Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | DNA-binding protein, 42 kDa containing protein | 0.0132 | 0.0283 | 0.0283 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0132 | 0.0283 | 0.5 |
Echinococcus granulosus | Xaa Pro aminopeptidase 3 | 0.0132 | 0.0283 | 0.0283 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.1045 | 0.8398 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.018 | 0.0711 | 0.0441 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0132 | 0.0283 | 0.0337 |
Loa Loa (eye worm) | DNA-binding protein | 0.0132 | 0.0283 | 0.0283 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.1045 | 0.8398 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0283 | 0.0283 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.1225 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0132 | 0.0283 | 0.0283 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.1045 | 0.8398 | 1 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0132 | 0.0283 | 0.0337 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.1045 | 0.8398 | 1 |
Treponema pallidum | methionine aminopeptidase (map) | 0.1045 | 0.8398 | 1 |
Echinococcus granulosus | xaa pro aminopeptidase | 0.0132 | 0.0283 | 0.0283 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0132 | 0.0283 | 0.0283 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1225 | 1 | 1 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0132 | 0.0283 | 0.0283 |
Entamoeba histolytica | peptidase, putative | 0.0132 | 0.0283 | 0.5 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0132 | 0.0283 | 0.0283 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0132 | 0.0283 | 0.0337 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0132 | 0.0283 | 0.0283 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0132 | 0.0283 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.018 | 0.0711 | 0.0441 |
Entamoeba histolytica | aminopeptidase, putative | 0.0132 | 0.0283 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0283 | 0.0283 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.1225 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1225 | 1 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.1225 | 1 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1225 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.1225 | 1 | 1 |
Loa Loa (eye worm) | metallopeptidase family M24 containing protein | 0.0132 | 0.0283 | 0.0283 |
Chlamydia trachomatis | methionine aminopeptidase | 0.1045 | 0.8398 | 1 |
Schistosoma mansoni | Xaa-Pro dipeptidase (M24 family) | 0.0132 | 0.0283 | 0.0337 |
Echinococcus granulosus | methionine aminopeptidase type I | 0.0132 | 0.0283 | 0.0283 |
Toxoplasma gondii | methionine aminopeptidase | 0.1045 | 0.8398 | 0.8351 |
Onchocerca volvulus | Dipeptidase C homolog | 0.0132 | 0.0283 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.018 | 0.0711 | 0.0441 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1045 | 0.8398 | 0.8398 |
Leishmania major | hypothetical protein, conserved | 0.018 | 0.0711 | 0.0441 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Schistosoma mansoni | chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) | 0.0132 | 0.0283 | 0.0337 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0132 | 0.0283 | 0.5 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0132 | 0.0283 | 0.0283 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.1045 | 0.8398 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Echinococcus multilocularis | xaa pro aminopeptidase | 0.0132 | 0.0283 | 0.0283 |
Entamoeba histolytica | Xaa-Pro dipeptidase, putative | 0.0132 | 0.0283 | 0.5 |
Echinococcus granulosus | FACT complex subunit SPT16 | 0.0132 | 0.0283 | 0.0283 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.1045 | 0.8398 | 0.8351 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0132 | 0.0283 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.1045 | 0.8398 | 1 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0132 | 0.0283 | 0.0337 |
Schistosoma mansoni | peptidase | 0.0132 | 0.0283 | 0.0337 |
Onchocerca volvulus | 0.0132 | 0.0283 | 0.5 | |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.1045 | 0.8398 | 1 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0132 | 0.0283 | 0.0283 |
Echinococcus multilocularis | FACT complex subunit SPT16 | 0.0132 | 0.0283 | 0.0283 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.018 | 0.0711 | 0.0441 |
Echinococcus multilocularis | methionine aminopeptidase, type I | 0.0132 | 0.0283 | 0.0283 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0132 | 0.0283 | 0.0283 |
Trypanosoma brucei | hypothetical protein, conserved | 0.018 | 0.0711 | 0.0441 |
Plasmodium falciparum | HP12 protein homolog, putative | 0.018 | 0.0711 | 0.0441 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0283 | 0.0283 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0132 | 0.0283 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.1225 | 1 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.1045 | 0.8398 | 0.8351 |
Giardia lamblia | Methionine aminopeptidase | 0.0132 | 0.0283 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.1225 | 1 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.1045 | 0.8398 | 1 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.1045 | 0.8398 | 0.8351 |
Brugia malayi | initiation factor 2-associated protein. | 0.0132 | 0.0283 | 0.0283 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.1225 | 1 | 1 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.1045 | 0.8398 | 1 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0132 | 0.0283 | 0.0283 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0132 | 0.0283 | 0.0337 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Onchocerca volvulus | FACT complex subunit SPT16 homolog | 0.0132 | 0.0283 | 0.5 |
Echinococcus multilocularis | Xaa Pro aminopeptidase 3 | 0.0132 | 0.0283 | 0.0283 |
Toxoplasma gondii | methionine aminopeptidase | 0.1225 | 1 | 1 |
Echinococcus multilocularis | Proliferation associated protein 2G4 | 0.0132 | 0.0283 | 0.0283 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0132 | 0.0283 | 0.0283 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0132 | 0.0283 | 0.5 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.1225 | 1 | 1 |
Echinococcus granulosus | Proliferation associated protein 2G4 | 0.0132 | 0.0283 | 0.0283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 163 uM | Inhibition of cAMP phosphodiesterase in bovine heart | ChEMBL. | 6265639 |
IC50 (binding) | = 163 uM | Inhibition of cAMP phosphodiesterase in bovine heart | ChEMBL. | 6265639 |
Relative potency (binding) | = 2.5 | Potency against cAMP phosphodiesterase relative to theophylline | ChEMBL. | 6265639 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.