Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0346 | 0.502 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0246 | 0.2824 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0246 | 0.2824 | 0.5 |
Onchocerca volvulus | 0.0246 | 0.2824 | 0.5 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0574 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0117 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0346 | 0.502 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0246 | 0.2824 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0246 | 0.2824 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0346 | 0.502 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0346 | 0.502 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0246 | 0.2824 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0533 | 0.9115 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0246 | 0.2824 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0346 | 0.502 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0246 | 0.2824 | 0.3098 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0346 | 0.502 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 15 % | Adjuvant arthritic activity in rat injected leg on day 3 tested at 50 mg/kg perorally | ChEMBL. | 6690686 |
Inhibition (functional) | = 20 % | Adjuvant arthritic activity in rat injected leg on day 16 tested at 50 mg/kg perorally | ChEMBL. | 6690686 |
Inhibition (functional) | = 21 % | Adjuvant arthritic activity in rat uninjected leg on day 16 tested at 50 mg/kg perorally | ChEMBL. | 6690686 |
Stimulation (functional) | = 59 % | Cutaneous oxazolone induced contact sensitivity in mouse and percent stimulation in right hind paw was determined at a dose 25 mg/kg perorally | ChEMBL. | 6690686 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.