Detailed information for compound 280175

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.494 | Formula: C23H29N3O4
  • H donors: 3 H acceptors: 3 LogP: 3.44 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C[C@@H](C(=O)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C
  • InChi: 1S/C23H29N3O4/c1-16(2)13-19(21(24)27)25-22(28)20(14-17-9-5-3-6-10-17)26-23(29)30-15-18-11-7-4-8-12-18/h3-12,16,19-20H,13-15H2,1-2H3,(H2,24,27)(H,25,28)(H,26,29)/t19-,20-/m0/s1
  • InChiKey: RPHKPDYJGQVFLN-PMACEKPBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.0186 0.1155
Schistosoma mansoni amine GPCR 0.0095 0.1156 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0095 0.1156 1
Echinococcus multilocularis neuropeptide Y receptor 0.0095 0.1156 1
Brugia malayi G-protein coupled receptor 0.0095 0.1156 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0718 1 1
Schistosoma mansoni amine GPCR 0.0095 0.1156 1
Schistosoma mansoni amine GPCR 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Mycobacterium ulcerans hypothetical protein 0.0079 0.093 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Echinococcus granulosus allatostatin A receptor 0.0095 0.1156 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0095 0.1156 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0186 0.1996
Echinococcus granulosus 7TM GPCR rhodopsin 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Onchocerca volvulus 0.0095 0.1156 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.0059 0.0059
Schistosoma mansoni opsin-like receptor 0.0095 0.1156 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.1156 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0186 0.1607
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.1156 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0095 0.1156 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0095 0.1156 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0095 0.1156 1
Echinococcus multilocularis sex peptide receptor 0.0095 0.1156 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0079 0.093 1
Echinococcus granulosus dro:myosuppressin receptor 0.0095 0.1156 1
Trypanosoma cruzi monoglyceride lipase, putative 0.0079 0.093 0.093
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0718 1 1
Brugia malayi hypothetical protein 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0186 0.1996
Schistosoma mansoni neuropeptide f receptor 76f 0.0095 0.1156 1
Plasmodium falciparum esterase, putative 0.0079 0.093 0.093
Echinococcus granulosus neuropeptide FF receptor 2 0.0095 0.1156 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0186 0.1996
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0095 0.1156 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Brugia malayi AKH receptor 0.0095 0.1156 1
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0186 0.1155
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Echinococcus multilocularis neuropeptide FF receptor 2 0.0095 0.1156 1
Echinococcus multilocularis neuropeptide receptor A26 0.0095 0.1156 1
Echinococcus multilocularis g protein coupled receptor 0.0095 0.1156 1
Brugia malayi Serotonin receptor 0.0095 0.1156 1
Echinococcus granulosus neuropeptide receptor 0.0095 0.1156 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.1156 1
Echinococcus granulosus neuropeptide Y receptor 0.0095 0.1156 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0059 0.0511
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.1156 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0095 0.1156 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0059 0.0511
Schistosoma mansoni alpha-1 adrenergic receptor 0.0095 0.1156 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.093 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0095 0.1156 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0186 0.1607
Echinococcus granulosus tm gpcr rhodopsin 0.0095 0.1156 1
Echinococcus multilocularis serotonin receptor 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0186 0.1996
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0186 0.1607
Echinococcus granulosus somatostatin receptor 0.0095 0.1156 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0186 0.1607
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0079 0.093 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0095 0.1156 1
Schistosoma mansoni hypothetical protein 0.0095 0.1156 1
Onchocerca volvulus 0.0095 0.1156 1
Brugia malayi cathepsin L-like precursor 0.0018 0.0059 0.0511
Loa Loa (eye worm) G-protein coupled receptor 0.0095 0.1156 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0095 0.1156 1
Echinococcus multilocularis neuropeptides capa receptor 0.0095 0.1156 1
Echinococcus granulosus g protein coupled receptor 0.0095 0.1156 1
Schistosoma mansoni neuropeptide F-like receptor 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0059 0.0635
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0095 0.1156 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Brugia malayi hypothetical protein 0.0095 0.1156 1
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0718 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0095 0.1156 1
Schistosoma mansoni amine GPCR 0.0095 0.1156 1
Schistosoma mansoni myosin xvIII 0.0095 0.1156 1
Schistosoma mansoni hypothetical protein 0.0095 0.1156 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.093 1
Echinococcus multilocularis g-protein coupled receptor 0.0095 0.1156 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0186 0.1155
Loa Loa (eye worm) neuropeptide F receptor 0.0095 0.1156 1
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0718 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.1156 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.1156 1
Plasmodium vivax vivapain-2 0.0027 0.0186 0.0186
Onchocerca volvulus 0.0095 0.1156 1
Brugia malayi hypothetical protein 0.0095 0.1156 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0095 0.1156 1
Trypanosoma brucei monoglyceride lipase, putative 0.0079 0.093 0.093
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0186 0.1996
Echinococcus granulosus hypothetical protein 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0186 0.1996
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0079 0.093 0.5
Echinococcus granulosus serotonin receptor 0.0095 0.1156 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.1156 1
Echinococcus granulosus g protein coupled receptor 0.0095 0.1156 1
Mycobacterium tuberculosis Possible lysophospholipase 0.0079 0.093 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0095 0.1156 1
Echinococcus multilocularis fmrfamide receptor 0.0095 0.1156 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0186 0.1996
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.0186 0.0186
Loa Loa (eye worm) TYRA-2 protein 0.0095 0.1156 1
Echinococcus granulosus cathepsin l1 0.0027 0.0186 0.1607
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.1156 1
Onchocerca volvulus 0.0095 0.1156 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.1156 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0079 0.093 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0095 0.1156 1
Schistosoma mansoni hypothetical protein 0.0095 0.1156 1
Echinococcus granulosus neuropeptide s receptor 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Brugia malayi GnHR receptor homolog 0.0095 0.1156 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0095 0.1156 1
Schistosoma mansoni biogenic amine receptor 0.0095 0.1156 1
Schistosoma mansoni biogenic amine receptor 0.0095 0.1156 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.1156 1
Brugia malayi follicle stimulating hormone receptor 0.0095 0.1156 1
Echinococcus granulosus G protein coupled receptor 139 0.0095 0.1156 1
Brugia malayi G protein-coupled receptor 0.0095 0.1156 1
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0718 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0186 0.1155
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0095 0.1156 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Onchocerca volvulus 0.0095 0.1156 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0095 0.1156 1
Echinococcus multilocularis cysteine protease 0.0027 0.0186 0.1607
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0186 0.1996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Schistosoma mansoni adenoreceptor 0.0095 0.1156 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.1156 1
Onchocerca volvulus 0.0095 0.1156 1
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0718 1 1
Brugia malayi hypothetical protein 0.0095 0.1156 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Schistosoma mansoni biogenic amine (5HT) receptor 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Onchocerca volvulus 0.0095 0.1156 1
Onchocerca volvulus 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Schistosoma mansoni hypothetical protein 0.0095 0.1156 1
Onchocerca volvulus 0.0027 0.0186 0.1155
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0095 0.1156 1
Brugia malayi G-protein coupled receptor 0.0095 0.1156 1
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0079 0.093 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Echinococcus granulosus sex peptide receptor 0.0095 0.1156 1
Onchocerca volvulus 0.0095 0.1156 1
Schistosoma mansoni neuropeptide receptor 0.0095 0.1156 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.1156 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Echinococcus granulosus tm gpcr rhodopsin 0.0095 0.1156 1
Plasmodium vivax vivapain-2 0.0027 0.0186 0.0186
Brugia malayi hypothetical protein 0.0095 0.1156 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0079 0.093 1
Onchocerca volvulus 0.0027 0.0186 0.1155
Echinococcus granulosus neuropeptides capa receptor 0.0095 0.1156 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.1156 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0095 0.1156 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.1156 1
Onchocerca volvulus 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Schistosoma mansoni opsin-like receptor 0.0095 0.1156 1
Onchocerca volvulus 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0186 0.1607
Onchocerca volvulus 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0095 0.1156 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Onchocerca volvulus 0.0027 0.0186 0.1155
Onchocerca volvulus Cathepsin F homolog 0.0027 0.0186 0.1155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0059 0.0635
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0186 0.1155
Brugia malayi larval opioid receptor 0.0095 0.1156 1
Echinococcus granulosus g-protein coupled receptor 0.0095 0.1156 1
Echinococcus multilocularis neuropeptide receptor 0.0095 0.1156 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0079 0.093 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0186 0.0186
Brugia malayi ORL1-like opioid receptor 0.0095 0.1156 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0095 0.1156 1
Echinococcus multilocularis fmrfamide receptor 0.0095 0.1156 1
Brugia malayi putative neuropeptide receptor 0.0095 0.1156 1
Echinococcus granulosus neuropeptides capa receptor 0.0095 0.1156 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0059 0.0511
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0186 0.1996
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0095 0.1156 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Entamoeba histolytica cysteine protease, putative 0.0027 0.0186 0.1996
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0186 0.1607
Brugia malayi Melatonin receptor type 1A 0.0095 0.1156 1
Echinococcus granulosus tm gpcr rhodopsin 0.0095 0.1156 1
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0718 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0095 0.1156 1
Brugia malayi hypothetical protein 0.0095 0.1156 1
Echinococcus granulosus neuropeptide receptor A26 0.0095 0.1156 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0079 0.093 1
Echinococcus multilocularis allatostatin A receptor 0.0095 0.1156 1
Echinococcus granulosus orexin receptor type 2 0.0095 0.1156 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0095 0.1156 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0095 0.1156 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0095 0.1156 1
Echinococcus multilocularis neuropeptide receptor 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0059 0.0635
Echinococcus multilocularis G-protein coupled receptor, putative 0.0095 0.1156 1
Onchocerca volvulus 0.0027 0.0186 0.1155
Brugia malayi putative neuropeptide receptor NPR1 0.0095 0.1156 1
Echinococcus multilocularis g protein coupled receptor 0.0095 0.1156 1
Loa Loa (eye worm) G-protein coupled receptor 0.0095 0.1156 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0095 0.1156 1
Onchocerca volvulus 0.0095 0.1156 1
Echinococcus multilocularis neuropeptide Y receptor 0.0095 0.1156 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0186 0.1607
Plasmodium falciparum lysophospholipase, putative 0.0079 0.093 0.093
Echinococcus multilocularis neuropeptides capa receptor 0.0095 0.1156 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0186 0.1996
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0718 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0186 0.0186
Brugia malayi RE15519p 0.0095 0.1156 1
Onchocerca volvulus 0.0027 0.0186 0.1155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0095 0.1156 1
Echinococcus multilocularis neuropeptide s receptor 0.0095 0.1156 1
Schistosoma mansoni neuropeptide receptor 0.0095 0.1156 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0079 0.093 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0095 0.1156 1
Brugia malayi Dopamine receptor protein 1 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0186 0.1607
Brugia malayi Cathepsin L-like precursor 0.0027 0.0186 0.1607
Echinococcus multilocularis serotonin receptor 0.0095 0.1156 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.1156 1
Brugia malayi hypothetical protein 0.0095 0.1156 1
Echinococcus granulosus fmrfamide receptor 0.0095 0.1156 1
Mycobacterium ulcerans lysophospholipase 0.0079 0.093 0.5
Leishmania major monoglyceride lipase, putative 0.0079 0.093 0.0759
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0095 0.1156 1
Plasmodium falciparum lysophospholipase, putative 0.0079 0.093 0.093
Plasmodium falciparum lysophospholipase, putative 0.0079 0.093 0.093
Onchocerca volvulus 0.0095 0.1156 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0095 0.1156 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0186 0.1607
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Echinococcus multilocularis somatostatin receptor 0.0095 0.1156 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.0186 0.0186
Echinococcus granulosus g protein coupled receptor 0.0095 0.1156 1
Brugia malayi neuropeptide F receptor 0.0095 0.1156 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0095 0.1156 1
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0718 1 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0095 0.1156 1
Brugia malayi Serotonin receptor 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Brugia malayi sulfakinin receptor protein 0.0095 0.1156 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0186 0.1996
Schistosoma mansoni histamine h1 receptor 0.0095 0.1156 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0095 0.1156 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.1156 1
Echinococcus multilocularis G protein coupled receptor 139 0.0095 0.1156 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Schistosoma mansoni amine GPCR 0.0095 0.1156 1
Trypanosoma brucei monoglyceride lipase, putative 0.0079 0.093 0.093
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0095 0.1156 1
Schistosoma mansoni neuropeptide receptor 0.0095 0.1156 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0095 0.1156 1
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0186 0.1607
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0095 0.1156 1
Loa Loa (eye worm) fibroinase 0.0027 0.0186 0.1155
Onchocerca volvulus 0.0095 0.1156 1
Schistosoma mansoni neuropeptide receptor 0.0095 0.1156 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0186 0.1607
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0186 0.1996
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0095 0.1156 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0095 0.1156 1
Echinococcus granulosus neuropeptide Y receptor 0.0095 0.1156 1
Schistosoma mansoni opsin-like receptor 0.0095 0.1156 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0095 0.1156 1
Loa Loa (eye worm) ctsf protein 0.0027 0.0186 0.1155
Onchocerca volvulus 0.0095 0.1156 1
Echinococcus granulosus neuropeptide receptor 0.0095 0.1156 1
Brugia malayi Dopamine receptor protein 2 0.0095 0.1156 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0095 0.1156 1
Loa Loa (eye worm) cysteine protease 0.0027 0.0186 0.1155
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0186 0.0186
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0095 0.1156 1
Loa Loa (eye worm) neuropeptide F receptor 0.0095 0.1156 1
Brugia malayi neuropeptide F receptor 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Echinococcus multilocularis cysteine protease 0.0027 0.0186 0.1607
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0095 0.1156 1
Schistosoma mansoni biogenic amine receptor 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Brugia malayi Dopamine receptor 0.0095 0.1156 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0186 0.1607
Onchocerca volvulus 0.0027 0.0186 0.1155
Plasmodium vivax PST-A protein 0.0079 0.093 0.093
Brugia malayi Cathepsin L-like precursor 0.0027 0.0186 0.1607
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0059 0.0511
Brugia malayi hypothetical protein 0.0095 0.1156 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0186 0.1607
Onchocerca volvulus 0.0095 0.1156 1
Echinococcus multilocularis g protein coupled receptor 0.0095 0.1156 1
Schistosoma mansoni neuropeptide F-like receptor 0.0095 0.1156 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0095 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.1156 1
Echinococcus granulosus cathepsin l1 0.0018 0.0059 0.0511
Echinococcus granulosus rhodopsin orphan GPCR 0.0095 0.1156 1
Brugia malayi hypothetical protein 0.0095 0.1156 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 1
Echinococcus multilocularis orexin receptor type 2 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0186 0.1996
Onchocerca volvulus 0.0027 0.0186 0.1155
Onchocerca volvulus Neuropeptide F receptor homolog 0.0095 0.1156 1
Brugia malayi hypothetical protein 0.0095 0.1156 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0186 0.1996
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.0186 0.0186

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 14 uM Inhibition of recombinant cathepsin-L (unknown origin) using Z-Phe-Arg-AMC as substrate by fluorescence assay ChEMBL. 23562595
Ki (binding) = 4341 uM Inhibition of recombinant cathepsin-B (unknown origin) using Z-Arg-Arg-AMC as substrate by fluorescence assay ChEMBL. 23562595
Reaction time (binding) = 1 hr Reaction time taken for alcalase catalyzed synthesis of the compound using CBz-Phe-OCP as acyl donor and Gly-NH2 as nucleophile ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.