Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.014 | 0.0166 | 0.0166 |
Echinococcus multilocularis | integrin alpha 3 | 0.0142 | 0.0195 | 0.0195 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0129 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0764 | 1 | 1 |
Echinococcus granulosus | integrin alpha 3 | 0.0142 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0166 | 0.0166 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0764 | 1 | 1 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0129 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0764 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0764 | 1 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.0874 | 0.0874 |
Echinococcus granulosus | carboxylesterase 5A | 0.0764 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0764 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0764 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0764 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0764 | 1 | 1 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0129 | 0 | 0.5 |
Schistosoma mansoni | integrin alpha | 0.0185 | 0.0874 | 0.0874 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0129 | 0 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.2448 | 0.2448 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0249 | 0.0249 |
Echinococcus multilocularis | acetylcholinesterase | 0.0764 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0129 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0764 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0764 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0129 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.2 nM | Affinity for purified human platelet glycoprotein alpha IIb beta3 integrin receptor in ELISA | ChEMBL. | 10021912 |
IC50 (binding) | = 1.2 nM | Affinity for purified human platelet glycoprotein alpha IIb beta3 integrin receptor in ELISA | ChEMBL. | 10021912 |
IC50 (functional) | = 55 nM | Inhibition of fibrinogen (Fg) interaction with GPIIb/IIIa in gel filtered platelets | ChEMBL. | 10021912 |
IC50 (functional) | = 55 nM | Inhibition of fibrinogen (Fg) interaction with GPIIb/IIIa in gel filtered platelets | ChEMBL. | 10021912 |
IC50 (functional) | = 114 nM | Inhibition of platelet aggregation in citrated human platelet rich plasma (PRP) | ChEMBL. | 10021912 |
IC50 (functional) | = 114 nM | Inhibition of platelet aggregation in citrated human platelet rich plasma (PRP) | ChEMBL. | 10021912 |
IC50 (functional) | = 221 nM | Inhbition of platelet aggregation in heparin treated human platelet rich plasma (PRP) | ChEMBL. | 10021912 |
IC50 (functional) | = 221 nM | Inhbition of platelet aggregation in heparin treated human platelet rich plasma (PRP) | ChEMBL. | 10021912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.