Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenosine deaminase | 0.0259 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0259 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0259 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0259 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0259 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0259 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0259 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0259 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0259 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0259 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0259 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0259 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0259 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0259 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0259 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0259 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0259 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0259 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 202 uM | Inhibition of human prostate cancer cell line PC-3 growth | ChEMBL. | 11965367 |
IC50 (functional) | = 202 uM | Inhibition of human prostate cancer cell line PC-3 growth | ChEMBL. | 11965367 |
IC50 (functional) | > 300 uM | Inhibition of human breast cancer cell line MDA-MB-231 growth | ChEMBL. | 11965367 |
IC50 (functional) | > 300 uM | Inhibition of human breast cancer cell line MDA-MB-231 growth | ChEMBL. | 11965367 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.