Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0063 | 0.0926 | 0.1906 |
Echinococcus multilocularis | bromodomain containing 2 | 0.007 | 0.1094 | 0.1094 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.01 | 0.1794 | 0.3657 |
Entamoeba histolytica | bromodomain-containing protein | 0.0035 | 0.0257 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0063 | 0.0926 | 0.1906 |
Entamoeba histolytica | bromodomain-containing protein | 0.0035 | 0.0257 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0257 | 0.2348 |
Trichomonas vaginalis | bromodomain-containing protein 4, brd4, putative | 0.0035 | 0.0257 | 0.2348 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0039 | 0.0372 | 0.0766 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0063 | 0.0926 | 0.1906 |
Schistosoma mansoni | bromodomain containing | 0.0152 | 0.3003 | 0.612 |
Echinococcus multilocularis | bromodomain containing protein 7 | 0.0141 | 0.2765 | 0.2765 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0063 | 0.0926 | 0.1906 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Brugia malayi | Bromodomain containing protein | 0.0152 | 0.3003 | 0.6182 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0063 | 0.0926 | 0.1906 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0063 | 0.0926 | 0.1906 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0046 | 0.0521 | 0.4769 |
Echinococcus multilocularis | Bromodomain containing protein | 0.045 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0063 | 0.0926 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0063 | 0.0926 | 0.1906 |
Onchocerca volvulus | 0.0034 | 0.0234 | 0.9126 | |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.2765 | 0.5635 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Brugia malayi | Bromodomain containing protein | 0.007 | 0.1094 | 0.2251 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0283 | 0.259 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.007 | 0.1094 | 0.2229 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0063 | 0.0926 | 0.1906 |
Onchocerca volvulus | 0.0035 | 0.0257 | 1 | |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0063 | 0.0926 | 0.1906 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0063 | 0.0926 | 1 |
Echinococcus multilocularis | Bromodomain containing protein | 0.0035 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0455 | 0.0936 |
Plasmodium falciparum | thioredoxin reductase | 0.0231 | 0.4858 | 1 |
Treponema pallidum | NADH oxidase | 0.0063 | 0.0926 | 1 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0063 | 0.0926 | 0.1906 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0063 | 0.0926 | 0.1906 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0063 | 0.0926 | 0.1906 |
Trichomonas vaginalis | histone acetyltransferase gcn5, putative | 0.0035 | 0.0257 | 0.2348 |
Echinococcus granulosus | bromodomain containing protein 7 | 0.0141 | 0.2765 | 0.2765 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Echinococcus granulosus | CREB binding protein | 0.0065 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | glutathione reductase | 0.0231 | 0.4858 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0231 | 0.4858 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0231 | 0.4858 | 1 |
Leishmania major | trypanothione reductase | 0.0231 | 0.4858 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0231 | 0.4858 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0063 | 0.0926 | 0.1906 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0063 | 0.0926 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0063 | 0.0926 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0063 | 0.0926 | 0.0926 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1094 | 0.2251 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0231 | 0.4858 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.007 | 0.1094 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0063 | 0.0926 | 0.8465 |
Brugia malayi | TAZ zinc finger family protein | 0.01 | 0.1794 | 0.3693 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0063 | 0.0926 | 0.1906 |
Echinococcus granulosus | bromodomain containing 2 | 0.007 | 0.1094 | 0.1094 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0063 | 0.0926 | 0.1906 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0063 | 0.0926 | 0.1906 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.007 | 0.1094 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0063 | 0.0926 | 0.1887 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.3003 | 0.6182 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0063 | 0.0926 | 0.0926 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0063 | 0.0926 | 0.1906 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0063 | 0.0926 | 0.1906 |
Schistosoma mansoni | CREB-binding protein 2 | 0.01 | 0.1794 | 0.3657 |
Giardia lamblia | Kinase, putative | 0.0035 | 0.0257 | 0.2774 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0046 | 0.0521 | 0.4769 |
Toxoplasma gondii | thioredoxin reductase | 0.0231 | 0.4858 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0063 | 0.0926 | 0.1906 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0039 | 0.0372 | 0.0766 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0063 | 0.0926 | 0.1906 |
Plasmodium falciparum | glutathione reductase | 0.0063 | 0.0926 | 0.1906 |
Loa Loa (eye worm) | CBP-B | 0.0072 | 0.1138 | 0.2343 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0063 | 0.0926 | 0.1906 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0063 | 0.0926 | 0.1906 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0231 | 0.4858 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0231 | 0.4858 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0063 | 0.0926 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0019 | 0.0038 |
Echinococcus granulosus | CREB binding protein | 0.01 | 0.1794 | 0.1794 |
Plasmodium vivax | glutathione reductase, putative | 0.0231 | 0.4858 | 1 |
Toxoplasma gondii | bromodomain-containing protein | 0.0035 | 0.0257 | 0.0529 |
Plasmodium falciparum | glutathione reductase | 0.0231 | 0.4858 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0071 | 0.112 | 0.112 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.0521 | 0.4769 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0233 | 0.4906 | 0.4906 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0046 | 0.0521 | 0.4769 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0063 | 0.0926 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0063 | 0.0926 | 0.1906 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0063 | 0.0926 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0035 | 0.0257 | 0.0529 |
Brugia malayi | Bromodomain containing protein | 0.007 | 0.1094 | 0.2251 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0046 | 0.0521 | 0.4769 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0063 | 0.0926 | 0.1906 |
Brugia malayi | glutathione reductase | 0.0231 | 0.4858 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0063 | 0.0926 | 0.1906 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0063 | 0.0926 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0063 | 0.0926 | 0.1906 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0063 | 0.0926 | 0.1906 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0233 | 0.4906 | 0.4906 |
Entamoeba histolytica | bromodomain-containing protein | 0.0035 | 0.0257 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0257 | 0.2348 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0063 | 0.0926 | 0.1906 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0063 | 0.0926 | 0.1906 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0063 | 0.0926 | 0.8465 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C50 (binding) | = 0.08 uM | Inhibitory concentration against ethidium bromide binding to DNA [poly(dA-dT)] | ChEMBL. | 2416922 |
C50 (binding) | = 0.13 uM | Inhibitory concentration against ethidium bromide binding to DNA [poly(dG-dC)] | ChEMBL. | 2416922 |
IC50 (functional) | = 2300 nM | Concentration of compound required to inhibit growth of L1210 leukemia cells in culture by 50% | ChEMBL. | 2416922 |
IC50 (binding) | = 5.4 uM | In vitro inhibition of Escherichia coli DNA-dependent RNA polymerase using both calf thymus and phage T7 DNA template | ChEMBL. | 2416922 |
IC50 (binding) | = 5.9 uM | In vitro inhibition of Escherichia coli DNA-dependent RNA polymerase using both calf thymus and phage T7 DNA template | ChEMBL. | 2416922 |
ILS (functional) | = 0 % | Percentage increase in life span (ILS) of compound treated tumor-bearing animals compared to tumor-bearing controls when treated at the optimal dose; ILS of 20% not reached at any dose level | ChEMBL. | 2416922 |
Optimal dose (functional) | = 8.9 mg kg-1 day-1 | Optimal dose of the compound administered ip as a solution in 0.1 mL of 30% v/v ethanol-water after intraperitoneal inoculation of 10e6 P388 leukemia cells. | ChEMBL. | 2416922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.