Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0178 | 0.0757 | 0.0655 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0178 | 0.0757 | 0.5 |
Brugia malayi | hypothetical protein | 0.0178 | 0.0757 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0757 | 0.0655 |
Brugia malayi | Carboxylesterase family protein | 0.1055 | 1 | 1 |
Onchocerca volvulus | 0.0178 | 0.0757 | 1 | |
Onchocerca volvulus | 0.0178 | 0.0757 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0178 | 0.0757 | 0.0655 |
Brugia malayi | Carboxylesterase family protein | 0.0178 | 0.0757 | 0.0655 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0178 | 0.0757 | 0.0655 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0178 | 0.0757 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1055 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0178 | 0.0757 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0757 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0757 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0757 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0757 | 0.0655 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0178 | 0.0757 | 0.0655 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0178 | 0.0757 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1055 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0178 | 0.0757 | 0.0655 |
Loa Loa (eye worm) | carboxylesterase | 0.1055 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0178 | 0.0757 | 0.0655 |
Brugia malayi | Carboxylesterase family protein | 0.0178 | 0.0757 | 0.0655 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0178 | 0.0757 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0757 | 0.0655 |
Echinococcus multilocularis | acetylcholinesterase | 0.1055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1055 | 1 | 1 |
Onchocerca volvulus | 0.0178 | 0.0757 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.1055 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0757 | 0.0655 |
Onchocerca volvulus | 0.0117 | 0.011 | 0.1446 | |
Onchocerca volvulus | 0.0178 | 0.0757 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.1055 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0178 | 0.0757 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0178 | 0.0757 | 0.0655 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0178 | 0.0757 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.0757 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1055 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0178 | 0.0757 | 0.0655 |
Loa Loa (eye worm) | carboxylesterase | 0.0178 | 0.0757 | 0.0655 |
Echinococcus multilocularis | acetylcholinesterase | 0.1055 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0178 | 0.0757 | 0.0655 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.3 uM | Binding affinity against human coagulation factor Xa | ChEMBL. | 11266180 |
Ki (binding) | = 0.3 uM | Binding affinity against human coagulation factor Xa | ChEMBL. | 11266180 |
Ki (binding) | = 3.9 uM | Binding affinity against human trypsin | ChEMBL. | 11266180 |
Ki (binding) | = 3.9 uM | Binding affinity against human trypsin | ChEMBL. | 11266180 |
Ki (binding) | = 5.1 uM | Binding affinity against human trypsin | ChEMBL. | 11266180 |
Ki (binding) | = 5.1 uM | Binding affinity against human trypsin | ChEMBL. | 11266180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.