0175 0.1836 0.1703
Loa Loa (eye worm) hypothetical protein 0.0086 0.0752 0.0678
Onchocerca volvulus 0.0091 0.0813 0.093
Echinococcus granulosus tumor protein p63 0.0664 0.7801 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0099 0.0911 0.1076
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0723 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.0121 0.0042
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0372 0.0401
Loa Loa (eye worm) hypothetical protein 0.0086 0.0752 0.0678
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0273 0.0706
Onchocerca volvulus 0.0567 0.6622 0.8545
Brugia malayi Trypsin family protein 0.0658 0.7732 0.7732
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Loa Loa (eye worm) hypothetical protein 0.0272 0.3019 0.2963
Brugia malayi Calcium binding EGF domain containing protein 0.0086 0.0752 0.0752
Schistosoma mansoni transient receptor potential channel 4 0.0099 0.0914 0.0842
Echinococcus multilocularis Mastin 0.0091 0.0813 0.095
Echinococcus multilocularis protein jagged 2 0.0033 0.0104 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0121 0.0121
Brugia malayi EGF-like domain containing protein 0.0033 0.0104 0.0104
Echinococcus multilocularis snurportin 1 0.0329 0.3716 0.471
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0601 0.0676
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0079 0.0089
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.0813 0.074
Loa Loa (eye worm) hypothetical protein 0.0074 0.0601 0.0526
Loa Loa (eye worm) hypothetical protein 0.0046 0.0264 0.0186
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.3751 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.016 1
Brugia malayi GCC2 and GCC3 family protein 0.0033 0.0104 0.0104
Brugia malayi PAN domain containing protein 0.0092 0.0822 0.0822
Toxoplasma gondii ABC1 family protein 0.0074 0.0601 0.1979
Trichomonas vaginalis glutaminase, putative 0.0844 1 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0086 0.0752 0.2526
Loa Loa (eye worm) carboxylesterase 0.0046 0.0264 0.0186
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0601 0.0836
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0601 0.0836
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Schistosoma mansoni transient receptor potential channel 0.0066 0.0504 0.0428
Echinococcus granulosus protein jagged 2 0.0033 0.0104 0.0032
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0091 0.0813 0.095
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0538 0.0462
Onchocerca volvulus 0.0092 0.0822 0.0942
Loa Loa (eye worm) hypothetical protein 0.0091 0.0813 0.074
Loa Loa (eye worm) hypothetical protein 0.0092 0.0822 0.0748
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0372 0.4744
Schistosoma mansoni acetylcholinesterase 0.0046 0.0264 0.0186
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0538 0.0462
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0723 0.2419
Mycobacterium tuberculosis Conserved protein 0.0074 0.0601 0.0836
Echinococcus granulosus snurportin 1 0.0329 0.3716 0.471
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0086 0.0752 0.0678
Schistosoma mansoni transient receptor potential channel 0.0066 0.0504 0.0428
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Schistosoma mansoni notch 0.0033 0.0104 0.0025
Schistosoma mansoni hypothetical protein 0.0034 0.0121 0.0042
Echinococcus multilocularis neurogenic locus notch protein 4 0.0033 0.0104 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Echinococcus multilocularis fibropellin Ia 0.0033 0.0104 0.0032
Loa Loa (eye worm) carboxylesterase 0.0272 0.3019 0.2963
Toxoplasma gondii PAN domain-containing protein 0.0092 0.0822 0.2778
Brugia malayi Importin beta-1 subunit 0.0031 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0092 0.0822 0.0748
Brugia malayi PAN domain containing protein 0.0092 0.0822 0.0822
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0911 0.0838
Echinococcus multilocularis GPCR, family 2 0.0034 0.0121 0.0054
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1311 0.1242
Schistosoma mansoni ap endonuclease 0.0037 0.016 0.0081
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.0508 0.0432
Onchocerca volvulus 0.0092 0.0822 0.0942
Loa Loa (eye worm) hypothetical protein 0.0066 0.0508 0.0432
Echinococcus multilocularis glycoprotein Antigen 5 0.0091 0.0813 0.095
Echinococcus granulosus fibropellin Ia 0.0033 0.0104 0.0032
Echinococcus granulosus protein jagged 1 0.0033 0.0104 0.0032
Echinococcus granulosus neurogenic locus notch protein 4 0.0033 0.0104 0.0032
Leishmania major hypothetical protein, conserved 0.0074 0.0601 0.1584
Loa Loa (eye worm) PAN domain-containing protein 0.0092 0.0822 0.0748
Echinococcus granulosus enteropeptidase 0.0091 0.0813 0.095
Echinococcus multilocularis acetylcholinesterase 0.0272 0.3019 0.3807
Echinococcus multilocularis notch 0.0033 0.0104 0.0032
Brugia malayi PAN domain containing protein 0.0092 0.0822 0.0822
Echinococcus granulosus carboxylesterase 5A 0.0272 0.3019 0.3807
Brugia malayi beta-lactamase family protein 0.0074 0.0601 0.0601
Onchocerca volvulus 0.0091 0.0813 0.093
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0131 0.0067
Echinococcus multilocularis fat cadherin tumor suppressor 0.0033 0.0104 0.0032
Echinococcus granulosus neurogenic locus notch protein 0.0033 0.0104 0.0032
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.0813 0.074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Schistosoma mansoni hypothetical protein 0.0074 0.0606 0.0531
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0723 0.2419
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0372 0.0379
Loa Loa (eye worm) hypothetical protein 0.0658 0.7732 0.7713
Toxoplasma gondii melibiase subfamily protein 0.0099 0.0911 0.3098
Mycobacterium ulcerans hypothetical protein 0.0091 0.0813 0.0664
Brugia malayi Delta serrate ligand family protein 0.0033 0.0104 0.0104
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0723 0.0833
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0121 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1375 0.1306
Plasmodium vivax importin-beta 2, putative 0.0031 0.0079 0.0089
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Loa Loa (eye worm) hypothetical protein 0.0034 0.0113 0.0034
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0601 0.0836
Loa Loa (eye worm) carboxylesterase 0.0046 0.0264 0.0186
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0911 0.0838
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Echinococcus multilocularis laminin 0.0086 0.0752 0.0872
Brugia malayi PAN domain containing protein 0.0092 0.0822 0.0822
Echinococcus multilocularis tissue type plasminogen activator 0.0255 0.2817 0.3545
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0601 0.1584
Brugia malayi Carboxylesterase family protein 0.0046 0.0264 0.0264
Brugia malayi Carboxylesterase family protein 0.0046 0.0264 0.0264
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0723 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1619 0.4304
Loa Loa (eye worm) hypothetical protein 0.0046 0.0264 0.0186
Loa Loa (eye worm) acetylcholinesterase 1 0.0272 0.3019 0.2963
Onchocerca volvulus 0.0074 0.0601 0.0652
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0091 0.0813 0.095
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0264 0.0186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0601 0.0676
Loa Loa (eye worm) hypothetical protein 0.0092 0.0822 0.0748
Brugia malayi EGF-like domain containing protein 0.0033 0.0104 0.0104
Brugia malayi Trypsin family protein 0.0091 0.0813 0.0813
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0723 1
Schistosoma mansoni hypothetical protein 0.0034 0.0121 0.0042
Toxoplasma gondii PAN/Apple domain-containing protein 0.0092 0.0822 0.2778
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.544 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Toxoplasma gondii microneme protein MIC17A 0.0092 0.0822 0.2778
Loa Loa (eye worm) hypothetical protein 0.0074 0.0601 0.0526
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.016 0.0405
Echinococcus granulosus protein jagged 1 0.0033 0.0104 0.0032
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.016 1
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0538 0.0462
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.0813 0.074
Brugia malayi Protein kinase domain containing protein 0.0255 0.2817 0.2817
Toxoplasma gondii calcium binding egf domain-containing protein 0.0086 0.0752 0.2526
Onchocerca volvulus 0.0046 0.0264 0.021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0131 0.0067
Echinococcus granulosus notch 0.0033 0.0104 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Echinococcus multilocularis tumor protein p63 0.0664 0.7801 1
Schistosoma mansoni hypothetical protein 0.0329 0.3716 0.3666
Schistosoma mansoni hypothetical protein 0.0033 0.0104 0.0025
Schistosoma mansoni hypothetical protein 0.0033 0.0104 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1375 0.1677
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0601 0.0836
Echinococcus granulosus slit 2 protein 0.0033 0.0104 0.0032
Loa Loa (eye worm) hypothetical protein 0.0074 0.0601 0.0526
Brugia malayi Cadherin domain containing protein 0.0033 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0086 0.0752 0.0678
Loa Loa (eye worm) hypothetical protein 0.0097 0.0889 0.0816
Loa Loa (eye worm) hypothetical protein 0.0092 0.0822 0.0748
Brugia malayi Carboxylesterase family protein 0.0046 0.0264 0.0264
Brugia malayi Trypsin family protein 0.0091 0.0813 0.0813
Brugia malayi Calcium binding EGF domain containing protein 0.0033 0.0104 0.0104
Echinococcus multilocularis neurogenic locus protein delta 0.0033 0.0104 0.0032
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0723 0.5
Brugia malayi Carboxylesterase family protein 0.0272 0.3019 0.3019
Plasmodium falciparum importin beta, putative 0.0031 0.0079 0.0089
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0504 0.055
Toxoplasma gondii subtilisin SUB12 0.0092 0.0822 0.2778
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.016 0.016
Mycobacterium leprae Probable lipase LipE 0.0074 0.0601 0.8181
Onchocerca volvulus 0.0255 0.2817 0.3557
Echinococcus granulosus Mastin 0.0091 0.0813 0.095
Loa Loa (eye worm) hypothetical protein 0.0091 0.0813 0.074
Loa Loa (eye worm) Notch2 0.0033 0.0104 0.0025
Echinococcus multilocularis neural cadherin 0.0033 0.0104 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1375 0.1306
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0264 0.0197
Loa Loa (eye worm) hypothetical protein 0.0074 0.0601 0.0526
Loa Loa (eye worm) hypothetical protein 0.0091 0.0813 0.074
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.016 0.0219
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0538 0.0593
Schistosoma mansoni slit 0.0033 0.0104 0.0025
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0099 0.0911 0.1076
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.016 0.1572
Echinococcus multilocularis enteropeptidase 0.0091 0.0813 0.095
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0601 0.8181
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0175 0.1836 0.3174
Onchocerca volvulus 0.0046 0.0264 0.021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Echinococcus multilocularis neurogenic locus notch protein 0.0033 0.0104 0.0032
Loa Loa (eye worm) RNA binding protein 0.0068 0.0538 0.0462
Echinococcus granulosus acetylcholinesterase 0.0272 0.3019 0.3807
Onchocerca volvulus 0.0092 0.0822 0.0942
Schistosoma mansoni hypothetical protein 0.0034 0.0121 0.0042
Onchocerca volvulus 0.0046 0.0264 0.021
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.016 0.0104
Toxoplasma gondii microneme protein MIC17B 0.0092 0.0822 0.2778
Loa Loa (eye worm) hypothetical protein 0.0037 0.016 0.0081
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0372 0.0401
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0601 0.0594
Loa Loa (eye worm) glutaminase 2 0.0844 1 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0723 0.0833
Schistosoma mansoni notch 0.0033 0.0104 0.0025
Toxoplasma gondii EGF family domain-containing protein 0.0033 0.0104 0.0177
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1311 0.1242
Brugia malayi Bromodomain containing protein 0.0037 0.0159 0.0159
Loa Loa (eye worm) TK/ROR protein kinase 0.0255 0.2817 0.2759
Mycobacterium tuberculosis Conserved protein 0.0074 0.0601 0.0836
Loa Loa (eye worm) hypothetical protein 0.0092 0.0822 0.0748
Onchocerca volvulus 0.0097 0.0889 0.1029
Brugia malayi beta-lactamase 0.0074 0.0601 0.0601
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.1024 0.0952
Loa Loa (eye worm) hypothetical protein 0.0074 0.0601 0.0526
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0504 0.055
Brugia malayi Trypsin-like protease protein 5 0.0091 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0042 0.0211 0.0133
Brugia malayi Calcium binding EGF domain containing protein 0.0033 0.0104 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1375 0.1306
Loa Loa (eye worm) PAN domain-containing protein 0.0092 0.0822 0.0748
Brugia malayi Bromodomain containing protein 0.0073 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0091 0.0813 0.074
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.3751 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0538 0.0462
Toxoplasma gondii kringle domain-containing protein 0.0255 0.2817 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0121 0.0042
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Brugia malayi PAN domain containing protein 0.0092 0.0822 0.0822
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Echinococcus multilocularis protein jagged 1 0.0033 0.0104 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.1375 0.1306
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0601 0.0526
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0723 0.2419
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.016 0.0405
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0264 0.0186
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0504 0.055
Schistosoma mansoni egf-like domain protein 0.0086 0.0752 0.0678
Loa Loa (eye worm) hypothetical protein 0.0086 0.0752 0.0678
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0658 0.7732 0.7713
Leishmania major hypothetical protein, conserved 0.0255 0.2817 0.7503
Echinococcus granulosus transmembrane protease serine 3 0.0091 0.0813 0.095
Leishmania major mitochondrial DNA polymerase beta 0.0332 0.3751 1
Mycobacterium ulcerans glutaminase 0.0844 1 1
Echinococcus multilocularis acetylcholinesterase 0.0272 0.3019 0.3807
Loa Loa (eye worm) hypothetical protein 0.0086 0.0752 0.0678
Loa Loa (eye worm) hypothetical protein 0.0046 0.0264 0.0186
Echinococcus granulosus Tolloid protein 1 0.0086 0.0752 0.0872
Mycobacterium ulcerans hypothetical protein 0.0074 0.0601 0.0449
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0601 0.0594
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0091 0.0813 0.0813
Echinococcus granulosus neurogenic locus protein delta 0.0033 0.0104 0.0032
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0601 0.0836
Loa Loa (eye worm) hypothetical protein 0.0046 0.0264 0.0186
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1619 0.4304
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0723 0.0572
Loa Loa (eye worm) beta-lactamase 0.0074 0.0601 0.0526
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0121 0.0042
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0264 0.0239
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.0889 0.0816
Schistosoma mansoni bromodomain containing protein 0.0062 0.0457 0.038
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0091 0.0813 0.074
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0264 0.0239
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0264 0.0197
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0264 0.0106
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0601 0.0594
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0092 0.0822 0.2778
Brugia malayi notch-like transmembrane receptor 0.0033 0.0104 0.0104
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0086 0.0752 0.0678
Echinococcus multilocularis carboxylesterase 5A 0.0272 0.3019 0.3807
Schistosoma mansoni hypothetical protein 0.0255 0.2817 0.2759
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0264 0.0256
Loa Loa (eye worm) hypothetical protein 0.004 0.0188 0.011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0601 0.0601
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0414 0.0433
Onchocerca volvulus 0.0092 0.0822 0.0942
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.016 0.038
Toxoplasma gondii microneme protein, putative 0.0092 0.0822 0.2778
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0264 0.0239
Brugia malayi Muscle positioning protein 4 0.0033 0.0104 0.0104
Brugia malayi PAN domain containing protein 0.0092 0.0822 0.0822
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0601 0.0594
Loa Loa (eye worm) hypothetical protein 0.0255 0.2817 0.2759
Schistosoma mansoni notch 0.0033 0.0104 0.0025
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0273 0.0706
Brugia malayi beta-lactamase family protein 0.0074 0.0601 0.0601
Brugia malayi Kringle domain containing protein 0.0255 0.2817 0.2817
Echinococcus granulosus glycoprotein Antigen 5 0.0091 0.0813 0.095
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.0813 0.074
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0273 0.0706
Onchocerca volvulus 0.0074 0.0601 0.0652
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.1375 0.1375
Brugia malayi Fibulin-1 precursor 0.0086 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Loa Loa (eye worm) hypothetical protein 0.0074 0.0601 0.0526
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.016 0.0081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Brugia malayi PAN domain containing protein 0.0092 0.0822 0.0822
Brugia malayi PAN domain containing protein 0.0092 0.0822 0.0822
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0091 0.0813 0.095
Brugia malayi PAN domain containing protein 0.0092 0.0822 0.0822
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0086 0.0752 0.0678
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.016 0.0152
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0606 0.0606
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0264 0.0186
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0273 0.0526
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0264 0.0197
Schistosoma mansoni hypothetical protein 0.0033 0.0104 0.0025
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0264 0.0239
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0504 0.055
Echinococcus granulosus tar DNA binding protein 0.0068 0.0538 0.0593
Loa Loa (eye worm) hypothetical protein 0.0074 0.0606 0.0531
Loa Loa (eye worm) PAN domain-containing protein 0.0092 0.0822 0.0748
Echinococcus granulosus transient receptor potential ion channel A 0.0096 0.0874 0.1029
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0372 0.0379
Schistosoma mansoni transient receptor potential channel 0.0099 0.0914 0.0842
Brugia malayi Carboxylesterase family protein 0.0046 0.0264 0.0264
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.0508 0.0432
Brugia malayi Melibiase family protein 0.0066 0.0508 0.0508
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0033 0.0104 0.0025
Echinococcus multilocularis neuroligin 0.0046 0.0264 0.0239
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.1024 0.1024
Echinococcus granulosus delta-like protein 1 0.0033 0.0104 0.0032
Echinococcus granulosus tissue type plasminogen activator 0.0255 0.2817 0.3545
Brugia malayi EGF-like domain containing protein 0.0033 0.0104 0.0104
Toxoplasma gondii hypothetical protein 0.0092 0.0822 0.2778
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0658 0.7732 0.7713
Echinococcus granulosus laminin 0.0086 0.0752 0.0872
Loa Loa (eye worm) hypothetical protein 0.0092 0.0822 0.0748
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0538 0.0538
Brugia malayi PAN domain containing protein 0.0092 0.0822 0.0822
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.3716 0.3666
Schistosoma mansoni cell polarity protein 0.0033 0.0104 0.0025
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0414 0.0433
Brugia malayi Probable ClpP-like protease 0.0084 0.0723 0.0723
Echinococcus granulosus GPCR family 2 0.0034 0.0121 0.0054
Trichomonas vaginalis esterase, putative 0.0074 0.0601 0.0594
Loa Loa (eye worm) hypothetical protein 0.0046 0.0264 0.0186
Schistosoma mansoni notch 0.0033 0.0104 0.0025
Mycobacterium ulcerans beta-lactamase 0.0074 0.0601 0.0449
Schistosoma mansoni hypothetical protein 0.0091 0.0813 0.074
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0601 0.0836
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0121 0.0054
Echinococcus granulosus acetylcholinesterase 0.0272 0.3019 0.3807
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0601 0.0594
Loa Loa (eye worm) hypothetical protein 0.0046 0.0264 0.0186
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.016 0.0152
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0264 0.0186
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0911 0.0838
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0264 0.0256
Loa Loa (eye worm) hypothetical protein 0.0062 0.0464 0.0388
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0154 0.0096
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0332 0.3751 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0601 0.1584
Schistosoma mansoni hypothetical protein 0.0033 0.0104 0.0025
Onchocerca volvulus Arrow homolog 0.0086 0.0752 0.085
Onchocerca volvulus 0.0091 0.0813 0.093
Onchocerca volvulus 0.0091 0.0813 0.093
Brugia malayi MH2 domain containing protein 0.0132 0.1311 0.1311
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.016 0.0405
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0255 0.2817 1
Schistosoma mansoni septate junction protein 0.0033 0.0104 0.0025
Echinococcus multilocularis neurogenic locus protein delta 0.0033 0.0104 0.0032
Toxoplasma gondii PAN domain-containing protein 0.0092 0.0822 0.2778
Echinococcus multilocularis fibrillin 1 0.0086 0.0752 0.0872
Schistosoma mansoni glutaminase 0.0844 1 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0723 0.0649
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1375 0.1677
Brugia malayi EGF-like domain containing protein 0.0033 0.0104 0.0104
Brugia malayi Cadherin domain containing protein 0.0033 0.0104 0.0104
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0121 0.0054
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.016 0.038
Schistosoma mansoni hypothetical protein 0.0033 0.0104 0.0025
Toxoplasma gondii exonuclease III APE 0.0037 0.016 0.038
Echinococcus granulosus neurogenic locus notch protein 0.0033 0.0104 0.0032
Brugia malayi Trypsin family protein 0.0091 0.0813 0.0813
Brugia malayi EGF-like domain containing protein 0.0033 0.0104 0.0104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1375 0.1677
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.1619 0.4194
Schistosoma mansoni laminin gamma-3 chain 0.0033 0.0104 0.0025
Loa Loa (eye worm) notch protein 0.0033 0.0104 0.0025
Echinococcus multilocularis transient receptor potential gamma protein 0.0099 0.0914 0.1081
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0538 0.0462
Brugia malayi EGF-like domain containing protein 0.0033 0.0104 0.0104
Onchocerca volvulus 0.0092 0.0822 0.0942
Echinococcus granulosus neuroligin 0.0046 0.0264 0.0239
Echinococcus multilocularis transient receptor potential ion channel A 0.0096 0.0874 0.1029
Brugia malayi Calcium binding EGF domain containing protein 0.0033 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0069 0.0545 0.047
Schistosoma mansoni hypothetical protein 0.0033 0.0104 0.0025
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0601 0.1421
Onchocerca volvulus 0.0092 0.0822 0.0942
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0723 0.2419
Loa Loa (eye worm) hypothetical protein 0.0092 0.0822 0.0748
Onchocerca volvulus 0.0046 0.0264 0.021
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0091 0.0813 0.095
Loa Loa (eye worm) hypothetical protein 0.0037 0.0154 0.0075
Toxoplasma gondii PAN domain-containing protein 0.0092 0.0822 0.2778
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0723 0.0572
Toxoplasma gondii microneme protein MIC4 0.0092 0.0822 0.2778
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0086 0.0752 0.0752
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0538 0.0462
Brugia malayi hypothetical protein 0.0091 0.0813 0.0813
Brugia malayi TAR-binding protein 0.0068 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0033 0.0104 0.0104
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0397 0.1039
Loa Loa (eye worm) hypothetical protein 0.0091 0.0813 0.074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0104 0.0025
Echinococcus multilocularis protein jagged 1 0.0033 0.0104 0.0032
Toxoplasma gondii hypothetical protein 0.0054 0.0356 0.1092
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0086 0.0752 0.0678
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0264 0.0239
Onchocerca volvulus 0.0091 0.0813 0.093
Echinococcus multilocularis transmembrane protease serine 3 0.0091 0.0813 0.095
Onchocerca volvulus 0.0658 0.7732 1
Schistosoma mansoni gliotactin 0.0046 0.0264 0.0186
Toxoplasma gondii PAN domain-containing protein 0.0092 0.0822 0.2778
Plasmodium falciparum cysteine repeat modular protein 1 0.0255 0.2817 1
Loa Loa (eye worm) hypothetical protein 0.0658 0.7732 0.7713
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0601 0.0449
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0601 0.0526
Brugia malayi EGF-like domain containing protein 0.0033 0.0104 0.0104
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0154 0.0154
Onchocerca volvulus 0.0074 0.0601 0.0652
Mycobacterium tuberculosis Conserved protein 0.0074 0.0601 0.0836
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0154 0.0096
Schistosoma mansoni ap endonuclease 0.0037 0.016 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0255 0.2817 0.7503
Loa Loa (eye worm) hypothetical protein 0.0108 0.1024 0.0952
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0723 1
Echinococcus granulosus transient receptor potential gamma protein 0.0099 0.0914 0.1081
Toxoplasma gondii PAN domain-containing protein 0.0092 0.0822 0.2778

Activities

Activity type Activity value Assay description Source Reference
Increase (functional) = 4 % In vivo inhibition of blood platelet aggregation induced by collagen, intraperitoneal administration ChEMBL. 7097724
Increase (functional) = 34 % In vivo inhibition of blood platelet aggregation induced by collagen, intraperitoneal administration ChEMBL. 7097724
S = 60 mg ml-1 Aqueous solubility at room temperature ChEMBL. 7097724

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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