TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 481.542 | Formula: C29H27N3O4
H donors: 0 H acceptors: 4 LogP: 5.41 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCn1c2c(=O)c(=O)c3c(c2cc2c1nc(=O)n(c2=O)c1ccccc1)cccc3
InChi: 1S/C29H27N3O4/c1-2-3-4-5-6-12-17-31-24-22(20-15-10-11-16-21(20)25(33)26(24)34)18-23-27(31)30-29(36)32(28(23)35)19-13-8-7-9-14-19/h7-11,13-16,18H,2-6,12,17H2,1H3
InChiKey: WUBOCIWDWNLGTL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Alpha-tubulin	0.0015	0	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0139	0.4932	0.4932
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0062	0.1858	1
Onchocerca volvulus		0.0066	0.2004	0.2219
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0139	0.4932	0.5535
Brugia malayi	Animal haem peroxidase family protein	0.0239	0.8911	0.8911
Schistosoma mansoni	retinoic acid receptor RXR	0.0139	0.4932	0.4932
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0034	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5188	0.5188
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0034	0.0034
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0926	0.0926
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0034	0.0034
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0139	0.4932	0.4932
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0184	0.6732	0.7555
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0062	0.1858	0.1858
Leishmania major	cathepsin L-like protease	0.0016	0.0034	0.0185
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0066	0.2004	0.2249
Onchocerca volvulus	Chorion peroxidase homolog	0.0239	0.8911	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0037	0.0868	0.4673
Echinococcus multilocularis	cysteine protease	0.0016	0.0034	0.0038
Echinococcus multilocularis	nuclear receptor nhr 48	0.0066	0.2004	0.2249
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Echinococcus multilocularis	ecdysone induced protein 78C	0.0139	0.4932	0.5535
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0868	0.0974
Brugia malayi	Nuclear hormone receptor-like 1	0.0073	0.2318	0.2318
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1165	0.1307
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0034	0.0034
Schistosoma mansoni	zinc finger protein	0.0066	0.2004	0.2004
Brugia malayi	ecdysteroid receptor	0.0139	0.4932	0.4932
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0073	0.2318	0.2601
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0034	0.0034
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0066	0.2004	0.2004
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0184	0.6732	0.7545
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0073	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0037	0.0868	0.4673
Onchocerca volvulus		0.0037	0.0868	0.0939
Echinococcus multilocularis	muscleblind protein	0.0145	0.5188	0.5822
Schistosoma mansoni	peroxidasin	0.0239	0.8911	0.8911
Onchocerca volvulus		0.0239	0.8911	1
Giardia lamblia	Beta tubulin	0.0015	0	0.5
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0066	0.2004	0.2249
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0034	0.037
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0139	0.4932	0.5535
Brugia malayi	nuclear hormone receptor	0.0139	0.4932	0.4932
Brugia malayi	hypothetical protein	0.0066	0.2004	0.2004
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0039	0.0926	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1165	0.1165
Schistosoma mansoni	peroxidasin	0.0239	0.8911	0.8911
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2318	0.2318
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Entamoeba histolytica	hypothetical protein	0.0035	0.0786	0.849
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0139	0.4932	0.5535
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0066	0.2004	0.2004
Loa Loa (eye worm)	aminopeptidase N	0.0037	0.0868	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0034	0.0034
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0039	0.0926	0.0794
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0034	0.0038
Brugia malayi	Nuclear hormone receptor-like 1	0.0139	0.4932	0.4932
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Brugia malayi	nuclear receptor RXR	0.0073	0.2318	0.2318
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0034	0.0034
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0139	0.4932	0.5535
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0926	0.4983
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0034	0.037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0139	0.4932	0.4932
Onchocerca volvulus	Peroxidasin homolog	0.0239	0.8911	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0037	0.0868	0.0974
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0184	0.6732	0.6732
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0034	0.0034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Loa Loa (eye worm)	glutaminase	0.0266	1	1
Leishmania major	cathepsin L-like protease	0.0062	0.1846	0.9934
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0139	0.4932	0.4932
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0348	0.0348
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0034	0.0034
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0926	0.0926
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0139	0.4932	0.4932
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0139	0.4932	0.4932
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0039	0.0926	0.4983
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0034	0.0034
Brugia malayi	Peroxidasin	0.0239	0.8911	0.8911
Brugia malayi	Steroid receptor seven-up type 2	0.0139	0.4932	0.4932
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0139	0.4932	0.5535
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0139	0.4932	0.4932
Loa Loa (eye worm)	DR-78	0.0066	0.2004	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0034	0.0034
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0034	0.0038
Onchocerca volvulus		0.0066	0.2004	0.2219
Onchocerca volvulus		0.0126	0.4413	0.4933
Loa Loa (eye worm)	glutaminase 2	0.0266	1	1
Brugia malayi	ecdysone receptor	0.0066	0.2004	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0037	0.0868	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0139	0.4932	0.4932
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0868	0.0974
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0139	0.4932	0.4932
Entamoeba histolytica	aminopeptidase, putative	0.0037	0.0868	0.9377
Echinococcus granulosus	ecdysone induced protein 78C	0.0139	0.4932	0.5535
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0139	0.4932	0.5535
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0034	0.0185
Brugia malayi	hypothetical protein	0.0035	0.0786	0.0786
Echinococcus multilocularis	peroxidasin	0.0239	0.8911	1
Echinococcus multilocularis	aminopeptidase N	0.0126	0.4413	0.4952
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0139	0.4932	0.4932
Onchocerca volvulus	Peroxidasin homolog	0.0239	0.8911	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0139	0.4932	0.4932
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Loa Loa (eye worm)	steroid hormone receptor	0.0139	0.4932	0.4932
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0062	0.1858	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0048	0.132	0.7105
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0034	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0139	0.4932	0.5535
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0037	0.0868	0.0974
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0034	0.0034
Echinococcus granulosus	nuclear receptor nhr 48	0.0066	0.2004	0.2249
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0073	0.2318	0.2318
Brugia malayi	Inositol-1	0.0039	0.0926	0.0926
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0139	0.4932	0.5535
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0139	0.4932	0.5535
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0139	0.4932	0.4932
Echinococcus granulosus	cathepsin l1	0.0016	0.0034	0.0038
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0037	0.0868	0.0974
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0019	0.0143	0.5
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0066	0.2004	0.2004
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0024	0.0348	0.0348
Schistosoma mansoni	coup transcription factor	0.0139	0.4932	0.4932
Brugia malayi	Blistered cuticle protein 3	0.0239	0.8911	0.8911
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0062	0.1858	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0073	0.2318	0.2601
Brugia malayi	Nuclear hormone receptor E75	0.0066	0.2004	0.2004
Loa Loa (eye worm)	prolyl oligopeptidase	0.0184	0.6732	0.6732
Schistosoma mansoni	nuclear receptor	0.0066	0.2004	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Leishmania major	cathepsin L-like protease	0.0062	0.1846	0.9934
Onchocerca volvulus	Dual oxidase homolog	0.0239	0.8911	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0066	0.2004	0.2249
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0139	0.4932	0.5535
Brugia malayi	nuclear hormone receptor	0.0066	0.2004	0.2004
Loa Loa (eye worm)	animal heme peroxidase	0.0239	0.8911	0.8911
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0034	0.037
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1165	0.1307
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0139	0.4932	0.4932
Schistosoma mansoni	glutaminase	0.0266	1	1
Brugia malayi	tailless protein	0.0066	0.2004	0.2004
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0926	0.4983
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1165	0.1165
Plasmodium vivax	vivapain-2	0.0016	0.0034	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0024	0.0348	0.0391
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0139	0.4932	0.4932
Brugia malayi	nuclear receptor NHR-67	0.0066	0.2004	0.2004
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0037	0.0868	0.0974
Brugia malayi	Peptidase family M1 containing protein	0.0126	0.4413	0.4413
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2318	0.2318
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0037	0.0868	0.4673
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1165	0.1307
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1276	0.1276
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.1846	0.9934
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0037	0.0868	0.0974
Leishmania major	cathepsin L-like protease	0.0016	0.0034	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0139	0.4932	0.4932
Onchocerca volvulus	Protein ultraspiracle homolog	0.0139	0.4932	0.5518
Echinococcus granulosus	aminopeptidase N	0.0126	0.4413	0.4952
Loa Loa (eye worm)	animal heme peroxidase	0.0239	0.8911	0.8911
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0786	0.0882
Brugia malayi	hypothetical protein	0.0066	0.2004	0.2004
Brugia malayi	Animal haem peroxidase family protein	0.0239	0.8911	0.8911
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0102	0.3454	0.3454
Brugia malayi	hypothetical protein	0.0037	0.0868	0.0868
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0034	0.0034
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0139	0.4932	0.4932
Giardia lamblia	Gamma tubulin	0.0015	0	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0139	0.4932	0.5535
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0139	0.4932	0.4932
Loa Loa (eye worm)	inositol-1	0.0039	0.0926	0.0926
Loa Loa (eye worm)	nuclear hormone receptor	0.0066	0.2004	0.2004
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0035	0.0765	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0139	0.4932	0.5518
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0024	0.0348	0.1875
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Echinococcus multilocularis	inositol monophosphatase 1	0.0039	0.0926	0.1039
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0066	0.2004	0.2219
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0926	0.0926
Brugia malayi	nuclear receptor RXR	0.0066	0.2004	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Giardia lamblia	Alpha-tubulin	0.0015	0	0.5
Echinococcus granulosus	peroxidasin	0.0239	0.8911	1
Echinococcus multilocularis	FTZ F1 alpha	0.0139	0.4932	0.5535
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0034	0.0038
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0786	0.0786
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0786	0.0882
Onchocerca volvulus	Peroxidase homolog	0.0239	0.8911	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0139	0.4932	0.4932
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0037	0.0868	0.0868
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0139	0.4932	0.4932
Schistosoma mansoni	nuclear receptor nhr-48	0.0066	0.2004	0.2004
Brugia malayi	Animal haem peroxidase family protein	0.0239	0.8911	0.8911
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2934	0.2934
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0926	0.0926
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0066	0.2004	0.2249
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0868	0.0974
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.1846	0.9934
Toxoplasma gondii	cathepsin CPL	0.0016	0.0034	0.0185
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0062	0.1858	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0026	0.0437	0.049
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0034	0.0185
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0062	0.1858	1
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Brugia malayi	hypothetical protein	0.0047	0.1276	0.1276
Loa Loa (eye worm)	fibroinase	0.0016	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0239	0.8911	0.8911
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0035	0.0765	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0139	0.4932	0.5535
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0184	0.6732	0.7555
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Onchocerca volvulus		0.0139	0.4932	0.5518
Brugia malayi	conserved hypotetical protein	0.0066	0.2004	0.2004
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0066	0.2004	0.2219
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2318	0.2318
Trichomonas vaginalis	glutaminase, putative	0.0266	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0139	0.4932	0.4932
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0062	0.1858	0.2085
Brugia malayi	Nuclear hormone receptor E75	0.0066	0.2004	0.2004
Schistosoma mansoni	thyroid hormone receptor	0.0139	0.4932	0.4932
Loa Loa (eye worm)	ctsf protein	0.0016	0.0034	0.0034
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5188	0.5188
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.5188	0.5822
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0139	0.4932	0.4932
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0037	0.0868	0.0868
Echinococcus granulosus	FTZ F1 alpha	0.0139	0.4932	0.5535
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0139	0.4932	0.4932
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0926	0.4983
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0037	0.0868	0.4673
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0139	0.4932	0.4932
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0139	0.4932	0.4932
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Onchocerca volvulus	Bile acid receptor homolog	0.0139	0.4932	0.5518
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0073	0.2318	0.2318
Plasmodium vivax	vivapain-2	0.0016	0.0034	1
Brugia malayi	nuclear receptor NHR-88	0.0139	0.4932	0.4932
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Echinococcus multilocularis	nmda type glutamate receptor	0.0026	0.0437	0.049
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0066	0.2004	0.2004
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0037	0.0868	0.4673
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2318	0.2318
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0037	0.0868	0.0868
Schistosoma mansoni	nuclear hormone receptor	0.0066	0.2004	0.2004
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0139	0.4932	0.5535
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0034	0.0034
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0066	0.2004	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0034	0.0038
Brugia malayi	nuclear hormone receptor family member odr-7	0.0066	0.2004	0.2004
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0019	0.0143	0.5
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0037	0.0868	0.4673
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0037	0.0868	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Loa Loa (eye worm)	hypothetical protein	0.0139	0.4932	0.4932
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0139	0.4932	0.5535
Loa Loa (eye worm)	hypothetical protein	0.0139	0.4932	0.4932
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1165	0.1165
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0062	0.1858	0.2085
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0034	0.0034
Brugia malayi	photoreceptor-specific nuclear receptor	0.0139	0.4932	0.4932
Echinococcus granulosus	muscleblind protein	0.0145	0.5188	0.5822
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0034	0.0034
Echinococcus granulosus	thyroid hormone receptor alpha	0.0066	0.2004	0.2249
Schistosoma mansoni	hypothetical protein	0.0035	0.0786	0.0786
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1165	0.1165
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0139	0.4932	0.4932
Onchocerca volvulus	Peroxidase homolog	0.0239	0.8911	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.0037	0.0868	0.0736
Loa Loa (eye worm)	blistered cuticle protein 3	0.0239	0.8911	0.8911
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0066	0.2004	0.2249
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0868	0.0974
Trichomonas vaginalis	inositol monophosphatase, putative	0.0039	0.0926	0.0926
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0139	0.4932	0.4932
Brugia malayi	Nuclear hormone receptor-like 1	0.0073	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0139	0.4932	0.4932
Mycobacterium ulcerans	glutaminase	0.0266	1	1
Brugia malayi	Animal haem peroxidase family protein	0.0239	0.8911	0.8911
Schistosoma mansoni	nuclear hormone receptor	0.0066	0.2004	0.2004
Loa Loa (eye worm)	animal heme peroxidase	0.0239	0.8911	0.8911
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2004	0.2004
Brugia malayi	Animal haem peroxidase family protein	0.0239	0.8911	0.8911
Brugia malayi	orphan nuclear receptor NR2E1	0.0066	0.2004	0.2004
Entamoeba histolytica	hypothetical protein	0.0035	0.0786	0.849
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0034	1
Giardia lamblia	Beta tubulin	0.0015	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0034	0.0034
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0066	0.2004	0.2249
Brugia malayi	nuclear receptor NHR-88	0.0066	0.2004	0.2004
Loa Loa (eye worm)	animal heme peroxidase	0.0239	0.8911	0.8911
Leishmania major	cathepsin L-like protease	0.0016	0.0034	0.0185
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0926	0.4983
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0066	0.2004	0.2249
Trypanosoma cruzi	aminopeptidase, putative	0.0037	0.0868	0.4673
Echinococcus granulosus	inositol monophosphatase 1	0.0039	0.0926	0.1039
Brugia malayi	hypothetical protein	0.0073	0.2318	0.2318
Echinococcus multilocularis	cysteine protease	0.0016	0.0034	0.0038
Entamoeba histolytica	hypothetical protein	0.0035	0.0786	0.849
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0039	0.0926	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0139	0.4932	0.4932
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Brugia malayi	Muscleblind-like protein	0.0145	0.5188	0.5188
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0066	0.2004	0.2249
Onchocerca volvulus		0.0239	0.8911	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.1633	0.8787
Loa Loa (eye worm)	hypothetical protein	0.0139	0.4932	0.4932
Loa Loa (eye worm)	cysteine protease	0.0016	0.0034	0.0034
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0034	0.0038
Brugia malayi	steroid hormone receptor	0.0139	0.4932	0.4932
Echinococcus granulosus	nmda type glutamate receptor	0.0026	0.0437	0.049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1846	0.9934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0034	0.0034
Onchocerca volvulus		0.0239	0.8911	1
Brugia malayi	prolyl oligopeptidase family protein	0.0184	0.6732	0.6732
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.1846	0.9934
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0139	0.4932	0.4932
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0034	0.0034
Giardia lamblia	Beta tubulin	0.0015	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0139	0.4932	0.4932
Trypanosoma brucei	Aminopeptidase M1, putative	0.0037	0.0868	0.4673
Chlamydia trachomatis	glutamine binding protein	0.0019	0.0143	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.1846	0.9934
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0034	0.0034
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0066	0.2004	0.2249
Loa Loa (eye worm)	hypothetical protein	0.0239	0.8911	0.8911
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0066	0.2004	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2318	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0113	0.3893	0.3893
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1165	0.1307
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0034	0.0034
Brugia malayi	prolyl oligopeptidase family protein	0.0062	0.1858	0.1858
Schistosoma mansoni	nuclear hormone receptor	0.0139	0.4932	0.4932
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0019	0.0143	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0034	0.0034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0034	0.0034
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0062	0.1858	1
Schistosoma mansoni	nuclear receptor	0.0066	0.2004	0.2004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0139	0.4932	0.4932
Brugia malayi	hypothetical protein	0.0073	0.2318	0.2318
Entamoeba histolytica	hypothetical protein	0.0035	0.0786	0.849
Leishmania major	cathepsin L-like protease	0.0016	0.0034	0.0185
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0034	0.0038
Leishmania major	cathepsin L-like protease	0.0016	0.0034	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0348	0.0348
Schistosoma mansoni	thyroid hormone receptor	0.0139	0.4932	0.4932
Schistosoma mansoni	RAR-like nuclear receptor	0.0139	0.4932	0.4932
Loa Loa (eye worm)	hypothetical protein	0.0139	0.4932	0.4932
Leishmania major	cathepsin L-like protease	0.0062	0.1846	0.9934
Brugia malayi	Peptidase family M1 containing protein	0.0037	0.0868	0.0868

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 3.1 uM	In vitro cytotoxicity determined against murine leukemia L1210 cells by MTT assay	ChEMBL.	No reference
IC50 (functional)	= 3.1 uM	In vitro cytotoxicity determined against murine leukemia L1210 cells by MTT assay	ChEMBL.	No reference
IC50 (functional)	= 22.9 uM	In vitro cytotoxicity determined against human epidermoid carcinoma KB cells by MTT assay	ChEMBL.	No reference
IC50 (functional)	= 22.9 uM	In vitro cytotoxicity determined against human epidermoid carcinoma KB cells by MTT assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 281382