Detailed information for compound 279588
Basic information
Technical information
Network
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Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Loa Loa (eye worm) | CMGC/CDK/CDK9 protein kinase | 0.0055 | 0.0315 | 0.0315 |
| Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0133 | 1 | 1 |
| Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0133 | 1 | 1 |
| Loa Loa (eye worm) | AUR protein kinase | 0.0133 | 1 | 1 |
| Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0133 | 1 | 1 |
| Toxoplasma gondii | aurora kinase | 0.0133 | 1 | 1 |
| Echinococcus granulosus | cyclin dependent kinase 7 | 0.0092 | 0.4893 | 0.4893 |
| Giardia lamblia | Aurora kinase | 0.0133 | 1 | 1 |
| Leishmania major | protein kinase, putative | 0.0133 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0133 | 1 | 1 |
| Trichomonas vaginalis | AGC family protein kinase | 0.0133 | 1 | 1 |
| Entamoeba histolytica | cell division protein kinase 2, putative | 0.0062 | 0.1137 | 0.1137 |
| Schistosoma mansoni | kinase | 0.0055 | 0.0315 | 0.0315 |
| Entamoeba histolytica | protein kinase , putative | 0.0133 | 1 | 1 |
| Trichomonas vaginalis | AGC family protein kinase | 0.0133 | 1 | 1 |
| Echinococcus granulosus | cyclin dependent kinase 9 | 0.0064 | 0.1452 | 0.1452 |
| Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0133 | 1 | 1 |
| Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0133 | 1 | 1 |
| Schistosoma mansoni | protein kinase | 0.0133 | 1 | 1 |
| Loa Loa (eye worm) | AUR protein kinase | 0.0133 | 1 | 1 |
| Entamoeba histolytica | protein kinase, putative | 0.0133 | 1 | 1 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.4893 | 0.4893 |
| Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0133 | 1 | 1 |
| Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0133 | 1 | 1 |
| Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0101 | 0.6029 | 0.6029 |
| Loa Loa (eye worm) | CMGC/CDK/CDK7 protein kinase | 0.0092 | 0.4893 | 0.4893 |
| Trichomonas vaginalis | AGC family protein kinase | 0.0133 | 1 | 1 |
| Brugia malayi | serine/threonine-protein kinase 6 | 0.0133 | 1 | 1 |
| Brugia malayi | serine/threonine kinase 12 | 0.0133 | 1 | 1 |
| Trichomonas vaginalis | AGC family protein kinase | 0.0133 | 1 | 1 |
| Echinococcus granulosus | aurora kinase A | 0.0133 | 1 | 1 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0133 | 1 | 1 |
| Trypanosoma brucei | aurora B kinase | 0.0133 | 1 | 1 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0055 | 0.0315 | 0.0315 |
| Echinococcus multilocularis | cyclin dependent kinase 7 | 0.0092 | 0.4893 | 0.4893 |
| Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0055 | 0.0315 | 0.0315 |
| Echinococcus multilocularis | aurora kinase A | 0.0133 | 1 | 1 |
| Trypanosoma cruzi | aurora B kinase, putative | 0.0133 | 1 | 1 |
| Brugia malayi | cyclin-dependent kinase 9 | 0.0055 | 0.0315 | 0.0315 |
| Loa Loa (eye worm) | AUR protein kinase | 0.0133 | 1 | 1 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.4893 | 0.4893 |
| Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0064 | 0.1452 | 0.1452 |
| Echinococcus granulosus | cyclin dependent kinase 9 | 0.0055 | 0.0315 | 0.0315 |
| Entamoeba histolytica | protein kinase, putative | 0.0133 | 1 | 1 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.0315 | 0.0315 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Average weight change (functional) | = -12.5 % | Average weight change in mice bearing sarcoma 180 ascites cells at dose 20 mg/kg | ChEMBL. | 7097727 |
| Average weight change (functional) | = -12.5 % | Average weight change in mice bearing sarcoma 180 ascites cells at dose 20 mg/kg | ChEMBL. | 7097727 |
| Average weight change (functional) | = -11.3 % | Average weight change in mice bearing sarcoma 180 ascites cells at dose 10 mg/kg | ChEMBL. | 7097727 |
| Average weight change (functional) | = -11.3 % | Average weight change in mice bearing sarcoma 180 ascites cells at dose 10 mg/kg | ChEMBL. | 7097727 |
| Average weight change (functional) | = -7.8 % | Average weight change in mice bearing sarcoma 180 ascites cells at dose 5 mg/kg | ChEMBL. | 7097727 |
| Average weight change (functional) | = -7.8 % | Average weight change in mice bearing sarcoma 180 ascites cells at dose 5 mg/kg | ChEMBL. | 7097727 |
| Average weight change (functional) | = -4.2 % | Average weight change in mice bearing sarcoma 180 ascites cells at dose 2.5 mg/kg | ChEMBL. | 7097727 |
| Average weight change (functional) | = -4.2 % | Average weight change in mice bearing sarcoma 180 ascites cells at dose 2.5 mg/kg | ChEMBL. | 7097727 |
| T/C (functional) | = 0.57 | Ratio of the survival time of treated to control animals at dose 20 mg/kg | ChEMBL. | 7097727 |
| T/C (functional) | = 1.42 | Ratio of the survival time of treated to control animals at dose 10 mg/kg | ChEMBL. | 7097727 |
| T/C (functional) | = 1.46 | Ratio of the survival time of treated to control animals at dose 5 mg/kg | ChEMBL. | 7097727 |
| T/C (functional) | = 2.07 | Ratio of the survival time of treated to control animals at dose 2.5 mg/kg | ChEMBL. | 7097727 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL162649
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.