TDR Targets

Basic information

Technical information

TDR Targets ID: 281305
Name: (2-methoxy-6-morpholin-4-yl-5-nitropyrimidin- 4-yl)methanol
MW: 270.242 | Formula: C10H14N4O5
H donors: 1 H acceptors: 5 LogP: -0.43 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1nc(N2CCOCC2)c(c(n1)CO)[N+](=O)[O-]
InChi: 1S/C10H14N4O5/c1-18-10-11-7(6-15)8(14(16)17)9(12-10)13-2-4-19-5-3-13/h15H,2-6H2,1H3
InChiKey: MBZAETPMRVYKCK-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(2-methoxy-6-morpholino-5-nitro-pyrimidin-4-yl)methanol
(2-methoxy-6-morpholino-5-nitro-4-pyrimidinyl)methanol
(2-methoxy-6-morpholin-4-yl-5-nitro-pyrimidin-4-yl)methanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	TAR-binding protein	0.0055	0.0214	0.0265
Trypanosoma cruzi	aminopeptidase P1, putative	0.0106	0.063	0.0468
Schistosoma mansoni	hypothetical protein	0.0031	0.0017	0.0017
Echinococcus multilocularis	xaa Pro dipeptidase	0.0106	0.063	0.063
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0838	0.6654	0.6654
Loa Loa (eye worm)	methionine aminopeptidase type I	0.1011	0.808	1
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0214	0.0214
Treponema pallidum	methionine aminopeptidase (map)	0.0838	0.6654	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0031	0.0017	0.0017
Toxoplasma gondii	methionine aminopeptidase	0.0838	0.6654	0.8085
Echinococcus multilocularis	FACT complex subunit SPT16	0.0106	0.063	0.063
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.1011	0.808	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0466	0.0577
Echinococcus multilocularis	transcription factor Dp 1	0.0036	0.0051	0.0051
Echinococcus granulosus	xaa pro aminopeptidase	0.0106	0.063	0.063
Giardia lamblia	Xaa-Pro dipeptidase	0.0106	0.063	0.5
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.1011	0.808	1
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0061	0.0264	0.4025
Schistosoma mansoni	hypothetical protein	0.0036	0.0051	0.0051
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0055	0.0214	0.0265
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Brugia malayi	metallopeptidase family M24 containing protein	0.0106	0.063	0.0779
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0432	0.3316	0.3316
Loa Loa (eye worm)	hypothetical protein	0.0063	0.028	0.0347
Echinococcus granulosus	tar DNA binding protein	0.0055	0.0214	0.0214
Schistosoma mansoni	hypothetical protein	0.0036	0.0051	0.0051
Echinococcus granulosus	transcription factor Dp 1	0.0036	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0106	0.063	0.0779
Toxoplasma gondii	hypothetical protein	0.0173	0.1185	0.0746
Chlamydia trachomatis	methionine aminopeptidase	0.0838	0.6654	1
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.1011	0.808	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0173	0.1185	0.1179
Leishmania major	aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Echinococcus granulosus	neuropeptide s receptor	0.0432	0.3316	0.3316
Brugia malayi	hypothetical protein	0.0031	0.0017	0.0021
Echinococcus multilocularis	tar DNA binding protein	0.0055	0.0214	0.0214
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.1011	0.808	1
Brugia malayi	metallopeptidase family M24 containing protein	0.0106	0.063	0.0779
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0838	0.6654	1
Leishmania major	hypothetical protein, conserved	0.0106	0.063	0.0468
Trypanosoma brucei	Facilitates chromatin transcription complex subunit spt16	0.0106	0.063	0.0468
Echinococcus multilocularis	expressed conserved protein	0.0081	0.0424	0.0424
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Echinococcus granulosus	Xaa Pro aminopeptidase 3	0.0106	0.063	0.063
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0106	0.063	0.0468
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0106	0.063	0.0468
Echinococcus granulosus	xaa Pro dipeptidase	0.0106	0.063	0.063
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Loa Loa (eye worm)	TAR-binding protein	0.0055	0.0214	0.0265
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0109	0.0109
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0838	0.6654	0.8085
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0043	0.0109	0.0134
Loa Loa (eye worm)	RNA binding protein	0.0055	0.0214	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0062	0.0077
Trypanosoma brucei	hypothetical protein, conserved	0.0173	0.1185	0.1179
Loa Loa (eye worm)	metallopeptidase family M24 containing protein	0.0106	0.063	0.0779
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0043	0.0109	0.0134
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0131	0.0162
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0106	0.063	0.0779
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.1011	0.808	1
Leishmania major	methionine aminopeptidase 2, putative	0.0106	0.063	0.0468
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0109	0.0109
Brugia malayi	initiation factor 2-associated protein.	0.0106	0.063	0.0779
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0106	0.063	0.0468
Giardia lamblia	Methionine aminopeptidase	0.0106	0.063	0.5
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Echinococcus multilocularis	protein dispatched 1	0.0042	0.0105	0.0105
Brugia malayi	CHE-14 protein	0.0037	0.0062	0.0077
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0838	0.6654	0.6654
Echinococcus multilocularis	xaa pro aminopeptidase	0.0106	0.063	0.063
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Echinococcus granulosus	neuropeptide receptor A26	0.0432	0.3316	0.3316
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0109	0.0109
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0031	0.0017	0.0017
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.0109	0.0109
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0106	0.063	0.063
Schistosoma mansoni	hypothetical protein	0.0063	0.028	0.028
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0106	0.063	0.0468
Entamoeba histolytica	peptidase, putative	0.0106	0.063	1
Entamoeba histolytica	hypothetical protein, conserved	0.0106	0.063	1
Echinococcus multilocularis	xaa Pro dipeptidase	0.0106	0.063	0.063
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0093	0.0521	0.0645
Brugia malayi	MH2 domain containing protein	0.0104	0.0617	0.0764
Loa Loa (eye worm)	transcription factor SMAD2	0.0104	0.0617	0.0764
Schistosoma mansoni	hypothetical protein	0.0036	0.0051	0.0051
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0838	0.6654	0.8085
Schistosoma mansoni	chromatin-specific transcription elongation factor 140 kDa subunit (M24 family)	0.0106	0.063	0.063
Schistosoma mansoni	Xaa-Pro dipeptidase (M24 family)	0.0106	0.063	0.063
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0838	0.6654	0.6654
Brugia malayi	RNA recognition motif domain containing protein	0.0055	0.0214	0.0265
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Echinococcus multilocularis	protein patched	0.0037	0.0062	0.0062
Plasmodium vivax	hypothetical protein, conserved	0.0173	0.1185	0.0746
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0087	0.0477	0.0477
Trypanosoma cruzi	aminopeptidase P, putative	0.0106	0.063	0.0468
Brugia malayi	DNA-binding protein, 42 kDa containing protein	0.0106	0.063	0.0779
Onchocerca volvulus	Huntingtin homolog	0.0114	0.0696	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0037	0.0062	0.0062
Trypanosoma brucei	Xaa-Pro aminopeptidase, putative	0.0106	0.063	0.0468
Loa Loa (eye worm)	MH2 domain-containing protein	0.0104	0.0617	0.0764
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0838	0.6654	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0173	0.1185	0.1179
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Echinococcus multilocularis	microtubule associated protein 2	0.1244	1	1
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0106	0.063	0.063
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0838	0.6654	1
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.1011	0.808	0.808
Giardia lamblia	Xaa-Pro dipeptidase	0.0106	0.063	0.5
Onchocerca volvulus	Huntingtin homolog	0.0114	0.0696	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0063	0.028	0.0347
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0214	0.0214
Schistosoma mansoni	microtubule-associated protein tau	0.1244	1	1
Echinococcus granulosus	methionine aminopeptidase type I	0.0106	0.063	0.063
Echinococcus granulosus	sterol regulatory element binding protein	0.0037	0.0062	0.0062
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Toxoplasma gondii	methionine aminopeptidase	0.1011	0.808	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0093	0.0521	0.0645
Brugia malayi	hypothetical protein	0.0114	0.0696	0.0861
Echinococcus granulosus	expressed conserved protein	0.0081	0.0424	0.0424
Entamoeba histolytica	aminopeptidase, putative	0.0106	0.063	1
Echinococcus granulosus	Protein patched homolog 1	0.0037	0.0062	0.0062
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0086	0.0466	0.7335
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.063	0.0779
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0214	0.0214
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0838	0.6654	1
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0838	0.6654	1
Mycobacterium ulcerans	methionine aminopeptidase	0.0838	0.6654	1
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0696	0.0861
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0061	0.0264	0.0264
Schistosoma mansoni	aminopeptidase P1 (M24 family)	0.0106	0.063	0.063
Trypanosoma brucei	methionine aminopeptidase, putative	0.1011	0.808	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0521	0.0645
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0061	0.0264	0.0264
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0838	0.6654	0.8085
Trypanosoma brucei	Metallopeptidase family M24, putative	0.0106	0.063	0.0468
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Brugia malayi	metallopeptidase family M24 containing protein	0.0106	0.063	0.0779
Schistosoma mansoni	patched 1	0.0037	0.0062	0.0062
Echinococcus multilocularis	Proliferation associated protein 2G4	0.0106	0.063	0.063
Brugia malayi	Methionine aminopeptidase protein type I	0.1011	0.808	1
Plasmodium falciparum	HP12 protein homolog, putative	0.0173	0.1185	0.0746
Echinococcus granulosus	xaa Pro dipeptidase	0.0106	0.063	0.063
Loa Loa (eye worm)	hypothetical protein	0.0106	0.063	0.0779
Trypanosoma cruzi	Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative	0.0106	0.063	0.0468
Echinococcus multilocularis	Niemann Pick C1 protein	0.0123	0.077	0.077
Echinococcus granulosus	FACT complex subunit SPT16	0.0106	0.063	0.063
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0106	0.063	0.0468
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Echinococcus multilocularis	Xaa Pro aminopeptidase 3	0.0106	0.063	0.063
Echinococcus granulosus	Niemann Pick C1 protein	0.0123	0.077	0.077
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.1011	0.808	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0696	0.0861
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.1011	0.808	0.808
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Echinococcus granulosus	Proliferation associated protein 2G4	0.0106	0.063	0.063
Loa Loa (eye worm)	DNA-binding protein	0.0106	0.063	0.0779
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.1011	0.808	1
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0061	0.0264	0.0326
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0061	0.0264	0.0326
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0838	0.6654	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0086	0.0466	0.0577
Schistosoma mansoni	hypothetical protein	0.0036	0.0051	0.0051
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0037	0.0062	0.0077
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0093	0.0521	0.0645
Echinococcus granulosus	Niemann Pick C1 protein	0.0086	0.0466	0.0466
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0106	0.063	0.063
Entamoeba histolytica	methionine aminopeptidase, putative	0.0106	0.063	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.0109	0.0109
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0106	0.063	0.063
Entamoeba histolytica	Xaa-Pro dipeptidase, putative	0.0106	0.063	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.0109	0.0109
Brugia malayi	RNA binding protein	0.0055	0.0214	0.0265
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0106	0.063	0.063
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0106	0.063	0.0468
Echinococcus multilocularis	neuropeptide s receptor	0.0432	0.3316	0.3316
Echinococcus multilocularis	Niemann Pick C1 protein	0.0086	0.0466	0.0466
Leishmania major	transcription factor-like protein	0.0106	0.063	0.0468
Leishmania major	hypothetical protein, conserved	0.0173	0.1185	0.1179
Echinococcus multilocularis	methionine aminopeptidase, type I	0.0106	0.063	0.063
Schistosoma mansoni	transcription factor LCR-F1	0.0031	0.0017	0.0017
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1
Echinococcus granulosus	methionyl aminopeptidase 2	0.0106	0.063	0.063
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.0109	0.0109
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0061	0.0264	0.0264
Schistosoma mansoni	peptidase	0.0106	0.063	0.063
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0106	0.063	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Control (functional)	= 100 %	The initial growth rate of cells in the presence of the compound at the screen concentration 100 mM in leukemic cells (L1210) of mice	ChEMBL.	9057863
Control (functional)	= 100 %	The initial growth rate of cells in the presence of the compound at the screen concentration 100 mM in human epidermoid carcinoma cells (H.Ep.2)	ChEMBL.	9057863
Control (functional)	= 100 %	The initial growth rate of cells in the presence of the compound at the screen concentration 100 mM in leukemic cells (L1210) of mice	ChEMBL.	9057863
Control (functional)	= 100 %	The initial growth rate of cells in the presence of the compound at the screen concentration 100 mM in human epidermoid carcinoma cells (H.Ep.2)	ChEMBL.	9057863
IC50 (functional)	e 0 mM	Concentration of the compound required to decrease the growth rate to 50% of control; cell proliferation was not slowed down at screen concentration 100 mM	ChEMBL.	9057863
IC50 (functional)	e 0 mM	The concentration of the compound required to decrease the estimate of the minimum fraction of leukemic cells (L1210) of mice that survived treatment to 50%; cell proliferation was not slowed down at screen concentration 100 mM	ChEMBL.	9057863
IC50 (functional)	e 0 mM	Concentration of the compound required to decrease the growth rate to 50% of control on H.Ep.2 cells; cell proliferation was not slowed at the screen concentration 100 mM	ChEMBL.	9057863
IC50 (functional)	e 0 mM	The concentration of the compound required to decrease the estimate of the minimum fraction of human epidermoid carcinoma cells that survived treatment to 50% (H.Ep.2); cell proliferation was not slowed down at screen concentration 100 mM	ChEMBL.	9057863

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL165414
PubChem: 10754489

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 281305