Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.0226 | 0.4717 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0226 | 0.4717 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
E12 (ADMET) | = 0.195 | E1/2 for the half-wave potential at pH=7.0 in V57 | ChEMBL. | 8576915 |
LFU (functional) | = 1.18 | log 1/MIC for fungi in mmol/L | ChEMBL. | 8576915 |
LID (functional) | = 2.01 | log 1/ID75 for the in vitro clonogenic L1210 assay with ID75 in micromol/L | ChEMBL. | 8576915 |
LLD (ADMET) | = 1.45 | log 1/LD50 for LD50 (mmol/kg) | ChEMBL. | 8576915 |
pKred | = 8.2 | Electrochemically observed pKa (pKred) of aziridines | ChEMBL. | 8576915 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.