Detailed information for compound 281293

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.493 | Formula: C21H34O2
  • H donors: 1 H acceptors: 2 LogP: 6.72 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC/C=C\C/C=C\C/C=C\CC1CC1CCCC(=O)O
  • InChi: 1S/C21H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-19-18-20(19)16-14-17-21(22)23/h6-7,9-10,12-13,19-20H,2-5,8,11,14-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-
  • InChiKey: TWXDNKFXRGUERB-QNEBEIHSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.1021 0.3056 0.3056
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0792
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0129 0.0327 0.0327
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0039 0.0052 0.0146
Trichomonas vaginalis esterase, putative 0.0037 0.0046 0.0127
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0057 0.0106 0.0247
Onchocerca volvulus 0.0097 0.023 0.2334
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0046 0.0129
Plasmodium vivax methionine aminopeptidase 2, putative 0.0129 0.0327 0.0792
Schistosoma mansoni hypothetical protein 0.0033 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.004 0.0053 0.0149
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Schistosoma mansoni hypothetical protein 0.0043 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0034 0.0037 0.0102
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0043 0.0065 0.0181
Echinococcus multilocularis neuroglian 0.0024 0.0007 0.0007
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0026 0.0011 0.0011
Brugia malayi beta-lactamase family protein 0.0037 0.0046 0.0129
Loa Loa (eye worm) glutaminase 0.0283 0.0798 0.2224
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.028 0.028
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.1195 0.3588 0.3588
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0088 0.0088
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0129 0.0327 0.0792
Echinococcus granulosus FACT complex subunit SPT16 0.0129 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0181
Echinococcus granulosus tar DNA binding protein 0.0051 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0129
Loa Loa (eye worm) methionine aminopeptidase type I 0.1195 0.3588 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0026 0.0073
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.1021 0.3056 0.3056
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0089 0.0089
Brugia malayi Calcitonin receptor-like protein seb-1 0.0137 0.0352 0.098
Brugia malayi Niemann-Pick C1 protein precursor 0.0079 0.0175 0.0489
Loa Loa (eye worm) hypothetical protein 0.0129 0.0327 0.0911
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0129 0.0327 0.3566
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0129 0.0327 0.0867
Echinococcus granulosus Niemann Pick C1 protein 0.0079 0.0175 0.0175
Mycobacterium ulcerans aminopeptidase 0.0129 0.0327 0.0932
Loa Loa (eye worm) hypothetical protein 0.0129 0.0327 0.0911
Echinococcus granulosus transcription factor Dp 1 0.0033 0.0033 0.0033
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0792
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0129
Plasmodium vivax peptidase, putative 0.0129 0.0327 0.0792
Trypanosoma cruzi hypothetical protein, conserved 0.0174 0.0464 0.1252
Leishmania major DNA polymerase eta, putative 0.004 0.0053 0.0101
Echinococcus granulosus twitchin 0.0024 0.0007 0.0007
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0129 0.0327 0.0867
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0089 0.0089
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0129 0.0327 0.0932
Echinococcus granulosus GPCR family 2 0.0043 0.0065 0.0065
Loa Loa (eye worm) RNA binding protein 0.0051 0.0089 0.0247
Giardia lamblia Methionine aminopeptidase 0.0129 0.0327 0.5
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0129 0.0327 0.0327
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Schistosoma mansoni microtubule-associated protein tau 0.3292 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.028 0.028
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0046 0.0081
Treponema pallidum methionine aminopeptidase (map) 0.1021 0.3056 1
Trypanosoma brucei methionine aminopeptidase, putative 0.1195 0.3588 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0057 0.0106 0.0247
Mycobacterium ulcerans methionine aminopeptidase 0.1021 0.3056 1
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0867
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0089 0.0089
Brugia malayi RNA binding protein 0.0051 0.0089 0.0247
Onchocerca volvulus 0.0051 0.0088 0.0537
Echinococcus multilocularis protein patched 0.0034 0.0037 0.0037
Plasmodium falciparum HP12 protein homolog, putative 0.0174 0.0464 0.0421
Loa Loa (eye worm) DNA-binding protein 0.0129 0.0327 0.0911
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0129 0.0327 0.0792
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0046 0.0081
Plasmodium vivax methionine aminopeptidase 1b, putative 0.1195 0.3588 1
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.1195 0.3588 1
Leishmania major methionine aminopeptidase 2, putative 0.0129 0.0327 0.0867
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0447 0.0447
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0867
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.1195 0.3588 0.3588
Echinococcus multilocularis Proliferation associated protein 2G4 0.0129 0.0327 0.0327
Echinococcus granulosus methionine aminopeptidase type I 0.0129 0.0327 0.0327
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0057 0.0106 0.0106
Loa Loa (eye worm) initiation factor 2-associated protein 0.0129 0.0327 0.0911
Trypanosoma brucei Metallopeptidase family M24, putative 0.0129 0.0327 0.0792
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0046 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0052 0.0052
Trypanosoma brucei glucosidase, putative 0.0037 0.0046 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0046 0.0127
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0057 0.0106 0.0168
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0867
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0046 0.083
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.1021 0.3056 0.851
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0029 0.0021 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0174 0.0464 0.118
Schistosoma mansoni transcription factor LCR-F1 0.0029 0.0021 0.0021
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0867
Brugia malayi glutaminase DH11.1 0.0283 0.0798 0.2224
Loa Loa (eye worm) MH2 domain-containing protein 0.0325 0.0927 0.2584
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Brugia malayi metallopeptidase family M24 containing protein 0.0129 0.0327 0.0911
Loa Loa (eye worm) glutaminase 2 0.0283 0.0798 0.2224
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0046 0.013
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0867
Loa Loa (eye worm) hypothetical protein 0.0137 0.0352 0.098
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0057 0.0106 0.2768
Toxoplasma gondii peptidase D, putative 0.0129 0.0327 0.0867
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0057 0.0106 0.0247
Brugia malayi Methionine aminopeptidase protein type I 0.1195 0.3588 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0718 0.2127 0.2127
Brugia malayi metallopeptidase family M24 containing protein 0.0129 0.0327 0.0911
Schistosoma mansoni alpha-glucosidase 0.0145 0.0375 0.0375
Schistosoma mansoni hypothetical protein 0.0033 0.0033 0.0033
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0129 0.0327 0.0867
Echinococcus granulosus tumor protein p63 0.0349 0.1 0.1
Echinococcus multilocularis sterol regulatory element binding protein 0.0034 0.0037 0.0037
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0129 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0129
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0129 0.0327 0.0792
Echinococcus multilocularis FACT complex subunit SPT16 0.0129 0.0327 0.0327
Toxoplasma gondii methionine aminopeptidase 0.1195 0.3588 1
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0129 0.0327 0.0327
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0043 0.0065 0.0065
Echinococcus multilocularis Niemann Pick C1 protein 0.0079 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0094 0.0219 0.061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0046 0.0046
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.1021 0.3056 0.3056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0052 0.0052
Mycobacterium ulcerans methionine aminopeptidase MapB 0.1021 0.3056 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Echinococcus multilocularis methionyl aminopeptidase 2 0.0129 0.0327 0.0327
Toxoplasma gondii creatinase domain-containing protein 0.0129 0.0327 0.0867
Brugia malayi MH2 domain containing protein 0.0325 0.0927 0.2584
Leishmania major transcription factor-like protein 0.0129 0.0327 0.0867
Schistosoma mansoni glutaminase 0.0283 0.0798 0.0798
Echinococcus multilocularis expressed conserved protein 0.0075 0.0161 0.0161
Trypanosoma cruzi aminopeptidase P, putative 0.0129 0.0327 0.0867
Leishmania major hypothetical protein, conserved 0.0037 0.0046 0.0081
Toxoplasma gondii transcriptional elongation factor FACT140 0.0129 0.0327 0.0867
Echinococcus granulosus xaa Pro dipeptidase 0.0129 0.0327 0.0327
Entamoeba histolytica aminopeptidase, putative 0.0129 0.0327 1
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.1021 0.3056 0.8369
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0129 0.0327 0.0327
Onchocerca volvulus Dipeptidase C homolog 0.0129 0.0327 0.3566
Onchocerca volvulus Tyrosine kinase homolog 0.0295 0.0833 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0052 0.0052
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0129 0.0327 0.0867
Schistosoma mansoni hypothetical protein 0.0094 0.0219 0.0219
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0051 0.0089 0.0247
Brugia malayi TAR-binding protein 0.0051 0.0089 0.0247
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0129 0.0327 0.0911
Echinococcus granulosus Proliferation associated protein 2G4 0.0129 0.0327 0.0327
Giardia lamblia Xaa-Pro dipeptidase 0.0129 0.0327 0.5
Schistosoma mansoni nephrin 0.0024 0.0007 0.0007
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0129 0.0327 0.0932
Echinococcus multilocularis xaa pro aminopeptidase 0.0129 0.0327 0.0327
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0043 0.0065 0.0065
Echinococcus multilocularis GPCR, family 2 0.0043 0.0065 0.0065
Loa Loa (eye worm) beta-lactamase 0.0037 0.0046 0.0129
Brugia malayi hypothetical protein 0.0105 0.0254 0.0708
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0043 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0026 0.0073
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0046 0.0129
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0867
Mycobacterium ulcerans dipeptidase PepE 0.0129 0.0327 0.0932
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0129 0.0327 0.0867
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.0447 0.1245
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0046 0.0127
Echinococcus multilocularis neuropeptide receptor A26 0.0809 0.2406 0.2406
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.0661 0.2041
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.1195 0.3588 1
Echinococcus granulosus xaa Pro dipeptidase 0.0129 0.0327 0.0327
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0129 0.0327 0.3566
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0043 0.0065 0.0065
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0046 0.0046
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0053 0.0101
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.006 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0052 0.0052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0029 0.0021 0.0021
Brugia malayi beta-lactamase family protein 0.0037 0.0046 0.0129
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0046 0.0127
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0137 0.0352 0.098
Giardia lamblia Xaa-Pro dipeptidase 0.0129 0.0327 0.5
Echinococcus granulosus neuropeptide s receptor 0.0809 0.2406 0.2406
Mycobacterium ulcerans glutaminase 0.0283 0.0798 0.2497
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0137 0.0352 0.098
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0046 0.0129
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0129 0.0327 0.0327
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0129 0.0327 0.0327
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0129 0.0327 0.0911
Onchocerca volvulus Huntingtin homolog 0.0105 0.0254 0.2643
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.1021 0.3056 1
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0129 0.0327 0.0932
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0057 0.0106 0.0295
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0046 0.0127
Toxoplasma gondii methionine aminopeptidase 0.1021 0.3056 0.851
Echinococcus granulosus methionyl aminopeptidase 2 0.0129 0.0327 0.0327
Schistosoma mansoni hypothetical protein 0.0029 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0105 0.0254 0.0708
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0053 0.002
Schistosoma mansoni peptidase 0.0129 0.0327 0.0327
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0057 0.0106 0.0295
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.0447 0.1245
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0039 0.0052 0.0146
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0046 0.013
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0867
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0079 0.0175 0.5045
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0315 0.0897 0.2499
Mycobacterium tuberculosis Dipeptidase PepE 0.0129 0.0327 0.0932
Schistosoma mansoni hypothetical protein 0.0033 0.0033 0.0033
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0057 0.0106 0.0106
Plasmodium vivax methionine aminopeptidase 1a, putative 0.1021 0.3056 0.8498
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0046 0.0127
Schistosoma mansoni hypothetical protein 0.0043 0.0065 0.0065
Brugia malayi RNA recognition motif domain containing protein 0.0051 0.0089 0.0247
Leishmania major hypothetical protein, conserved 0.0174 0.0464 0.1252
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0792
Echinococcus multilocularis roundabout 2 0.0031 0.0026 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0089 0.0089
Echinococcus multilocularis transcription factor Dp 1 0.0033 0.0033 0.0033
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0057 0.0106 0.0106
Leishmania major hypothetical protein, conserved 0.0129 0.0327 0.0867
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0052 0.0052
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0129 0.0327 0.0867
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0046 0.013
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.1021 0.3056 1
Echinococcus granulosus neuroglian 0.0024 0.0007 0.0007
Echinococcus multilocularis tumor protein p63 0.0349 0.1 0.1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0046 0.013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0129
Schistosoma mansoni hypothetical protein 0.0043 0.0065 0.0065
Echinococcus granulosus expressed conserved protein 0.0075 0.0161 0.0161
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0129 0.0327 0.0327
Schistosoma mansoni hypothetical protein 0.0043 0.0065 0.0065
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0046 0.0046
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0129 0.0327 0.0867
Trypanosoma brucei hypothetical protein, conserved 0.0174 0.0464 0.118
Schistosoma mansoni patched 1 0.0034 0.0037 0.0037
Schistosoma mansoni alpha glucosidase 0.0037 0.0046 0.0046
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0034 0.0037 0.0102
Schistosoma mansoni DNA polymerase eta 0.004 0.0053 0.0053
Entamoeba histolytica hypothetical protein, conserved 0.0129 0.0327 1
Echinococcus multilocularis microtubule associated protein 2 0.3292 1 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0046 0.0081
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.1195 0.3588 1
Echinococcus multilocularis methionine aminopeptidase, type I 0.0129 0.0327 0.0327
Trichomonas vaginalis glutaminase, putative 0.0283 0.0798 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0046 0.0081
Echinococcus granulosus xaa pro aminopeptidase 0.0129 0.0327 0.0327
Brugia malayi beta-lactamase 0.0037 0.0046 0.0129
Loa Loa (eye worm) TAR-binding protein 0.0051 0.0089 0.0247
Echinococcus granulosus sterol regulatory element binding protein 0.0034 0.0037 0.0037
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0046 0.013
Brugia malayi latrophilin 2 splice variant baaae 0.0094 0.0219 0.061
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0046 0.0081
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0129 0.0327 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0447 0.0447
Entamoeba histolytica peptidase, putative 0.0129 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0254 0.0708
Brugia malayi metallopeptidase family M24 containing protein 0.0129 0.0327 0.0911
Loa Loa (eye worm) latrophilin receptor protein 2 0.0043 0.0065 0.0181
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0867
Schistosoma mansoni alpha-glucosidase 0.0145 0.0375 0.0375
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0046 0.0129
Chlamydia trachomatis methionine aminopeptidase 0.1021 0.3056 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0129
Mycobacterium ulcerans dipeptidase 0.0129 0.0327 0.0932
Echinococcus granulosus dna polymerase eta 0.004 0.0053 0.0053
Onchocerca volvulus 0.0288 0.0812 0.9739
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0129
Brugia malayi CHE-14 protein 0.0034 0.0037 0.0102
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0046 0.013
Echinococcus multilocularis xaa Pro dipeptidase 0.0129 0.0327 0.0327
Entamoeba histolytica methionine aminopeptidase, putative 0.0129 0.0327 1
Trypanosoma cruzi hypothetical protein, conserved 0.0174 0.0464 0.1252
Brugia malayi Latrophilin receptor protein 2 0.0043 0.0065 0.0181
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0081 0.0179 0.0179
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Echinococcus granulosus roundabout 2 0.0031 0.0026 0.0026
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.1021 0.3056 1
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0129 0.0327 0.0792
Echinococcus granulosus neuropeptide receptor A26 0.0809 0.2406 0.2406
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0129 0.0327 0.0327
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0129 0.0327 0.0792
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.1195 0.3588 1
Schistosoma mansoni cell adhesion molecule 0.0026 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0079 0.0175 0.0489
Loa Loa (eye worm) hypothetical protein 0.0129 0.0327 0.0911
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0051 0.0088 0.0246
Brugia malayi hypothetical protein 0.0029 0.0021 0.0059
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.1021 0.3056 1
Echinococcus multilocularis dna polymerase eta 0.004 0.0053 0.0053
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.1195 0.3588 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Echinococcus multilocularis neuropeptide s receptor 0.0809 0.2406 0.2406
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.1021 0.3056 1
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0053 0.0149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0052 0.0052
Echinococcus granulosus Protein patched homolog 1 0.0034 0.0037 0.0037
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0046 0.013
Toxoplasma gondii hypothetical protein 0.0174 0.0464 0.1252
Onchocerca volvulus Huntingtin homolog 0.0105 0.0254 0.2643
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.003
Plasmodium vivax FACT complex subunit SPT16, putative 0.0129 0.0327 0.0792
Echinococcus multilocularis xaa Pro dipeptidase 0.0129 0.0327 0.0327
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0046 0.083
Brugia malayi initiation factor 2-associated protein. 0.0129 0.0327 0.0911
Loa Loa (eye worm) transcription factor SMAD2 0.0325 0.0927 0.2584
Schistosoma mansoni hypothetical protein 0.0033 0.0033 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0051 0.0089 0.0089
Brugia malayi Immunoglobulin I-set domain containing protein 0.0315 0.0897 0.2499
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0046 0.013
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0129 0.0327 0.3813
Trypanosoma cruzi aminopeptidase P1, putative 0.0129 0.0327 0.0867
Echinococcus multilocularis protein dispatched 1 0.0039 0.0051 0.0051
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0046 0.013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0046 0.0046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0052 0.0052
Onchocerca volvulus 0.0129 0.0327 0.3566
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.1195 0.3588 1
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0046 0.0081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0046 0.0046
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0129 0.0327 0.0867
Echinococcus multilocularis tar DNA binding protein 0.0051 0.0089 0.0089

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 5 % Inhibitory activity against 5-lipoxygenase at a dose of 0.1 mM ChEMBL. 6298421
Inhibition (binding) = 5 % Inhibitory activity against 5-lipoxygenase at a dose of 0.1 mM ChEMBL. 6298421

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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