Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Schistosoma mansoni | camp/cgmp cyclic nucleotide phosphodiesterase | 0.0443 | 0.0601 | 0.2068 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0443 | 0.0601 | 0.5 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3807 | 0.9668 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1299 | 0.2908 | 0.2908 |
Toxoplasma gondii | GAF domain-containing protein | 0.0319 | 0.0269 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1299 | 0.2908 | 0.2908 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1299 | 0.2908 | 0.2908 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1299 | 0.2908 | 0.3008 |
Plasmodium falciparum | GAF domain-related protein, putative | 0.0319 | 0.0269 | 0.5 |
Onchocerca volvulus | 0.0219 | 0 | 0.5 | |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.0443 | 0.0601 | 0.2068 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0319 | 0.0269 | 1 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.3931 | 1 | 1 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0443 | 0.0601 | 0.5 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0443 | 0.0601 | 0.5 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0319 | 0.0269 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1299 | 0.2908 | 0.2908 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1299 | 0.2908 | 0.2908 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0443 | 0.0601 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0319 | 0.0269 | 0.5 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1299 | 0.2908 | 0.3008 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DosT | 0.0319 | 0.0269 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0319 | 0.0269 | 0.4478 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0443 | 0.0601 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0319 | 0.0269 | 0.5 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Echinococcus granulosus | dual 3'5' cyclic AMP and GMP phosphodiesterase | 0.0443 | 0.0601 | 0.0601 |
Onchocerca volvulus | 0.0219 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.0601 | 0.0622 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0319 | 0.0269 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0443 | 0.0601 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1299 | 0.2908 | 0.2908 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0443 | 0.0601 | 0.0601 |
Toxoplasma gondii | hypothetical protein | 0.0319 | 0.0269 | 0.5 |
Onchocerca volvulus | 0.0219 | 0 | 0.5 | |
Onchocerca volvulus | 0.0219 | 0 | 0.5 | |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1299 | 0.2908 | 0.3008 |
Echinococcus granulosus | carboxylesterase 5A | 0.1299 | 0.2908 | 0.2908 |
Echinococcus granulosus | acetylcholinesterase | 0.1299 | 0.2908 | 0.2908 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1299 | 0.2908 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3488 | 0.8808 | 0.911 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0319 | 0.0269 | 0.4478 |
Onchocerca volvulus | 0.0219 | 0 | 0.5 | |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0319 | 0.0269 | 0.4478 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Echinococcus multilocularis | dual 3',5' cyclic AMP and GMP phosphodiesterase | 0.0443 | 0.0601 | 0.0601 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.3931 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0319 | 0.0269 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1299 | 0.2908 | 0.3008 |
Mycobacterium ulcerans | putative regulatory protein | 0.0319 | 0.0269 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0319 | 0.0269 | 0.4478 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0443 | 0.0601 | 1 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0319 | 0.0269 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 27 uM | Inhibitory activity against dihydrofolate reductase from pneumocystis carnii | ChEMBL. | 9548816 |
IC50 (binding) | > 27 uM | Inhibitory activity against dihydrofolate reductase from rat liver | ChEMBL. | 9548816 |
IC50 (binding) | > 27 uM | Inhibitory activity against dihydrofolate reductase from Toxoplasma gondii | ChEMBL. | 9548816 |
IC50 (binding) | > 27 uM | Inhibitory activity against dihydrofolate reductase from pneumocystis carnii | ChEMBL. | 9548816 |
IC50 (binding) | > 27 uM | Inhibitory activity against dihydrofolate reductase from rat liver | ChEMBL. | 9548816 |
IC50 (binding) | > 27 uM | Inhibitory activity against dihydrofolate reductase from Toxoplasma gondii | ChEMBL. | 9548816 |
Selectivity ratio (binding) | 0 | Selectivity ratio between the IC50 values of DHFR from rat liver and DHFR from Pneumocystis carinii; ND=Not determined | ChEMBL. | 9548816 |
Selectivity ratio (binding) | 0 | Selectivity ratio between the IC50 values of DHFR from rat liver and DHFR from Toxoplasma gondii; ND =Not Determined | ChEMBL. | 9548816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.