Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.1207 | 0.8761 | 0.8761 |
Brugia malayi | Protein kinase domain containing protein | 0.0127 | 0.0099 | 0.0099 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1362 | 1 | 0.5 |
Echinococcus granulosus | jun protein | 0.0354 | 0.1921 | 0.1921 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1362 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1362 | 1 | 0.5 |
Echinococcus multilocularis | Ankyrin | 0.0115 | 0.0004 | 0.0004 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1362 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1362 | 1 | 0.5 |
Brugia malayi | Uncoordinated protein 44 | 0.0114 | 0.000000053205 | 0.000000053205 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0354 | 0.1921 | 0.1921 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1362 | 1 | 1 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0114 | 0.000000053205 | 0.000000053205 |
Brugia malayi | hypothetical protein | 0.0278 | 0.1311 | 0.1311 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1362 | 1 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0354 | 0.1921 | 0.1921 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0354 | 0.1921 | 0.1921 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 0.1843 | 0.1843 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1362 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1362 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1362 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1362 | 1 | 0.5 |
Echinococcus granulosus | Ankyrin | 0.0115 | 0.0004 | 0.0004 |
Trypanosoma brucei | protein kinase, putative | 0.1362 | 1 | 0.5 |
Brugia malayi | Death domain containing protein | 0.0114 | 0.000000053205 | 0.000000053205 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1362 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1362 | 1 | 0.5 |
Brugia malayi | bZIP transcription factor family protein | 0.0354 | 0.1921 | 0.1921 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0114 | 0.000000053205 | 0.000000053205 |
Schistosoma mansoni | hypothetical protein | 0.0288 | 0.1389 | 0.1389 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1362 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0004 | 0.0004 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0115 | 0.0004 | 0.0004 |
Schistosoma mansoni | jun-related protein | 0.0288 | 0.1389 | 0.1389 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0114 | 0.000000053205 | 0.000000053205 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.1207 | 0.8761 | 0.8761 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1362 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1362 | 1 | 1 |
Onchocerca volvulus | 0.0278 | 0.1311 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.1362 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1362 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1362 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 12 ug ml-1 | In vitro cytotoxicity was determined against L1210 leukemia cell from mouse. | ChEMBL. | 2299637 |
ID50 (functional) | > 10 ug ml-1 | Dose to inhibit plaque formation in vero cells infected with herpes simplex virus type1(HSV-1,strainJLJ) was determined | ChEMBL. | 2299637 |
Ki (functional) | = 0.61 mM | Inhibition constant was determined for the facilitated transport of [3N]-thymidine by murine erythrocyte NBMPR-sensitive nucleoside transporter. | ChEMBL. | 2299637 |
Survival (functional) | = 37 % | Percent survival of L1210 cells in suspension was determined after a dose of 10 microg/mL in mouse | ChEMBL. | 2299637 |
T/C (functional) | = 103 % | In vivo cytotoxicity was determined against P388 mouse leukemia cells expressed as % treated/control | ChEMBL. | 2299637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.