Detailed information for compound 280223

Basic information

Technical information
  • TDR Targets ID: 280223
  • Name: 6-N-[2-(1H-imidazol-5-yl)ethyl]-4-N-(3-methyl phenyl)pyrido[3,4-d]pyrimidine-4,6-diamine
  • MW: 345.401 | Formula: C19H19N7
  • H donors: 3 H acceptors: 4 LogP: 3.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)Nc1ncnc2c1cc(NCCc1c[nH]cn1)nc2
  • InChi: 1S/C19H19N7/c1-13-3-2-4-14(7-13)26-19-16-8-18(22-10-17(16)24-12-25-19)21-6-5-15-9-20-11-23-15/h2-4,7-12H,5-6H2,1H3,(H,20,23)(H,21,22)(H,24,25,26)
  • InChiKey: HYWSAKRCBCFZNH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N6-[2-(1H-imidazol-5-yl)ethyl]-N4-(m-tolyl)pyrido[3,4-d]pyrimidine-4,6-diamine
  • N6-[2-(1H-imidazol-5-yl)ethyl]-N4-(3-methylphenyl)pyrido[3,4-d]pyrimidine-4,6-diamine
  • 2-(1H-imidazol-5-yl)ethyl-[4-(m-toluidino)pyrido[3,4-d]pyrimidin-6-yl]amine
  • N'-[2-(3H-imidazol-4-yl)ethyl]-N-(3-methylphenyl)pyrido[4,5-e]pyrimidine-4,6-diamine
  • 2-(3H-imidazol-4-yl)ethyl-[4-[(3-methylphenyl)amino]pyrido[4,5-e]pyrimidin-6-yl]amine
  • PD158780 Analog 9u

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0096 0.096 0.0921
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0237 0.4362 1
Schistosoma mansoni tyrosine kinase 0.0096 0.096 0.0921
Echinococcus granulosus epidermal growth factor receptor 0.018 0.2985 0.6811
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.2985 0.6843
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0237 0.4362 0.5
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0237 0.4362 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.0985 0.218
Trypanosoma brucei RNA helicase, putative 0.0472 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.0985 0.2257
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0237 0.4362 0.5
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0237 0.4362 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.0985 0.218
Schistosoma mansoni hypothetical protein 0.0237 0.4362 0.4338
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.0043 0.0099
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0237 0.4362 1
Schistosoma mansoni tyrosine kinase 0.0097 0.0985 0.0945
Schistosoma mansoni tyrosine kinase 0.0097 0.0985 0.0945
Entamoeba histolytica hypothetical protein, conserved 0.0237 0.4362 0.5
Schistosoma mansoni tyrosine kinase 0.0096 0.096 0.0921
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0237 0.4362 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.4362 0.5
Schistosoma mansoni tyrosine kinase 0.018 0.2985 0.2955
Entamoeba histolytica DNA repair and recombination protein, putative 0.0237 0.4362 0.5
Echinococcus multilocularis insulin receptor 0.0058 0.0043 0.0099
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.2985 1
Giardia lamblia Rrm3p helicase 0.0237 0.4362 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.2985 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.3 nM Inhibit of phosphorylation of a tyrosine/glutamic acid copolymer by epidermal growth factor receptor prepared from human A431 carcinoma cell vesicles by immunoaffinity chromatography. ChEMBL. 9513602
IC50 (binding) = 1.3 nM Inhibit of phosphorylation of a tyrosine/glutamic acid copolymer by epidermal growth factor receptor prepared from human A431 carcinoma cell vesicles by immunoaffinity chromatography. ChEMBL. 9513602
S > 30 nM Aqueous solubility (20 degree C) ChEMBL. 9513602

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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