Detailed information for compound 281816

Basic information

Technical information
  • TDR Targets ID: 281816
  • Name: 5-cyclohexylidenepentyl 2-(1-methylpiperidin- 1-ium-1-yl)ethyl phosphate
  • MW: 373.467 | Formula: C19H36NO4P
  • H donors: 0 H acceptors: 2 LogP: 3.03 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[N+]1(CCCCC1)CCOP(=O)(OCCCCC=C1CCCCC1)[O-]
  • InChi: 1S/C19H36NO4P/c1-20(14-8-4-9-15-20)16-18-24-25(21,22)23-17-10-3-7-13-19-11-5-2-6-12-19/h13H,2-12,14-18H2,1H3
  • InChiKey: LNVFQXSQFQKDTM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-cyclohexylidenepentyl 2-(1-methyl-1-piperidin-1-iumyl)ethyl phosphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0559 0.5693 1
Brugia malayi bHLH-PAS transcription factor 0.0037 0.021 0.0368
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0032 0.0032
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0337 0.2985
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.053 0.0931
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.047 0.0821
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.047 0.0821
Loa Loa (eye worm) hypothetical protein 0.0099 0.0867 0.0867
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.047 0.0821
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Brugia malayi SPARC precursor 0.0039 0.0232 0.0407
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0122 0.038
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.0186 0.0322
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0046 0.0124
Brugia malayi secreted modular calcium-binding protein 1 0.0039 0.0232 0.0407
Loa Loa (eye worm) hypothetical protein 0.0368 0.3683 0.3683
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0166 0.1568 0.1568
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.1123 1
Onchocerca volvulus Putative organic anion transporter 0.0099 0.0867 0.2989
Schistosoma mansoni lamin 0.0027 0.0113 0.0157
Trypanosoma cruzi agmatinase, putative 0.0128 0.1174 0.2058
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0013 0.003
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Echinococcus granulosus lamin dm0 0.0027 0.0113 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0122 0.0214
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0002 0.0003
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0046 0.0064
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0474 0.4202
Schistosoma mansoni arginase 0.0353 0.3532 0.4909
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0113 0.0199
Schistosoma mansoni hypothetical protein 0.0172 0.1635 0.2272
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0122 0.0214
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0122 0.0169
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0021 0.0048 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.047 0.0821
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0232 0.0232
Echinococcus granulosus Mastin 0.0021 0.0048 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.047 0.0821
Onchocerca volvulus 0.029 0.2871 1
Echinococcus granulosus agrin 0.0039 0.0232 0.0322
Brugia malayi hypothetical protein 0.0099 0.0867 0.1523
Schistosoma mansoni microtubule-associated protein tau 0.0702 0.7195 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.047 0.0821
Echinococcus granulosus carbonic anhydrase II 0.0559 0.5693 0.7913
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0122 0.0169
Brugia malayi hypothetical protein 0.0021 0.0048 0.0084
Trypanosoma brucei unspecified product 0.0055 0.0399 0.0697
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0046 0.0124
Loa Loa (eye worm) hypothetical protein 0.0021 0.0046 0.0046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.023 0.0399
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0233 0.0324
Loa Loa (eye worm) hypothetical protein 0.0099 0.0867 0.0867
Plasmodium falciparum arginase 0.0353 0.3532 0.959
Toxoplasma gondii protease inhibitor PI2 0.0039 0.0232 0.0623
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0474 0.0658
Loa Loa (eye worm) hypothetical protein 0.0051 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.0122
Schistosoma mansoni rab6-interacting 0.004 0.0246 0.0342
Echinococcus multilocularis dna polymerase kappa 0.0061 0.047 0.0653
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0046 0.0124
Leishmania major p-glycoprotein 0.0021 0.0046 0.0077
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0474 1
Trypanosoma brucei unspecified product 0.0024 0.0074 0.0125
Loa Loa (eye worm) hypothetical protein 0.0099 0.0867 0.0867
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0144 0.0249
Schistosoma mansoni agrin 0.0039 0.0232 0.0322
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.023 0.0319
Brugia malayi polk-prov protein 0.0038 0.0221 0.0388
Echinococcus multilocularis dna polymerase eta 0.0034 0.0186 0.0258
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0032 0.0052
Onchocerca volvulus Putative organic anion transporter 0.0099 0.0867 0.2989
Schistosoma mansoni multidrug resistance protein 0.0021 0.0046 0.0064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0474 1
Schistosoma mansoni DNA polymerase eta 0.0034 0.0186 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0122 0.0122
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0122 0.038
Onchocerca volvulus 0.0037 0.021 0.0687
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0048
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0046 0.0064
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.023 0.2026
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0046 0.0064
Loa Loa (eye worm) doublecortin family protein 0.004 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0013
Schistosoma mansoni lipoxygenase 0.004 0.0246 0.0342
Loa Loa (eye worm) hypothetical protein 0.005 0.0353 0.0353
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.1123 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0993 0.8837
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0993 0.8837
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0048 0.0067
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.053 0.0927
Onchocerca volvulus 0.0099 0.0867 0.2989
Echinococcus multilocularis RUN 0.004 0.0246 0.0342
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.2299 0.2299
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0046 0.0064
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0046 0.0124
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.178 0.6184
Echinococcus granulosus carbonic anhydrase 0.0368 0.3683 0.5119
Leishmania major DNA polymerase kappa, putative 0.0041 0.0256 0.0446
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0021 0.0048 0.0067
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.053 0.0737
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0186 0.0326
Echinococcus multilocularis transmembrane protease serine 3 0.0021 0.0048 0.0067
Entamoeba histolytica Arginase, putative 0.0353 0.3532 1
Trichomonas vaginalis taga, putative 0.0021 0.0046 0.0124
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0013 0.0029
Trypanosoma brucei cytochrome P450, putative 0.002 0.0032 0.0052
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0122 0.0214
Echinococcus multilocularis enteropeptidase 0.0021 0.0048 0.0067
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0232 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0353 0.3532 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0046 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0221 0.0384
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.047 0.0821
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0474 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0221
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.023 0.0403
Schistosoma mansoni organic anion transporter 0.0099 0.0867 0.1205
Loa Loa (eye worm) hypothetical protein 0.0021 0.0046 0.0046
Echinococcus multilocularis Mastin 0.0021 0.0048 0.0067
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0032 0.0052
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0099 0.0867 0.0867
Schistosoma mansoni single-minded 0.0049 0.0345 0.0479
Loa Loa (eye worm) hypothetical protein 0.0039 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0034 0.0186 0.0186
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0046 0.0064
Echinococcus multilocularis carbonic anhydrase 0.0368 0.3683 0.5119
Loa Loa (eye worm) hypothetical protein 0.0039 0.0232 0.0232
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0122 0.0169
Schistosoma mansoni loxhd1 0.004 0.0246 0.0342
Schistosoma mansoni smdr2 0.0021 0.0046 0.0064
Brugia malayi follicle stimulating hormone receptor 0.0236 0.2299 0.4038
Plasmodium vivax arginase, putative 0.0353 0.3532 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0122 0.0169
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0122 0.0214
Brugia malayi hypoxia-induced factor 1 0.0153 0.1433 0.2517
Loa Loa (eye worm) hypothetical protein 0.029 0.2871 0.2871
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0474 0.128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0232 0.0232
Mycobacterium ulcerans hypothetical protein 0.0021 0.0048 0.0968
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0046 0.0124
Loa Loa (eye worm) CYP4Cod1 0.002 0.0032 0.0032
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0256 0.0446
Echinococcus granulosus dna polymerase eta 0.0034 0.0186 0.0258
Trypanosoma cruzi MFS transporter, putative 0.0099 0.0867 0.152
Brugia malayi Trypsin-like protease protein 5 0.0021 0.0048 0.0084
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0046 0.0124
Echinococcus multilocularis glycoprotein Antigen 5 0.0021 0.0048 0.0067
Echinococcus granulosus carbonic anhydrase 0.0368 0.3683 0.5119
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0122 0.0169
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0232 0.0623
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.023 0.0399
Trypanosoma brucei agmatinase, putative 0.0128 0.1174 0.2058
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0993 0.8837
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0993 0.8837
Brugia malayi Trypsin family protein 0.0021 0.0048 0.0084
Echinococcus multilocularis microtubule associated protein 2 0.0702 0.7195 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.047 0.0821
Loa Loa (eye worm) hypothetical protein 0.0099 0.0867 0.0867
Onchocerca volvulus 0.0039 0.0232 0.0764
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.0122
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0232 0.0407
Onchocerca volvulus 0.0099 0.0867 0.2989
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0122 0.038
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0993 0.8837
Brugia malayi N-terminal motif family protein 0.0186 0.178 0.3127
Schistosoma mansoni multidrug resistance protein 0.0021 0.0046 0.0064
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0046 0.0124
Schistosoma mansoni ap endonuclease 0.0039 0.023 0.0319
Leishmania major hypothetical protein, conserved 0.0018 0.0013 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0122 0.0169
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0021 0.0044 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0122 0.0122
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.0186 0.0258
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.0046 0.0119
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0122 0.0169
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0013 0.0029
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0246 0.0342
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0246 0.0342
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0232 0.0623
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0122 0.0169
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0048
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.029 0.2871 0.399
Trypanosoma cruzi agmatinase, putative 0.0128 0.1174 0.2058
Brugia malayi nuclear hormone receptor 0.0028 0.0122 0.0214
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0368 0.3683 0.6469
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.023 0.0643
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.047 0.1324
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0046 0.0077
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0346 0.0346
Toxoplasma gondii thioredoxin reductase 0.0049 0.0337 0.0909
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0099 0.0867 0.1205
Trypanosoma brucei unspecified product 0.0024 0.0074 0.0125
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0046 0.0124
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0099 0.0867 0.0867
Onchocerca volvulus 0.0099 0.0867 0.2989
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0048 0.0067
Loa Loa (eye worm) hypothetical protein 0.0099 0.0867 0.0867
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.047 0.9919
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0021 0.0048 0.0067
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0246 0.0342
Brugia malayi intermediate filament protein 0.0027 0.0113 0.0199
Loa Loa (eye worm) hypothetical protein 0.004 0.0246 0.0246
Plasmodium falciparum thioredoxin reductase 0.0049 0.0337 0.0909
Leishmania major DNA polymerase eta, putative 0.0034 0.0186 0.0322
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0474 0.0828
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.0122
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0368 0.3683 0.6469
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0246 0.069
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0013 0.0018
Onchocerca volvulus 0.0021 0.0048 0.0122
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0122 0.0169
Onchocerca volvulus 0.0021 0.0048 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0122 0.0169
Echinococcus multilocularis lamin dm0 0.0027 0.0113 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0144 0.0249
Onchocerca volvulus 0.0099 0.0867 0.2989
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Schistosoma mansoni organic anion transporter 0.0099 0.0867 0.1205
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.0186 0.0258
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0365 0.0641
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.023 0.0319
Brugia malayi PAS domain containing protein 0.0049 0.0345 0.0605
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0122 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0122 0.0214
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.023 0.8951
Echinococcus multilocularis geminin 0.0172 0.1635 0.2272
Trichomonas vaginalis Arginase, putative 0.0353 0.3532 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0337 0.0469
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.047 0.0821
Echinococcus granulosus transmembrane protease serine 3 0.0021 0.0048 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0122 0.0169
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.023 0.023
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0368 0.3683 0.6469
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0007 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0122 0.0214
Schistosoma mansoni multidrug resistance protein 0.0021 0.0046 0.0064
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.053 0.1388
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0122 0.0169
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.053 0.0927
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0046 0.0064
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0559 0.5693 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0046 0.0124
Mycobacterium ulcerans putative regulatory protein 0.0037 0.021 0.4396
Echinococcus multilocularis musashi 0.0027 0.0113 0.0157
Onchocerca volvulus 0.004 0.0246 0.0815
Echinococcus multilocularis carbonic anhydrase II 0.0559 0.5693 0.7913
Loa Loa (eye worm) hypothetical protein 0.0039 0.0232 0.0232
Mycobacterium tuberculosis Probable reductase 0.0111 0.0993 0.8837
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0474 0.0658
Schistosoma mansoni hypothetical protein 0.0035 0.0194 0.027
Onchocerca volvulus Putative organic anion transporter 0.0099 0.0867 0.2989
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.021 0.0291
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.053 0.0737
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0048
Schistosoma mansoni coup transcription factor 0.0028 0.0122 0.0169
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0122 0.0122
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0046 0.0124
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0046 0.0124
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0186 0.0326
Schistosoma mansoni follistatin 0.0039 0.0232 0.0322
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0246 0.0342
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0337 0.0469
Schistosoma mansoni hypothetical protein 0.0021 0.0048 0.0067
Brugia malayi Trypsin family protein 0.0021 0.0048 0.0084
Echinococcus granulosus microtubule associated protein 2 0.0702 0.7195 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0046 0.0064
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0044
Echinococcus multilocularis expressed protein 0.0039 0.0232 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.047 0.0821
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0122 0.0169
Toxoplasma gondii exonuclease III APE 0.0039 0.023 0.0617
Echinococcus multilocularis arginase 2, mitochondrial 0.0353 0.3532 0.4909
Brugia malayi hypothetical protein 0.004 0.0246 0.0432
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0048 0.0067
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.0186 0.0258
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0046 0.0119
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0046 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0013 0.0019
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0232 0.0407
Plasmodium vivax glutathione reductase, putative 0.0049 0.0337 0.0948
Trichomonas vaginalis conserved hypothetical protein 0.0353 0.3532 1
Brugia malayi Trypsin family protein 0.0021 0.0048 0.0084
Schistosoma mansoni ap endonuclease 0.0039 0.023 0.0319
Loa Loa (eye worm) hypothetical protein 0.0099 0.0867 0.0867
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0046 0.0124
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0337 0.0948
Brugia malayi glutathione reductase 0.0049 0.0337 0.0592
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0122 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0365 0.0365
Echinococcus granulosus geminin 0.0172 0.1635 0.2272
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0044 0.0061
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0046 0.0124
Brugia malayi Kringle domain containing protein 0.0018 0.0013 0.0023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0122 0.0169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0122 0.0122
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0122 0.0169
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0046 0.0124
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0232 0.0623
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0122 0.0169
Schistosoma mansoni hypothetical protein 0.0368 0.3683 0.5119
Trichomonas vaginalis abcb9, putative 0.0021 0.0046 0.0124
Echinococcus granulosus enteropeptidase 0.0021 0.0048 0.0067
Onchocerca volvulus 0.0021 0.0048 0.0122
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.0186 0.0186
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0122 0.0169
Brugia malayi Doublecortin family protein 0.004 0.0246 0.0432
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Onchocerca volvulus 0.005 0.0353 0.119
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0046 0.0124
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Echinococcus multilocularis agrin 0.0039 0.0232 0.0322
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0046 0.0391
Echinococcus multilocularis tumor protein p63 0.0344 0.3434 0.4772
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Giardia lamblia DINP protein human, muc B family 0.0041 0.0256 1
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0099 0.0867 0.1205
Trypanosoma brucei trypanothione reductase 0.0049 0.0337 0.0588
Loa Loa (eye worm) agrin synaptic family protein 0.0039 0.0232 0.0232
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.2393 0.2393
Loa Loa (eye worm) trypsin family protein 0.0021 0.0048 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.047 0.0821
Schistosoma mansoni lipoxygenase 0.0112 0.1004 0.1396
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0368 0.3683 0.6469
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0144 0.0249
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.029 0.2871 0.399
Echinococcus granulosus tumor protein p63 0.0344 0.3434 0.4772
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0048 0.0067
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0122 0.0169
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.023 0.0399
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0032 0.0626
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.053 0.053
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0021 0.0048 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0122 0.0214
Echinococcus multilocularis carbonic anhydrase 0.0368 0.3683 0.5119
Brugia malayi nuclear receptor NHR-88 0.0028 0.0122 0.0214
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.023 0.0643
Toxoplasma gondii hypothetical protein 0.0368 0.3683 1
Trypanosoma cruzi arginase, putative 0.0128 0.1174 0.2058
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.0353 0.3532 0.4909
Echinococcus granulosus follistatin 0.0039 0.0232 0.0322
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0186 0.1635
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0021 0.0048 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0122 0.0214
Echinococcus granulosus dna polymerase kappa 0.0061 0.047 0.0653
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0122 0.0169
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.023 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.047 0.0821
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0048 0.0067
Echinococcus granulosus Solute carrier organic anion transporter family 0.0099 0.0867 0.1205
Onchocerca volvulus 0.0027 0.0113 0.0349
Onchocerca volvulus 0.0269 0.2648 0.9219
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0122 0.0214
Brugia malayi sodium-independent organic anion transporter family protein 0.0099 0.0867 0.1523
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.053 0.0927
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0122 0.0169
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0186 0.0322
Loa Loa (eye worm) hypothetical protein 0.0368 0.3683 0.3683
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0046 0.0064
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0122 0.0169
Echinococcus granulosus intermediate filament protein 0.0027 0.0113 0.0157
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0353 0.0491
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.053 0.0927
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0122 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.047 0.0821
Onchocerca volvulus 0.0028 0.0122 0.038
Onchocerca volvulus 0.004 0.0246 0.0815
Trypanosoma cruzi arginase, putative 0.0128 0.1174 0.2058
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0233 0.0324
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0337 0.0337
Leishmania major trypanothione reductase 0.0049 0.0337 0.0588
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0048 0.0067
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.047 0.9919
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0113 0.0113
Brugia malayi ecdysteroid receptor 0.0028 0.0122 0.0214
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0345 0.0479
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0032 0.0032
Plasmodium falciparum glutathione reductase 0.0049 0.0337 0.0909
Brugia malayi hypothetical protein 0.004 0.0246 0.0432
Onchocerca volvulus 0.0027 0.0113 0.0349
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.0122
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0122 0.0214
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0046 0.0124
Brugia malayi Trypsin family protein 0.029 0.2871 0.5042
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0122 0.0169
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.2393 0.2393
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0046 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0221 0.0384
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0368 0.3683 0.6469
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.1123 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.047 0.0821
Brugia malayi Cytochrome P450 family protein 0.002 0.0032 0.0056
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0559 0.5693 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0046 0.0046
Brugia malayi Cytochrome P450 family protein 0.005 0.0346 0.0608
Trichomonas vaginalis abcb9, putative 0.0021 0.0046 0.0124
Onchocerca volvulus 0.0099 0.0867 0.2989
Schistosoma mansoni carbonic anhydrase-related 0.0368 0.3683 0.5119
Echinococcus granulosus lamin 0.0027 0.0113 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.047 0.0821
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0246 0.0342
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0099 0.0867 0.1205
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0256 0.2263
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0256 0.0446
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.023 0.0617
Schistosoma mansoni rab6-interacting 0.004 0.0246 0.0342
Trypanosoma brucei carbonic anhydrase-like protein 0.0559 0.5693 1
Onchocerca volvulus 0.0021 0.0048 0.0122
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.023 1
Echinococcus multilocularis lamin 0.0027 0.0113 0.0157
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0112 0.1004 0.1396
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0113 0.0113
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0046 0.0064
Schistosoma mansoni carbonic anhydrase-related 0.0368 0.3683 0.5119
Echinococcus granulosus arginase 2 mitochondrial 0.0353 0.3532 0.4909
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0122 0.0169
Onchocerca volvulus 0.0021 0.0048 0.0122
Brugia malayi Cytochrome P450 family protein 0.002 0.0032 0.0056
Leishmania major cytochrome p450-like protein 0.002 0.0032 0.0052
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.1433 0.1433
Schistosoma mansoni lamin 0.0027 0.0113 0.0157
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0122 0.0169
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0122 0.0169
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.0186 0.0258
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0365 0.0641
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.0122
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0046 0.0124
Brugia malayi hypothetical protein 0.0099 0.0867 0.1523
Trypanosoma brucei DNA polymerase IV, putative 0.0055 0.0399 0.0697
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.053 0.0737
Brugia malayi Thioredoxin reductase 0.0049 0.0337 0.0592
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0559 0.5693 1
Schistosoma mansoni hypothetical protein 0.0021 0.0048 0.0067
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0046 0.0124
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0474 0.0658
Onchocerca volvulus 0.0021 0.0046 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0122 0.0214
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0013 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0122 0.0214
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0002 0.0003
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0039 0.0232 0.0407
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0046 0.0124
Brugia malayi ABC transporter family protein 0.0021 0.0046 0.0081
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0559 0.5693 0.7913
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.0122
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0046 0.0124
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0122 0.0169
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0046 0.0124
Trichomonas vaginalis abcb9, putative 0.0021 0.0046 0.0124
Leishmania major arginase 0.0353 0.3532 0.6203
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0046 0.0124
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0122 0.0169
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0013 0.0013
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0046 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0122 0.0169
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0368 0.3683 0.3683
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.047 0.1324
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0046 0.0124
Loa Loa (eye worm) carbonic anhydrase 3 0.0559 0.5693 0.5693
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0194
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0559 0.5693 0.7913
Echinococcus granulosus carbonic anhydrase 0.0368 0.3683 0.5119
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0112 0.1004 0.1396
Brugia malayi steroid hormone receptor 0.0028 0.0122 0.0214
Loa Loa (eye worm) hypothetical protein 0.004 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.0113
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0559 0.5693 0.5693
Schistosoma mansoni hypothetical protein 0.004 0.0246 0.0342
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0002 0.0004
Brugia malayi prostaglandin transporter 0.0099 0.0867 0.1523
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.0186 0.04
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.0046 0.0119
Brugia malayi sodium-independent organic anion transporter family protein 0.0099 0.0867 0.1523
Brugia malayi Protein kinase domain containing protein 0.0018 0.0013 0.0023
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0046 0.0124
Brugia malayi sodium-independent organic anion transporter family protein 0.0099 0.0867 0.1523
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0046 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0122 0.0122
Brugia malayi multidrug resistance protein 3 0.0021 0.0046 0.0081
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0122 0.0214
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.0122
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0039 0.0232 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0122 0.0214
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.023 0.0526
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0474 0.0658
Loa Loa (eye worm) hypothetical protein 0.0186 0.178 0.178
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0048
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0246 0.0342
Echinococcus granulosus RUN 0.004 0.0246 0.0342
Schistosoma mansoni carbonic anhydrase-related 0.0368 0.3683 0.5119
Schistosoma mansoni polycystin 1-related 0.004 0.0246 0.0342
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0048 0.0067
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0048
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0046 0.0124
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0046 0.0064
Brugia malayi hypothetical protein 0.0166 0.1568 0.2754
Plasmodium falciparum carbonic anhydrase 0.0368 0.3683 1
Echinococcus multilocularis follistatin 0.0039 0.0232 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0122 0.0214
Schistosoma mansoni carbonic anhydrase 0.0368 0.3683 0.5119
Echinococcus granulosus glycoprotein Antigen 5 0.0021 0.0048 0.0067
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0122 0.0122
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0122 0.0169
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.023 0.0643
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0046 0.0046
Brugia malayi MH2 domain containing protein 0.0245 0.2393 0.4203
Loa Loa (eye worm) glutathione reductase 0.0049 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0108
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.023 0.4821
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0046 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0122 0.0122
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.023 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0194 0.0341
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.1123 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.0046 1
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0246 0.0662
Schistosoma mansoni intermediate filament proteins 0.0027 0.0113 0.0157
Echinococcus multilocularis 0.0353 0.3532 0.4909
Schistosoma mansoni hypothetical protein 0.0172 0.1635 0.2272
Echinococcus multilocularis carbonic anhydrase 0.0368 0.3683 0.5119
Echinococcus granulosus single minded 2 0.0037 0.021 0.0291
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0337 0.0588
Toxoplasma gondii transporter, major facilitator family protein 0.0099 0.0867 0.2349
Loa Loa (eye worm) hypothetical protein 0.029 0.2871 0.2871
Leishmania major agmatinase-like protein 0.0128 0.1174 0.2059
Leishmania major carbonic anhydrase-like protein 0.0559 0.5693 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM In vitro anti-leishmanial activity against promastigote cultures of Leishmania infantum MON 235 ChEMBL. 12593656
IC50 (functional) > 100 uM In vitro anti-leishmanial activity against promastigote cultures of Leishmania donovani MON 703 ChEMBL. 12593656
IC50 (functional) > 100 uM Antileishmanial activity against Leishmania infantum LEM235 by MTT assay ChEMBL. 17158053
IC50 (functional) > 100 uM Antileishmanial activity against Leishmania donovani LEM703 by MTT assay ChEMBL. 17158053
IC50 (functional) > 100 uM In vitro anti-leishmanial activity against promastigote cultures of Leishmania infantum MON 235 ChEMBL. 12593656
IC50 (functional) > 100 uM In vitro anti-leishmanial activity against promastigote cultures of Leishmania donovani MON 703 ChEMBL. 12593656
IC50 (functional) > 100 uM Antileishmanial activity against Leishmania infantum LEM235 by MTT assay ChEMBL. 17158053
IC50 (functional) > 100 uM Antileishmanial activity against Leishmania donovani LEM703 by MTT assay ChEMBL. 17158053

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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