Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y1 | Starlite/ChEMBL | References |
Homo sapiens | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | neuropeptide Y receptor Y1 | 384 aa | 345 aa | 22.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.13 | 0.6402 | 0.9458 |
Loa Loa (eye worm) | hypothetical protein | 0.0965 | 0.4345 | 0.4345 |
Loa Loa (eye worm) | serotonin transporter b | 0.13 | 0.6402 | 0.6402 |
Loa Loa (eye worm) | hypothetical protein | 0.13 | 0.6402 | 0.6402 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1309 | 0.6454 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1888 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.13 | 0.6402 | 0.6402 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.13 | 0.6402 | 0.6402 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.13 | 0.6402 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1888 | 1 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.13 | 0.6402 | 0.9458 |
Loa Loa (eye worm) | norepinephrine transporter | 0.13 | 0.6402 | 0.6402 |
Loa Loa (eye worm) | hypothetical protein | 0.13 | 0.6402 | 0.6402 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1888 | 1 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.13 | 0.6402 | 0.9919 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.136 | 0.6768 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.136 | 0.6768 | 1 |
Onchocerca volvulus | 0.13 | 0.6402 | 0.5 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.13 | 0.6402 | 0.9458 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1888 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.000000045 M | Concentration that inhibited 50% of total specific binding of [125I]-PYY ligand to human NPY-Y5 receptor | ChEMBL. | 11858996 |
IC50 (binding) | = 0.000000045 M | Concentration that inhibited 50% of total specific binding of [125I]-PYY ligand to human NPY-Y5 receptor | ChEMBL. | 11858996 |
IC50 (binding) | = 0.000014 M | Concentration of the compound that inhibited 50% of total specific binding of [125I]-PYY ligand to human NPY-Y1 receptor | ChEMBL. | 11858996 |
IC50 (binding) | = 0.000014 M | Concentration of the compound that inhibited 50% of total specific binding of [125I]-PYY ligand to human NPY-Y1 receptor | ChEMBL. | 11858996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.