Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0153 | 0.2123 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0153 | 0.2123 | 0.3106 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0153 | 0.2123 | 0.3106 |
Echinococcus granulosus | dihydrofolate reductase | 0.0468 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6833 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6833 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0468 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1542 | 0.1542 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6833 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0468 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0468 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0153 | 0.2123 | 0.2123 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0153 | 0.2123 | 0.0686 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0153 | 0.2123 | 0.3106 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 0.6833 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0153 | 0.2123 | 0.2123 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0153 | 0.2123 | 0.2123 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0468 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1542 | 0.1542 |
Brugia malayi | Dihydrofolate reductase | 0.0468 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1542 | 0.1542 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0468 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0468 | 1 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0153 | 0.2123 | 0.3106 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0153 | 0.2123 | 0.0686 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0153 | 0.2123 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1542 | 0.1542 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6833 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0153 | 0.2123 | 0.3106 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0153 | 0.2123 | 0.3106 |
Onchocerca volvulus | 0.013 | 0.1542 | 0.5 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.0468 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0153 | 0.2123 | 0.2123 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1542 | 0.1542 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0153 | 0.2123 | 0.2123 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6833 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0153 | 0.2123 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0153 | 0.2123 | 0.0686 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0153 | 0.2123 | 0.3106 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.11 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.11 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.88 uM | Inhibitory activity of the compound against rat liver dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.88 uM | Inhibitory activity of the compound against rat liver dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.96 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.96 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (functional) | = 1 uM | Inhibition of Toxoplasma gondii cell growth | ChEMBL. | 8632434 |
IC50 (functional) | = 1 uM | Inhibition of Toxoplasma gondii cell growth | ChEMBL. | 8632434 |
Selectivity (binding) | = 0.92 | Ratio of IC50 rat liver DHFR vs IC50 of P. carinii DHFR | ChEMBL. | 8632434 |
Selectivity (binding) | = 8 | Ratio of IC50 rat liver DHFR vs IC50 of T. gondii DHFR | ChEMBL. | 8632434 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 | 8632434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.