Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0485 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0233 | 0.2857 | 0.2857 |
Schistosoma mansoni | adapter molecule crk | 0.0204 | 0.2035 | 0.2035 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0204 | 0.2035 | 0.2035 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0355 | 0.632 | 0.632 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0204 | 0.2035 | 0.2035 |
Loa Loa (eye worm) | TK protein kinase | 0.0384 | 0.7143 | 0.7143 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0204 | 0.2035 | 0.2035 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0485 | 1 | 1 |
Onchocerca volvulus | 0.0132 | 0 | 0.5 | |
Onchocerca volvulus | 0.0132 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0384 | 0.7143 | 0.7143 |
Schistosoma mansoni | tyrosine kinase | 0.0233 | 0.2857 | 0.2857 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0204 | 0.2035 | 0.2035 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0233 | 0.2857 | 0.2857 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0485 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0281 | 0.4213 | 0.4213 |
Entamoeba histolytica | protein kinase, putative | 0.0281 | 0.4213 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0204 | 0.2035 | 0.2035 |
Echinococcus granulosus | tyrosine kinase | 0.0384 | 0.7143 | 0.7143 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0485 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0233 | 0.2857 | 0.2857 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0204 | 0.2035 | 0.2035 |
Echinococcus granulosus | NCK adaptor protein | 0.0204 | 0.2035 | 0.2035 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0233 | 0.2857 | 0.2857 |
Brugia malayi | Variant SH3 domain containing protein | 0.0204 | 0.2035 | 0.2035 |
Echinococcus multilocularis | NCK adaptor protein | 0.0204 | 0.2035 | 0.2035 |
Onchocerca volvulus | 0.0132 | 0 | 0.5 | |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0485 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0485 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0485 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.0384 | 0.7143 | 0.7143 |
Loa Loa (eye worm) | SRC-1 | 0.0485 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0384 | 0.7143 | 0.7143 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0485 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0485 | 1 | 1 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0204 | 0.2035 | 0.2035 |
Onchocerca volvulus | 0.0132 | 0 | 0.5 | |
Loa Loa (eye worm) | TK protein kinase | 0.0281 | 0.4213 | 0.4213 |
Schistosoma mansoni | tyrosine kinase | 0.0233 | 0.2857 | 0.2857 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0485 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0384 | 0.7143 | 0.7143 |
Schistosoma mansoni | tyrosine kinase | 0.0485 | 1 | 1 |
Onchocerca volvulus | 0.0132 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0485 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0233 | 0.2857 | 0.2857 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0233 | 0.2857 | 0.2857 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0384 | 0.7143 | 0.7143 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.2035 | 0.2035 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0384 | 0.7143 | 0.7143 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0355 | 0.632 | 0.632 |
Schistosoma mansoni | tyrosine kinase | 0.0485 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0233 | 0.2857 | 0.2857 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0485 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0485 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0485 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0485 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0485 | 1 | 1 |
Schistosoma mansoni | nck2/grb4 | 0.0204 | 0.2035 | 0.2035 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0281 | 0.4213 | 0.4213 |
Onchocerca volvulus | 0.0132 | 0 | 0.5 | |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0204 | 0.2035 | 0.2035 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0485 | 1 | 1 |
Brugia malayi | Variant SH3 domain containing protein | 0.0204 | 0.2035 | 0.2035 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 40 mg kg-1 | Compound was evaluated for anticonvulsant activity by maximal electroshock assay(MES) in mice after ip administration | ChEMBL. | 7205879 |
ND50 (functional) | > 40 mg kg-1 | Dose of compound causing a neurological deficit in 50% of mice after ip administration | ChEMBL. | 7205879 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.